Alpha Smooth Muscle Actin (αSMA) Immunohistochemistry Use in the Differentiation of Pancreatic Cancer from Chronic Pancreatitis
Abstract
:1. Introduction
2. Material and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Baseline Characteristics of the Study Group | |||
---|---|---|---|
Number of Patients | PDAC Patients | CP Patients | |
83 | 31 | ||
Age | 59.6 ± 8.74 (34–76) | 49.7 ± 9.65 (23–64) | |
Sex | Female | 37 (45%) | 9 (29%) |
Male | 46 (55%) | 22 (71%) | |
Symptoms | Jaundice | 37 (45%) | 5 (16%) |
BMI | 25.15 ± 3.73 | 22.84 ± 4.72 | |
Blood tests | Fasting glucose | 118.44 ± 34.02 | 103.26 ± 20.05 |
CA 19-9 serum level | 217.3 ± 348.7 | 68.3 ± 135.8 | |
Comorbidities | DM | 29 (47%) | 11 (35.5%) |
DM newly diagnosed | 12 (14.5%) | 3 (9.6%) | |
TNM Classification | IA | 5 (6%) | n/a |
IB | 21 (25%) | n/a | |
IIA | 19 (23%) | n/a | |
IIB | 32 (38.5%) | n/a | |
III | 3 (3.6%) | n/a | |
IV | 3 (3.6%) | n/a | |
Tumor Grading | G-1 | 16 (19.3%) | n/a |
G-2 | 60 (72.3%) | n/a | |
G-3 | 7 (8.4%) | n/a | |
Localization | Head of the pancreas | 68 (82%) | 27 (87%) |
Body of the pancreas | 8 (9.6%) | 0 | |
Tail of the pancreas | 7 (8.4%) | 4 (13%) | |
Tumor Dimension [cm] | 3.45 (0.5–6.0) | n/a | |
Type of operations | Whipple’s operation | 63 (76%) | 25 (81%) |
Resection of the body and tail of pancreas | 8 (9.6%) | 0 | |
Resection of the tail of the pancreas | 3 (3.6%) | 4 (13%) | |
Beger operation | 0 | 2 (6%) | |
Total pancreatectomy | 9 (10.8%) | 0 |
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Winter, K.; Dzieniecka, M.; Strzelczyk, J.; Wągrowska-Danilewicz, M.; Danilewicz, M.; Małecka-Wojciesko, E. Alpha Smooth Muscle Actin (αSMA) Immunohistochemistry Use in the Differentiation of Pancreatic Cancer from Chronic Pancreatitis. J. Clin. Med. 2021, 10, 5804. https://doi.org/10.3390/jcm10245804
Winter K, Dzieniecka M, Strzelczyk J, Wągrowska-Danilewicz M, Danilewicz M, Małecka-Wojciesko E. Alpha Smooth Muscle Actin (αSMA) Immunohistochemistry Use in the Differentiation of Pancreatic Cancer from Chronic Pancreatitis. Journal of Clinical Medicine. 2021; 10(24):5804. https://doi.org/10.3390/jcm10245804
Chicago/Turabian StyleWinter, Katarzyna, Monika Dzieniecka, Janusz Strzelczyk, Małgorzata Wągrowska-Danilewicz, Marian Danilewicz, and Ewa Małecka-Wojciesko. 2021. "Alpha Smooth Muscle Actin (αSMA) Immunohistochemistry Use in the Differentiation of Pancreatic Cancer from Chronic Pancreatitis" Journal of Clinical Medicine 10, no. 24: 5804. https://doi.org/10.3390/jcm10245804
APA StyleWinter, K., Dzieniecka, M., Strzelczyk, J., Wągrowska-Danilewicz, M., Danilewicz, M., & Małecka-Wojciesko, E. (2021). Alpha Smooth Muscle Actin (αSMA) Immunohistochemistry Use in the Differentiation of Pancreatic Cancer from Chronic Pancreatitis. Journal of Clinical Medicine, 10(24), 5804. https://doi.org/10.3390/jcm10245804