Perspectives on New Vaccines against Arboviruses Using Insect-Specific Viruses as Platforms
Abstract
:1. Introduction
2. Overview of Health Public Problems Caused by Arboviruses
3. Currently Available Arbovirus Vaccines
4. Interaction between Insect-Specific Viruses and Arboviruses
5. Perspectives for the Prevention of Disease Caused by Arboviruses
5.1. ISVs as Platforms for Vaccine against Arboviruses
5.1.1. Advantages and Disadvantages of ISV-Based Vaccines
5.1.2. Perspectives for the Use of ISV-Based Vaccines
5.1.3. Strategies of Research
6. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Arboviruses | ISV | Strategy | Titers In Vitro | Animal Challenge | Reference (Year) |
---|---|---|---|---|---|
Chikungunya (CHIKV) | Eilat virus (EILV) | Development of a chimeric virus with EILV cDNA clone and the CHIKV structural proteins: E1, E2 and C | 1010 PFU/mL | C57BL/6 mouse, A129 IFNα/βR−/− mice, nonhuman primates (NHPs) (cynomolgus macaques) | 2017 |
Eastern equine encephalitis virus (EEEV), Venezuelan equine encephalitis virus (VEEV) | Eilat virus (EILV) | Development of a chimeric virus with EILV cDNA clone and the EEEV and VEEV structural proteins: E1, E2 and C | 106 to 108 PFU/mL | CD-1 mice | 2018 |
Dengue (DENV), Yellow Fever (YFV), Zika (ZIKV), West Nile (WNV), Japanese Encephalitis (JEV) | Binjari virus (BINJV) | Development of a chimeric virus using BINJV as backbone for structural protein genes (prME) of DENV, YFV, ZIKV, WNV and JEV | Up to 109.5 cell culture infectious dose/ml | Murine IFNAR−/− mouse models | 2019 |
Search Strategy | (Insect Specific Viruses Vaccine) and (Insect Specific Viruses, Vaccines, Arboviruses) | (Insect Specific Viruses, Vaccines) and (Insect Specific Viruses), Vaccines) | “Insect-Specific Viruses” “Vaccine” Not Review | “Insect-Specific Viruses” “Vaccine” “Arbovirus” Not Review |
---|---|---|---|---|
Source | Pubmed.gov | Pubmed.gov | Google Scholar | Google Scholar |
Time Frame | 1971–2020 | 1971–2020 | 1970–2021 | 1970–2021 |
Citation Number | 64 | 824 | 207 | 154 |
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Carvalho, V.L.; Long, M.T. Perspectives on New Vaccines against Arboviruses Using Insect-Specific Viruses as Platforms. Vaccines 2021, 9, 263. https://doi.org/10.3390/vaccines9030263
Carvalho VL, Long MT. Perspectives on New Vaccines against Arboviruses Using Insect-Specific Viruses as Platforms. Vaccines. 2021; 9(3):263. https://doi.org/10.3390/vaccines9030263
Chicago/Turabian StyleCarvalho, Valéria L., and Maureen T. Long. 2021. "Perspectives on New Vaccines against Arboviruses Using Insect-Specific Viruses as Platforms" Vaccines 9, no. 3: 263. https://doi.org/10.3390/vaccines9030263