Is Bilirubin Associated with the Severity of Ischemic Stroke? A Dose Response Meta-Analysis

Song, Yumeng; Zhang, Xiaohong; Li, Chaoxiu; Xu, Shuang; Zhou, Baosen; Wu, Xiaomei

doi:10.3390/jcm11123262

Open AccessReview

Is Bilirubin Associated with the Severity of Ischemic Stroke? A Dose Response Meta-Analysis

by

Yumeng Song

^1,†

,

Xiaohong Zhang

^2,†,

Chaoxiu Li

¹,

Shuang Xu

³,

Baosen Zhou

^1,* and

Xiaomei Wu

^1,*

¹

Department of Clinical Epidemiology and Center of Evidence Based Medicine, The First Hospital of China Medical University, Shenyang 110000, China

²

Department of Clinical Epidemiology, The Fourth Hospital of China Medical University, Shenyang 110000, China

³

Technology Service Department, Library of China Medical University, Shenyang 110000, China

^*

Authors to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

J. Clin. Med. 2022, 11(12), 3262; https://doi.org/10.3390/jcm11123262

Submission received: 30 March 2022 / Revised: 26 May 2022 / Accepted: 6 June 2022 / Published: 7 June 2022

(This article belongs to the Topic Age-Related Neurodegenerative Diseases and Stroke)

Download

Browse Figures

Review Reports Versions Notes

Abstract

There is no consensus on the role of bilirubin in acute ischemic stroke. Higher levels of serum bilirubin may provide a treatment advantage in oxidative-stress-mediated diseases but also may simply reflect the strength of the oxidative stress. As of 28 February 2022, the relevant studies were selected from four databases (PubMed, Web of science, Cochrane, and CNKI) through a retrieval strategy, and strict literature screening and quality evaluation were carried out. The dose–response relationship was fitted with a restricted cubic splines function. We found that the serum total bilirubin level and the direct bilirubin level were positively correlated with the severity of ischemic stroke. The direct bilirubin level was linearly correlated with the severity of stroke (P for non-linearity = 0.55), and the direct bilirubin increase of 1 μmol/L may be related to the 1% increase in the possibility of having moderate or severe ischemic stroke. High bilirubin levels are associated with stroke severity in patients with ischemic stroke and may serve as a marker of the intensity of initial oxidative stress.

Keywords: bilirubin; stroke severity; ischemic stroke; oxidative stress

Share and Cite

MDPI and ACS Style

Song, Y.; Zhang, X.; Li, C.; Xu, S.; Zhou, B.; Wu, X. Is Bilirubin Associated with the Severity of Ischemic Stroke? A Dose Response Meta-Analysis. J. Clin. Med. 2022, 11, 3262. https://doi.org/10.3390/jcm11123262

AMA Style

Song Y, Zhang X, Li C, Xu S, Zhou B, Wu X. Is Bilirubin Associated with the Severity of Ischemic Stroke? A Dose Response Meta-Analysis. Journal of Clinical Medicine. 2022; 11(12):3262. https://doi.org/10.3390/jcm11123262

Chicago/Turabian Style

Song, Yumeng, Xiaohong Zhang, Chaoxiu Li, Shuang Xu, Baosen Zhou, and Xiaomei Wu. 2022. "Is Bilirubin Associated with the Severity of Ischemic Stroke? A Dose Response Meta-Analysis" Journal of Clinical Medicine 11, no. 12: 3262. https://doi.org/10.3390/jcm11123262

APA Style

Song, Y., Zhang, X., Li, C., Xu, S., Zhou, B., & Wu, X. (2022). Is Bilirubin Associated with the Severity of Ischemic Stroke? A Dose Response Meta-Analysis. Journal of Clinical Medicine, 11(12), 3262. https://doi.org/10.3390/jcm11123262

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Menu

Is Bilirubin Associated with the Severity of Ischemic Stroke? A Dose Response Meta-Analysis

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI