Obesity Surgery Improves Hypogonadism and Sexual Function in Men without Effects in Sperm Quality
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Baseline (n = 12) | 18 Months (n = 11) | |
---|---|---|
Age (years) | 45 ± 4.87 | 46.17 ± 4.86 |
BMI (kg/m2) | 42.37 ± 4.44 | 29.6 ± 3.77 * |
Diabetes mellitus, n (%) | 3 (25) | 2 (18.2) |
Hypertension, n (%) | 5 (41.7) | 2 (18.2) |
Dyslipidemia, n (%) | 10 (83.3) | 1 (9.1) * |
OSA, n (%) | 6 (50) | 3 (27.3) |
Hepatic steatosis † (%) | 11 (9.7) | - |
NAFLD fibrosis score | −1.34 ± 1.01 | −1.69 ± 0.94 |
Fasting glycemia (mmol/L) | 6.18 ± 1.47 | 5.71 ± 2.27 |
HbA1c (%) | 5.75 ± 0.62 | 5.45 ± 0.97 * |
Triglycerides (mmol/L) | 3.66 ± 1.36 | 0.98 ± 0.41 * |
Total cholesterol (mmol/L) | 4.86 ± 0.91 | 4.44 ± 0.96 * |
LDLc (mmol/L) | 3.08 ± 0.77 | 2.63 ± 0.72 * |
HDLc (mmol/L) | 1.06 ± 0.16 | 1.36 ± 0.27 * |
Hormone Variables | Before Surgery (n = 12) | 6 Months (n = 11) | 12 Months (n = 12) | 18 Months (n = 11) |
---|---|---|---|---|
Total testosterone (nmol/L) | 11.83 ± 4.99 | 21.19 ± 5.97 ** | 20.77 ± 6.61 ** | 22.91 ± 4.88 ** |
Free testosterone (nmol/L) | 0.28 ± 0.06 | 0.42 ± 0.10 ** | 0.41 ± 0.15 * | 0.41 ± 0.05 ** |
SHBG (nmol/L) | 22.54 ± 12.10 | 39.13 ± 10.82 ** | 41.49 ± 12.55 ** | 41.30 ± 14.41 ** |
Estradiol (nmol/L) | 0.11 ± 0.36 | 0.11 ± 0.38 | 0.11 ± 0.02 | 0.10 ± 0.05 |
Prolactin (mUI/L) | 223.00 ± 142.3 | 142.972 ± 85.14 | 212.196 ± 156.09 | 213.22 ± 184.33 |
LH (UI/L) | 2.91 ± 1.47 | 2.96 ± 0.97 | 2.93 ± 1.41 | 3.41 ± 1.23 |
MOSH (N (%)) | 4 (33.3%) | 0 (0) * | 0 (0) * | 0 (0) * |
FSH (UI/L) | 4.28 ± 1.5 | 4.37 ± 1.7 | 4.53 ± 1.00 | 5.32 ± 1.68 * |
Semen parameters | Before Surgery (n = 12) | 6 Months (n = 11) | 12 Months (n = 12) | 18 Months (n = 11) |
Semen volume (mL) | 2.9 ± 1.75 | 2.59 ± 0.81 | 3.13 ± 1.85 | 3.16 ± 1.48 |
Semen pH | 7.63 ± 0.25 | 7.66 ± 0.29 | 7.56 ± 0.18 | 7.57 ± 0.10 |
Sperm concentration (×106/mL) | 48.75 ± 34.43 | 40.21 ± 31.41 | 39.43 ± 29.26 | 44.85 ± 43.6 |
Total sperm count (×106) | 118.95 ± 79.91 | 110.12 ± 102.37 | 106.35 ± 105.46 | 157.08 ± 206.28 |
Leucocyte concentration (×106/mL) | 0.17 ± 0.39 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.31 ± 0.62 |
Sperm progressive motility (%) | 38.66 ± 17.68 | 33.9 ± 20.62 | 31.12 ± 12.79 | 26 ± 14.71 |
Sperm with normal morphology (%) | 5.83 ± 4.50 | 5.55 ± 4.54 | 3.14 ± 1.67 | 2.82 ± 2.08 * |
Sperms with multiple defects (%) | 43.83 ± 9.90 | 45.55 ± 8.65 | 49.57 ± 8.16 * | 46.55 ± 8.26 |
Teratozoospermia Index (%) | 1.55 ± 0.12 | 1.57 ± 0.11 | 1.60 ± 0.11 | 1.57 ± 0.10 |
Sperm DNA fragmentation (%) | 25.27 ± 9.23 | 29.56 ± 13.48 | 34.43 ± 11.04 | 34.22 ± 13.89 |
Degraded sperm (%) | 3.18 ± 3.74 | 1.67 ± 0.87 | 2.57 ± 0.79 | 4.22 ± 5.36 |
Patients with one or more abnormal semen parameters † (N (%)) | 9 (75) | 6 (54.5) | 7 (58.3) | 9 (81.8) |
Erectile Function Variables | Before Surgery (n = 12) | 6 Months (n = 11) | 12 Months (n = 12) | 18 Months (n = 11) |
---|---|---|---|---|
Erectile function | 23.08 ± 7.57 | 27.18 ± 6.19 * | 26.82 ± 4.21 | 27 ± 4.26 |
Orgasmic function | 9.25 ± 3.67 | 11.18 ± 3.06 | 11.18 ± 4.14 | 11.60 ± 2.011 |
Sexual desire | 9.55 ± 1.036 | 9.18 ± 1.94 | 9.36 ± 1.28 | 9.90 ± 0.316 |
Intercourse satisfaction | 6.75 ± 1.76 | 6.73 ± 1.27 | 6.36 ± 1.80 | 6.90 ± 1.96 |
Overall satisfaction | 6.17 ± 2.08 | 7.64 ± 2.06 | 7.73 ± 2.53 | 7.70 ± 2.45 |
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Miñambres, I.; Sardà, H.; Urgell, E.; Genua, I.; Ramos, A.; Fernández-Ananin, S.; Balagué, C.; Sánchez-Quesada, J.L.; Bassas, L.; Pérez, A. Obesity Surgery Improves Hypogonadism and Sexual Function in Men without Effects in Sperm Quality. J. Clin. Med. 2022, 11, 5126. https://doi.org/10.3390/jcm11175126
Miñambres I, Sardà H, Urgell E, Genua I, Ramos A, Fernández-Ananin S, Balagué C, Sánchez-Quesada JL, Bassas L, Pérez A. Obesity Surgery Improves Hypogonadism and Sexual Function in Men without Effects in Sperm Quality. Journal of Clinical Medicine. 2022; 11(17):5126. https://doi.org/10.3390/jcm11175126
Chicago/Turabian StyleMiñambres, Inka, Helena Sardà, Eulalia Urgell, Idoia Genua, Analía Ramos, Sonia Fernández-Ananin, Carmen Balagué, Jose Luis Sánchez-Quesada, Lluís Bassas, and Antonio Pérez. 2022. "Obesity Surgery Improves Hypogonadism and Sexual Function in Men without Effects in Sperm Quality" Journal of Clinical Medicine 11, no. 17: 5126. https://doi.org/10.3390/jcm11175126