Next Article in Journal
Awareness and Knowledge About Preventive Vaccinations Among Patients with Hematological Malignancies
Previous Article in Journal
Evaluating the Immunogenicity of an Intranasal Microparticle Combination Vaccine for COVID-19 and Influenza
Previous Article in Special Issue
Understanding Reasons for Vaccination Hesitancy and Implementing Effective Countermeasures: An Online Survey of Individuals Unvaccinated against COVID-19
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Vaccines
Volume 13
Issue 3
10.3390/vaccines13030283
vaccines-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Efficacy of COVID-19 Vaccination in People Living with HIV/AIDS in a Northern Brazil: Cross-Sectional Study

by
Carolinne de Jesus Santos e Santos
1,
Ricardo Roberto de Souza Fonseca
2,
Sandra Souza Lima
2,
Thais Mayara da Silva Carvalho
2,
Letícia França das Mercês
2,
Maria Eduarda de Sousa Avelino
2,
Diogo Oliveira de Araújo
2,
Felipe Bonfim Freitas
3,
Igor Brasil-Costa
4,
Aldemir Branco Oliveira-Filho
5,
Antonio Carlos Rosário Vallinoto
1,2,† and
Luiz Fernando Almeida Machado
1,2,*,†
1
Biology of Infectious and Parasitic Agents Post-Graduate Program, Federal University of Pará, Belém 66075-110, PA, Brazil
2
Virology Laboratory, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil
3
Evandro Chagas Institute, Health Ministry of Brazil, Ananindeua 67030-000, PA, Brazil
4
Immunology Laboratory, Evandro Chagas Institute, Health Ministry of Brazil, Ananindeua 67030-000, PA, Brazil
5
Study and Research Group on Vulnerable Populations, Institute for Coastal Studies, Federal University of Pará, Bragança 68600-000, PA, Brazil
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Vaccines 2025, 13(3), 283; https://doi.org/10.3390/vaccines13030283
Submission received: 4 November 2024 / Revised: 26 February 2025 / Accepted: 5 March 2025 / Published: 7 March 2025
(This article belongs to the Special Issue Vaccination with Public Health Perspective: Prevention and Control Strategies)
Browse Figures
Versions Notes

Abstract

Background/Objectives: The evaluation of the efficacy of COVID-19 vaccination in immunocompromised individuals, such as people living with HIV/AIDS (PLWH), still is of great global importance. The present study aimed to describe the presence of anti-SARS-CoV-2 IgG antibodies in PLWH vaccinated and unvaccinated against COVID-19 in the city of Belém, northern Brazil. Methods: A cross-sectional study involving 510 PLWH was conducted from December 2021 to May 2022. Participants answered a sociodemographic questionnaire and subsequently underwent an anti-SARS-CoV-2 enzyme immunoassay for the detection of IgG antibodies, as well as quantification of CD4+ T lymphocytes and HIV-1 plasma viral load. Results: Most participants were male (70%), aged 25–50 years (72%), single (71.4%), and low-income (50.4%). The prevalence of anti-SARS-CoV-2 IgG antibodies was 94.3% (481/510), with most vaccinated individuals having received at least two doses of a COVID-19 vaccine. An association was observed between antibody levels and the number of vaccine doses, CD4+ T lymphocyte count, CD4+/CD8+ T lymphocyte ratio, and HIV-1 viral load. Conclusions: PLWH developed high levels of antibodies against SARS-CoV-2 after receiving the vaccine, demonstrating that COVID-19 vaccination is of fundamental importance for the protection against severe COVID-19 in this specific group of immunocompromised individuals.
Keywords: HIV; anti-SARS-CoV-2; COVID-19 vaccine; public health HIV; anti-SARS-CoV-2; COVID-19 vaccine; public health

Share and Cite

MDPI and ACS Style

Santos, C.d.J.S.e.; Fonseca, R.R.d.S.; Lima, S.S.; Carvalho, T.M.d.S.; das Mercês, L.F.; Avelino, M.E.d.S.; de Araújo, D.O.; Freitas, F.B.; Brasil-Costa, I.; Oliveira-Filho, A.B.; et al. Efficacy of COVID-19 Vaccination in People Living with HIV/AIDS in a Northern Brazil: Cross-Sectional Study. Vaccines 2025, 13, 283. https://doi.org/10.3390/vaccines13030283

AMA Style

Santos CdJSe, Fonseca RRdS, Lima SS, Carvalho TMdS, das Mercês LF, Avelino MEdS, de Araújo DO, Freitas FB, Brasil-Costa I, Oliveira-Filho AB, et al. Efficacy of COVID-19 Vaccination in People Living with HIV/AIDS in a Northern Brazil: Cross-Sectional Study. Vaccines. 2025; 13(3):283. https://doi.org/10.3390/vaccines13030283

Chicago/Turabian Style

Santos, Carolinne de Jesus Santos e, Ricardo Roberto de Souza Fonseca, Sandra Souza Lima, Thais Mayara da Silva Carvalho, Letícia França das Mercês, Maria Eduarda de Sousa Avelino, Diogo Oliveira de Araújo, Felipe Bonfim Freitas, Igor Brasil-Costa, Aldemir Branco Oliveira-Filho, and et al. 2025. "Efficacy of COVID-19 Vaccination in People Living with HIV/AIDS in a Northern Brazil: Cross-Sectional Study" Vaccines 13, no. 3: 283. https://doi.org/10.3390/vaccines13030283

APA Style

Santos, C. d. J. S. e., Fonseca, R. R. d. S., Lima, S. S., Carvalho, T. M. d. S., das Mercês, L. F., Avelino, M. E. d. S., de Araújo, D. O., Freitas, F. B., Brasil-Costa, I., Oliveira-Filho, A. B., Rosário Vallinoto, A. C., & Machado, L. F. A. (2025). Efficacy of COVID-19 Vaccination in People Living with HIV/AIDS in a Northern Brazil: Cross-Sectional Study. Vaccines, 13(3), 283. https://doi.org/10.3390/vaccines13030283

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop