Comparison of the Effect of MFAT and MFAT + PRP on Treatment of Hip Osteoarthritis: An Observational, Intention-to-Treat Study at One Year
Abstract
:1. Introduction
2. Materials and Methods
2.1. Inclusion Criteria
2.2. Statistical Methods
2.2.1. Reproducibility of Analysis and Replicability of Results
2.2.2. Missing Values
2.2.3. Study Flow Chart
2.3. Patients
2.4. Harvesting Adipose Tissue
2.5. Preparation of PRP
2.6. Injection Protocol
2.7. Responder Classification
3. Results
3.1. General Outcomes
3.2. Response to Treatment
3.2.1. VAS
3.2.2. OHS
3.3. Complications
4. Discussion
Study Limitations
5. Conclusions
Author Contributions
Funding
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Gender | Treatment | No. of Patients | Mean Age on Procedure (SD) | Mean BMI on Procedure (SD) |
---|---|---|---|---|
FEMALE | MFAT | 36 | 65 (13) | 26 (7) |
MALE | 21 | 56 (10) | 31 (7) | |
FEMALE | MFAT + PRP | 37 | 60 (8) | 26 (4) |
MALE | 53 | 60 (11) | 27 (5) |
Gender | OA Grade | MFAT | MFAT + PRP |
---|---|---|---|
FEMALE | 1 | 6 | 6 |
2 | 11 | 7 | |
3 | 12 | 6 | |
4 | 7 | 18 | |
MALE | 1 | 5 | 8 |
2 | 1 | 9 | |
3 | 5 | 10 | |
4 | 10 | 26 | |
TOTAL | 57 | 90 |
Treatment | Patient Reported Outcome | Super-Responder | Responder | TOTAL Responders | TOTAL Non-Responder | Lost to Follow-Up | Total |
---|---|---|---|---|---|---|---|
MFAT | VAS | 14 | 8 | 22 | 13 | 22 | 57 |
OHS | 11 | 11 | 22 | 5 | 30 | ||
MFAT + PRP | VAS | 20 | 12 | 32 | 12 | 46 | 90 |
OHS | 11 | 4 | 15 | 8 | 67 |
Measure | Outcome | Treatment | Difference of the Means | 95% Credible Interval of the Difference of the Means | |
---|---|---|---|---|---|
VAS | Pain reduction (−) | MFAT | −20.771 | −41.117 | −0.857 |
MFAT + PRP | −12.767 | −28.882 | +3.543 | ||
OHS | Function Improvement (+) | MFAT | +6.568 | −0.715 | +13.640 |
MFAT + PRP | +7.339 | +0.993 | +13.920 |
Treatment | Conversion to THR | OA Grade | ||
---|---|---|---|---|
KL 2 | KL 3 | KL 4 | ||
MFAT | 10 | 0 | 4 | 6 |
MFAT + PRP | 10 | 1 | 2 | 7 |
Measure | Outcome | Treatment | Difference of the Means | 95% Credible Interval of the Difference of the Means | |
---|---|---|---|---|---|
VAS | Difference in pain reduction (mean) | µ1–µ2 | −9.190 | −27.610 | 9.291 |
OHS | Difference in functional improvement (+) | µ1–µ2 | −0.145 | −7.011 | 6.677 |
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Heidari, N.; Slevin, M.; Zeinolabediny, Y.; Meloni, D.; Olgiati, S.; Wilson, A.; Noorani, A.; Azamfirei, L. Comparison of the Effect of MFAT and MFAT + PRP on Treatment of Hip Osteoarthritis: An Observational, Intention-to-Treat Study at One Year. J. Clin. Med. 2022, 11, 1056. https://doi.org/10.3390/jcm11041056
Heidari N, Slevin M, Zeinolabediny Y, Meloni D, Olgiati S, Wilson A, Noorani A, Azamfirei L. Comparison of the Effect of MFAT and MFAT + PRP on Treatment of Hip Osteoarthritis: An Observational, Intention-to-Treat Study at One Year. Journal of Clinical Medicine. 2022; 11(4):1056. https://doi.org/10.3390/jcm11041056
Chicago/Turabian StyleHeidari, Nima, Mark Slevin, Yasmin Zeinolabediny, Davide Meloni, Stefano Olgiati, Adrian Wilson, Ali Noorani, and Leonard Azamfirei. 2022. "Comparison of the Effect of MFAT and MFAT + PRP on Treatment of Hip Osteoarthritis: An Observational, Intention-to-Treat Study at One Year" Journal of Clinical Medicine 11, no. 4: 1056. https://doi.org/10.3390/jcm11041056