Catalase Predicts In-Hospital Mortality after Out-of-Hospital Cardiac Arrest
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Baseline Characteristics
3.2. Catalase and 30-Day Mortality of OHCA Survivors
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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UniProt ID | Protein Name | Gene Name | Peptide Sequence | Precursor m/z | Precursor Charge | Product m/z | Product Charge | Fragment Ion | Collision Energy |
---|---|---|---|---|---|---|---|---|---|
P04040 | Catalase | CAT | FNTANDDNVTQVR | 747.35 | 2 | 1131.54 | 1 | y10 | 22.1 |
P04040 | Catalase | CAT | FNTANDDNVTQVR | 747.35 | 2 | 1060.5 | 1 | y9 | 22.1 |
P04040 | Catalase | CAT | FNTANDDNVTQVR | 747.35 | 2 | 831.43 | 1 | y7 | 22.1 |
Total Study Population (n = 96) | Low Catalase (n = 48) | High Catalase (n = 48) | p-Value | |
---|---|---|---|---|
Age, yr, median (IQR) | 58 (48–69) | 56 (46–69) | 59 (50–69) | 0.548 |
Female sex, n (%) | 22 (22.9) | 8 (16.7) | 14 (29.2) | 0.145 |
Cardiac arrest witnessed, n (%) | 79 (82.3) | 40 (83.3) | 39 (81.3) | 0.789 |
Location of collapse | 0.66 | |||
Private, n (%) | 47 (49.0) | 28 (58.3) | 19 (39.6) | |
Public, n (%) | 49 (51.0) | 20 (41.7) | 29 (60.4) | |
Cause of cardiac arrest (%) | 0.629 | |||
Cardiac, n (%) | 83 (86.5) | 43 (89.6) | 40 (83.3) | |
Pulmonary, n (%) | 11 (11.5) | 4 (8.3) | 7 (14.6) | |
Unknown, n (%) | 2 (2.1) | 1 (2.1) | 1 (2.1) | |
First monitored rhythm (%) | 0.234 | |||
Shockable rhythm | ||||
Ventricular fibrillation, n (%) | 69 (71.9) | 38 (79.2) | 31 (64.6) | |
Ventricular tachycardia, n (%) | 1 (1.0) | 1 (2.1) | 0 (0.0) | |
Asystole, n (%) | 9 (9.4) | 2 (4.2) | 7 (14.6) | |
Pulseless electrical activity, n (%) | 13 (13.5) | 6 (12.5) | 7 (14.6) | |
Unknown first rhythm, n (%) | 4 (4.2) | 1 (2.1) | 3 (6.3) | |
Time from cardiac arrest to event—in minutes | ||||
Start of life support, min, median (IQR) | 11 (3–14) | 11 (1–14) | 11 (4–15) | 0.926 |
Return of spontaneous circulation, min, median (IQR) | 28 (15–44) | 27 (15–43) | 32 (15–46) | 0.755 |
Administration of epinephrine, min, median (IQR) | 11 (9–15) | 12 (11–15) | 11 (5–15) | 0.263 |
Dose of epinephrine administered, mg, median (IQR) | 3 (2–5) | 3 (1–5) | 4 (3–5) | 0.225 |
Mode of cooling | 0.509 | |||
Invasive, n (%) | 71 (74.0) | 34 (70.8) | 37 (77.1) | |
Non-invasive, n (%) | 13 (13.5) | 8 (16.7) | 5 (10.4) | |
Combined, n (%) | 8 (8.3) | 5 (10.4) | 3 (6.3) | |
Unknown, n (%) | 4 (4.2) | 1 (2.1) | 3 (6.3) | |
Medical history | ||||
Hypertension, n (%) | 35 (36.5) | 20 (41.7) | 15 (31.3) | 0.289 |
History of smoking, n (%) | 37 (38.5) | 18 (37.5) | 19 (39.6) | 0.834 |
Diabetes, n (%) | 15 (15.6) | 6 (12.5) | 9 (18.8) | 0.374 |
Acute myocardial infarction, n (%) | 16 (16.7) | 10 (20.8) | 6 (12.5) | 0.273 |
COPD, n (%) | 10 (10.4) | 3 (6.3) | 7 (14.6) | 0.181 |
Coronary artery disease, n (%) | 18 (18.8) | 11 (22.9) | 7 (14.6) | 0.296 |
Laboratory values at admission | ||||
Catalase, median (IQR) | 8.25 (7.64–8.81) | |||
pO2 mmHg, median (IQR) | 61.15 (25.68–215.00) | 61.15 (24.80–61.15) | 65.5 (27.50–191.00) | 0.793 |
pCO2 mmHg, median (IQR) | 15.70 (7.48–23.85) | 12.25 (7.33–21.10) | 16.10 (10.25–26.00) | 0.155 |
pH, median (IQR) | 7.18 (7.08–7.23) | 7.18 (7.11–7.25) | 7.16 (7.07–7.22) | 0.199 |
Sodium mmol/L, median (IQR) | 138 (136–140) | 138 (136–140) | 138 (136–139) | 0.490 |
Potassium mmol/L, median (IQR) | 3.85 (3.48–4.54) | 3.73 (3.46–4.70) | 3.92 (3.60–4.53) | 0.732 |
Bicarbonate mmol/L, median (IQR) | 8.30 (5.88–10.93) | 8.50 (4.70–10.93) | 8.30 (6.33–11.10) | 0.401 |
Base excess mmol/L, median (IQR) | 9.10 (6.00–12.75) | 8.40 (4.88–12.55) | 9.85 (7.23–12.90) | 0.120 |
Lactate mmol/L, median (IQR) | 7.20 (4.90–9.90) | 6.70 (4.60–9.55) | 7.50 (5.55–10.75) | 0.207 |
Creatinine, mg/dL, median (IQR) | 1.27 (1.04–1.54) | 1.33 (1.00–1.57) | 1.26 (1.05–1.50) | 0.573 |
Blood urea nitrate, mg/dL, median (IQR) | 15.10 (12.00–19.90) | 15.50 (10.90–20.05) | 14.95 (12.38–19.68) | 0.994 |
NT-proBNP, pg/mL, median (IQR) | 441 (118–1862) | 333 (87–2070) | 799 (145–1552) | 0.595 |
S100B, µg/L, median (IQR) | 0.10 (0.06–0.21) | 0.09 (0.06–0.15) | 0.12 (0.08–0.30) | 0.025 |
Neuron specific enolase, µg/L, median (IQR) | 30.65 (17.85–74.18) | 27.80 (14.33–49.05) | 35.45 (19.55–87.38) | 0.07 |
Univariate Models | Multivariable Models | |||
---|---|---|---|---|
Parameter | HR (95% CI) | p-value | HR (95% CI) | p-value |
Catalase | 2.26 (1.49–3.42) | <0.001 | 2.13 (1.07–4.23) | 0.032 |
Clinical Confounders | ||||
Age, years * | 1.02 (0.99–1.06) | 0.130 | 1.05 (1.00–1.11) | 0.052 |
Presence of a shockable rhythm | 0.18 (0.07–0.406) | <0.001 | 0.35 (0.11–1.06) | 0.063 |
Time to ROSC, min * | 1.00 (0.98–1.02) | 0.961 | 1.00 (0.98–1.01) | 0.822 |
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Früh, A.; Bileck, A.; Muqaku, B.; Wurm, R.; Neuditschko, B.; Arfsten, H.; Galli, L.; Kriechbaumer, L.; Hubner, P.; Goliasch, G.; et al. Catalase Predicts In-Hospital Mortality after Out-of-Hospital Cardiac Arrest. J. Clin. Med. 2021, 10, 3906. https://doi.org/10.3390/jcm10173906
Früh A, Bileck A, Muqaku B, Wurm R, Neuditschko B, Arfsten H, Galli L, Kriechbaumer L, Hubner P, Goliasch G, et al. Catalase Predicts In-Hospital Mortality after Out-of-Hospital Cardiac Arrest. Journal of Clinical Medicine. 2021; 10(17):3906. https://doi.org/10.3390/jcm10173906
Chicago/Turabian StyleFrüh, Anton, Andrea Bileck, Besnik Muqaku, Raphael Wurm, Benjamin Neuditschko, Henrike Arfsten, Lukas Galli, Lukas Kriechbaumer, Pia Hubner, Georg Goliasch, and et al. 2021. "Catalase Predicts In-Hospital Mortality after Out-of-Hospital Cardiac Arrest" Journal of Clinical Medicine 10, no. 17: 3906. https://doi.org/10.3390/jcm10173906