The Efficacy, Safety and Satisfaction Associated with Switching from Brinzolamide 1% and Brimonidine 0.1% to a Fixed Combination of Brinzolamide 1% and Brimonidine 0.1% in Glaucoma Patients
, Kazuyuki Hirooka 1,*, Mikio Nagayama 2, Atsushi Hirota 3, Hideki Mochizuki 4, Takeshi Sagara 5, Katsuyoshi Suzuki 6, Hideaki Okumichi 1 and Yoshiaki Kiuchi 1
Sylvain Roy
Round 1
Reviewer 1 Report
The purpose of this study is to evaluate glaucoma patients for the efficacy, safety and satisfaction associated with switching from brinzolamide 1% and brimonidine 0.1% to a fixed combination of brinzolamide 1% and brimonidine 0.1%. And they concluded both an improvement of the degree of SPK and an increase in treatment satisfaction occurred after switching from brinzolamide 1% and brimonidine 0.1% to BBFC, even though there were sustained IOP values throughout the 12-week evaluation period.
Although they concluded the result technically sound and reasonable, too many previous studies demonstrated fixed combination glaucoma drugs might yield improvement of ocular surface considering decreasing BAK or other preservatives, and sustainable IOP lowering effects compared to combination of each drugs.
And this study populations showed relatively small. It might lead statistical insignificance due to small number of sample size.
Author Response
Although they concluded the result technically sound and reasonable, too many previous studies demonstrated fixed combination glaucoma drugs might yield improvement of ocular surface considering decreasing BAK or other preservatives, and sustainable IOP lowering effects compared to combination of each drugs.
One of the most important findings of this study is an improved satisfaction after switching to BBFC. These results are very important for physician.
And this study populations showed relatively small. It might lead statistical insignificance due to small number of sample size.
A significant improvement in the degree of SPK were obtained when switching to BBFC. Furthermore, after switching to BBFC, patients who required multiple IOP-lowering medications reported an improved satisfaction with their medical treatment. These results are clinically reasonable. Therefore, although only a relatively small number of cases were evaluated in this study, our results are clinically meaningful outcomes.
Reviewer 2 Report
This is an interesting paper reporting on the advantages of switching from 2 separate medications to a fixed combination to lower and control IOP in glaucoma patients. I don't have any specific comments pertaining to this manuscript.
Author Response
This is an interesting paper reporting on the advantages of switching from 2 separate medications to a fixed combination to lower and control IOP in glaucoma patients. I don't have any specific comments pertaining to this manuscript.
Thank you very much.
Reviewer 3 Report
- Please add the mean untreated IOP of the study patients.
- Please add the more specific information of the medications (i.e. pharmaceutical company, country & preservatives) used in the Method section.
Author Response
Please add the mean untreated IOP of the study patients.
We have shown the mean untreated IOP of the study patients in Table 1
Please add the more specific information of the medications (i.e. pharmaceutical company, country & preservatives) used in the Method section.
Lines 76-78, Lines 89-90 We have added the more specific information of the medications.
Round 2
Reviewer 1 Report
The authors made good author response. Thank you
