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Article

Prevalence of Osteoporosis Assessed by DXA and/or CT in Severe Obese Patients

by
Marion Halin
1,
Edem Allado
2,3,
Eliane Albuisson
4,5,
Laurent Brunaud
6,7,8,
Isabelle Chary-Valckenaere
1,9,
Damien Loeuille
1,9,
Didier Quilliot
6,7,10 and
Marine Fauny
1,11,*
1
Department of Rheumatology, University Hospital, F-54000 Nancy, France
2
University Center of Sports Medicine and Adapted Physical Activity, CHRU-Nancy, F-54000 Nancy, France
3
DevAH, Université de Lorraine, F-54000 Nancy, France
4
Unité de Méthodologie, Data Management et Statistiques (UMDS), Département MPI, DRCI, CHRU-Nancy, F-54000 Nancy, France
5
IECL, CNRS, Université de Lorraine, F-54000 Nancy, France
6
Unité Multidisciplinaire de la Chirurgie de L’obésité (UMCO), University Hospital, F-54000 Nancy, France
7
Inserm UMRS 1256 N-GERE (Nutrition-Genetics-Environmental Risks), Faculty of Medicine, University de Lorraine, F-54000 Nancy, France
8
Department of Digestive, Hepato-Biliary and Endocrine Surgery, University Hospital, F-54000 Nancy, France
9
Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), UMR 7365 CNRS—University of Lorraine, F-54000 Nancy, France
10
Department of Endocrinology Diabetology and Nutrition, University Hospital, F-54000 Nancy, France
11
Department of Rheumatology, Saint Charles Hospital, F-54200 Toul, France
 
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Author to whom correspondence should be addressed.
J. Clin. Med. 2022, 11(20), 6114; https://doi.org/10.3390/jcm11206114
Submission received: 2 September 2022 / Revised: 7 October 2022 / Accepted: 15 October 2022 / Published: 17 October 2022
(This article belongs to the Section Endocrinology & Metabolism)
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Abstract

The primary objective was to evaluate bone fragility prevalence on dual X-ray absorptiometry (DXA) and computed tomography (CT) in patients with severe obesity. The secondary objective was to evaluate the risk factors for bone fragility. This monocentric study was conducted in patients with grade 2 and 3 obesity. Bone mineral density (BMD) and T-score were studied on DXA, and the scanographic bone attenuation coefficient of L1 (SBAC-L1) was measured on CT. Among the 1386 patients included, 1013 had undergone both DXA and CT within less than 2 years. The mean age was 48.4 (±11.4) years, 77.6% were women, and the mean BMI was 45.6 (±6.7) kg/m². Eight patients (0.8%) had osteoporosis in at least one site. The mean SBAC-L1 was 192.3 (±52.4) HU; 163 patients (16.1%) were under the threshold of 145 HU. Older age (OR[CI95] = 1.1 [1.08–1.16]), lower BMD on the femoral neck and spine (OR[CI95] = 0.04[0.005–0.33] and OR[CI95] = 0.001[0.0001–0.008], respectively), and higher lean mass (OR[CI95] = 1.1 [1.03–1.13]) were significantly associated with an SBAC-L1 ≤ 145 HU in multivariate analysis. Approximately 16% of patients with severe obesity were under the SBAC-L1 threshold, while less than 1% were classified as osteoporotic on DXA.
Keywords: obesity; bone mineral density (BMD); scanographic bone attenuation coefficient (SBAC-L1); tomodensitometry/CT; dual-energy X-ray absorptiometry (DXA) obesity; bone mineral density (BMD); scanographic bone attenuation coefficient (SBAC-L1); tomodensitometry/CT; dual-energy X-ray absorptiometry (DXA)

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MDPI and ACS Style

Halin, M.; Allado, E.; Albuisson, E.; Brunaud, L.; Chary-Valckenaere, I.; Loeuille, D.; Quilliot, D.; Fauny, M. Prevalence of Osteoporosis Assessed by DXA and/or CT in Severe Obese Patients. J. Clin. Med. 2022, 11, 6114. https://doi.org/10.3390/jcm11206114

AMA Style

Halin M, Allado E, Albuisson E, Brunaud L, Chary-Valckenaere I, Loeuille D, Quilliot D, Fauny M. Prevalence of Osteoporosis Assessed by DXA and/or CT in Severe Obese Patients. Journal of Clinical Medicine. 2022; 11(20):6114. https://doi.org/10.3390/jcm11206114

Chicago/Turabian Style

Halin, Marion, Edem Allado, Eliane Albuisson, Laurent Brunaud, Isabelle Chary-Valckenaere, Damien Loeuille, Didier Quilliot, and Marine Fauny. 2022. "Prevalence of Osteoporosis Assessed by DXA and/or CT in Severe Obese Patients" Journal of Clinical Medicine 11, no. 20: 6114. https://doi.org/10.3390/jcm11206114

APA Style

Halin, M., Allado, E., Albuisson, E., Brunaud, L., Chary-Valckenaere, I., Loeuille, D., Quilliot, D., & Fauny, M. (2022). Prevalence of Osteoporosis Assessed by DXA and/or CT in Severe Obese Patients. Journal of Clinical Medicine, 11(20), 6114. https://doi.org/10.3390/jcm11206114

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