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Volume 9
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10.3390/vaccines9050473
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Article

Comparative Evaluation of Lumpy Skin Disease Virus-Based Live Attenuated Vaccines

by
Andy Haegeman
1,*,
Ilse De Leeuw
1,
Laurent Mostin
2,
Willem Van Campe
2,
Laetitia Aerts
3,
Estelle Venter
4,5,
Eeva Tuppurainen
6,
Claude Saegerman
7 and
Kris De Clercq
1
1
Infectious Diseases in Animals, Exotic and Particular Diseases, Sciensano, Groeselenberg 99, B-1180 Brussels, Belgium
2
Experimental Center Machelen, Sciensano, Kerklaan 68, B-1830 Machelen, Belgium
3
EURL for Diseases Caused by Capripox Viruses, Sciensano, Groeselenberg 99, B-1180 Brussels, Belgium
4
Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Onderstepoort 0110, South Africa
5
College of Public Health, Medical and Veterinary Sciences, Discipline: Veterinary Science, James Cook University, Townsville, QLD 4811, Australia
6
Institut für Internationale Tiergesundheit/One Health, Friedrich-Loeffler-Institut Federal Research Institute for Animal Health, 17489 Greifswald-Insel Riems, Germany
7
Fundamental and Applied Research for Animals & Health (FARAH) Center, Research Unit of Epidemiology and Risk Analysis Applied to Veterinary Sciences (UREAR-ULiège), Faculty of Veterinary Medicine, University of Liege, 4000 Liege, Belgium
*
Author to whom correspondence should be addressed.
Vaccines 2021, 9(5), 473; https://doi.org/10.3390/vaccines9050473
Submission received: 31 March 2021 / Revised: 28 April 2021 / Accepted: 3 May 2021 / Published: 8 May 2021
(This article belongs to the Special Issue Controlled Clinical Evaluation of Veterinary Vaccines)
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Abstract

Vaccines form the cornerstone of any control, eradication and preventative strategy and this is no different for lumpy skin disease. However, the usefulness of a vaccine is determined by a multiplicity of factors which include stability, efficiency, safety and ease of use, to name a few. Although the vaccination campaign in the Balkans against lumpy skin disease virus (LSDV) was successful and has been implemented with success in the past in other countries, data of vaccine failure have also been reported. It was therefore the purpose of this study to compare five homologous live attenuated LSDV vaccines (LSDV LAV) in a standardized setting. All five LSDV LAVs studied were able to protect against a challenge with virulent LSDV. Aside from small differences in serological responses, important differences were seen in side effects such as a local reaction and a Neethling response upon vaccination between the analyzed vaccines. These observations can have important implications in the applicability in the field for some of these LSDV LAVs.
Keywords: lumpy skin disease; vaccine evaluation; live attenuated vaccines; lumpy skin disease vaccine lumpy skin disease; vaccine evaluation; live attenuated vaccines; lumpy skin disease vaccine

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MDPI and ACS Style

Haegeman, A.; De Leeuw, I.; Mostin, L.; Campe, W.V.; Aerts, L.; Venter, E.; Tuppurainen, E.; Saegerman, C.; De Clercq, K. Comparative Evaluation of Lumpy Skin Disease Virus-Based Live Attenuated Vaccines. Vaccines 2021, 9, 473. https://doi.org/10.3390/vaccines9050473

AMA Style

Haegeman A, De Leeuw I, Mostin L, Campe WV, Aerts L, Venter E, Tuppurainen E, Saegerman C, De Clercq K. Comparative Evaluation of Lumpy Skin Disease Virus-Based Live Attenuated Vaccines. Vaccines. 2021; 9(5):473. https://doi.org/10.3390/vaccines9050473

Chicago/Turabian Style

Haegeman, Andy, Ilse De Leeuw, Laurent Mostin, Willem Van Campe, Laetitia Aerts, Estelle Venter, Eeva Tuppurainen, Claude Saegerman, and Kris De Clercq. 2021. "Comparative Evaluation of Lumpy Skin Disease Virus-Based Live Attenuated Vaccines" Vaccines 9, no. 5: 473. https://doi.org/10.3390/vaccines9050473

APA Style

Haegeman, A., De Leeuw, I., Mostin, L., Campe, W. V., Aerts, L., Venter, E., Tuppurainen, E., Saegerman, C., & De Clercq, K. (2021). Comparative Evaluation of Lumpy Skin Disease Virus-Based Live Attenuated Vaccines. Vaccines, 9(5), 473. https://doi.org/10.3390/vaccines9050473

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