The Relationship between the SARC-F Score and the Controlling Nutritional Status Score in Gastrointestinal Diseases
Abstract
:1. Introduction
2. Patients and Methods
2.1. Patients and Our Study
2.2. The CONUT Score
2.3. Statistics
3. Results
3.1. Patient Baseline Features
3.2. SARC-F Score Based on the Nutritional Condition
3.3. The Percentage of Subjects with SARC-F Score ≥ 4 Based on the Nutritional Condition
3.4. SARC-F Score Based on the Nutritional Condition in Subjects with and without Advanced Cancer
3.5. The Percentage of Subjects with SARC-F Score ≥ 4 Based on the Nutritional Condition in Subjects with and without Advanced Cancer
3.6. SARC-F Score Based on the Nutritional Condition Stratified by the Anatomical Categories of Disease
3.7. The Percentage of Subjects with SARC-F Score ≥ 4 Based on the Nutritional Condition Stratified by the Anatomical Categories of Disease
3.8. Uni- and Multivariate Analysis of Variables for the CONUT Score ≥ 2 or the CONUT Score ≥ 5
3.9. Multivariate Analysis Using Cumulative Logistic Model
3.10. ROC Analysis for the Malnutrition as Evaluated by the CONUT Score
3.11. ROC Analysis of the CONUT Score for the SARC-F Score 4 or More
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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n or Median (IQR) | |
---|---|
Age (years) | 71 (62–77) |
Gender, male/female | 438/297 |
Type of disease | |
Upper gastrointestinal disease | 234 |
Lower gastrointestinal disease | 190 |
Biliary and pancreatic disease | 176 |
Liver disease | 135 |
Advanced cancer, yes | 188 |
Body mass index (kg/m2) | 22.2 (19.7–24.5) |
C reactive protein (mg/dL) | 0.22 (0.06–1.21) |
eGFR (ml/min/1.73 m2) | 68 (55–81) |
Serum albumin | |
≥3.5 g/dL | 534 |
≥3.0 g/dL, <3.5 g/dL | 116 |
≥2.5 g/dL, <3.0 g/dL | 54 |
<2.5 g/dL | 31 |
Total cholesterol | |
≥180 mg/dL | 375 |
≥140 mg/dL, <180 mg/dL | 243 |
≥100 mg/dL, <140 mg/dL | 98 |
<100 mg/dL | 19 |
Total lymphocyte count | |
≥1600/μL | 232 |
≥1200/μL, <1600/μL | 191 |
≥800/μL, <1200/μL | 185 |
<800/μL | 127 |
CONUT score | |
Normal (0 or 1 point) | 271 |
Mild malnutrition (2–4 points) | 310 |
Moderate malnutrition (5–8 points) | 127 |
Severe malnutrition (9–12 points) | 27 |
The CONUT Score ≥ 2 | Univariate | Multivariate | ||
---|---|---|---|---|
p Value | OR | 95% CI | p Value | |
SARC-F score (per one) | <0.0001 | 1.233 | [1.109, 1.372] | <0.0001 |
Age (per one year) | 0.0485 | 1.007 | [0.994, 1.020] | 0.3256 |
BMI (per one kg/m2) | 0.020 | 0.948 | [0.910, 0.988] | 0.0107 |
eGFR (per one ml/min/1.73 m2) | 0.002 | 0.988 | [0.980, 0.997] | 0.0044 |
CRP (per one mg/dl) | <0.0001 | 1.845 | [1.508, 2.257] | <0.0001 |
The CONUT Score ≥ 5 | Univariate | Multivariate | ||
pValue | OR | 95% CI | pValue | |
SARC-F score (per one) | <0.0001 | 1.233 | [1.134, 1.341] | <0.0001 |
Age (per one year) | 0.0908 | |||
BMI (per one kg/m2) | 0.5227 | |||
eGFR (per one ml/min/1.73 m2) | 0.001 | 0.988 | [0.979, 0.996] | 0.0041 |
CRP (per one mg/dl) | <0.0001 | 1.260 | [1.184, 1.341] | <0.0001 |
Estimates | Standard Error | p Value | 95% CI | |
---|---|---|---|---|
SARC-F score | −0.266 | 0.0989 | 0.0071 | [−0.456, −0.065] |
Age | −0.0128 | 0.0202 | 0.5250 | [−0.055, 0.0244] |
BMI | 0.1196 | 0.0608 | 0.0491 | [0.004, 0.242] |
eGFR | 0.0218 | 0.0101 | 0.0312 | [0.002, 0.042] |
CRP | −0.8115 | 0.1089 | <0.0001 | [−1.041, −0.613] |
The CONUT Score ≥ 2 | AUC | Sensitivity (%) | Specificity (%) | Cutoff Point |
---|---|---|---|---|
SARC-F score | 0.60 | 42.0 | 74.5 | 1 |
Age (year) | 0.57 | 56.5 | 56.8 | 71 |
BMI (kg/m2) | 0.55 | 33.8 | 67.1 | 20.2 |
eGFR (ml/min/1.73 m2) | 0.57 | 32.8 | 83.4 | 58 |
CRP (mg/dl) | 0.70 | 57.8 | 77.5 | 0.27 |
The CONUT Score ≥ 5 | AUC | Sensitivity (%) | Specificity (%) | Cutoff Point |
SARC-F score | 0.63 | 43.5 | 81.4 | 2 |
Age (year) | 0.55 | 61.0 | 51.0 | 71 |
BMI (kg/m2) | 0.52 | 20.3 | 87.6 | 18.3 |
eGFR (ml/min/1.73 m2) | 0.59 | 47.1 | 72.2 | 55 |
CRP (mg/dl) | 0.79 | 77.9 | 68.2 | 0.32 |
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Ikegami, T.; Nishikawa, H.; Goto, M.; Matsui, M.; Asai, A.; Ushiro, K.; Ogura, T.; Takeuchi, T.; Nakamura, S.; Kakimoto, K.; et al. The Relationship between the SARC-F Score and the Controlling Nutritional Status Score in Gastrointestinal Diseases. J. Clin. Med. 2022, 11, 582. https://doi.org/10.3390/jcm11030582
Ikegami T, Nishikawa H, Goto M, Matsui M, Asai A, Ushiro K, Ogura T, Takeuchi T, Nakamura S, Kakimoto K, et al. The Relationship between the SARC-F Score and the Controlling Nutritional Status Score in Gastrointestinal Diseases. Journal of Clinical Medicine. 2022; 11(3):582. https://doi.org/10.3390/jcm11030582
Chicago/Turabian StyleIkegami, Takako, Hiroki Nishikawa, Masahiro Goto, Masahiro Matsui, Akira Asai, Kosuke Ushiro, Takeshi Ogura, Toshihisa Takeuchi, Shiro Nakamura, Kazuki Kakimoto, and et al. 2022. "The Relationship between the SARC-F Score and the Controlling Nutritional Status Score in Gastrointestinal Diseases" Journal of Clinical Medicine 11, no. 3: 582. https://doi.org/10.3390/jcm11030582