Intraoperative Quantification of MDS-UPDRS Tremor Measurements Using 3D Accelerometry: A Pilot Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Subjects
2.2. Materials
2.3. Measurements
2.4. Data Pre-Processing
2.5. Accelerometry Measures
2.6. Objective MDS-UPDRS Scores
2.6.1. Postural, Kinetic and Rest Tremor Amplitude
2.6.2. Constancy of Rest Tremor
2.7. Statistical Analysis
3. Results
3.1. Accelerometry Measures
3.2. Objective MDS-UPDRS Scores
4. Discussion
4.1. Contributions
4.2. Accelerometry Measures
4.3. Objective MDS-UPDRS Scores
4.4. Inconsistencies
4.5. Future Perspectives
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Score | Scoring Criteria MDS-UPDRS Items 3.15–3.17 | Score | Scoring Criteria MDS-UPDRS Item 3.18 |
---|---|---|---|
0 | No tremor | 0 | No tremor |
1 | ≤1 cm in maximal amplitude | 1 | Tremor is present ≤25% of the time |
2 | >1 cm but <3 cm in maximal amplitude | 2 | Tremor is present 26–50% of the time |
3 | 3–10 cm in maximal amplitude | 3 | Tremor is present 51–75% of the time |
4 | >10 cm in maximal amplitude | 4 | Tremor is present >75% of the time |
MDS-UPDRS Test | Outcome Measure | R | R2 * | Coefficient ** | 95%CI | p |
---|---|---|---|---|---|---|
3.15 Postural tremor | Log(PAUCtremor) | 0.869 | 0.755 | 3.171 | 2.737, 3.605 | <0.001 |
Log(Amplitude) | 0.805 | 0.648 | 1.312 | 1.079, 1.544 | <0.001 | |
3.16 Kinetic tremor | Log(PAUCtremor) | 0.379 | 0.144 | 1.749 | 0.584, 2.914 | 0.004 |
Log(Amplitude) | 0.513 | 0.264 | 1.030 | 0.560, 1.499 | <0.001 | |
3.17 Rest tremor amplitude | Log(PAUCtremor) | 0.904 | 0.818 | 4.256 | 3.769, 3.769 | <0.001 |
Log(Amplitude) | 0.912 | 0.832 | 2.032 | 1.811, 2.253 | <0.001 | |
3.18 Rest tremor constancy | Log(PAUCtremor/s) | 0.857 | 0.735 | 2.322 | 1.985, 2.660 | <0.001 |
Ttremor | 0.974 | 0.949 | 7.180 | 6.779, 7.581 | <0.001 |
MDS-UPDRS Test | Concordance | Cohen’s κ | 95%CI | RMSE | MAE |
---|---|---|---|---|---|
3.15 Postural tremor | 76.1% | 0.614 | 0.563, 0.665 | 0.569 | 0.268 |
3.16 Kinetic tremor | 69.6% | 0.239 | 0.137, 0.341 | 0.641 | 0.339 |
3.17 Rest tremor amplitude | 77.1% | 0.620 | 0.597, 0.643 | 0.521 | 0.243 |
3.18 Rest tremor constancy | 84.3% | 0.726 | 0.628, 0.824 | 0.493 | 0.186 |
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Smid, A.; Elting, J.W.J.; van Dijk, J.M.C.; Otten, B.; Oterdoom, D.L.M.; Tamasi, K.; Heida, T.; van Laar, T.; Drost, G. Intraoperative Quantification of MDS-UPDRS Tremor Measurements Using 3D Accelerometry: A Pilot Study. J. Clin. Med. 2022, 11, 2275. https://doi.org/10.3390/jcm11092275
Smid A, Elting JWJ, van Dijk JMC, Otten B, Oterdoom DLM, Tamasi K, Heida T, van Laar T, Drost G. Intraoperative Quantification of MDS-UPDRS Tremor Measurements Using 3D Accelerometry: A Pilot Study. Journal of Clinical Medicine. 2022; 11(9):2275. https://doi.org/10.3390/jcm11092275
Chicago/Turabian StyleSmid, Annemarie, Jan Willem J. Elting, J. Marc C. van Dijk, Bert Otten, D. L. Marinus Oterdoom, Katalin Tamasi, Tjitske Heida, Teus van Laar, and Gea Drost. 2022. "Intraoperative Quantification of MDS-UPDRS Tremor Measurements Using 3D Accelerometry: A Pilot Study" Journal of Clinical Medicine 11, no. 9: 2275. https://doi.org/10.3390/jcm11092275