Impact of HLA Mismatching on Early Subclinical Inflammation in Low-Immunological-Risk Kidney Transplant Recipients
Abstract
:1. Introduction
2. Material and Methods
Statistical Analysis
3. Results
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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All (n = 105) | NI (n = 51) | SCI (n = 54) | p Value | |
---|---|---|---|---|
Donor age (yr) | 53.7 ± 12.6 | 52.4 ± 13.3 | 55.0 ± 11.8 | 0.311 |
ECD (%) | 42.7 | 36.0 | 49.1 | 0.181 |
Recipient age (yr) | 53.4 ± 12.4 | 53.5 ± 12.0 | 53.4 ± 12.9 | 0.980 |
Recipient BMI (kg/m2) | 27.0 ± 4.4 | 28.0 ± 4.4 | 26.1 ± 4.3 | 0.030 * |
Male (%) | 73.3 | 72.5 | 74.1 | 0.860 |
Living donor (%) | 14.6 | 16.0 | 13.2 | 0.688 |
Prior CVD (%) | 19.4 | 18.0 | 20.8 | 0.724 |
Hemodialysis (%) | 68.3 | 72.0 | 64.8 | 0.686 |
Cause of ESRD (%) | ||||
Glomerulonephritis | 21.0 | 17.6 | 24.1 | 0.357 |
Diabetes | 16.2 | 23.5 | 9.3 | |
APKD | 22.9 | 23.5 | 22.2 | |
Interstitial nephropathy | 6.7 | 3.9 | 9.3 | |
Nephrosclerosis | 9.5 | 11.8 | 7.4 | |
Unknown | 12.4 | 9.8 | 14.8 | |
Other | 11.4 | 9.8 | 13.0 | |
Induction therapy (%) | ||||
Basiliximab | 59 | 51 | 66.7 | 0.112 |
Thymoglobulin | 41 | 49 | 33.3 | |
Transfusion prior KT | 15.1 | 18.6 | 12.0 | 0.375 |
DGF (%) | 25.5 | 24.0 | 26.9 | 0.735 |
Tacrolimus levels (ng/mL) | 9.4 ± 2.5 | 9.7 ± 2.9 | 9.2 ± 2.1 | 0.286 |
Total HLA mismatches †, median (IQR) | 6 (5–8) | 5.5 (4–7) | 7 (6–8.5) | 0.008 * |
Class I HLA mismatches #, median (IQR) | 4 (3–5) | 4 (3–5) | 4 (3–5) | 0.200 |
Class II HLA mismatches ^, median (IQR) | 2 (1–3) | 2 (1–2) | 2 (2–3.5) | 0.004 * |
Proteinuria (mg/dL) | 286.2 ± 224.9 | 297 ± 229 | 279 ± 225 | 0.763 |
Creatinine (mg/dL) | 1.5 ± 0.4 | 1.4 ± 0.5 | 1.6 ± 0.4 | 0.018 * |
MDRD-4 (mL/min) | 54.1 ± 19.7 | 60.0 ± 23.4 | 48.5 ± 13.6 | 0.003 * |
OR | 95% CI | p Value | |
---|---|---|---|
Model 1 | |||
Recipient age | 1.00 | 0.96–1.04 | 0.924 |
DGF | 1.53 | 0.55–4.26 | 0.414 |
Transfusion prior KT | 0.68 | 0.21–2.26 | 0.530 |
Tacrolimus levels | 0.89 | 0.75–1.07 | 0.212 |
Total HLA mismatches † | 1.32 | 1.06–1.64 | 0.013 * |
Model 2 | |||
Recipient age | 1.00 | 0.97–1.04 | 0.964 |
DGF | 1.53 | 0.56–4.21 | 0.409 |
Transfusion prior KT | 0.73 | 0.22–2.47 | 0.614 |
Tacrolimus levels | 0.89 | 0.75–1.06 | 0.192 |
Class II HLA mismatches ^ | 1.51 | 1.04–2.19 | 0.032 * |
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Hernández, D.; Vázquez, T.; Alonso-Titos, J.; León, M.; Caballero, A.; Cobo, M.A.; Sola, E.; López, V.; Ruiz-Esteban, P.; Cruzado, J.M.; et al. Impact of HLA Mismatching on Early Subclinical Inflammation in Low-Immunological-Risk Kidney Transplant Recipients. J. Clin. Med. 2021, 10, 1934. https://doi.org/10.3390/jcm10091934
Hernández D, Vázquez T, Alonso-Titos J, León M, Caballero A, Cobo MA, Sola E, López V, Ruiz-Esteban P, Cruzado JM, et al. Impact of HLA Mismatching on Early Subclinical Inflammation in Low-Immunological-Risk Kidney Transplant Recipients. Journal of Clinical Medicine. 2021; 10(9):1934. https://doi.org/10.3390/jcm10091934
Chicago/Turabian StyleHernández, Domingo, Teresa Vázquez, Juana Alonso-Titos, Myriam León, Abelardo Caballero, María Angeles Cobo, Eugenia Sola, Verónica López, Pedro Ruiz-Esteban, Josep María Cruzado, and et al. 2021. "Impact of HLA Mismatching on Early Subclinical Inflammation in Low-Immunological-Risk Kidney Transplant Recipients" Journal of Clinical Medicine 10, no. 9: 1934. https://doi.org/10.3390/jcm10091934