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Background:
Systematic Review

A Systematic Review of the Safety of Blocking the IL-1 System in Human Pregnancy

by
Marie-Eve Brien
1,
Virginie Gaudreault
1,
Katia Hughes
1,
Dexter J. L. Hayes
2,
Alexander E. P. Heazell
2 and
Sylvie Girard
3,4,*
1
Ste-Justine Hospital Research Center, Montreal, QC H3T 1C5, Canada
2
Maternal and Fetal Health Research Centre, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK
3
Department of Obstetrics and Gynecology, Universite de Montreal, Montreal, QC H3T 1J4, Canada
4
Department of Obstetrics and Gynecology, Department of Immunology, Mayo Clinic, Rochester, MN 55902, USA
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2022, 11(1), 225; https://doi.org/10.3390/jcm11010225
Submission received: 10 December 2021 / Revised: 26 December 2021 / Accepted: 29 December 2021 / Published: 31 December 2021
(This article belongs to the Special Issue Diagnostic or Therapeutic Strategies for Pregnancy Complications)
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Abstract

:
Blockade of the interleukin-1 (IL-1) pathway has been used therapeutically in several inflammatory diseases including arthritis and cryopyrin-associated periodic syndrome (CAPS). These conditions frequently affect women of childbearing age and continued usage of IL-1 specific treatments throughout pregnancy has been reported. IL-1 is involved in pregnancy complications and its blockade could have therapeutic potential. We systematically reviewed all reported cases of IL-1 blockade in human pregnancy to assess safety and perinatal outcomes. We searched several databases to find reports of specific blockade of the IL-1 pathway at any stage of pregnancy, excluding broad spectrum or non-specific anti-inflammatory intervention. Our literature search generated 2439 references of which 22 studies included, following extensive review. From these, 88 different pregnancies were assessed. Most (64.8%) resulted in healthy term deliveries without any obstetrical/neonatal complications. Including pregnancy exposed to Anakinra or Canakinumab, 12 (15.0%) resulted in preterm birth and one stillbirth occurred. Regarding neonatal complications, 2 cases of renal agenesis (2.5%) were observed, and 6 infants were diagnosed with CAPS (7.5%). In conclusion, this systematic review describes that IL-1 blockade during pregnancy is not associated with increased adverse perinatal outcomes, considering that treated women all presented an inflammatory disease associated with elevated risk of pregnancy complications.

1. Introduction

Pregnancy complications are often associated with inflammation at the maternal-fetal interface. During pregnancy complication, such as preeclampsia (PE), preterm birth (PTB) and fetal growth restriction (FGR), inflammation can be found in the maternal circulation as well as in the placenta. Uncontrolled inflammation can negatively affect placental function [1,2,3,4,5,6]. Any alteration in placental function is associated with neonatal complications and altered child development particularly neurodevelopmental delay [7,8,9,10]. Therapeutically targeting inflammation in pregnancy has been challenging since inflammatory processes are also involved in physiological pregnancies, especially at the time of implantation and parturition [11,12,13,14,15,16] and a proinflammatory profile can be observed toward the end of uncomplicated pregnancy [16,17,18]. Therefore, there is a need to differentiate between physiological and pathological inflammation in order to develop and apply novel anti-inflammatory strategies in the clinical setting.
Inflammation has been observed at all stages of pregnancy [19,20,21,22,23,24,25,26]. Inflammation can occur in response to bacterial or viral infections (collectively referred to as pathogens-associated molecular patterns—PAMPs), as well as in response to sterile or endogenous mediators, termed damage-associated molecular pattern—DAMPs or alarmins, the latter increasingly associated with pathological pregnancies [27,28,29,30,31,32]. In order to mitigate the effects of dysregulated inflammation during pregnancy, multiple broad-spectrum anti-inflammatory therapies have been used and developed with interesting results [33,34]. Amongst these therapies, corticosteroids and nonsteroidal anti-inflammatory drugs (NSAIDs) are the most prevalent. However, studies have investigated the effect of corticosteroids during pregnancy and found an association between corticosteroid use and pregnancy/neonatal complications [35,36,37,38]. In a systematic review, Bandoli G. et al. found little to no association between corticosteroids and adverse pregnancy outcomes [35] whilst other groups reported concerns such as higher rate of cerebral palsy among children who had been exposed to repeated doses of corticosteroids or impaired growth of the lung parenchyma in cases of treatment without premature birth [36,37,38]. As for NSAIDs, acting through the inhibition of cyclooxygenase enzymes (COX-1 and COX-2), a study by Bérard A. et al., showed elevated risk of prematurity associated with the use of COX-2 inhibitors [39]. However, NSAIDs use during the first trimester of pregnancy was not associated with congenital malformations [40].
In case of pregnancies complicated with infections, antibiotics are often used. However, several studies have shown the detrimental effects of antibiotics on the development of the newborn. In the ORACLE series of clinical studies, the use of some antibiotics in pregnancy has been associated with elevated incidence of neurodevelopmental disorders [41,42]. Others have found increased risk of spontaneous miscarriage [43], without any association with congenital malformation [44]. All these drugs have benefits, but also major risk associated with their use. Since these are not specific and affect several inflammatory pathways at once, it is possible that pathways important in physiological pregnancy are impacted and responsible for the side effects observed. Targeting specific inflammatory mediators/pathways involved in pathological pregnancies could provide an efficient mean to mitigate the negative impact of inflammation, subsequently protecting the placenta and developing fetus, whilst having less deleterious effects.
The interleukin-1 (IL-1) system has been consistently associated with pregnancy complications such as preterm birth, including chorioamnionitis, FGR and PE [1,5,6,32,45,46,47,48,49] as well as high-risk pregnancies with reduced fetal movements [50]. The IL-1 system has been targeted in several animal models of pregnancy complications and blockade of this pathway appears to reduce the incidence of complications and protect the placenta as well as both fetal/neonatal development [4,51,52,53,54,55,56,57,58] and as reviewed previously by us, with emphasis on means of blocking the IL-1 pathway and their mechanisms of action with schematic representation [59]. Aside from studies in animal models, Il-1 blockers have been used for many years to help mitigate/resolve inflammatory conditions in humans [60,61,62,63]. The IL-1 receptor antagonist, IL-1Ra, is the most commonly used IL-1 system antagonist and is known under the generic name Anakinra (brand name Kineret). Anakinra has been approved for clinical use for over 20 years and has been commonly used for several chronic inflammatory conditions (such as arthritis and lupus) and in the pediatric population [60,64,65,66,67,68]. Canakinumab, brand name Ilaris, is a monoclonal antibody targeting IL-1β which has been approved for inflammatory condition such as cryopyrin-associated periodic syndromes (CAPS), since 2009 [69,70]. These inflammatory conditions commonly affect women of reproductive age and continued usage of Anakinra and/or Canakinumab during pregnancy has been reported [71,72,73]. Despite their wide range of beneficial effects, these drugs are not yet approved for use in pregnant women and are used solely when the benefit of continuing the treatment during the pregnancy outweigh the risk.
In light of the important need for targeted anti-inflammatory therapies during pregnancy, the evidence that the IL-1 system is central to both PAMPs and DAMPs-induced inflammation at the maternal-fetal interface, our objective was to perform a systematic review of all reports of any specific blockers of the IL-1 system being used during human pregnancy, to assess their potential impact on pregnancy outcome and neonatal health.

2. Materials and Methods

The systematic review is reported in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines [74]. The review protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO) on 6 July 2020 (CRD42020197186).

2.1. Information Sources, Search Strategy and Eligibility Criteria

Literature searches were conducted in PubMed, EMBASE, MEDLINE, Cochrane Database of Systematic Reviews and Google Scholar. The search was not limited by dates but was limited to titles, abstracts and manuscripts written in English and French (for practical reasons). Reviews were excluded to ensure inclusion of original research only. Abstract from conferences were included as well, unless the same data was published and therefore only the final research article was included to avoid duplication of the same cases. Reference lists of included studies were checked for any other relevant papers. Manuscripts were identified with the search terms ’pregnancy’ and ’IL-1 blockage’ or ’IL-1 blockade’ or ‘IL-1 receptor agonist’ or ‘IL-1ra’ or ‘Anakinra’ or ‘Kineret’ or ‘Rilonacept’ or ‘Canakinumab’ or ‘Rytvela’. All searches were completed by 9 July 2021. An example search is included in Data S1.
We included cohort studies (prospective and retrospective), case series and case reports which reported the used of IL-1 blockage during pregnancy. We included all studies involving pregnant individuals who received IL-1 blockage at any stage during their pregnancy.
Our main objective was to document pregnancy outcomes related to treatment (i.e., IL-1 blockade) with IL-1 antagonists during pregnancy. The medical indication for the treatment, chronic inflammatory pathologies diagnosed prior to pregnancy in most cases, was also considered. Data regarding the rates of pregnancy complications (including: congenital anomalies, hypertensive disorders of pregnancy, preterm birth—delivery before 37 weeks of gestation, FGR, neonatal and maternal death) were extracted. We compared all these outcomes to the reported incidence in the general population and population of women with inflammatory pathologies.

2.2. Data Extraction

Duplicates were removed, and all citations were screened for relevance using the full abstract and indexing terms. Two out of three reviewers (MEB, VG or KH) had to agree that a study for it to be included, according to the pre-specified inclusion and exclusion criteria. When available, full-length manuscripts were obtained. Two reviewers (MEB and VG) made final inclusions decisions independently and a third reviewer (SG) was consulted to resolve any conflict when necessary.

2.3. Assessment of Risk of Bias and Methodological Quality

Included cohort studies were assessed using the Risk of Bias in Non-randomised Studies—of Interventions (ROBINS-I) with 7 domains, since all the studies included in this systematic review were observational. This method categorises each study by low, moderate, serious, critical risk of bias or no information [75]. If a study’ risk of bias was categorised as serious or critical, the effect of removing this study was tested and the relevant outcome reported. Individual case reports were assessed using a specific tool to assess the methodological quality of case reports [76]. This assesses 8 characteristics in 4 domains of selection, ascertainment, causality and reporting.

2.4. Data Synthesis

Studies with continuous data (i.e., birthweight and gestational age) were taken to obtain overall means and standard deviations. It was intended to investigate effect of exposure to IL-1 blockade at different times of pregnancy, but data could not be stratified by trimester of exposure since too many data were missing.

3. Results

The search strategy (Figure 1) identified 2439 articles. After removing duplicates (n = 742), 1697 papers were screened based on their title and abstracts. 1569 papers were excluded based of irrelevant to the question, exposure not during pregnancy and IL-1 blockade effects were not reported. On this basis, resulting in 128 papers for which full text was evaluated. 106 studies were excluded as they were reviews, conference abstract with original article already included, missing information or reports of animal studies, meaning 22 papers were included in the final synthesis. The 22 included studies were 9 case reports, 13 cohort studies (6 retrospective and 7 prospective).

3.1. Risk of Bias/Methodological Quality of Included Studies

The majority of studies included in this systematic review had a low risk of bias in the assessed domains as evaluated with the ROBINS-I tool. The majority of the case reports included adequate case ascertainment and follow-up, but there was limited data about the causal relationship between exposure to Anakinra and Canakinumab and adverse reactions (Table S1). It is important to note that almost half of the studies included in this systematic review were published conference abstracts and therefore provided limited data which could impact the results presented. Furthermore, five pregnancies were exposed to both Anakinra and Canakinumab which could affect the classification of the intervention and their outcomes.

3.2. Study Characteristics

Characteristics of each study and summary of findings are presented in Table 1. Within the 22 studies included, 88 individual pregnancies were reported. 75 pregnancies (85.2%) received Anakinra and 13 (14.8%) Canakinumab. Of these 88 pregnancies, 5.7% were exposed to both agents over the course of their pregnancy. The indications for these treatments were mostly cryopyrin-associated periodic syndrome—CAPS (34.1%), including familial cold autoinflammatory syndrome—FCAS, neonatal-onset multisystem inflammatory disorder—NOMID and Muckle-Wells syndrome—MWS; familial Mediterranean fever—FMF (33.0%); and adult-onset Still’s disease—AOSD or systemic juvenile idiopathic arthritis—SJIA (20.4%). The remaining cases (11 women/12.5%) received treatment for the “TNF receptor associated periodic syndrome”—TRAPS (3.4%), haemophagocytic lymphohistiocytosis—HLH (2.3%) or other pathologies such as idiopathic pericarditis, Cogan syndrome or chronic inflammatory rheumatic disease (6.8%).
Of the 88 pregnancies, 4 women (4.5%) were still pregnant at the time of publication without any follow up available for their pregnancies. Of these women, three were within their first trimester and one in the second trimester, all without any complication reported to date. In the rest of pregnancies, three (3.4%) resulted in miscarriage during the first trimester (two exposed to Anakinra and one to Canakinumab). Two of these spontaneous miscarriages occurred in the same patient, the first whilst on Canakinumab and the second with Anakinra since she presented with refractory Cogan syndrome. Unfortunately, the patient only had a partial clinical and biochemical response of her underlying diseases despite dose escalation of both treatment regimens. Finally, one patient on Anakinra terminated her pregnancy electively. For the rest of the analysis, these patients were excluded due to the lack of information.

3.3. Duration of Exposure to Drugs during Pregnancy

In 48 cases (60.0%) of the remaining 80 pregnancies, the women were already taking the medication prior to getting pregnant; in 6 cases, this was unknown. In 50 cases (62.5%), the drug therapy was continued throughout pregnancy (when it was started either prior to or during the first trimester until birth). In nine cases, treatment was stopped after the first trimester and, in 2 cases, after the second trimester, due to the lack of data on safety of these drugs in pregnancy. In 13 cases, treatment was started either during the second half of pregnancy (10 patients) or during the third trimester (3 patients). Of these 13 cases, 4 were due to a lack of improvement with their previous treatment (i.e., colchicine or prednisone), 2 women were diagnosed with AOSD or HLH while pregnant and no information was given for the remaining seven women. Details of the treatment duration is shown in a flow chart (Figure 2). Information concerning each pregnancy separately are shown in Table 2.

3.4. Anakinra Use during Pregnancy and Maternal/Fetal Outcome

Women treated with Anakinra received doses ranging from 50 to 200 mg/daily, but the majority (59.4%) received 100 mg/day. In 20 cases (29.0%), this information was unavailable.
Of the 69 pregnancies exposed to Anakinra, 63.8% had term births, 17.4% were preterm (mean gestational age: 34.1 weeks (range: 28–36.9)) and for the rest (18.8%) this information was not given. Overall, the mean gestational age at delivery in the Anakinra exposed group was 37.9 (28.0–41.1) weeks. Within Anakinra-exposed pregnancies, 63.8% had no adverse obstetric outcome and 26.1% had complications with the most predominant being preterm birth (12/18) while the rest presented one or more of the following complication; vaginal bleeding, hypertension and/or oligohydramnios. One case ended in stillbirth, and the women received Anakinra for familial Mediterranean fever from 34 weeks of gestation to the time of stillbirth (37 weeks). No additional information was available about this event. It is also important to note that one twin dichorionic-diamniotic pregnancy occurred with the demise of one fetus due to bilateral renal agenesis at 30 weeks’ gestation. However, the surviving twin had no abnormality and was born at 38.7 weeks. This pregnancy was treated from the first trimester with Anakinra for neonatal-onset multisystem inflammatory disorder. The obstetric data were not available in 10.1% of the cases.
As for the neonates, 86.4% were healthy whereas 13.6% presented some mild complications. Of these, five babies were diagnosed with CAPS whereas three presented with other problems such as hypotrophic, respiratory distress syndrome, renal agenesis, ectopic neurohypophysis, right hydrocele and/or heart murmur. Rates of breastfeeding were available for 42 pregnancies with half of them being breastfeed; however, it was not clear if the treatment was maintained during this time.

3.5. Canakinumab Use during Pregnancy and Maternal/Fetal Outcome

The women using Canakinumab received doses starting from a single 120 mg dose to 300 mg/8 weeks but 54.5% received 150 mg/8 weeks. Of the 11 pregnancies exposed to Canakinumab, 90.9% delivered at term and the mean gestational age in this population was 38.8 (37.0–40.0) weeks whilst for the remaining one case the information was unavailable. In this group, 90.0% had no adverse obstetrical outcome with only one woman developing gestational diabetes and one without any information.
All the babies exposed to Canakinumab were healthy with one presenting the same NLPR3 mutation as the mother. Rates of breastfeeding were available for 5 cases and 80.0% were breastfeed but again, no data on treatment during this period.

4. Discussion

This systematic review aimed to review the effects of IL-1 antagonists used during pregnancy in humans. We found 22 studies including 12 original articles and 10 conference abstracts published which were reporting at least one pregnancy exposed to IL-1 blockade. Of these 22 studies, data extraction was performed, and 88 different pregnancies were included in this systematic review. Furthermore, some pregnancies were reported more than once and therefore the extraction were combined to obtained complete information whilst avoiding duplicates.
Of the 88 pregnancies included, 85.2% of women received Anakinra whereas 14.8% received Canakinumab. This disparity could be due to the fact that Anakinra has been approved for therapeutic use for over 20 years as opposed to Canakinumab [65]. Furthermore, Canakinumab has a higher cost and is less widely used [77]. In a recent review by Soh and Moretto, the authors summarize the European League Against Rheumatism—EULAR and British Society on Rheumatology—BSR guidelines for biologic therapies used during pregnancy [61]. In the EULAR guidelines, Anakinra is tolerated in early pregnancy and can be continued during pregnancy if there are no other options. On the other hand, the BSR guidelines reports insufficient data to recommend the use of Anakinra during pregnancy, but stipulate that “unintentional use during first trimester is unlikely to cause harm”. Furthermore, these guidelines states that it is “not recommended to continue the treatment during gestation”. The data for Canakinumab are even more sparse. One case report measured its transplacental transfer and found a cord blood to maternal blood ratio of 2.11 [78] which needs to be further studied.
Autoimmune diseases often have negative impact on fertility and pregnancy outcomes [76,77]. Two factors can be considered to affect the course of pregnancy, the disease or the treatment for this disease. In the exposed pregnancies included in this review, the indications for treatment were CAPS (34.1%), Familial Mediterranean Fever (FMF-33%), and AOSD/SJIA (20.4%). There is only one report, to our knowledge, of CAPS during pregnancy treated with medication other than those targeting the IL-1 system [78]. This study reported a rate of miscarriage of 30% as compared to 10% for CAPS-patients treated with Anakinra [78]. Only two studies reported pregnancy with those pathologies all exposed to Anakinra or Canakinumab, therefore it is difficult to distinguish the treatment effect to that from the inflammatory pathology itself [75,78]. There is only one report of untreated pregnancies with different autoimmune disease that the one that are reported in this study making the evaluation of the pathologies themselves difficult. In this study, the authors compared pregnancy with or without all kind of DMARDs and healthy pregnancy. However, this study did not discriminate for different treatments and only three pregnancies were exposed to Anakinra [79]. Autoimmune diseases often have negative impact on fertility and pregnancy outcomes [79,80]. Two factors can be considered to affect the course of pregnancy, the disease or the treatment for this disease. In the exposed pregnancies included in this review, the indications for treatment were CAPS (34.1%), Familial Mediterranean Fever (FMF-33%), and AOSD/SJIA (20.4%). There is only one report, to our knowledge, of CAPS during pregnancy treated with medication other than those targeting the IL-1 system [81]. This study reported a rate of miscarriage of 30% as compared to 10% for CAPS-patients treated with Anakinra [81]. Only two studies reported pregnancy with those pathologies all exposed to Anakinra or Canakinumab, therefore it is difficult to distinguish the treatment effect to that from the inflammatory pathology itself [78,81]. There is only one report of untreated pregnancies with different autoimmune disease that the one that are reported in this study making the evaluation of the pathologies themselves difficult. In this study, the authors compared pregnancy with or without all kind of DMARDs and healthy pregnancy. However, this study did not discriminate for different treatments and only three pregnancies were exposed to Anakinra [82].
For patients with FMF, increased rates of miscarriage, premature rupture of membranes and low birth weight were observed compared to pregnant women without the disease [80]. In this study, 80% of women received Colchicine and none received anti-inflammatory treatment [80]. Furthermore, one retrospective study by Ben-Chetrit et al., reported an elevated rate of spontaneous abortion in untreated FMF as opposed to those treated with Colchicine [83]. Unfortunately, Colchicine resistance is often observed in FMF patients and Anakinra is increasingly used to prevent flare-ups of the disease [73]. As for AOSD, 5 case reports and 17 pregnancies were reviewed by [84]. In this cohort, most women were exposed to corticosteroid with several reported adverse outcomes such as spontaneous miscarriage observed (9.1%), premature delivery (18.2%) and FGR (9.1%). In the current systematic review, 3/14 pregnancies complicated with AOSD ended in premature delivery which is comparable to that reported by Mok et al. In a study by Garcia-Fernandez et al., on women with SJIA, 20% had preterm delivery [85], which is in contrast to the current work in which we observed no preterm delivery in SJIA with anti-IL-1 treatment. This difference could be explained by the treatment since most women in this systematic review received Anakinra as opposed to corticosteroid or other DMARDs.
We reported three miscarriages out of 88 pregnancies. All these losses occurred during the first trimester and two were exposed to Anakinra whereas one exposed to Canakinumab. This is in accordance with the literature that most miscarriages will occur during the first trimester; however, it is very difficult to measure the rate of miscarriages in the general population. Furthermore, in this cohort, two out of the three miscarriage occurs in the same women who had Cogan syndrome, a rare and severe autoimmune disease. In the literature, only eight cases of successful pregnancy with this disease have been reported [86,87,88,89,90,91]. Thus, it cannot be concluded that the therapy caused pregnancy loss in these women.
In the current work, the rate of preterm birth was 17.6% (all conditions combined) as opposed to a baseline of 11.1% [92]. However, the reported rate of preterm birth in a population with inflammatory disease is known to be higher; namely 13.6% in FMF [80], 18.1% in AOSD [84] and 20% in SJIA [85]. Although the rate of preterm birth are similar overall, it is important to keep in mind that there is no report of untreated pregnancies with those inflammatory pathologies. Only one study reported a preterm birth rate of 9% in pregnancy with inflammatory pathologies without DMARDs treatment. The maternal condition in this study were Sjögren syndrome, undifferentiated connective tissue disease (UTCD), systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS) and others [82].
Our review reports neonatal complications in 13.6% of pregnancies exposed to Anakinra and 10.0% for those exposed to Canakinumab, totaling 13.2% who had complications overall. Of the 10 babies who had complications, six were diagnosed with CAPS whereas three had minor developmental delays or other problems and one died at 37 weeks (stillbirth). One baby of a FMF mother was hypotrophic, had respiratory distress syndrome and hyperbillirubilemia at birth; however, this baby was delivered prematurely at 33 + 5 weeks and was healthy at 12 months of age [93]. Baby born preterm has more neonatal complication then their counterpart born at 37 week and onwards [94,95]. Another baby born to a mother with SJIA had right hydrocele and heart murmur at birth but these complications could be due to maternal exacerbation of symptom such as oligohydramnios and hypertension. At the follow up, this baby had no major long-term complications nor malformations [96]. Finally, one baby born to a mother with active refractory AOSD had renal agenesis and ectopic neurohypophysis [97]. This is the second case of renal agenesis in Anakinra-exposed patient. The first case was in a mother diagnose with NOMID and it was a twin dichorionic-diamniotic pregnancy with fetal demise of one fetus with bilateral renal agenesis at 30 weeks. The surviving twin had no congenital abnormality and was born at 38.7 weeks. This case of congenital malformation could potentially be explained by the increased risk factor of renal tract abnormalities in twin birth as mentioned by the authors [97,98]. Furthermore, a study by Wiesel et al. reported that renal agenesis occurs in 58 of 709,030 live birth, significantly lower than 2 cases out of 88 pregnancies in this systematic review. One group has made a hypothesis that a link between uncontrolled maternal disease and renal abnormalities can occurs [96] but the potential link between renal malformation and IL-1 pathway should be the focus of future studies.
It is interesting to note that three studies, not included in the current systematic review, have evaluated 10 men who received IL-1 blockade prior to conception, resulting in 13 pregnancies. In those studies, six men had CAPS, two AOSD, one SJIA and one FMF. Seven received Anakinra (100 mg/day) and three were treated with Canakinumab (150 mg/8 weeks) at the time of conception. No adverse effect on the child wellbeing were reported after paternal exposure to IL-1 blockage [97,99,100].
This is the first systematic review to examine the effects of IL-1 blockade during pregnancy and we provide a summary of all pregnancies exposed to Anakinra or Canakinumab. Our study also highlighted the current lack of data and identified research gaps to be addressed, particularly the difference between the effects on pregnancy of the inflammatory pathology being treated as compared to the treatment itself. Our study was limited by the fact that abstracts from conferences were also included, in order to cover all exposed pregnancies, but some information were missing in relation to doses and outcomes in these abstracts.

5. Conclusions

In conclusion, this review summarizes all the pregnancy exposed to Il-1 blockage and no major obstetrical and neonatal complication was reported. Il-1 blockage during pregnancy could be safe and beneficial in cases of pregnancy with inflammatory conditions.

Supplementary Materials

The following are available online at https://www.mdpi.com/article/10.3390/jcm11010225/s1; Data S1: Search strategy used for this systematic review. Table S1: Search strategy used for this systematic review.

Author Contributions

Conceptualization and methodology, M.-E.B. and S.G.; data curation, M.-E.B., V.G., K.H. and S.G.; writing original draft preparation, M.-E.B. and S.G., writing review and editing, M.-E.B., D.J.L.H., A.E.P.H. and S.G.; supervision, S.G. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Institutional Review Board Statement

Not applicable.

Informed Consent Statement

Not applicable.

Conflicts of Interest

The authors declare no conflict of interest.

References

  1. Aye, I.L.; Jansson, T.; Powell, T.L. Interleukin-1beta inhibits insulin signaling and prevents insulin-stimulated system A amino acid transport in primary human trophoblasts. Mol. Cell. Endocrinol. 2013, 381, 46–55. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  2. Bainbridge, S.A.; Roberts, J.M.; von Versen-Hoynck, F.; Koch, J.; Edmunds, L.; Hubel, C.A. Uric acid attenuates trophoblast invasion and integration into endothelial cell monolayers. Am. J. Physiol. Cell Physiol. 2009, 297, C440–C450. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  3. Bainbridge, S.A.; von Versen-Höynck, F.; Roberts, J.M. Uric acid inhibits placental system A amino acid uptake. Placenta 2009, 30, 195–200. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  4. Lei, J.; Vermillion, M.S.; Jia, B.; Xie, H.; Xie, L.; McLane, M.W.; Sheffield, J.S.; Pekosz, A.; Brown, A.; Klein, S.L.; et al. IL-1 receptor antagonist therapy mitigates placental dysfunction and perinatal injury following Zika virus infection. JCI Insight 2019, 4, e122678. [Google Scholar] [CrossRef]
  5. Mulla, M.J.; Myrtolli, K.; Potter, J.; Boeras, C.; Kavathas, P.B.; Sfakianaki, A.K.; Tadesse, S.; Norwitz, E.R.; Guller, S.; Abrahams, V.M. Uric acid induces trophoblast IL-1beta production via the inflammasome: Implications for the pathogenesis of preeclampsia. Am. J. Reprod. Immunol. 2011, 65, 542–548. [Google Scholar] [CrossRef] [Green Version]
  6. Brien, M.E.; Duval, C.; Palacios, J.; Boufaied, I.; Hudon-Thibeault, A.A.; Nadeau-Vallee, M.; Vaillancourt, C.; Sibley, C.P.; Abrahams, V.M.; Jones, R.L.; et al. Uric Acid Crystals Induce Placental Inflammation and Alter Trophoblast Function via an IL-1-Dependent Pathway: Implications for Fetal Growth Restriction. J. Immunol. 2017, 198, 443–451. [Google Scholar] [CrossRef] [Green Version]
  7. Depino, A.M. Perinatal inflammation and adult psychopathology: From preclinical models to humans. Semin. Cell Dev. Biol. 2018, 77, 104–114. [Google Scholar] [CrossRef]
  8. Hagberg, H.; Gressens, P.; Mallard, C. Inflammation during fetal and neonatal life: Implications for neurologic and neuropsychiatric disease in children and adults. Ann. Neurol. 2012, 71, 444–457. [Google Scholar]
  9. Van Vliet, E.O.; de Kieviet, J.F.; van der Voorn, J.P.; Been, J.V.; Oosterlaan, J.; van Elburg, R.M. Placental pathology and long-term neurodevelopment of very preterm infants. Am. J. Obstet. Gynecol. 2012, 206, e481–e487. [Google Scholar] [CrossRef] [Green Version]
  10. Neiger, R. Long-Term Effects of Pregnancy Complications on Maternal Health: A Review. J. Clin. Med. 2017, 6, 76. [Google Scholar] [CrossRef] [Green Version]
  11. Erlebacher, A. Immunology of the maternal-fetal interface. Annu. Rev. Immunol. 2013, 31, 387–411. [Google Scholar] [CrossRef]
  12. Moffett, A.; Loke, C. Immunology of placentation in eutherian mammals. Nat. Rev. Immunol. 2006, 6, 584–594. [Google Scholar] [CrossRef]
  13. Mor, G.; Cardenas, I.; Abrahams, V.; Guller, S. Inflammation and pregnancy: The role of the immune system at the implantation site. Ann. N. Y. Acad. Sci. 2011, 1221, 80–87. [Google Scholar] [CrossRef] [Green Version]
  14. Menon, R.; Richardson, L.S.; Lappas, M. Fetal membrane architecture, aging and inflammation in pregnancy and parturition. Placenta 2019, 79, 40–45. [Google Scholar] [CrossRef]
  15. Romero, R.; Espinoza, J.; Gonçalves, L.F.; Kusanovic, J.P.; Friel, L.A.; Nien, J.K. Inflammation in preterm and term labour and delivery. Semin. Fetal Neonatal Med. 2006, 11, 317–326. [Google Scholar] [CrossRef]
  16. Brien, M.E.; Boufaied, I.; Bernard, N.; Forest, J.C.; Giguere, Y.; Girard, S. Specific inflammatory profile in each pregnancy complication: A comparative study. Am. J. Reprod. Immunol. 2020, 84, e13316. [Google Scholar] [CrossRef]
  17. Salazar Garcia, M.D.; Mobley, Y.; Henson, J.; Davies, M.; Skariah, A.; Dambaeva, S.; Gilman-Sachs, A.; Beaman, K.; Lampley, C.; Kwak-Kim, J. Early pregnancy immune biomarkers in peripheral blood may predict preeclampsia. J. Reprod. Immunol. 2018, 125, 25–31. [Google Scholar] [CrossRef]
  18. Freeman, D.J.; McManus, F.; Brown, E.A.; Cherry, L.; Norrie, J.; Ramsay, J.E.; Clark, P.; Walker, I.D.; Sattar, N.; Greer, I.A. Short- and long-term changes in plasma inflammatory markers associated with preeclampsia. Hypertension 2004, 44, 708–714. [Google Scholar] [CrossRef] [Green Version]
  19. Ferguson, K.K.; Meeker, J.D.; McElrath, T.F.; Mukherjee, B.; Cantonwine, D.E. Repeated measures of inflammation and oxidative stress biomarkers in preeclamptic and normotensive pregnancies. Am. J. Obstet. Gynecol. 2017, 216, e521–e527. [Google Scholar] [CrossRef] [Green Version]
  20. Redman, C.W.; Staff, A.C. Preeclampsia, biomarkers, syncytiotrophoblast stress, and placental capacity. Am. J. Obstet. Gynecol. 2015, 213, S9.e1–S9.e4. [Google Scholar] [CrossRef]
  21. Taylor, B.D.; Ness, R.B.; Klebanoff, M.A.; Zoh, R.; Bass, D.; Hougaard, D.M.; Skogstrand, K.; Haggerty, C.L. First and second trimester immune biomarkers in preeclamptic and normotensive women. Pregnancy Hypertens. 2016, 6, 388–393. [Google Scholar] [CrossRef] [Green Version]
  22. Taylor, B.D.; Tang, G.; Ness, R.B.; Olsen, J.; Hougaard, D.M.; Skogstrand, K.; Roberts, J.M.; Haggerty, C.L. Mid-pregnancy circulating immune biomarkers in women with preeclampsia and normotensive controls. Pregnancy Hypertens. 2016, 6, 72–78. [Google Scholar] [CrossRef] [Green Version]
  23. Ronzoni, S.; Steckle, V.; D’Souza, R.; Murphy, K.E.; Lye, S.; Shynlova, O. Cytokine Changes in Maternal Peripheral Blood Correlate With Time-to-Delivery in Pregnancies Complicated by Premature Prelabor Rupture of the Membranes. Reprod. Sci. 2018, 26, 1266–1276. [Google Scholar] [CrossRef]
  24. Giguere, Y.; Masse, J.; Theriault, S.; Bujold, E.; Lafond, J.; Rousseau, F.; Forest, J.C. Screening for pre-eclampsia early in pregnancy: Performance of a multivariable model combining clinical characteristics and biochemical markers. BJOG 2015, 122, 402–410. [Google Scholar] [CrossRef]
  25. Kuc, S.; Wortelboer, E.J.; van Rijn, B.B.; Franx, A.; Visser, G.H.; Schielen, P.C. Evaluation of 7 serum biomarkers and uterine artery Doppler ultrasound for first-trimester prediction of preeclampsia: A systematic review. Obstet. Gynecol. Surv. 2011, 66, 225–239. [Google Scholar] [CrossRef] [Green Version]
  26. Yu, N.; Cui, H.; Chen, X.; Chang, Y. First trimester maternal serum analytes and second trimester uterine artery Doppler in the prediction of preeclampsia and fetal growth restriction. Taiwan J. Obstet. Gynecol. 2017, 56, 358–361. [Google Scholar] [CrossRef]
  27. Bianchi, M.E. DAMPs, PAMPs and alarmins: All we need to know about danger. J. Leukoc. Biol. 2007, 81, 1–5. [Google Scholar] [CrossRef]
  28. Matzinger, P. The danger model: A renewed sense of self. Science 2002, 296, 301–305. [Google Scholar] [CrossRef] [Green Version]
  29. Brien, M.E.; Baker, B.; Duval, C.; Gaudreault, V.; Jones, R.L.; Girard, S. Alarmins at the maternal-fetal interface: Involvement of inflammation in placental dysfunction and pregnancy complications (1). Can. J. Physiol. Pharmacol. 2019, 97, 206–212. [Google Scholar] [CrossRef]
  30. Nadeau-Vallee, M.; Obari, D.; Palacios, J.; Brien, M.E.; Duval, C.; Chemtob, S.; Girard, S. Sterile inflammation and pregnancy complications: A review. Reproduction 2016, 152, R277–R292. [Google Scholar] [CrossRef]
  31. Sharps, M.C.; Baker, B.C.; Guevara, T.; Bischof, H.; Jones, R.L.; Greenwood, S.L.; Heazell, A.E.P. Increased placental macrophages and a pro-inflammatory profile in placentas and maternal serum in infants with a decreased growth rate in the third trimester of pregnancy. Am. J. Reprod. Immunol. 2020, 84, e13267. [Google Scholar] [CrossRef] [PubMed]
  32. Saji, F.; Samejima, Y.; Kamiura, S.; Sawai, K.; Shimoya, K.; Kimura, T. Cytokine production in chorioamnionitis. J. Reprod. Immunol. 2000, 47, 185–196. [Google Scholar] [CrossRef]
  33. Russo, R.C.; Garcia, C.C.; Teixeira, M.M. Anti-inflammatory drug development: Broad or specific chemokine receptor antagonists? Curr. Opin. Drug Discov. Dev. 2010, 13, 414–427. [Google Scholar]
  34. Grainger, D.J.; Reckless, J. Broad-spectrum chemokine inhibitors (BSCIs) and their anti-inflammatory effects in vivo. Biochem. Pharmacol. 2003, 65, 1027–1034. [Google Scholar] [CrossRef]
  35. Bandoli, G.; Palmsten, K.; Forbess Smith, C.J.; Chambers, C.D. A Review of Systemic Corticosteroid Use in Pregnancy and the Risk of Select Pregnancy and Birth Outcomes. Rheum. Dis. Clin. N. Am. 2017, 43, 489–502. [Google Scholar] [CrossRef]
  36. Shanks, A.L.; Grasch, J.L.; Quinney, S.K.; Haas, D.M. Controversies in antenatal corticosteroids. Semin. Fetal Neonatal Med. 2019, 24, 182–188. [Google Scholar] [CrossRef]
  37. Wapner, R.J.; Sorokin, Y.; Mele, L.; Johnson, F.; Dudley, D.J.; Spong, C.Y.; Peaceman, A.M.; Leveno, K.J.; Malone, F.; Caritis, S.N.; et al. Long-term outcomes after repeat doses of antenatal corticosteroids. N. Engl. J. Med. 2007, 357, 1190–1198. [Google Scholar] [CrossRef]
  38. Bandyopadhyay, A.; Slaven, J.E.; Evrard, C.; Tiller, C.; Haas, D.M.; Tepper, R.S. Antenatal corticosteriods decrease forced vital capacity in infants born fullterm. Pediatr. Pulmonol. 2020, 55, 2630–2634. [Google Scholar] [CrossRef]
  39. Bérard, A.; Sheehy, O.; Girard, S.; Zhao, J.P.; Bernatsky, S. Risk of preterm birth following late pregnancy exposure to NSAIDs or COX-2 inhibitors. Pain 2018, 159, 948–955. [Google Scholar] [CrossRef]
  40. Daniel, S.; Matok, I.; Gorodischer, R.; Koren, G.; Uziel, E.; Wiznitzer, A.; Levy, A. Major malformations following exposure to nonsteroidal antiinflammatory drugs during the first trimester of pregnancy. J. Rheumatol. 2012, 39, 2163–2169. [Google Scholar] [CrossRef]
  41. Kenyon, S.; Pike, K.; Jones, D.R.; Brocklehurst, P.; Marlow, N.; Salt, A.; Taylor, D.J. Childhood outcomes after prescription of antibiotics to pregnant women with spontaneous preterm labour: 7-year follow-up of the ORACLE II trial. Lancet 2008, 372, 1319–1327. [Google Scholar] [CrossRef] [Green Version]
  42. Kenyon, S.; Pike, K.; Jones, D.R.; Brocklehurst, P.; Marlow, N.; Salt, A.; Taylor, D.J. Childhood outcomes after prescription of antibiotics to pregnant women with preterm rupture of the membranes: 7-year follow-up of the ORACLE I trial. Lancet 2008, 372, 1310–1318. [Google Scholar] [CrossRef] [Green Version]
  43. Muanda, F.T.; Sheehy, O.; Bérard, A. Use of antibiotics during pregnancy and risk of spontaneous abortion. CMAJ 2017, 189, E625–E633. [Google Scholar] [CrossRef] [Green Version]
  44. Muanda, F.T.; Sheehy, O.; Bérard, A. Use of antibiotics during pregnancy and the risk of major congenital malformations: A population based cohort study. Br. J. Clin. Pharmacol. 2017, 83, 2557–2571. [Google Scholar] [CrossRef] [Green Version]
  45. Reis, A.S.; Barboza, R.; Murillo, O.; Barateiro, A.; Peixoto, E.P.M.; Lima, F.A.; Gomes, V.M.; Dombrowski, J.G.; Leal, V.N.C.; Araujo, F.; et al. Inflammasome activation and IL-1 signaling during placental malaria induce poor pregnancy outcomes. Sci. Adv. 2020, 6, eaax6346. [Google Scholar] [CrossRef] [Green Version]
  46. Equils, O.; Kellogg, C.; McGregor, J.; Gravett, M.; Neal-Perry, G.; Gabay, C. The role of the IL-1 system in pregnancy and the use of IL-1 system markers to identify women at risk for pregnancy complications. Biol. Reprod. 2020, 103, 684–694. [Google Scholar] [CrossRef]
  47. Southcombe, J.H.; Redman, C.W.; Sargent, I.L.; Granne, I. Interleukin-1 family cytokines and their regulatory proteins in normal pregnancy and pre-eclampsia. Clin. Exp. Immunol. 2015, 181, 480–490. [Google Scholar] [CrossRef] [Green Version]
  48. Licini, C.; Tossetta, G.; Avellini, C.; Ciarmela, P.; Lorenzi, T.; Toti, P.; Gesuita, R.; Voltolini, C.; Petraglia, F.; Castellucci, M.; et al. Analysis of cell-cell junctions in human amnion and chorionic plate affected by chorioamnionitis. Histol. Histopathol. 2016, 31, 759–767. [Google Scholar]
  49. Tossetta, G.; Paolinelli, F.; Avellini, C.; Salvolini, E.; Ciarmela, P.; Lorenzi, T.; Emanuelli, M.; Toti, P.; Giuliante, R.; Gesuita, R.; et al. IL-1β and TGF-β weaken the placental barrier through destruction of tight junctions: An in vivo and in vitro study. Placenta 2014, 35, 509–516. [Google Scholar] [CrossRef]
  50. Girard, S.; Heazell, A.E.; Derricott, H.; Allan, S.M.; Sibley, C.P.; Abrahams, V.M.; Jones, R.L. Circulating cytokines and alarmins associated with placental inflammation in high-risk pregnancies. Am. J. Reprod. Immunol. 2014, 72, 422–434. [Google Scholar] [CrossRef] [Green Version]
  51. Girard, S.; Sébire, H.; Brochu, M.E.; Briota, S.; Sarret, P.; Sébire, G. Postnatal administration of IL-1Ra exerts neuroprotective effects following perinatal inflammation and/or hypoxic-ischemic injuries. Brain Behav. Immun. 2012, 26, 1331–1339. [Google Scholar] [CrossRef] [Green Version]
  52. Girard, S.; Tremblay, L.; Lepage, M.; Sebire, G. IL-1 receptor antagonist protects against placental and neurodevelopmental defects induced by maternal inflammation. J. Immunol. 2010, 184, 3997–4005. [Google Scholar] [CrossRef]
  53. Leitner, K.; Al Shammary, M.; McLane, M.; Johnston, M.V.; Elovitz, M.A.; Burd, I. IL-1 receptor blockade prevents fetal cortical brain injury but not preterm birth in a mouse model of inflammation-induced preterm birth and perinatal brain injury. Am. J. Reprod. Immunol. 2014, 71, 418–426. [Google Scholar] [CrossRef] [Green Version]
  54. Nadeau-Vallee, M.; Chin, P.Y.; Belarbi, L.; Brien, M.E.; Pundir, S.; Berryer, M.H.; Beaudry-Richard, A.; Madaan, A.; Sharkey, D.J.; Lupien-Meilleur, A.; et al. Antenatal Suppression of IL-1 Protects against Inflammation-Induced Fetal Injury and Improves Neonatal and Developmental Outcomes in Mice. J. Immunol. 2017, 198, 2047–2062. [Google Scholar] [CrossRef]
  55. Nadeau-Vallee, M.; Quiniou, C.; Palacios, J.; Hou, X.; Erfani, A.; Madaan, A.; Sanchez, M.; Leimert, K.; Boudreault, A.; Duhamel, F.; et al. Novel Noncompetitive IL-1 Receptor-Biased Ligand Prevents Infection- and Inflammation-Induced Preterm Birth. J. Immunol. 2015, 195, 3402–3415. [Google Scholar] [CrossRef] [Green Version]
  56. McDuffie, R.S., Jr.; Davies, J.K.; Leslie, K.K.; Lee, S.; Sherman, M.P.; Gibbs, R.S. A randomized controlled trial of interleukin-1 receptor antagonist in a rabbit model of ascending infection in pregnancy. Infect. Dis. Obstet. Gynecol. 2001, 9, 233–237. [Google Scholar] [CrossRef] [Green Version]
  57. Presicce, P.; Park, C.W.; Senthamaraikannan, P.; Bhattacharyya, S.; Jackson, C.; Kong, F.; Rueda, C.M.; DeFranco, E.; Miller, L.A.; Hildeman, D.A.; et al. IL-1 signaling mediates intrauterine inflammation and chorio-decidua neutrophil recruitment and activation. JCI Insight 2018, 3, e98306. [Google Scholar] [CrossRef]
  58. Karisnan, K.; Bakker, A.J.; Song, Y.; Noble, P.B.; Pillow, J.J.; Pinniger, G.J. Interleukin-1 receptor antagonist protects against lipopolysaccharide induced diaphragm weakness in preterm lambs. PLoS ONE 2015, 10, e0124390. [Google Scholar]
  59. Nadeau-Vallee, M.; Obari, D.; Quiniou, C.; Lubell, W.D.; Olson, D.M.; Girard, S.; Chemtob, S. A critical role of interleukin-1 in preterm labor. Cytokine Growth Factor Rev. 2016, 28, 37–51. [Google Scholar] [CrossRef]
  60. Prieto-Peña, D.; Dasgupta, B. Biologic agents and small-molecule inhibitors in systemic autoimmune conditions: An update. Pol. Arch. Intern. Med. 2020, 131, 171–181. [Google Scholar] [CrossRef]
  61. Soh, M.C.; Moretto, M. The use of biologics for autoimmune rheumatic diseases in fertility and pregnancy. Obstet. Med. 2020, 13, 5–13. [Google Scholar] [CrossRef] [PubMed]
  62. Götestam Skorpen, C.; Hoeltzenbein, M.; Tincani, A.; Fischer-Betz, R.; Elefant, E.; Chambers, C.; da Silva, J.; Nelson-Piercy, C.; Cetin, I.; Costedoat-Chalumeau, N.; et al. The EULAR points to consider for use of antirheumatic drugs before pregnancy, and during pregnancy and lactation. Ann. Rheum. Dis. 2016, 75, 795–810. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  63. Nuki, G.; Bresnihan, B.; Bear, M.B.; McCabe, D. Long-term safety and maintenance of clinical improvement following treatment with anakinra (recombinant human interleukin-1 receptor antagonist) in patients with rheumatoid arthritis: Extension phase of a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2002, 46, 2838–2846. [Google Scholar] [CrossRef] [PubMed]
  64. Buckley, L.F.; Viscusi, M.M.; Van Tassell, B.W.; Abbate, A. Interleukin-1 blockade for the treatment of pericarditis. Eur. Heart J. Cardiovasc. Pharmacother. 2018, 4, 46–53. [Google Scholar] [CrossRef] [Green Version]
  65. Kary, S.; Burmester, G.R. Anakinra: The first interleukin-1 inhibitor in the treatment of rheumatoid arthritis. Int. J. Clin. Pract. 2003, 57, 231–234. [Google Scholar]
  66. Ramírez, J.; Cañete, J.D. Anakinra for the treatment of rheumatoid arthritis: A safety evaluation. Expert Opin. Drug Saf. 2018, 17, 727–732. [Google Scholar] [CrossRef]
  67. Dinarello, C.A.; van der Meer, J.W. Treating inflammation by blocking interleukin-1 in humans. Semin. Immunol. 2013, 25, 469–484. [Google Scholar] [CrossRef] [Green Version]
  68. Vastert, S.J.; Jamilloux, Y.; Quartier, P.; Ohlman, S.; Osterling Koskinen, L.; Kullenberg, T.; Franck-Larsson, K.; Fautrel, B.; de Benedetti, F. Anakinra in children and adults with Still’s disease. Rheumatology 2019, 58, vi9–vi22. [Google Scholar] [CrossRef]
  69. Church, L.D.; McDermott, M.F. Canakinumab, a fully-human mAb against IL-1beta for the potential treatment of inflammatory disorders. Curr. Opin. Mol. Ther. 2009, 11, 81–89. [Google Scholar]
  70. Savic, S.; McDermott, M.F. Inflammation: Canakinumab for the cryopyrin-associated periodic syndromes. Nat. Rev. Rheumatol. 2009, 5, 529–530. [Google Scholar] [CrossRef]
  71. Ortona, E.; Pierdominici, M.; Maselli, A.; Veroni, C.; Aloisi, F.; Shoenfeld, Y. Sex-based differences in autoimmune diseases. Ann. Ist. Super. Sanita 2016, 52, 205–212. [Google Scholar]
  72. Fischer-Betz, R.; Specker, C. Pregnancy in systemic lupus erythematosus and antiphospholipid syndrome. Best Pract. Res. Clin. Rheumatol. 2017, 31, 397–414. [Google Scholar] [CrossRef]
  73. Ugurlu, S.; Ergezen, B.; Egeli, B.H.; Selvi, O.; Ozdogan, H. Anakinra treatment in patients with familial Mediterranean fever: A single-centre experience. Rheumatology 2021, 60, 2327–2332. [Google Scholar] [CrossRef]
  74. Moher, D.; Liberati, A.; Tetzlaff, J.; Altman, D.G. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Med. 2009, 6, e1000097. [Google Scholar] [CrossRef] [Green Version]
  75. Sterne, J.A.; Hernán, M.A.; Reeves, B.C.; Savović, J.; Berkman, N.D.; Viswanathan, M.; Henry, D.; Altman, D.G.; Ansari, M.T.; Boutron, I.; et al. ROBINS-I: A tool for assessing risk of bias in non-randomised studies of interventions. BMJ 2016, 355, i4919. [Google Scholar] [CrossRef] [Green Version]
  76. Murad, M.H.; Sultan, S.; Haffar, S.; Bazerbachi, F. Methodological quality and synthesis of case series and case reports. BMJ Evid.-Based Med. 2018, 23, 60–63. [Google Scholar] [CrossRef] [Green Version]
  77. Sfriso, P.; Bindoli, S.; Doria, A.; Feist, E.; Galozzi, P. Canakinumab for the treatment of adult-onset Still’s disease. Expert Rev. Clin. Immunol. 2020, 16, 129–138. [Google Scholar] [CrossRef]
  78. Egawa, M.; Imai, K.; Mori, M.; Miyasaka, N.; Kubota, T. Placental Transfer of Canakinumab in a Patient with Muckle-Wells Syndrome. J. Clin. Immunol. 2017, 37, 339–341. [Google Scholar] [CrossRef]
  79. Mijatovic, V.; Hompes, P.G.; Wouters, M.G. Familial Mediterranean fever and its implications for fertility and pregnancy. Eur. J. Obstet. Gynecol. Reprod. Biol. 2003, 108, 171–176. [Google Scholar] [CrossRef]
  80. Yasar, O.; Iskender, C.; Kaymak, O.; Taflan Yaman, S.; Uygur, D.; Danisman, N. Retrospective evaluation of pregnancy outcomes in women with familial Mediterranean fever. J. Matern. Fetal Neonatal Med. 2014, 27, 733–736. [Google Scholar] [CrossRef]
  81. Chang, Z.; Spong, C.Y.; Jesus, A.A.; Davis, M.A.; Plass, N.; Stone, D.L.; Chapelle, D.; Hoffmann, P.; Kastner, D.L.; Barron, K.; et al. Anakinra use during pregnancy in patients with cryopyrin-associated periodic syndromes (CAPS). Arthritis Rheum. 2014, 66, 3227–3232. [Google Scholar] [CrossRef] [Green Version]
  82. De Lorenzo, R.; Ramirez, G.A.; Punzo, D.; Lorioli, L.; Rovelli, R.; Canti, V.; Barera, G.; Rovere-Querini, P. Neonatal outcomes of children born to mothers on biological agents during pregnancy: State of the art and perspectives. Pharmacol. Res. 2020, 152, 104583. [Google Scholar] [CrossRef]
  83. Ben-Chetrit, E.; Ben-Chetrit, A.; Berkun, Y.; Ben-Chetrit, E. Pregnancy outcomes in women with familial Mediterranean fever receiving colchicine: Is amniocentesis justified? Arthritis Care Res. 2010, 62, 143–148. [Google Scholar] [CrossRef]
  84. Mok, M.Y.; Lo, Y.; Leung, P.Y.; Lau, C.S. Pregnancy outcome in patients with adult onset Still’s disease. J. Rheumatol. 2004, 31, 2307–2309. [Google Scholar]
  85. García-Fernández, A.; Gerardi, M.C.; Crisafulli, F.; Filippini, M.; Fredi, M.; Gorla, R.; Lazzaroni, M.G.; Lojacono, A.; Nalli, C.; Ramazzotto, F.; et al. Disease course and obstetric outcomes of pregnancies in juvenile idiopathic arthritis: Are there any differences among disease subtypes? A single-centre retrospective study of prospectively followed pregnancies in a dedicated pregnancy clinic. Clin. Rheum. 2021, 40, 239–244. [Google Scholar] [CrossRef]
  86. Bakalianou, K.; Salakos, N.; Iavazzo, C.; Danilidou, K.; Papadias, K.; Kondi-Pafiti, A. A rare case of uneventful pregnancy in a woman with Cogan’s syndrome. Clin. Exp. Obstet. Gynecol. 2008, 35, 301–302. [Google Scholar]
  87. Currie, C.; Wax, J.R.; Pinette, M.G.; Blackstone, J.; Cartin, A. Cogan’s syndrome complicating pregnancy. J. Matern. Fetal Neonatal Med. 2009, 22, 928–930. [Google Scholar] [CrossRef]
  88. Deliveliotou, A.; Moustakarias, T.; Argeitis, J.; Vaggos, G.; Vitoratos, N.; Hassiakos, D. Successful full-term pregnancy in a woman with Cogan’s syndrome: A case report. Clin. Rheum. 2007, 26, 2181–2183. [Google Scholar] [CrossRef]
  89. Riboni, F.; Cosma, S.; Perini, P.G.; Benedetto, C. Successful Pregnancy in a Patient with Atypical Cogan’s Syndrome. Isr. Med. Assoc. J. 2016, 18, 495–496. [Google Scholar]
  90. Tarney, C.M.; Wilson, K.; Sewell, M.F. Cogan syndrome in pregnancy. Obstet. Gynecol. 2014, 124, 428–431. [Google Scholar] [CrossRef]
  91. Venhoff, N.; Thiel, J.; Schramm, M.A.; Jandova, I.; Voll, R.E.; Glaser, C. Case Report: Effective and Safe Treatment with Certolizumab Pegol in Pregnant Patients With Cogan’s Syndrome: A Report of Three Pregnancies in Two Patients. Front. Immunol. 2020, 11, 616992. [Google Scholar] [CrossRef] [PubMed]
  92. Blencowe, H.; Cousens, S.; Chou, D.; Oestergaard, M.; Say, L.; Moller, A.B.; Kinney, M.; Lawn, J. Born too soon: The global epidemiology of 15 million preterm births. Reprod. Health 2013, 10 (Suppl. 1), S2. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  93. Venhoff, N.; Voll, R.E.; Glaser, C.; Thiel, J. IL-1-blockade with Anakinra during pregnancy: Retrospective analysis of efficacy and safety in female patients with familial Mediterranean fever. Z. Rheum. 2018, 77, 127–134. [Google Scholar] [CrossRef] [PubMed]
  94. Romero, R.; Dey, S.K.; Fisher, S.J. Preterm labor: One syndrome, many causes. Science 2014, 345, 760–765. [Google Scholar] [CrossRef] [Green Version]
  95. Saigal, S.; Doyle, L.W. An overview of mortality and sequelae of preterm birth from infancy to adulthood. Lancet 2008, 371, 261–269. [Google Scholar] [CrossRef]
  96. Smith, C.J.F.; Chambers, C.D. Five successful pregnancies with antenatal anakinra exposure. Rheumatology 2018, 57, 1271–1275. [Google Scholar] [CrossRef] [Green Version]
  97. Youngstein, T.; Hoffmann, P.; Gül, A.; Lane, T.; Williams, R.; Rowczenio, D.M.; Ozdogan, H.; Ugurlu, S.; Ryan, J.; Harty, L.; et al. International multi-centre study of pregnancy outcomes with interleukin-1 inhibitors. Rheumatology 2017, 56, 2102–2108. [Google Scholar] [CrossRef] [Green Version]
  98. Rider, R.A.; Stevenson, D.A.; Rinsky, J.E.; Feldkamp, M.L. Association of twinning and maternal age with major structural birth defects in Utah, 1999 to 2008. Birth Defects Res. A Clin. Mol. Teratol. 2013, 97, 554–563. [Google Scholar] [CrossRef]
  99. Viktil, K.K.; Engeland, A.; Furu, K. Use of antirheumatic drugs in mothers and fathers before and during pregnancy-a population-based cohort study. Pharmacoepidemiol. Drug Saf. 2009, 18, 737–742. [Google Scholar] [CrossRef]
  100. Drechsel, P.; Stüdemann, K.; Niewerth, M.; Horneff, G.; Fischer-Betz, R.; Seipelt, E.; Spähtling-Mestekemper, S.; Aries, P.; Zink, A.; Klotsche, J.; et al. Pregnancy outcomes in DMARD-exposed patients with juvenile idiopathic arthritis-results from a JIA biologic registry. Rheumatology 2020, 59, 603–612. [Google Scholar] [CrossRef]
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Figure 1. PRISMA flow chart of the systemic review of studies investigating the effect of IL-1 blockage during pregnancy.
Figure 1. PRISMA flow chart of the systemic review of studies investigating the effect of IL-1 blockage during pregnancy.
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Figure 2. Flow chart of IL-1 blockade exposure during pregnancy (for the 11 pregnancies that stopped treatment during their 1st or 2nd trimester, treatment was initiated before conception and therefore they were included in the n = 48).
Figure 2. Flow chart of IL-1 blockade exposure during pregnancy (for the 11 pregnancies that stopped treatment during their 1st or 2nd trimester, treatment was initiated before conception and therefore they were included in the n = 48).
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Table
Table 1. Characteristics and summary from studies included.
Table 1. Characteristics and summary from studies included.
Study Study DesignYear of PublicationPopulationNumber of Pregnancies Included in This StudyIndication for TreatmentTreatment; DosesOutcomeNotes
1Case
report		200911AOSDAnakinra;
100 mg/day		Healthy term baby
2Case
report		201122AOSDAnakinra;
100 mg/day		Two healthy babies, one PTB 36 weeks
3Retrospective cohort study2013511SOJIAAnakinra; NATerm babyBig cohort of SOJIA patients but only one pregnant
4Prospective
cohort study		201499FCAS (6)
NOMID (1)
MWS/NOMID (1)		Anakinra; mostly 100 mg/day but also 239–300 mg/dayAll term babies, three with FCAS, one with MWS and one twin pregnancy resulted in one death at 30 weeks
5Prospective
cohort study		201540FMFAnakinra;
100 mg/day		All healthy babies, one PTB 36 weeksData in another study already
included
6Prospective
cohort study		201563FMFAnakinra;
100 mg/day or NA		All healthy babies, one PTB 36 weeksData in another study already
included
7Prospective
cohort study		2015791Chronic
inflammatory rheumatic disease		Anakinra; NAVoluntary pregnancy terminationBig cohort of
biological drug
during pregnancy, only one took
anakinra
8Case
report		201711FMFAnakinra;
100 mg/day		Healthy term baby
9Prospective
cohort study		201855AOSD (3)
SOJIA (2)		Anakinra;
100 mg/day		All healthy term
babies but one with right hydrocele, heart murmur and resolved low birthweight
10Retrospective cohort study201844FMFAnakinra;
100 mg/day–2 days		All healthy babies but one PTB at 33 weeks with hypotrophic, respiratory distress syndrome,
hyperbilirubinemia and poor drinking
11Prospective
cohort study		20191312FMFAnakinra;
100 mg/day or NA		One miscarriage, two PTB, one stillbirth but overall healthy babiesTwo pregnancies still ongoing, no
obstetrical
information and two pregnancies with data in another study already
included
12Case
report		201911FMFAnakinra;
100 mg/day		Term healthy babyCohort of four
patients with FMF, only one pregnant
13Prospective
cohort study		2019541FMFAnakinra;
100 mg/day		Obstetrical and
neonatal information NA		Cohort of patient with FMF, only one pregnant
14Case
report		201911HLHAnakinra;
200 mg/twice daily		Healthy but had anaemia and marrow suppression
15Retrospective cohort study2020163AOSDAnakinra; NAAll healthy babies but one had PTB at 28 weeksCohort of child
exposed to DMARDs, only 3
exposed to anakinra during pregnancy
16Case
report		202011HLHAnakinra; NAPTB at 31 weeks and IUGR but overall healthy
17Case
report		201711MWSCanakinumab; 150 mg/
4–8 weeks		Healthy term baby
18Case
report		201811SOJIACanakinumab; NAHealthy term baby
19Retrospective cohort study2020231FMFCanakinumab; 150 mg/
6–8 weeks		One healthy term pregnancy and one without informationCohort of patient with FMF, only 2 pregnant
20Retrospective cohort study201377AOSD (1)
CAPS (3)
TRAPS (1)
FMF (1)
Idiopathic pericarditis (1)		Anakinra; NA (6), Canakinumab;
NA (1)		All healthy babies, one PTB 36 weeks and one with unilateral reduced hearing at 6 weeksTwo pregnancies still ongoing, no
obstetrical
information
21Case
report		201511MWSCanakinumab; NA and Anakinra; NAHealthy but with CAPS
22Retrospective cohort study20174331AOSD (4)
CAPS (16)
Cogan syndrome (2)
FMF (5)
Idiopathic pericarditis (1)
TRAPS (2)
Un-SAID (1)		Anakinra; mostly
100 mg/day but also 50–300 mg/day
Canakinumab; 150 mg/
4–8 weeks		Two miscarriage (same women), two PTB, all healthy
babies but one with left renal agenesis and ectopic
neurohypophysis with hormone
deficiency		43 pregnancies
exposed to IL-1
inhibitor but 11 were male exposure
HLH: hemophagocytic lymphohistiocytosis, FMF: familial mediterranean fever, AOSD: adult-onset Still’s disease, FCAS: familial cold autoinflammatory Syndrome, NOMID: neonatal-onset multisystem inflammatory disease, MWS: Muckle-Wells syndrome, sJIA: systemic juvenile idiopathic arthritis, CAPS: cryopyrin-associated autoinflammatory syndromes, NA: not available.
Table
Table 2. Pregnancies details with maternal characteristic and neonatal outcomes.
Table 2. Pregnancies details with maternal characteristic and neonatal outcomes.
Pregnancy IDPregnancy from StudyIndication for
Treatment		TreatmentDosesExposure TimeMode of DeliveryGA at Delivery (Weeks)Birth Weight (g)Obstetric ComplicationChild SexChild
Wellbeing		Breasfeeding
114HLHAnakinra200 mg/
twice daily		22 w–BC-
section		NANANoneNAAnaemia and bone marrow suppressionNA
219FMF + amyloidosisCanakinumab150 mg/6 weeksPC–8 wNATermNANoneNAHealthyNA
319FMFCanakinumab150 mg/8 weeksPC–PPTNANANANANANANA
4 *7Chronic inflammatory rheumatic diseaseAnakinraNANAVaginalNANAVoluntary abortionNANANA
51AOSDAnakinra100 mg/
day		PC–BVaginal40.72700Placental
retention
requiring
manual
abruption		FHealthyYes
64FCASAnakinra100 mg/
day		PC–BVaginal41.03742NoneNAHealthyNo
74FCASAnakinra100 mg/
day		PC–BVaginal41.03629NoneNAFCASNo
84FCASAnakinra100 mg/
day		PC–BVaginal38.03402NoneNAFCASYes
94FCASAnakinra100 mg/
day		PC–BVaginal37.03459NoneNAHealthyNo
104FCASAnakinra100 mg/
day		PC–BVaginal37.72977NoneNAFCASNo
114FCASAnakinra100 mg/
day		PC–BVaginal39.03345NoneNAHealthyNo
124NOMIDAnakinra300 mg/
day		PC–BC-
section		40.04139Chronic
hypertension		NAHealthyYes
134NOMIDAnakinra239–300 mg/
day		PC–BVaginalA: 38.7
B: 30.0		A: 2637
B: NA 		A: None
B: PTB		NAA: Healthy B: Renal agenesis (death)A: Yes
B: No
144MWS/NOMIDAnakinra100 mg/
day		PC–BC-
section		Term3515NoneNAMWSNo
1515AOSDAnakinraNAPC–BC-
section		28.01175PTBFHealthyNA
1615AOSDAnakinraNAPC–BVaginal40.03480NoneMHealthyNA
1715AOSDAnakinraNAPC–BVaginal38.03450NoneMHealthyNA
1912FMFAnakinra100 mg/
day		6 w–BC-
section		Term3340NoneFHealthyYes
2017MWSCanakinumab150 mg/
8 weeks,
then every 4–5 weeks		PC–34 wC-
section		39.02994NoneFHealthy with NLRP3
mutation		NA
2211FMFAnakinra100 mg/
day		PC–29 w + 33 w–BC-
section		38.0NAIncision site infection in postpartumMHealthyNA
2411FMFAnakinraNA16 w–BC-
section		31.0NAPTBF-F twinsHealthyNA
2511FMFAnakinraNA23 w–BC-
section		37.0NANAFHealthyNA
2611FMFAnakinraNA32 w–BC-
section		40.0NANAFHealthyNA
2711FMFAnakinraNAPC–B with 1 month interruptionC-
section		38.0NANAFHealthyNA
2811FMFAnakinraNA34 w–BVaginal37.0NAStillbirthM NA
2911FMFAnakinraNA6 w–BC-
section		36.0NAPTBFHealthyNA
3011FMFAnakinraNANANANANANANANANA
31 *11FMFAnakinraNA5 w–8 w (ongoing)NANANANANANANA
32 *11FMFAnakinraNAPC–8 w (ongoing)NANANANANANANA
332AOSDAnakinra100 mg/
day		PC–BVaginal39.03100NoneMHealthyNo
342AOSDAnakinraNA12 w–BC-
section		36.02800PTBMHealthyNo
3518sJIACanakinumabNAPC–35 wVaginal39.0NAForceps +
minor
episiotomy wound
infection		MHealthyNA
3621MWSCanakinumab and Ana kinraNAPC–BNANANANAMHealthy with CAPSYes
378FMFAnakinra100 mg/
day		PC–BC-
section		38.02700NoneNAHealthyYes
38 *20CAPSAnakinraNAPC–NA (ongoing)NANANANANANANA
39 *20CAPSCanakinumabNAPC–8 w (ongoing)NANANANANANANA
4020CAPSAnakinraNAPC–BVaginalNANANoneMHealthyNo
4120TRAPSAnakinraNAPC–BVaginalNANANoneMUnilateral reduced hearing at 6 weeksNo
4220FMFAnakinra100 mg/
day		21 w–BC-
section		36.0NAVaginal bleeding, PTBMHealthyYes
4320idiopathic pericarditisAnakinraNAPC–BVaginalNANANoneMHealthyNo
4420AOSDAnakinraNA22 w–33 wVaginalNANANoneMHealthyNo
506FMFAnakinra100 mg/
day		12 w–BVaginal40.0NANoneFHealthyYes
526FMFAnakinraNA15 w–BVaginal38.0NANoneMLow
thrombocyte count treated by IVIG		NA
543sJIAAnakinraNAP–BNATermNANANANANA
5513FMFAnakinra100 mg/
day		P–BNANANANoneNANANA
569sJIAAnakinra100 mg/
day		PC–20.4 wC-
section		37.12419Hypertension,
oligohydramnios, breech presentation		MJaundice, right
hydrocele and heart murmur		No
579AOSDAnakinra100 mg/
day		20 w–38.1 wVaginal40.12940NoneMJaundiceNA
589AOSDAnakinra100 mg/
day		PC–
16.6 w + 19.4 w–
37.3 w		C-
section		39.43632NoneMJaundiceYes
599AOSDAnakinra100 mg/
day		PC–
2 w + 9.6 w–
36.7 w		Vaginal38.73519NoneMTongue-tiedYes
609sJIAAnakinra100 mg/
day		PC–
37.3 w		Vaginal39.42640OligohydramniosFHealthyNo
6110FMFAnakinra100 mg/
day		P–BC-
section		40.64025NoneNAHealthyYes
6210FMFAnakinra100 mg/
day		2e trimester–BC-
section		33.73320PTBNAHealthy, hypotrophic,
respiratory distress syndrome, hyperbilirubinemia and poor drinking		No
6310FMFAnakinra100 mg/2 daysP–BC-
section		39.34030Premature bleedingNAHealthyNA
6410FMFAnakinra100 mg/2 daysP–BC-
section		36.43320PTBNAHealthyNA
6616HLHAnakinraNA22 w–BC-
section		31.7NAPTB, IUGR, abnormal umbilical
artery
Doppler and subsequent cardiotocography was abnormal		MNeonatal unit briefly but healthyNA
6722CAPSCanakinumab150 mg/
8 weeks		PC–8 wC-
section		38.03540Gestationnal diabetesMHealthyNo
6822CAPSCanakinumab150 mg/
8 weeks		PC–12 wVaginal40.04480NoneFHealthyYes
6922CAPSCanakinumab150 mg/
8 weeks		1 w–36 wNA40.03570NoneMHealthyNA
7022CAPSCanakinumab120 mg (single dose)PNA38.03290NoneMHealthyYes
7122Un-SAIDCanakinumab300 mg/
8 weeks		PC–BVaginal39.0NANoneMHealthyNA
7222FMFCanakinumab150 mg/
4 weeks		PC–BC-
section		37.03300NoneMHealthyYes
7322FMFCanakinumab150 mg/
8 weeks		PC–4 wC-
section		40.03300NoneFHealthyYes
74 *22Cogan syndromeCanakinumab150 mg/
4 weeks		PC–4 wVaginal4.0NAMiscarriageNA NA
7522CAPSAnakinra50 mg/
day		PC–BVaginal39.03940NoneMHealthyNo
7622CAPSAnakinra50 mg/
day		PC–BVaginal39.0NANoneFHealthyNo
7722CAPSAnakinra100 mg/
day		PC–BVaginal41.13600NoneMHealthyYes
7822CAPSAnakinra100 mg/
day		PPT–BVaginal40.04480NoneFHealthyYes
7922CAPSAnakinra100 mg/
day		36 w–BNA40.03570NoneMHealthyNA
8022CAPSAnakinra100 mg/
day		1 w–PPTNA36.92830PTBMHealthyNo
8122CAPSAnakinra100 mg/
day		PC–BC-
section		38.9NAC-section due to failure to progressNAHealthyNA
8222CAPSAnakinra100 mg/
day		PC–6 wC-
section		40.0NANoneMHealthyNA
8322CAPSAnakinra100 mg/
day		PC–BNANANANoneMHealthyYes
8422CAPSAnakinra100 mg/
day		NANA40.1NANoneFHealthyNA
8522CAPSAnakinra100 mg/
day		NANANANANoneFHealthyNA
8622CAPSAnakinra100 mg/
day		NANANANANoneFHealthyNA
8722FMFAnakinra100 mg/
day		PC–BC-
section		36.12170Vaginal bleeding, PTBMHealthyYes
8822FMFAnakinra100 mg/
day		12 w–BVaginal40.03170NoneFHealthyYes
8922FMFAnakinra100 mg/
day		PC–BVaginal36.01600PTBFHealthyYes
9022idiopathic pericarditisAnakinra100 mg/
day		PC–PPTVaginal38.32930NoneMHealthyNo
9122AOSDAnakinra200–300 mg/
day		PC–16 wNA37.02450NoneFHealthyNo
9222AOSDAnakinra100 mg/
day		22 w–
33 w		NA35.12020PTBMHealthyYes
9322AOSDAnakinra100 mg/
day		9 w–BC-
section		38.1NANoneMLeft renal agenesisYes
9422AOSDAnakinra100 mg/
day		NAVaginal38.03060NoneFHealthyYes
9522TRAPSAnakinra100 mg/
day		PC–BVaginal41.03230NoneMHealthyYes
9622TRAPSAnakinra100 mg/
day		PC–BNANANANoneFHealthyNA
HLH: hemophagocytic lymphohistiocytosis, FMF: familial mediterranean fever, AOSD: adult-onset Still’s disease, FCAS: familial cold autoinflammatory Syndrome, NOMID: neonatal-onset multisystem inflammatory disease, MWS: Muckle-Wells syndrome, sJIA: systemic juvenile idiopathic arthritis, CAPS: cryopyrin-associated autoinflammatory syndromes, NA: not available, PC: prior to conception, B: birth, PPT: pregnancy positive test, P: pregnancy, GA: gestational age, PTB: preterm birth, IUGR: intra-uterine growth restriction, M: male, F: female, *: Excluded from further analysis since data missing.
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Brien, M.-E.; Gaudreault, V.; Hughes, K.; Hayes, D.J.L.; Heazell, A.E.P.; Girard, S. A Systematic Review of the Safety of Blocking the IL-1 System in Human Pregnancy. J. Clin. Med. 2022, 11, 225. https://doi.org/10.3390/jcm11010225

AMA Style

Brien M-E, Gaudreault V, Hughes K, Hayes DJL, Heazell AEP, Girard S. A Systematic Review of the Safety of Blocking the IL-1 System in Human Pregnancy. Journal of Clinical Medicine. 2022; 11(1):225. https://doi.org/10.3390/jcm11010225

Chicago/Turabian Style

Brien, Marie-Eve, Virginie Gaudreault, Katia Hughes, Dexter J. L. Hayes, Alexander E. P. Heazell, and Sylvie Girard. 2022. "A Systematic Review of the Safety of Blocking the IL-1 System in Human Pregnancy" Journal of Clinical Medicine 11, no. 1: 225. https://doi.org/10.3390/jcm11010225

APA Style

Brien, M. -E., Gaudreault, V., Hughes, K., Hayes, D. J. L., Heazell, A. E. P., & Girard, S. (2022). A Systematic Review of the Safety of Blocking the IL-1 System in Human Pregnancy. Journal of Clinical Medicine, 11(1), 225. https://doi.org/10.3390/jcm11010225

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