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Article

Effect of Significant Coronary Artery Stenosis on Prognosis in Patients with Vasospastic Angina: A Propensity Score-Matched Analysis

by
Hyun-Jin Kim
1,†,
Min-Ho Lee
2,†,
Sang-Ho Jo
3,*,
Won-Woo Seo
4,
Hack-Lyoung Kim
5,
Kwan-Yong Lee
6,
Tae-Hyun Yang
7,
Sung-Ho Her
8,
Seung-Hwan Han
9,
Byoung-Kwon Lee
10,
Keun-Ho Park
11,
Seung-Woon Rha
12,
Hyeon-Cheol Gwon
13,
Dong-Ju Choi
14 and
Sang-Hong Baek
15
1
Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine, Seoul 04763, Korea
2
Division of Cardiology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul 04401, Korea
3
Cardiovascular Center, Hallym University Sacred Heart Hospital, Anyang-si 14068, Korea
4
Division of Cardiology, Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul 05355, Korea
5
Cardiovascular Center, Seoul National University Boramae Medical Center, Seoul 07061, Korea
6
Department of Cardiovascular Medicine, Incheon St. Mary’s Hospital, The Catholic University of Korea, Incheon 21431, Korea
7
Department of Cardiovascular Medicine, Busan Paik Hospital, Inje University, Busan 47392, Korea
8
Department of Cardiovascular Medicine, St. Vincent’s Hospital, The Catholic University of Korea, Suwon 16247, Korea
9
Department of Cardiovascular Medicine, Gil Medical Center, Gachon University, Incheon 21565, Korea
10
Department of Cardiovascular Medicine, Gangnam Severance Hospital, Yonsei University, Seoul 06273, Korea
11
The Heart Center, Chosun Medical Center, Gwangju 61453, Korea
12
Department of Cardiovascular Medicine, Guro Hospital, Korea University, Seoul 08308, Korea
13
Department of Cardiovascular Medicine, Samsung Medical Center, Sungkyunkwan University, Seoul 06351, Korea
14
Division of Cardiology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam 13620, Korea
15
Division of Cardiology, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul 06649, Korea
 
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*
Author to whom correspondence should be addressed.
†
Hyun-Jin Kim and Min-Ho Lee are co-first authors, and both authors contributed equally to this manuscript.
J. Clin. Med. 2021, 10(15), 3341; https://doi.org/10.3390/jcm10153341
Submission received: 14 July 2021 / Revised: 25 July 2021 / Accepted: 27 July 2021 / Published: 28 July 2021
(This article belongs to the Section Cardiology)
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Abstract

Vasospastic angina (VA) is a functional disease of the coronary artery and occurs in an angiographically normal coronary artery. However, it may also occur with coronary artery stenosis. We investigated the effect of coronary artery stenosis on clinical outcomes in VA patients. Study data were obtained from a prospective multicenter registry that included patients who had symptoms of VA. Patients were classified into two groups according to presence of significant coronary artery stenosis. Among 1920 patients with VA, 189 patients were classified in the “significant stenosis” group. The one-year composite clinical events rate was significantly higher in the significant stenosis group than in the “no significant stenosis” group (5.8% vs. 1.4%, respectively; p < 0.001). Additionally, the prevalence of ACS was significantly greater in the “significant stenosis” group (4.8% vs. 0.9%, respectively; p < 0.001). After propensity score matching, the adverse effects of significant stenosis remained. In addition, significant stenosis was independently associated with a 6.67-fold increased risk of ACS in VA patients. In conclusion, significant coronary artery stenosis can increase the adverse clinical outcomes in VA patients at long-term follow-up. Clinicians should manage traditional risk factors associated with atherosclerosis and control vasospasm as well as reduce the burden of atherosclerosis.
Keywords: vasospastic angina; coronary artery stenosis; acute coronary syndrome vasospastic angina; coronary artery stenosis; acute coronary syndrome

Share and Cite

MDPI and ACS Style

Kim, H.-J.; Lee, M.-H.; Jo, S.-H.; Seo, W.-W.; Kim, H.-L.; Lee, K.-Y.; Yang, T.-H.; Her, S.-H.; Han, S.-H.; Lee, B.-K.; et al. Effect of Significant Coronary Artery Stenosis on Prognosis in Patients with Vasospastic Angina: A Propensity Score-Matched Analysis. J. Clin. Med. 2021, 10, 3341. https://doi.org/10.3390/jcm10153341

AMA Style

Kim H-J, Lee M-H, Jo S-H, Seo W-W, Kim H-L, Lee K-Y, Yang T-H, Her S-H, Han S-H, Lee B-K, et al. Effect of Significant Coronary Artery Stenosis on Prognosis in Patients with Vasospastic Angina: A Propensity Score-Matched Analysis. Journal of Clinical Medicine. 2021; 10(15):3341. https://doi.org/10.3390/jcm10153341

Chicago/Turabian Style

Kim, Hyun-Jin, Min-Ho Lee, Sang-Ho Jo, Won-Woo Seo, Hack-Lyoung Kim, Kwan-Yong Lee, Tae-Hyun Yang, Sung-Ho Her, Seung-Hwan Han, Byoung-Kwon Lee, and et al. 2021. "Effect of Significant Coronary Artery Stenosis on Prognosis in Patients with Vasospastic Angina: A Propensity Score-Matched Analysis" Journal of Clinical Medicine 10, no. 15: 3341. https://doi.org/10.3390/jcm10153341

APA Style

Kim, H.-J., Lee, M.-H., Jo, S.-H., Seo, W.-W., Kim, H.-L., Lee, K.-Y., Yang, T.-H., Her, S.-H., Han, S.-H., Lee, B.-K., Park, K.-H., Rha, S.-W., Gwon, H.-C., Choi, D.-J., & Baek, S.-H. (2021). Effect of Significant Coronary Artery Stenosis on Prognosis in Patients with Vasospastic Angina: A Propensity Score-Matched Analysis. Journal of Clinical Medicine, 10(15), 3341. https://doi.org/10.3390/jcm10153341

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