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Volume 8
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Article

A Herpesvirus of Turkey-Based Vector Vaccine Reduces Transmission of Newcastle Disease Virus in Commercial Broiler Chickens with Maternally Derived Antibodies

by
Timea Tatár-Kis
1,
Egil A.J. Fischer
2,
Christophe Cazaban
3,
Edit Walkó-Kovács
1,
Zalan G. Homonnay
1,
Francisca C. Velkers
2,
Vilmos Palya
1 and
J. Arjan Stegeman
2,*
1
Scientific Support and Investigation Unit, Ceva-Phylaxia, 1107 Budapest, Hungary
2
Population Health Department, Veterinary Medicine Faculty, Utrecht University, 3584 CL Utrecht, The Netherlands
3
Science and Investigation Department, Ceva Animal Health, 33500 Libourne, France
*
Author to whom correspondence should be addressed.
Vaccines 2020, 8(4), 614; https://doi.org/10.3390/vaccines8040614
Submission received: 18 September 2020 / Revised: 8 October 2020 / Accepted: 13 October 2020 / Published: 16 October 2020
(This article belongs to the Special Issue Vaccine Research against Significant Viral Diseases of Poultry)
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Abstract

Newcastle Disease is one of the most important infectious poultry diseases worldwide and is associated with high morbidity, mortality, and economic loss. In several countries, vaccination is applied to prevent and control outbreaks; however, information on the ability of vaccines to reduce transmission of ND virus (NDV) is sparse. Here we quantified the transmission of velogenic NDV among 42-day-old broilers. Chickens were either vaccinated with a single dose of a vector vaccine expressing the F protein (rHVT-ND) at day-old in the presence of maternally derived antibodies or kept unvaccinated. Seeders were challenged 8 h before the co-mingling with the corresponding contacts from the same group. Infection was monitored by daily testing of cloacal and oro-nasal swabs with reverse transcription-real-time PCR and by serology. Vaccinated birds were completely protected against clinical disease and virus excretion was significantly reduced compared to the unvaccinated controls that all died during the experiment. The reproduction ratio, which is the average number of secondary infections caused by an infectious bird, was significantly lower in the vaccinated group (0.82 (95% CI 0.38–1.75)) than in the unvaccinated group (3.2 (95% CI 2.06–4.96)). Results of this study demonstrate the potential of rHVT-ND vaccine in prevention and control of ND outbreaks.
Keywords: recombinant vaccine; Newcastle disease; transmission; challenge experiment; shedding control; poultry; reproduction number; R recombinant vaccine; Newcastle disease; transmission; challenge experiment; shedding control; poultry; reproduction number; R

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MDPI and ACS Style

Tatár-Kis, T.; Fischer, E.A.J.; Cazaban, C.; Walkó-Kovács, E.; Homonnay, Z.G.; Velkers, F.C.; Palya, V.; Stegeman, J.A. A Herpesvirus of Turkey-Based Vector Vaccine Reduces Transmission of Newcastle Disease Virus in Commercial Broiler Chickens with Maternally Derived Antibodies. Vaccines 2020, 8, 614. https://doi.org/10.3390/vaccines8040614

AMA Style

Tatár-Kis T, Fischer EAJ, Cazaban C, Walkó-Kovács E, Homonnay ZG, Velkers FC, Palya V, Stegeman JA. A Herpesvirus of Turkey-Based Vector Vaccine Reduces Transmission of Newcastle Disease Virus in Commercial Broiler Chickens with Maternally Derived Antibodies. Vaccines. 2020; 8(4):614. https://doi.org/10.3390/vaccines8040614

Chicago/Turabian Style

Tatár-Kis, Timea, Egil A.J. Fischer, Christophe Cazaban, Edit Walkó-Kovács, Zalan G. Homonnay, Francisca C. Velkers, Vilmos Palya, and J. Arjan Stegeman. 2020. "A Herpesvirus of Turkey-Based Vector Vaccine Reduces Transmission of Newcastle Disease Virus in Commercial Broiler Chickens with Maternally Derived Antibodies" Vaccines 8, no. 4: 614. https://doi.org/10.3390/vaccines8040614

APA Style

Tatár-Kis, T., Fischer, E. A. J., Cazaban, C., Walkó-Kovács, E., Homonnay, Z. G., Velkers, F. C., Palya, V., & Stegeman, J. A. (2020). A Herpesvirus of Turkey-Based Vector Vaccine Reduces Transmission of Newcastle Disease Virus in Commercial Broiler Chickens with Maternally Derived Antibodies. Vaccines, 8(4), 614. https://doi.org/10.3390/vaccines8040614

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