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COVID-19 in Children with Down Syndrome: Data from the Trisomy 21 Research Society Survey

J. Clin. Med. 2021, 10(21), 5125; https://doi.org/10.3390/jcm10215125

by David Emes^1,†, Anke Hüls^2,3,†

, Nicole Baumer⁴, Mara Dierssen^5,6,7, Shiela Puri⁸, Lauren Russell², Stephanie L. Sherman⁹, Andre Strydom^10,11,12, Stefania Bargagna¹³, Ana Cláudia Brandão¹⁴, Alberto C. S. Costa¹⁵

, Patrick T. Feany², Brian Allen Chicoine¹⁶

, Sujay Ghosh¹⁷

, Anne-Sophie Rebillat¹⁸, Giuseppina Sgandurra^13,19

, Diletta Valentini²⁰, Tilman R. Rohrer²¹, Johannes Levin^22,23,24, Monica Lakhanpaul^{25,26,27,*,‡}

and on behalf of the Trisomy 21 Research Society COVID-19 Initiative Study Group^§ Show full author list Hide full author list

Reviewer 1: Anonymous

Reviewer 2: Anonymous

J. Clin. Med. 2021, 10(21), 5125; https://doi.org/10.3390/jcm10215125

Submission received: 21 September 2021 / Revised: 21 October 2021 / Accepted: 27 October 2021 / Published: 31 October 2021

(This article belongs to the Section Mental Health)

Round 1

Reviewer 1 Report

This comprehensive international study on COVID19 in children with Down syndrome provided much needed information on the clinical presentation and the risk factors of COVID 19 in this special population. The manuscript is well-organized, clear and understandable. Conclusions provide critical data for rational guidelines, but are balanced with caveats and explanation of limitations. This study was only possible with the cooperation of many investigators in different disciplines, and is an example of important research that can be accomplished in a short period of time with clinical usefulness for a vulnerable population.

I have a few minor questions and edits:

Under Materials and Methods, T21 DS Survey, line 2 " … individuals with DS who had COVID-192 ." ( delete 2)
Likewise, Discussion 4.1 Hospitalization and Outcomes , line 6 "...much lower than for adults with DS2, …" (delete 2)
Discussion 4.1 Hospitalization and Outcomes, paragraph 2, " Risk factors for a severe course of COFID-19 are well-documented for the adult population, …" Suggest … "adult GENERAL population" (for clarity).
Discussion 4.1 Hospitalization and Outcomes, paragraph 3, "Pre-existing epilepsy as a risk factor for infection..." This point was unclear. Either provide elaboration or eliminate reference to infection,
Section 4.1, paragraph 3, line 19: "ACE" should be spelled out if this is the first appearance of this term.
On the same line : …"(TMPRSS2) TMPRSS2..." (delete the duplicate)
Section 4.3, paragraph 2 lines2 & 3: " We had limited data concerning about..." Use one word or the other not both.

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COVID-19 in Children with Down Syndrome: Data from the Trisomy 21 Research Society Survey

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