Immunization against Hepatitis B Surface Antigen (HBsAg) in a Cohort of Nursing Students Two Decades after Vaccination: Surprising Feedback
Abstract
:1. Introduction
2. Materials and Methods
2.1. Serological Tests
2.2. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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n = 520 | Vaccination during Infancy (n = 436) | Vaccination during Adolescence (n = 84) | p-Value |
---|---|---|---|
Mean age ± DS | 20.5 ± 1.6 | 29.3 ± 4.9 | <0.001 |
Gender, n (%) | |||
Male | 147 (33.7) | 34 (40.5) | 0.14 |
Female | 289 (66.3) | 50 (59.5) | |
Years from vaccination, mean ± DS | 20.5 ± 1.6 | 17.3 ± 4.9 | <0.001 |
Anti-HBs titers, n (%) | |||
<10 mIU/mL | 298 (68.3) | 26 (31.0) | <0.001 |
≥10 mIU/mL | 138 (31.7) | 58 (69.0) |
Crude OR | 95% CI | p-Value | AdjOR | 95%CI | p-Value | |
---|---|---|---|---|---|---|
Years since HBV vaccination | 0.87 | 0.81–0.93 | <0.01 | 0.96 | 0.89–1.03 | 0.25 |
Gender | ||||||
Male | ref | 0.60 | ref | 0.80 | ||
Female | 0.90 | 0.62–1.31 | 0.95 | 0.64–1.40 | ||
HBV vaccination timing | ||||||
vaccinated during infancy | ref | <0.001 | ref | <0.001 | ||
vaccinated during adolescence | 4.81 | 2.90–7.97 | 4.21 | 2.43–7.30 |
Vaccination during Infancy n (%) | Vaccination during Adolescence n (%) | p-Value | |
---|---|---|---|
Anti-HBs titers at the control visit (third year), (n = 449) | |||
<10 mIU/mL | 75 (20.0) | 6 (8.1) | <0.01 |
≥10 mIU/mL | 300 (80.0) | 68 (91.9) | |
Anti-HBs titers at the control visit (third year) among students not boosted after their first visit, (n = 170) | |||
<10 mIU/mL | 23 (19.3) | 4 (7.9) | 0.06 |
≥10 mIU/mL | 96 (80.7) | 47 (92.1) | |
Anti-HBs titers at the control visit (third year) among students boosted after their first visit, (n = 279) | |||
<10 mIU/mL | 52 (20.3) | 2 (8.7) | 0.18 |
≥10 mIU/mL | 204 (79.7) | 21 (91.3) |
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Verso, M.G.; Costantino, C.; Vitale, F.; Amodio, E. Immunization against Hepatitis B Surface Antigen (HBsAg) in a Cohort of Nursing Students Two Decades after Vaccination: Surprising Feedback. Vaccines 2020, 8, 1. https://doi.org/10.3390/vaccines8010001
Verso MG, Costantino C, Vitale F, Amodio E. Immunization against Hepatitis B Surface Antigen (HBsAg) in a Cohort of Nursing Students Two Decades after Vaccination: Surprising Feedback. Vaccines. 2020; 8(1):1. https://doi.org/10.3390/vaccines8010001
Chicago/Turabian StyleVerso, Maria Gabriella, Claudio Costantino, Francesco Vitale, and Emanuele Amodio. 2020. "Immunization against Hepatitis B Surface Antigen (HBsAg) in a Cohort of Nursing Students Two Decades after Vaccination: Surprising Feedback" Vaccines 8, no. 1: 1. https://doi.org/10.3390/vaccines8010001
APA StyleVerso, M. G., Costantino, C., Vitale, F., & Amodio, E. (2020). Immunization against Hepatitis B Surface Antigen (HBsAg) in a Cohort of Nursing Students Two Decades after Vaccination: Surprising Feedback. Vaccines, 8(1), 1. https://doi.org/10.3390/vaccines8010001