Molecular Subtypes, Metastatic Pattern and Patient Age in Breast Cancer: An Analysis of Italian Network of Cancer Registries (AIRTUM) Data
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Data Sources
2.3. Statistical Analysis
2.4. Outcome and Follow-Up
3. Results
3.1. Setting
3.2. Molecular Subtypes
3.3. Sites of Metastasis at Diagnosis
3.4. Survival
4. Discussion
4.1. Incidence Rate
4.2. Age at Diagnosis
4.3. Stage at Diagnosis
4.4. Molecular Subtypes
4.5. Metastases
4.6. Survival
4.7. Strengths and Limitations
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Age (Years) | <50 | 50–69 | >69 | ||
---|---|---|---|---|---|
Total Patients | n = 8831 | ||||
n (%) | n (%) | n (%) | p-Value * | ||
Number | 1969 (22.3) | 3679 (41.7) | 3183 (36.0) | <0.001 | |
Stage (TNM) | I | 730 (37.1) | 1633 (44.4) | 840 (26.4) | <0.001 |
II | 612 (31.1) | 932 (25.3) | 793 (24.9) | ||
III | 278 (14.1) | 445 (12.1) | 407 (12.8) | ||
IV | 57 (2.9) | 161 (4.4) | 184 (5.8) | ||
Unknown | 292 (14.8) | 508 (13.8) | 959 (30.1) | ||
Metastasis | No | 1375 (69.8) | 2456 (66.8) | 1909 (60.0) | <0.001 |
Yes | 57 (2.9) | 161 (4.4) | 184 (5.8) | ||
Unknown | 537 (27.3) | 1062 (28.9) | 1090 (34.2) | ||
Tumor histology | Ductal | 1540 (78.2) | 2773 (75.4) | 2125 (66.8) | <0.001 |
Lobular | 248 (12.6) | 596 (16.2) | 473 (14.9) | ||
Other | 92 (4.7) | 143 (3.9) | 315 (9.9) | ||
NOS | 89 (4.5) | 167 (4.5) | 270 (8.5) | ||
Receptor expression | HER2-/HR+ | 826 (61.8) | 1603 (65.8) | 1369 (69.8) | <0.001 |
HER2+/HR+ | 275 (20.6) | 482 (19.8) | 336 (17.1) | ||
HER2+/HR− | 104 (7.8) | 157 (6.4) | 93 (4.7) | ||
HER2−/HR− | 131 (9.8) | 196 (8.0) | 163 (8.3) | ||
Unknown | 633 (7.2) | 1241 (14.1) | 1222 (13.8) |
Age (Years) | <50 | 50–69 | >69 | ||||||
---|---|---|---|---|---|---|---|---|---|
n | % | n | % | n | % | Total | % | p-Value * | |
Multiple sites | 31 | 44.3 | 72 | 41.9 | 45 | 30.4 | 148 | 37.9 | <0.001 |
Bone | 13 | 18.6 | 34 | 19.8 | 32 | 21.6 | 79 | 20.3 | 0.006 |
Liver | 6 | 8.6 | 19 | 11.0 | 18 | 12.2 | 43 | 11.0 | 0.025 |
Other | 7 | 10.0 | 32 | 18.6 | 24 | 16.2 | 63 | 16.2 | <0.001 |
Lung | 3 | 4.3 | 5 | 2.9 | 20 | 13.5 | 28 | 7.1 | <0.001 |
Brain | 3 | 4.2 | 4 | 2.3 | 3 | 2.0 | 10 | 2.6 | 0.904 |
Unknown site | 7 | 10.0 | 6 | 3.5 | 6 | 4.1 | 19 | 4.9 | 0.948 |
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Tagliabue, G.; Fabiano, S.; Contiero, P.; Barigelletti, G.; Castelli, M.; Mazzoleni, G.; Boschetti, L.; Fanetti, A.C.; Puppo, A.; Musolino, A.; et al. Molecular Subtypes, Metastatic Pattern and Patient Age in Breast Cancer: An Analysis of Italian Network of Cancer Registries (AIRTUM) Data. J. Clin. Med. 2021, 10, 5873. https://doi.org/10.3390/jcm10245873
Tagliabue G, Fabiano S, Contiero P, Barigelletti G, Castelli M, Mazzoleni G, Boschetti L, Fanetti AC, Puppo A, Musolino A, et al. Molecular Subtypes, Metastatic Pattern and Patient Age in Breast Cancer: An Analysis of Italian Network of Cancer Registries (AIRTUM) Data. Journal of Clinical Medicine. 2021; 10(24):5873. https://doi.org/10.3390/jcm10245873
Chicago/Turabian StyleTagliabue, Giovanna, Sabrina Fabiano, Paolo Contiero, Giulio Barigelletti, Maurizio Castelli, Guido Mazzoleni, Lorenza Boschetti, Anna Clara Fanetti, Antonella Puppo, Antonino Musolino, and et al. 2021. "Molecular Subtypes, Metastatic Pattern and Patient Age in Breast Cancer: An Analysis of Italian Network of Cancer Registries (AIRTUM) Data" Journal of Clinical Medicine 10, no. 24: 5873. https://doi.org/10.3390/jcm10245873