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Article

Health-Related Quality of Life following Surgery for Native and Prosthetic Valve Infective Endocarditis

by
Shekhar Saha
1,2,*,
Ralitsa Mladenova
1,
Caroline Radner
1,2,
Konstanze Maria Horke
1,2,
Joscha Buech
1,2,
Philipp Schnackenburg
1,2,
Ahmad Ali
1,2,
Sven Peterss
1,2,
Gerd Juchem
1,2,
Maximilian Luehr
1,3,
Christian Hagl
1,2 and
Dominik Joskowiak
1,2
1
Department of Cardiac Surgery, Ludwig Maximillian University of Munich, 81377 Munich, Germany
2
German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, 80802 Munich, Germany
3
Department of Cardiothoracic Surgery, University Hospital Cologne, 50937 Cologne, Germany
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2022, 11(13), 3599; https://doi.org/10.3390/jcm11133599
Submission received: 6 April 2022 / Revised: 12 June 2022 / Accepted: 18 June 2022 / Published: 22 June 2022
(This article belongs to the Section Cardiology)
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Abstract

Objectives: The objective of this study was to compare the long-term outcomes and health-related quality of life (HRQOL) of patients following surgery for infective native valve endocarditis (NVE) and prosthetic valve endocarditis (PVE). Methods: We retrospectively identified 633 consecutive patients who had undergone surgery for infective endocarditis at our center between January 2005 and October 2018. The patients were interviewed, and the SF-36 survey was used to assess the HRQOL of survivors. Propensity score matching (2:1) was performed with data from a German reference population. Multivariable analysis incorporated binary logistic regression using a forward stepwise (conditional) model. Results: The median age of the cohort was 67 (55–74) years, and 75.6% were male. Operative mortality was 13.7% in the NVE group and 21.6% in the PVE group (p = 0.010). The overall survival at 1 year was 88.0% and was comparable between the groups. The physical health summary scores were 49 (40–55) for the NVE patients and 45 (37–52) for the PVE patients (p = 0.043). The median mental health summary scores were 52 (35–57) and 49 (41–56), respectively (p = 0.961). On comparison of the HRQOL to the reference population, the physical health summary scores were comparable. However, significant differences were observed with regard to the mental health summary scores (p = 0.005). Conclusions: Our study shows that there are significant differences in the various domains of HRQOL, not only between NVE and PVE patients, but also in comparison to healthy individuals. In addition to preoperative health status, it is important to consider the patient’s expectations regarding surgery. Further prospective studies are required.
Keywords: infective endocarditis; health-related quality of life; valve replacement infective endocarditis; health-related quality of life; valve replacement
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MDPI and ACS Style

Saha, S.; Mladenova, R.; Radner, C.; Horke, K.M.; Buech, J.; Schnackenburg, P.; Ali, A.; Peterss, S.; Juchem, G.; Luehr, M.; et al. Health-Related Quality of Life following Surgery for Native and Prosthetic Valve Infective Endocarditis. J. Clin. Med. 2022, 11, 3599. https://doi.org/10.3390/jcm11133599

AMA Style

Saha S, Mladenova R, Radner C, Horke KM, Buech J, Schnackenburg P, Ali A, Peterss S, Juchem G, Luehr M, et al. Health-Related Quality of Life following Surgery for Native and Prosthetic Valve Infective Endocarditis. Journal of Clinical Medicine. 2022; 11(13):3599. https://doi.org/10.3390/jcm11133599

Chicago/Turabian Style

Saha, Shekhar, Ralitsa Mladenova, Caroline Radner, Konstanze Maria Horke, Joscha Buech, Philipp Schnackenburg, Ahmad Ali, Sven Peterss, Gerd Juchem, Maximilian Luehr, and et al. 2022. "Health-Related Quality of Life following Surgery for Native and Prosthetic Valve Infective Endocarditis" Journal of Clinical Medicine 11, no. 13: 3599. https://doi.org/10.3390/jcm11133599

APA Style

Saha, S., Mladenova, R., Radner, C., Horke, K. M., Buech, J., Schnackenburg, P., Ali, A., Peterss, S., Juchem, G., Luehr, M., Hagl, C., & Joskowiak, D. (2022). Health-Related Quality of Life following Surgery for Native and Prosthetic Valve Infective Endocarditis. Journal of Clinical Medicine, 11(13), 3599. https://doi.org/10.3390/jcm11133599

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