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Volume 11
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10.3390/jcm11236972
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Article

Coexistence of Multiple Myositis-Specific Antibodies in Patients with Idiopathic Inflammatory Myopathies

by
Hung-Ling Huang
1,
Wen-Chih Lin
2,
Wei-Lun Tsai
3,
Chia-Tse Weng
4,
Meng-Yu Weng
4,
Chun-Hsin Wu
4 and
Yuan-Ting Sun
3,5,*
1
Department of Neurology, Tainan Hospital, Ministry of Health and Welfare, Tainan 700, Taiwan
2
Department of Physical Medicine and Rehabilitation, Chiali Branch, Chi Mei Medical Centre, Tainan 722, Taiwan
3
Department of Medical Genomics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
4
Department of Internal Medicine, Division of Allergy, Immunology, and Rheumatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
5
Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2022, 11(23), 6972; https://doi.org/10.3390/jcm11236972
Submission received: 21 October 2022 / Revised: 21 November 2022 / Accepted: 22 November 2022 / Published: 25 November 2022
(This article belongs to the Section Immunology)
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Abstract

The mutual exclusivity of myositis-specific antibodies (MSAs) has been reported before, but the coexistence of 2 or more MSAs was still found in a few case reports. This study aims to confirm the existence and prevalence of double MSAs in patients with idiopathic inflammatory myopathy (IIM) and to clarify the clinical features of these patients. One hundred fifty-one patients with IIM diagnosed from 1 July 2018 to 31 July 2022, at National Cheng Kung University Hospital, Taiwan, were enrolled and divided into two groups, patients with ≤1 MSA (n = 128, 84.8%) and those with ≥2 MSAs (n = 23, 15.2%) according to the initial serology results. After being re-examined by ANA-IIF assay, 8 out of 23 patients were confirmed to have ≥2 MSAs. The demographic data and clinical features were presented. The prevalence of double-positive MSAs among IIM was 5.3% in this cohort. The coexistence of two MSAs in an IIM patient does exist but is rare. Patients with two MSAs belonging to two distinct IIM subtypes presented clinical features skewed to one subtype instead of “mixed phenotypes”. No apparent difference in clinical severity was found between patients with ≥2 MSAs and ≤1 MSA. Longer follow-ups and more studies are required to characterize the patients of IIM with ≥2 MSAs.
Keywords: idiopathic inflammatory myopathies; myositis specific antibodies; exclusivity idiopathic inflammatory myopathies; myositis specific antibodies; exclusivity

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MDPI and ACS Style

Huang, H.-L.; Lin, W.-C.; Tsai, W.-L.; Weng, C.-T.; Weng, M.-Y.; Wu, C.-H.; Sun, Y.-T. Coexistence of Multiple Myositis-Specific Antibodies in Patients with Idiopathic Inflammatory Myopathies. J. Clin. Med. 2022, 11, 6972. https://doi.org/10.3390/jcm11236972

AMA Style

Huang H-L, Lin W-C, Tsai W-L, Weng C-T, Weng M-Y, Wu C-H, Sun Y-T. Coexistence of Multiple Myositis-Specific Antibodies in Patients with Idiopathic Inflammatory Myopathies. Journal of Clinical Medicine. 2022; 11(23):6972. https://doi.org/10.3390/jcm11236972

Chicago/Turabian Style

Huang, Hung-Ling, Wen-Chih Lin, Wei-Lun Tsai, Chia-Tse Weng, Meng-Yu Weng, Chun-Hsin Wu, and Yuan-Ting Sun. 2022. "Coexistence of Multiple Myositis-Specific Antibodies in Patients with Idiopathic Inflammatory Myopathies" Journal of Clinical Medicine 11, no. 23: 6972. https://doi.org/10.3390/jcm11236972

APA Style

Huang, H.-L., Lin, W.-C., Tsai, W.-L., Weng, C.-T., Weng, M.-Y., Wu, C.-H., & Sun, Y.-T. (2022). Coexistence of Multiple Myositis-Specific Antibodies in Patients with Idiopathic Inflammatory Myopathies. Journal of Clinical Medicine, 11(23), 6972. https://doi.org/10.3390/jcm11236972

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