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Cardiac Complications Following Cardiac Surgery Procedures
 
 
Article
Peer-Review Record

Perioperative Individualized Goal Directed Therapy for Cardiac Surgery: A Historical-Prospective, Comparative Effectiveness Study

J. Clin. Med. 2021, 10(3), 400; https://doi.org/10.3390/jcm10030400
by Davinder Ramsingh 1, Huayong Hu 1, Manshu Yan 1,*, Ryan Lauer 1, David Rabkin 2, Jason Gatling 1, Rosario Floridia 2, Mckinzey Martinez 1, Ihab Dorotta 1 and Anees Razzouk 2
Reviewer 1:
Reviewer 2: Anonymous
J. Clin. Med. 2021, 10(3), 400; https://doi.org/10.3390/jcm10030400
Submission received: 31 December 2020 / Revised: 18 January 2021 / Accepted: 18 January 2021 / Published: 21 January 2021
(This article belongs to the Special Issue New Updates on Cardiovascular and Thoracic Surgery)

Round 1

Reviewer 1 Report

Excellent revision . I don’t have more comments . 

Author Response

Thank you for reviewing our manuscript. We appreciate your prior suggestions for the revision and your approval for the revision. 

Reviewer 2 Report

Thank you for sharing.  The subjective nature of “goal setting” (along with expecting inotrope/vasopressin for > 12 hours) & lack of rigorous risk-score matching make reproducibility and validity challenging. Using vasopressin inotrope score + STS risk scoring to compare groups would be valuable.

Monitoring for KDIGO class 1-3 AKI would also augment comparison of effects of GDT (or simply STS definition of ARF if necessary info not recorded).

Additionally, the ICU LOS is extraordinarily long-compared to STS benchmarks-in groups one & two, requiring explanation.

Author Response

Thank you for reviewing our manuscript. Please see attachment for the reviewers response. 

Author Response File: Author Response.docx

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