Macular Structure–Function Relationships of All Retinal Layers in Primary Open-Angle Glaucoma Assessed by Microperimetry and 8 × 8 Posterior Pole Analysis of OCT
Abstract
:1. Introduction
2. Materials and Methods
- Caucasian race and age between 40 and 90 years;
- Diagnosis of primary open-angle glaucoma (POAG) with threat to fixation according to our clinical records;
- Refractive error of 3 dioptres or less of spherical equivalent and;
- Best corrected visual acuity of 0.5 or better in the Snellen scale.
- Intraocular pressure > 21 mmHg in at least three different days;
- Glaucomatous optic disc changes and/or characteristic glaucomatous SAP abnormalities, as judged by a glaucoma specialist (J.J.G.M.), and;
- Open anterior chamber angle in gonioscopy.
- Previous intraocular or refractive surgery, or laser procedure in the six months before the recruitment;
- History of ocular trauma;
- Use of ocular or systemic medications that could affect the VF;
- Presence of other ophthalmic or systemic significant diseases (eyelid, corneal, lens or retinal disease, diabetes) that could influence microperimetry or OCT results.
- Autorefractometry;
- Best Corrected Visual Acuity (BCVA), using decimal scale;
- Intraocular pressure estimation using applanation tonometry.
- The nearest stimuli from vertical and horizontal main axes were located at 1.5 degrees from these axes;
- The stimuli were separated 3 degrees from each.
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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Demographic and Clinical Data | Glaucoma Group | Control Group | Significance (Test) |
---|---|---|---|
Eyes and laterality | n = 60 Right eyes = 30 Left eyes = 30 | n = 31 Right eyes = 15 Left eyes = 16 | 1 (Fisher’s test) |
Age (years) | 73 (15) | 67 (31) | 0.07 (Mann–Whitney test) |
Sex | 29 men 32 women | 9 men 22 women | 0.11 (Fisher’s test) |
BCVA | 0.9 (0.3) | 1 (1.9) | 0.07 (Mann–Whitney test) |
IOP (mmHg) | 20 (7) | 17 (4) | 0.004 (Mann–Whitney test) |
Spherical equivalent | 0.25 (4) | 1 (2) | 0.04 (Mann–Whitney test) |
Vertical cupping | 0.8 (0.3) | 0.4 (0.2) | <0.001 (Mann–Whitney test) |
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Garcia-Medina, J.J.; Rotolo, M.; Rubio-Velazquez, E.; Pinazo-Duran, M.D.; del-Rio-Vellosillo, M. Macular Structure–Function Relationships of All Retinal Layers in Primary Open-Angle Glaucoma Assessed by Microperimetry and 8 × 8 Posterior Pole Analysis of OCT. J. Clin. Med. 2021, 10, 5009. https://doi.org/10.3390/jcm10215009
Garcia-Medina JJ, Rotolo M, Rubio-Velazquez E, Pinazo-Duran MD, del-Rio-Vellosillo M. Macular Structure–Function Relationships of All Retinal Layers in Primary Open-Angle Glaucoma Assessed by Microperimetry and 8 × 8 Posterior Pole Analysis of OCT. Journal of Clinical Medicine. 2021; 10(21):5009. https://doi.org/10.3390/jcm10215009
Chicago/Turabian StyleGarcia-Medina, Jose Javier, Maurilia Rotolo, Elena Rubio-Velazquez, Maria Dolores Pinazo-Duran, and Monica del-Rio-Vellosillo. 2021. "Macular Structure–Function Relationships of All Retinal Layers in Primary Open-Angle Glaucoma Assessed by Microperimetry and 8 × 8 Posterior Pole Analysis of OCT" Journal of Clinical Medicine 10, no. 21: 5009. https://doi.org/10.3390/jcm10215009