Custom-Made 3D-Printed Implants for Anterior Column Reconstruction in the Upper Cervical Spine after Intralesional Extracapsular Excision—Report of 2 Cases and Literature Review
Abstract
:1. Introduction
2. Materials and Methods
Design of the Implant
3. Results
3.1. Case Report 1
3.2. Case Report 2
3.3. Reconstruction
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Patient | Age (Years), Sex | Diagnosis | Enneking | WBB | Previous Treatments | Approach | Margin | Local Control (Months) | Overall Survival (Months) | Oncological Status |
---|---|---|---|---|---|---|---|---|---|---|
1 | 65, M | Recurrent chordoma C2 | IB | 8-5/A-D | RT (70.4 Gy carbon-ion, Δt = 4 y) Extracapsular debulking and reconstruction w/ allograft and carbon-fiber buttress plate (Δt = 2 y) | A | Intralesional | 18 | 20 | DOC |
2 | 75, M | Recurrent chordoma C2 | IB | 8-3/A-D | Extracapsular debulking (Δt = 8 m) RT (74 Gy proton-ion, Δt = 2 m) | A+P | Intralesional | 12 | 32 | DOD |
Authors | Year | Article Type | n | Diagnosis | Age, Sex | Previous Treatments | Surgical Treatment | Approach | Adjuvant Treatments | Proximal Fixation | Distal Fixation | Follow-Up | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Xu N et al. [9] | 2016 | Case report | 1 | C2 Ewing sarcoma | 12, M | None | Single-level (C2) IL spondylectomy | P (C0-C6) + A (extraoral retropharyngeal) staged (2 weeks) | CHT + RT | Divergent TI-screws in C1 lateral masses | Titanium wiring in DVB (C3; TI-screws insertion not possible) | 1 year | |
Li X et al. [10] | 2017 | Case report | 1 | C2-C3-C4 thyroid ca. metastasis | 53, F | None | 3-level (C2-C4) IL corpectomy + thyroidectomy and lateral lymph nodes dissection | A and P (C1-C6) | Radioiodine I131 | Divergent TI-screws in C1 lateral masses | 2 TI-screws in DVB (C5) | 1 year | |
Mobbs RJ et al. [11] | 2017 | Case report | 1 | C1-C2 chordoma | 63, M | CT-guided transoral biopsy | 2-level (C1-C2) IL excision | P (C0-C3) and A (transoral) | RT | 2 TiP-screws in the clivus | 2 TI-screws in DVB (C3) | 9 months | |
He S et al. [12] | 2019 | Case report | 1 | C2-C7 chondrosarcoma | 27 | Posterior open biopsy | 6-level (C2-C7) IL en bloc resection | P (C0-T2) and A (retropharyngeal) staged (1 week) | Local cisplatinum intra-op. | Divergent TI-screws in C1 lateral masses | 2 TiP-screws in DVB (T1) | 14 months | |
He S et al. [13] | 2019 | Case series | 7 | C1-C3 (4 patients) C1-C2 (3 patients) | Average 47.6 ± 19.0 (range 12–72) | - - - | Multi-level IL spondylectomy (4 3-level, 3 2-level) | P and A (retropharyngeal) staged | - - - | TI-screws in occipital condyles | 2 TiP-screws in DVB | Average 14.8 (range 7.3–24.2) | |
| |||||||||||||
Parr WHC et al. [14] | 2020 | Case report | 1 | C3-C4-C5 chordoma | 45, M | CT-guided biopsy | 3-level IL spondylectomy | P (C2-C6) and A staged (3 days) | RT (proton-beam) | 2 TI-screws in C2 | 2 TI-screws in DVB (C6) | 17 months | |
Li Y et al. [15] | 2020 | Case report | 1 | C1 plasmocytoma | 57, M | CT-guided transoral biopsy | IL tumor debulking | A (retropharyngeal) and P (C0-C3) | RT (57 Gy/27 ft.) | 1 TI-screw in occipital condyle | 1 TI- and 1 TiP-screw in DVB (C2) | (Not reported) | |
Wei F et al. [16] | 2020 | Case series | 9 | 7 C2 2 C2-C3 | Average 31.4 (range 12–59) | CT-guided biopsy | Single- and multi-level IL spondylectomy | P (4 cases to C0, 5 to C1) and A (retropharyngeal) staged (average 14.4 days) | RT, CHT (in 2 cases) | Divergent TI-screws in C1 lateral masses | 2 TiP-screws in DVB (not possible in 2 cases) | Average 28.6 (range 12–42) | |
| |||||||||||||
Yang X et al. [17] | 2020 | Case report | 1 | C3-C4-C5-C6-C7-T1 chordoma | 40, F | 2 tumor debulkings | 6-level IL extracapsular excision | A (retropharyngeal) and P (C1-T3) | None | 3 TiP-screws in vertebral body of C2 | 3 TiP-screws in DVB (T2) | 9 months | |
Hunn SAM et al. [18] | 2020 | Case report | 2 | C2 thyroid ca. metastasis | 56, F | None | Single-level (C2) IL corpectomy | A (retropharyngeal) | and P (C1-C3) | RT and CHT | 2 TiP-screws in C1 lateral masses | 3 TiP-screws in DVB (C3) | 14 months |
C2-C3 myeloma | 63, M | None | 2-level (C2-C3) IL corpectomy | and P (C1-C4) | (Not reported) | 3 TiP-screws in DVB (C4) | 4 months | ||||||
Baldassarre BM et al. [19] | 2021 | Case report | 1 | C1-C2 chordoma | 45 | Biopsy | IL excision | P (C0-C4) and A (retropharyngeal) staged (1 day) | RT (proton beam) | Saddle for anterior arch of C1 | 2 TiP-screws in DVB (C3) | 12 months |
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Girolami, M.; Griffoni, C.; Asunis, E.; Falzetti, L.; Bandiera, S.; Barbanti Brodano, G.; Ghermandi, R.; Pipola, V.; Terzi, S.; Pesce, E.; et al. Custom-Made 3D-Printed Implants for Anterior Column Reconstruction in the Upper Cervical Spine after Intralesional Extracapsular Excision—Report of 2 Cases and Literature Review. J. Clin. Med. 2022, 11, 6058. https://doi.org/10.3390/jcm11206058
Girolami M, Griffoni C, Asunis E, Falzetti L, Bandiera S, Barbanti Brodano G, Ghermandi R, Pipola V, Terzi S, Pesce E, et al. Custom-Made 3D-Printed Implants for Anterior Column Reconstruction in the Upper Cervical Spine after Intralesional Extracapsular Excision—Report of 2 Cases and Literature Review. Journal of Clinical Medicine. 2022; 11(20):6058. https://doi.org/10.3390/jcm11206058
Chicago/Turabian StyleGirolami, Marco, Cristiana Griffoni, Emanuela Asunis, Luigi Falzetti, Stefano Bandiera, Giovanni Barbanti Brodano, Riccardo Ghermandi, Valerio Pipola, Silvia Terzi, Eleonora Pesce, and et al. 2022. "Custom-Made 3D-Printed Implants for Anterior Column Reconstruction in the Upper Cervical Spine after Intralesional Extracapsular Excision—Report of 2 Cases and Literature Review" Journal of Clinical Medicine 11, no. 20: 6058. https://doi.org/10.3390/jcm11206058