Imaging Biomarkers in Animal Models of Drug-Induced Lung Injury: A Systematic Review

Round 1

Reviewer 1 Report

This is a severe interessant and extensive Review about imaging biomarkers in animal models of drug-induced lung injury, which describes adequately and extensively advantages and pitfalls of these imaging biomarkers. I have no specific comments or suggestions.

Reviewer 2 Report

In this study, the authors performed a comprehensive systematic search and analysis of the published data on imaging biomarkers in animal models of drug-induced lung injury. Drug pneumotoxicity is an important cause for interstitial lung disease (ILD) and should be taken into account for the differential diagnosis of the group of ILDs of known causes or associations. Due to non-specific radiologic patterns of drug pneumotoxicity and an increasing number of drugs with potency to trigger lung injury it would be of interest to develop imaging biomarkers which could improve the often difficult differential diagnosis of ILD and help identify subjects in whom simple drug withdrawal may not be enough to stop the progression of lung lesions. The study protocol and design are appropriate and the extracted data are interesting. Limitations of the study are recognized by the authors. This systematic review provides an overview of imaging techniques employed for the study of drug-induced lung injury and points out unmet needs for future development. The manuscript is also well-organized and written.

Reviewer 3 Report

The review was carried out according to international guidelines. The topic of the review has been adequately investigated and commented on in all its aspects.