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Volume 10
Issue 21
10.3390/jcm10214839
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Article
Peer-Review Record

Extracorporeal Membrane Oxygenation for COVID 2019-Acute Respiratory Distress Syndrome: Comparison between First and Second Waves (Stage 2)

J. Clin. Med. 2021, 10(21), 4839; https://doi.org/10.3390/jcm10214839
by Nicolas Dognon 1, Alexandre Gaudet 1,2, Erika Parmentier-Decrucq 1, Sylvain Normandin 1, André Vincentelli 3,4, Mouhamed Moussa 4,5, Julien Poissy 1,6, Thibault Duburcq 1,* and Lille Intensive Care COVID-19 Group †
Reviewer 1: Anonymous
Reviewer 2:
Chamira Rodrigo
Reviewer 3: Anonymous
J. Clin. Med. 2021, 10(21), 4839; https://doi.org/10.3390/jcm10214839
Submission received: 8 September 2021 / Revised: 15 October 2021 / Accepted: 19 October 2021 / Published: 21 October 2021
(This article belongs to the Section Intensive Care)

Round 1

Reviewer 1 Report

With great interest I read the manuscript "Extracorporeal Membrane Oxygenation for COVID 2019-acute respiratory distress syndrome: Comparison between first and second waves".

It is extremely well investigated, worked off and written.

Author Response

Dear Reviewer, 

Please find attached our author's reply to the Review Report

With kind regards 

Author Response File: Author Response.pdf

Reviewer 2 Report

The authors have undertaken a study to compare ECMO outcomes between two waves of the SARS-CoV-2 pandemic. The finding of increased mortality during the second wave is an interesting finding, and the hypotheses generated to explain this finding seem reasonable. The meaningfulness of the data however, is limited due to the weaknesses already discussed by the authors (retrospective single center design, small size, residual confounding etc).

In addition to demographics, and treatment factors, were there differences in circulating virus strains between the first and second wave?

Author Response

Dear Reviewer, 

Please find attached our author's reply to the Review Report 

With kind regards

Author Response File: Author Response.pdf

Reviewer 3 Report

This paper analyze differences in V-V ECMO patients between 1th and 2nd waves in a single tertiary center. I appreciated the precise analysis of the ventilation mode during ECMO run. Regarding discussion, I have some suggestions. I think it would be necessary to point out the different "workload" on the national health system between two waves: don't you think that different survival rate is related to a selection bias (was patients' access to advanced care like ECMO the same in the first wave?)? I think it would be very interesting to discuss mortality rate between similar age groups in the two waves, and not only data regarding ECMO patients. Moreover, please use CONSORT flowchart for figure 1 (http://www.consort-statement.org/consort-statement/flow-diagram)

Author Response

Dear Reviewer, 

Please find attached our author's reply to the Review Report 

With kind regards

Author Response File: Author Response.pdf

Round 2

Reviewer 3 Report

Paper was properly revised

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