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Review

The Key Comorbidities in Patients with Rheumatoid Arthritis: A Narrative Review

by
Peter C. Taylor
1,*,
Fabiola Atzeni
2,
Alejandro Balsa
3,
Laure Gossec
4,5,
Ulf Müller-Ladner
6 and
Janet Pope
7
1
Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, UK
2
Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy
3
Rheumatology Unit, Hospital Universitario La Paz, La Paz Institute for Health Research IdiPAZ, Universidad Autónoma de Madrid, Paseo de la Castellana, 261, 28046 Madrid, Spain
4
Institut Pierre Louis d’Epidémiologie et de Santé Publique, Sorbonne Université, 75006 Paris, France
5
Rheumatology Department, Pitié-Salpêtrière Hospital, AP-HP, Sorbonne Université, 75013 Paris, France
6
Department of Rheumatology and Clinical Immunology, Justus Liebig University Gießen, Campus Kerckhoff, 61231 Bad Nauheim, Germany
7
St. Joseph’s Health Care, Schulich School of Medicine, University of Western Ontario, London, ON N6A 5C1, Canada
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2021, 10(3), 509; https://doi.org/10.3390/jcm10030509
Submission received: 18 December 2020 / Revised: 22 January 2021 / Accepted: 23 January 2021 / Published: 1 February 2021
(This article belongs to the Collection Systemic Manifestations and Complications of Rheumatoid Arthritis)
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Abstract

Comorbidities in patients with rheumatoid arthritis (RA) are often associated with poor health outcomes and increased mortality. Treatment decisions should take into account these comorbidities due to known or suspected associations with certain drug classes. In clinical practice, it is critical to balance potential treatment benefit against the possible risks for comorbidities as well as the articular manifestations of RA. This review summarises the current literature relating to prevalence and risk factors for the important comorbidities of cardiovascular disease, infections, lymphomas and nonmelanoma skin cancers in patients with RA. The impact on patient outcomes and the interplay between these comorbidities and the therapeutic options currently available, including tumour necrosis factor inhibitors and newer biological therapies, are also explored. As newer RA therapies are developed, and patients gain wider and earlier access to advanced therapies, in part due to the emergence of biosimilars, it is important to consider the prevention or treatment of comorbidities as part of the overall management of RA.
Keywords: rheumatoid arthritis; comorbidities; extra-articular manifestations; tumour necrosis factor; cardiovascular disease; infections; lymphoma; nonmelanoma skin cancers rheumatoid arthritis; comorbidities; extra-articular manifestations; tumour necrosis factor; cardiovascular disease; infections; lymphoma; nonmelanoma skin cancers

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MDPI and ACS Style

Taylor, P.C.; Atzeni, F.; Balsa, A.; Gossec, L.; Müller-Ladner, U.; Pope, J. The Key Comorbidities in Patients with Rheumatoid Arthritis: A Narrative Review. J. Clin. Med. 2021, 10, 509. https://doi.org/10.3390/jcm10030509

AMA Style

Taylor PC, Atzeni F, Balsa A, Gossec L, Müller-Ladner U, Pope J. The Key Comorbidities in Patients with Rheumatoid Arthritis: A Narrative Review. Journal of Clinical Medicine. 2021; 10(3):509. https://doi.org/10.3390/jcm10030509

Chicago/Turabian Style

Taylor, Peter C., Fabiola Atzeni, Alejandro Balsa, Laure Gossec, Ulf Müller-Ladner, and Janet Pope. 2021. "The Key Comorbidities in Patients with Rheumatoid Arthritis: A Narrative Review" Journal of Clinical Medicine 10, no. 3: 509. https://doi.org/10.3390/jcm10030509

APA Style

Taylor, P. C., Atzeni, F., Balsa, A., Gossec, L., Müller-Ladner, U., & Pope, J. (2021). The Key Comorbidities in Patients with Rheumatoid Arthritis: A Narrative Review. Journal of Clinical Medicine, 10(3), 509. https://doi.org/10.3390/jcm10030509

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