3. Results
The study group included 610 patients who had undergone LSG, 269 patients (44%) were men and 341 (56%) were women. Median age of patients was 43 (36–53) years and median BMI was 46.48 (42.24–51.53) kg/m2. The total number of patients scheduled for LSG at the analyzed time frame was 626, 16 patients were excluded from the study due to the lack of necessary data.
Overall early complications (<30 days) occurred in 35 patients (early morbidity rate 5.74%). All complications were categorized according to Clavien-Dindo classification and are presented in
Table 1. Patients who developed more than one complication were classified to the highest grade of complications. Complications occurred in 15 men and 20 women (47%/53%) with median preoperative BMI = 45.36 kg/m
2. Early complications were more likely to be developed by patients who had admitted to being active smokers (57.14% vs. 0.52%,
p-value < 0.001). The most complications appeared in grade II and III. The most frequent type of complication in grade II was surgical infection and in grade III—gastric leak (six patients) and staple line bleeding (five patients). The analysis revealed two patients’ death due to the septic shock caused by gastric leak. The mortality rate in analyzed group was 0.33%. Comparison between patients with early morbidity and those without is presented in
Table 2.
The risk factors associated with early complications were smoking, gastroesophageal reflux diseases, hypercholesterolemia, cholelithiasis, length of hospital stay and operation duration. As presented in
Table 3, independent risk factors for developing early complications were hypercholesterolemia (OR 3.73;
p-value = 0.023) and smoking (OR = 274.66,
p-value < 0.001).
The total incidence of late complications that occurred ≥30 days and <12 months after LSG was 1.64%. Late complications appeared in two men and eight women (20/80%). Five patients developed grade II complications according to Clavien-Dindo Classification (dumpling syndrome, optic neuropathy, staple-line ulcer and severe gastroesophageal reflux disease). Another five patients required surgical intervention due to hiatal hernia (one case) and trocar site hernia (four patients). All complications that occurred 30 days after the surgery are listed in
Table 4. Comparison between patients with >30 days morbidity and those without is presented in
Table 5.
As shown in
Table 6, independent risk factors for developing late complications (>30 days) include smoking (OR = 8.12,
p-value = 0.008), peptic ulcer disease (OR = 6.75,
p-value = 0.035) and co-existence of hiatal hernia (OR = 13.62,
p-value = 0.043).
4. Discussion
This study confirms that laparoscopic sleeve gastrectomy is a relatively safe bariatric procedure with 30-day morbidity rate being 5.74% and 30-day mortality rate of 0.3%. Our data reveals that tobacco smoking within 2 months before the bariatric surgery is associated with higher risk of both early and late complications, while hypercholesterolemia only increases the risk of early complications. Other factors that may influence postoperative course are co-existence of hiatal hernia, gastroesophageal reflux disease, cholelithiasis, peptic ulcer disease and operation-related factors such as operation duration and length of hospital stay.
Bariatric/metabolic surgery in morbidly obese patients is associated with the decrease in overall mortality in comparison with the control group treated conventionally [
11]. However, obesity itself is known as a risk factor for developing surgical complications [
12]. According to Sjöström et al., other factors that increase the risk of mortality during bariatric surgery are male gender, daily smoking and coexisting conditions such as diabetes, previous stroke and cancer, a history of myocardial infarction and lipid-lowering therapy [
11]. Aminian et al. developed a risk calculator for perioperative complications after LSG that included male gender, BMI, presence of diabetes, history of congestive heart failure (CHF), steroid use for chronic condition, preoperative hematocrit level and preoperative serum total bilirubin level [
13]. Besides the patient-related risk factors, there are also the procedure-related risk factors that may affect the incidence of complications after the surgical procedure such as procedure duration, occurrence of intraoperative complications, number of staple firings used and surgical experience of the surgeon [
14,
15].
In our study, we analyzed patient-related factors for developing early and late complications after laparoscopic sleeve gastrectomy. The research reveals that smoking is a factor significantly influencing the occurrence of <30 and >30 days after the surgery complications. Currently, no other individual factor has such a negative impact on human health as smoking [
16]. According to Polish Guidelines on Metabolic and Bariatric Surgery smoking cessation is recommended at least 6 weeks before the surgical intervention [
7,
17]. Study conducted by Haskins et al. showed that tobacco use had a significant increase in prolonged intubation, reintubation, sepsis and length of hospital stay regardless of the type of the laparoscopic bariatric procedure. However, smoking did not lead to the increased risk of mortality for bariatric procedures [
18]. Inadomi et al. conducted research to explore the relationship between smoking and short-term bariatric surgery outcomes. Their study revealed that risk-adjusted rate of severe complications among bariatric patients in the recent smoker group was significantly higher in comparison with the non-smoker group. However, the increased risk for developing severe complications applied only to the patients who had undergone Roux-en-Y gastric bypass (OR 1.34; 95% CI, 1.01–1.77) [
19]. Another study conducted by Haskins et al. showed that smoking patients were more likely to experience a composite morbidity event (4.3% versus 3.7%,
p-value = 0.04) and serious morbidity event (0.9% versus 0.6%,
p-value = 0.003) [
20]. The above analyses are in line with our study. However, Husain et al. did not identify any independent risk factor of severe complications after laparoscopic sleeve gastrectomy [
6].
The precise mechanism by which smoking has a deleterious effect on surgical outcomes remains unknown. It is thought to be the result of both, long-term consequences of tobacco use and acute toxic results [
21]. Smoking contributes to the damage of the gastric mucosa by increasing the apoptosis within the gastrointestinal tract. Increased apoptosis inhibits proliferation of mucosal cells that leads to impaired protective function and healing processes [
22,
23]. It has been also proven that nicotine, the major addictive agent in cigarettes, is a vasoconstrictor that reduces the blood flow, resulting in tissues ischemia. Additionally, it activates the sympathetic system and causes the release of catecholamines that leads to decrease in prostaglandins production and increases the platelets aggregation [
24]. Moreover, carbon monoxide binds to hemoglobin reducing oxygen content that leads to tissue hypoxia [
25]. The summarized impact of nicotine and carbon monoxide contributes to delay in all aspects of wound healing and leads to postoperative wound infection and gastric leak. Tobacco abuse also decreases the tension of lower esophageal sphincter what promotes retrograde flow of stomach contents to esophagus and causes symptoms of gastroesophageal reflux diseases (GERD) [
26].
Abdominal obesity is a central point of metabolic syndrome (MS) components. It has been widely proven that laparoscopic sleeve gastrectomy has a considerable efficiency in the treatment of obesity-related diseases [
27]. However, co-existing diseases may also cause an increased risk for the occurrence of complications. In our study, it has been demonstrated that hypercholesterolemia increases the risk of perioperative morbidity (OR 3.72; 95% CI, 1.20–11.56). Lorente et al. also proved that dyslipidemia is statistically relevant risk factor predicting overall and severe complications rate after bariatric surgery [
28]. Additionally, hypercholesterolemia is a major cardiovascular risk factor that promotes the development of coronary artery disease [
29]. Dorman et al. showed that patients with cardiac comorbidities that included: history of congestive heart failure, myocardial infarction or angina, previous coronary intervention or cardiac surgery are at higher risk of major postoperative events [
30]. Diabetes is another commonly encountered diseases in patients who are candidates for bariatric surgery. A few studies have identified diabetes as a risk factor for severe complications: NSQIP study (OR = 2.04) and the Longitudinal Assessment of Bariatric Surgery study (LABS study) (OR = 1.46) [
31,
32]. Additionally, NSQIP study showed that postoperative complications were two times more likely to appear in patients after LSG (OR 2.06; 95% CI, 1.57–2.72) when compared to patients undergoing laparoscopic adjustable gastric banding (LAGB) [
31]. In the recent study conducted by Guetta et al., patients with type 2 diabetes mellitus (T2DM) had significantly higher early complications rate than non-T2DM patients (13.3% vs. 7.0%,
p-value = 0.01). Analysis of glycated hemoglobin level (HbA1c) as an independent variable showed that for every 1% elevation in HbA1c, there was an increase of 1.314 for early complications (
p-value = 0.008; 95% CI, 1.07–1.61) and 1.407 for severe complications (
p-value = 0.013; 95% CI, 1.07–1.84) [
5]. These conclusions were not confirmed in our research.
Patients scheduled for bariatric surgery are considered to be at higher risk of perioperative risk due to the morbid obesity itself. However, there are also procedure-related factors that may increase the incidence of complications after laparoscopic sleeve gastrectomy. In our study, two factors: operation duration and length of hospital stay were found to have an impact on increased risk of perioperative issues, however they cannot be considered as independent factors for developing complications. In a study conducted by Sanni et al., the mean operative time for LSG was 93.3 ± 45.9 min (
p-value < 0.0001). However, the operation time was not proved to have an influence on incidence of perioperative complications [
31]. Additional procedures during the LSG, e.g., adhesiolysis or diaphragmatic crura repair may significantly extend the length of the procedure. However, an analysis performed by Major et al. did not show that additional procedures during laparoscopic sleeve gastrectomy are associated with the increased perioperative risk rate [
14]. Husain et al. proved that long operation time (>120 min) for sleeve gastrectomy is a risk factor associated with severe complications after the procedure (III, IV and V grade according to Clavien-Dindo classification) [
20]. Length of stay (LOS) after laparoscopic sleeve gastrectomy varies among different bariatric centers due to the non-identical discharge criteria. Fletcher et al. showed that patients with prolonged hospitalization defined as ≥3 days more often experienced organ space surgical site infection, pneumonia, pulmonary embolism, acute kidney injury, cardiac arrest and bleeding requiring transfusion. Their study also revealed statistically significant higher reoperation and readmission rates for hospitalizations ≥ 3 days when compared to 2 days (
p-value < 0.001) [
33]. Longer LOS was also a predictor of readmission in the study by Lois et al., in which they proved that patients with hospitalizations of more than 3 days were four times as likely to be readmitted than patients with one-day hospital stay after bariatric surgery (
p-value < 0.001) [
34].
The most common early complications that were observed in our study group were gastric leak and staple-line bleeding. Gastric leak is one the most serious and life-threatening complication that occurs in up to 5% of patients undergoing LSG [
35]. The multicentre study conducted by Benedix et al. confirmed that male gender and BMI 50–50.9 kg/m
2 are associated with significantly higher leak rates (2.5 vs. 1.6%,
p = 0.02 and
p < 0.01) [
36]. Patients with gastric leak may be totally asymptomatic or present symptoms of septic shock, such as fever, abdominal pain, tachycardia, tachypnoea and peritonitis [
37]. The management of gastric leak is dependent on the clinical status of the patient and it includes: conservative treatment (withholding food and fluids, intravenous hydration, broad spectrum antibiotheraphy, and proton pump inhibitor administration), endoscopic intervention such as implementation of endoprothesis or endoscopic double-pigtail catheter (EDPC) or surgical management (lavage and drainage of peritoneal cavity) [
38,
39].
The limitations of the present study are its non-randomized design, the relatively small sample of patients and short follow-up time, which was limited by the desire to provide complete data. However, this could result in underestimation of the real risk of developing >30 days complications after LSG. In addition, the real number of smoking patients may be greater as we suppose not everyone admitted to being an active smoker.