Albuminuria Pre-Emptively Identifies Cardiac Patients at Risk of Contrast-Induced Nephropathy
Abstract
:1. Introduction
2. Materials and Methods
2.1. Ethical Aspects
2.2. Patients and Clinical Protocol
2.3. Data Collection
2.4. Collection of Samples
2.5. Quantification of Early Kidney Damage Biomarkers in Urine Samples
2.6. Analysis of Biomarkers of Predisposition to Kidney Damage
2.7. Statistical Analysis
3. Results
3.1. Patient Characteristics and the Contrast Media Used
3.2. Evaluation of Urinary Biomarkers
3.3. Ability of Risk Factors and Biomarkers of Predisposition to Predict the Development of CIN
Parameter | B (Mean ± SEM) | Wald | p-Value |
---|---|---|---|
Constant | −2.53 ± 0.40 | 40.60 | <0.001 |
Urinary albumin | 0.11 ± 0.02 | 20.76 | <0.001 |
Sensitivity: 95.4%; Specificity: 52.2%; Total percentage: 86.4% | |||
Model summary: −2LL: 82.32; Cox and Snell’s R2: 0.24; Nagelkerke’s R2: 0.38 | |||
Variables discarded by the model: Transferrin (p-value = 0.295) GM2AP (p-value = 0.051) Age (p-value = 0.913) BMI (p-value = 0.444) eGFR CKD-EPI (p-value = 0.736) |
3.4. Risk and Incidence of CIN Based on Albuminuria
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Controls (n = 122) | CIN (n = 31) | p-Value | |
---|---|---|---|
Gender (% men) | 76.2 | 71.0 | n.s. |
Age (years) | 76 (39, 92) | 81 (41, 90) | <0.01 |
BMI (kg/m2) | 27.6 (19.4, 50.8) | 26.6 (17.3, 42.8) | <0.05 |
Arterial hypertension (%) | 55.2 | 70.4 | n.s. |
Diabetes mellitus (%) | 27.6 | 33.3 | n.s. |
Hypercholesterolemia (%) | 37.7 | 33.3 | n.s. |
Dyslipidemia (%) | 43.1 | 33.3 | n.s. |
Smoking (%) | 18.1 | 11.1 | n.s. |
Previous kidney failure (%) | 5.2 | 7.4 | n.s. |
Plasma creatinine (mg/dL) | 0.96 (0.53, 3.63) | 1.09 (0.34, 2.99) | n.s. |
eGFR MDRD-IDMS (mL/min/1.73 m2) | 75.3 (16.3, 134.0) | 55.2 (15.0, 180.9) | n.s. |
eGFR CKD-EPI (mL/min/1.73 m2) | 76.5 (14.5, 118.5) | 53.4 (14.1, 126.6) | <0.05 |
Contrast type (Iohexol/Iodixanol/Other/Unknown) | 27/84/2/9 | 5/22/0/4 | n.s. |
Volume of contrast medium administered (mL) Contrast delivered volume | 250 (17, 820) | 300 (90, 500) | n.s. |
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Vicente-Vicente, L.; Casanova, A.G.; Hernández-Sánchez, M.T.; Prieto, M.; Martínez-Salgado, C.; López-Hernández, F.J.; Cruz-González, I.; Morales, A.I. Albuminuria Pre-Emptively Identifies Cardiac Patients at Risk of Contrast-Induced Nephropathy. J. Clin. Med. 2021, 10, 4942. https://doi.org/10.3390/jcm10214942
Vicente-Vicente L, Casanova AG, Hernández-Sánchez MT, Prieto M, Martínez-Salgado C, López-Hernández FJ, Cruz-González I, Morales AI. Albuminuria Pre-Emptively Identifies Cardiac Patients at Risk of Contrast-Induced Nephropathy. Journal of Clinical Medicine. 2021; 10(21):4942. https://doi.org/10.3390/jcm10214942
Chicago/Turabian StyleVicente-Vicente, Laura, Alfredo G. Casanova, M. Teresa Hernández-Sánchez, Marta Prieto, Carlos Martínez-Salgado, Francisco J. López-Hernández, Ignacio Cruz-González, and Ana I. Morales. 2021. "Albuminuria Pre-Emptively Identifies Cardiac Patients at Risk of Contrast-Induced Nephropathy" Journal of Clinical Medicine 10, no. 21: 4942. https://doi.org/10.3390/jcm10214942