Plasma microRNA-320a as a Potential Biomarker of Physiological Changes during Training in Professional Volleyball Players
Abstract
:1. Introduction
2. Materials and Methods
2.1. Subjects and Study Design
2.2. Training Cycle Characterization
2.3. MicroRNAs Concentration Analysis
2.4. IGF1R Expression Analysis
2.5. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Parameter | Period I | Period II | Period III | Period IV | p-Value |
---|---|---|---|---|---|
miR-223 | 0.73 ± 0.37 | 0.18 ± 0.05 | 0.98 ± 0.57 | 0.37 ± 0.18 | <0.0001 |
miR-320a | 0.74 ± 0.43 | 0.62 ± 0.2 | 1.19 ± 0.44 | 0.67 ± 0.24 | 0.00021 |
miR-486 | 0.75 ± 0.38 | 1.07 ± 0.42 | 1.44 ± 0.58 | 1.04 ± 0.49 | 0.0037 |
IGF1R | 1.91 ± 1.57 | 3.15 ± 1.76 | 3.84 ± 2.55 | 2.41 ± 1.08 | 0.00092 |
CK (U/L) | 101.82 ± 51.12 | 126.92 ± 96.27 | 145.25 ± 61.12 | 210.58 ± 80.91 | <0.0001 |
Cortisol (µg/dL) | 25.57 ± 7.45 | 19.36 ± 3.97 | 17.27 ± 4.09 | 16.66 ± 4.26 | <0.0001 |
Body Composition Parameter | Period I | Period II | Period III | Period IV | p-Value |
---|---|---|---|---|---|
Weight, kg | 77.3 ± 10.08 | 77.83 ± 10.12 | 77.98 ± 10.61 | 78.17 ± 10.49 | 0.064 |
BMI, kg/m2 | 22.68 ± 2.18 | 22.8 ± 2.21 | 22.83 ± 2.22 | 22.85 ± 2.18 | 0.33 |
Fat, % | 20.83 ± 3.77 | 19.38 ± 3.08 | 19.14 ± 3.71 | 18.66 ± 3.58 | 0.00001 A |
Fat mass, kg | 16.33 ± 4.76 | 15.28 ± 4.22 | 15.09 ± 4.73 | 14.89 ± 4.7 | 0.00048 B |
FFM, kg | 60.98 ± 6.38 | 62.56 ± 6.57 | 62.96 ± 6.64 | 63.53 ± 6.85 | <0.00001 C |
TBW, kg | 44.63 ± 4.66 | 45.81 ± 4.81 | 46.16 ± 4.9 | 46.45 ± 5.05 | <0.00001 D |
BMR, kJ | 7568.75 ± 848.73 | 7740.33 ± 881.37 | 7835.58 ± 959.55 | 7828.5 ± 910.59 | 0.00015 E |
miR-223 | miR-320a | miR-486 | IGF1R | WEIGHT | BMI | BMR | FAT% | FAT MASS | FFM | TBW | CK | Cortisol | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
miR-223 | 1 | 0.54 (p < 0.001) | 0.06 | −0.16 | −0.19 | −0.03 | −0.16 | −0.11 | −0.18 | −0.18 | −0.18 | 0.004 | 0.02 |
miR-320a | 0.54 (p < 0.001) | 1 | 0.73 (p < 0.001) | 0.2 | 0.03 | −0.12 | 0.06 | 0.02 | −0.01 | 0.06 | 0.05 | 0.09 | −0.29 (p = 0.048) |
miR-486 | 0.06 | 0.73 (p < 0.001) | 1 | 0.23 | 0.17 | −0.09 | 0.21 | 0.03 | 0.09 | 0.21 | 0.2 | 0.05 | −0.49 (p < 0.001) |
IGF1R | −0.16 | 0.2 | 0.23 | 1 | −0.13 | −0.37 p = 0.01 | −0.09 | −0.1 | −0.08 | −0.06 | −0.06 | −0.19 | −0.23 |
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Podgórski, R.; Cieśla, M.; Podgórska, D.; Bajorek, W.; Płonka, A.; Czarny, W.; Trybulski, R.; Król, P. Plasma microRNA-320a as a Potential Biomarker of Physiological Changes during Training in Professional Volleyball Players. J. Clin. Med. 2022, 11, 263. https://doi.org/10.3390/jcm11010263
Podgórski R, Cieśla M, Podgórska D, Bajorek W, Płonka A, Czarny W, Trybulski R, Król P. Plasma microRNA-320a as a Potential Biomarker of Physiological Changes during Training in Professional Volleyball Players. Journal of Clinical Medicine. 2022; 11(1):263. https://doi.org/10.3390/jcm11010263
Chicago/Turabian StylePodgórski, Rafał, Marek Cieśla, Dominika Podgórska, Wojciech Bajorek, Artur Płonka, Wojciech Czarny, Robert Trybulski, and Paweł Król. 2022. "Plasma microRNA-320a as a Potential Biomarker of Physiological Changes during Training in Professional Volleyball Players" Journal of Clinical Medicine 11, no. 1: 263. https://doi.org/10.3390/jcm11010263