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Case Report

Long-Term Results after Placing Dental Implants in Patients with Papillon-Lefèvre Syndrome: Results 2.5–20 Years after Implant Insertion

by
Katrin Nickles
1,*,†,
Mischa Krebs
2,†,
Beate Schacher
1,
Hari Petsos
1 and
Peter Eickholz
1
1
Department of Periodontology, Center for Dentistry and Oral Medicine (Carolinum), Johann Wolfgang Goethe-University Frankfurt am Main, 60596 Frankfurt, Germany
2
Department of Oral Surgery and Implantology, Center for Dentistry and Oral Medicine (Carolinum), Johann Wolfgang Goethe-University Frankfurt am Main, 60596 Frankfurt, Germany
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
J. Clin. Med. 2022, 11(9), 2438; https://doi.org/10.3390/jcm11092438
Submission received: 7 April 2022 / Revised: 21 April 2022 / Accepted: 25 April 2022 / Published: 26 April 2022
(This article belongs to the Special Issue Periodontitis: Current Status and the Future)
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Abstract

:
Aim: A retrospective evaluation of patients with Papillon-Lefèvre syndrome (PLS) treated with dental implants to identify factors that may influence treatment outcomes. Methods: All PLS patients with dental implants currently registered at the Department of Periodontology, Goethe-University Frankfurt (20–38 years; mean: 29.6 years), were recruited. Five patients from three families (two pairs of siblings) with a total of 48 dental implants (inserted in different dental institutions) were included with a follow-up time of 2.5–20 years (mean: 10.4 years). Results: Implant failure occurred in three patients (at least 15 implants). Nearly all patients demonstrated peri-implantitis in more or less advanced stages; 60% of patients demonstrated bone loss ≥50% around the implants. Two patients did not follow any supportive therapy. Conclusions: Implants in PLS patients who did not follow any maintenance programme had a high risk of peri-implantitis and implant loss.

1. Introduction

Papillon-Lefèvre syndrome (PLS) is an infrequent genetic disorder characterised by palmoplantar hyperkeratosis combined with rapidly progressive severe periodontitis affecting both the deciduous and permanent dentitions [1]. The prevalence of PLS is 1–4 per million [2] with no sex or race predominance and is inherited as an autosomal-recessive trait. A loss-of-function mutation affecting the cathepsin C gene (CTSC) on chromosome 11q14.1-q14.3 has traditionally been related to the disorder [3,4], its main functions being protein degradation and proenzyme activation [5].
As periodontal therapy often fails in PLS patients [6,7,8], they typically lose their teeth early in life and eventually become edentulous with significant ridge resorption. For an increasing number of cases of PLS patients, it is reported that periodontitis may be arrested even in the long term. In those cases, therapy consists of treatment of the infection with the extraction of severely diseased teeth, combined mechanical and antibiotic periodontal treatment, oral hygiene instructions, intensive maintenance therapy, and microbiological monitoring [9,10,11].
However, PLS patients who have lost many or all teeth need prosthetic rehabilitation. Over the last few years, dental implants have become a common treatment alternative to replace missing teeth. The use of dental implants in young patients with rapidly progessing periodontitis (1999 classification: aggressive periodontitis; 2018 classification: periodontitis grade C) has already been reported [12,13]. Patients with periodontitis grade C (GAgP) had a five times greater risk of implant failure, a three times larger risk of mucositis, and 14 times higher risk of peri-implantitis [13]. Swierkot et al. concluded that patients with treated periodontitis grade C (GAgP) are more susceptible to mucositis and peri-implantitis and experience lower implant survival and success rates than periodontally healthy individuals [13].
Based on the fact that PLS is a rare disease, there are limited studies (mainly case reports) with small numbers of patients assessed in the literature. To the best of our knowledge, just eight articles report outcomes of dental implants in PLS patients [11,14,15,16,17,18,19,20]. Furthermore, long-term results are only occasionally reported.
Therefore, the aim of the present retrospective study was to analyse (long-term) outcomes of dental implants in five PLS patients and to identify factors that may influence treatment outcomes. As is presently best known, this is the largest group of PLS patients treated with dental implants reported thus far.

2. Materials and Methods

Patients and Data Collection

We studied all PLS patients with dental implants registered at the Department of Periodontology, Center for Dentistry and Oral Medicine, Johann Wolfgang Goethe-University Frankfurt (20–38 years; mean: 29.6 years). In all patients, the diagnosis of PLS was based on the clinical findings during the initial examination and confirmed by detecting mutations in the cathepsin C gene by analysing blood samples. The study was registered by the Institutional Review Board for Human Studies of the Medical Faculty Goethe-University under the number 31/05 in 2005.
Five patients (four female) were included. They belonged to three families and included two pairs of siblings. Implant therapy in two patients was performed exclusively at the Department of Oral Surgery and Implantology in Frankfurt, and in the three other patients, it was carried out at external dental clinics or by local dentists or oral surgeons. The initial periodontal therapy in Patients 1 and 2 had been described previously [21] as well as the periodontal development of Patients 1, 2, 3, and 4 [11]. All data were collected from the documents in the patients’ files. The patients included in our study are listed in Table 1.

3. Results

3.1. Implant Therapy

Patients 1 and 2 were treated at the Department of Oral Surgery and Implantology, Center for Dentistry and Oral Medicine (Carolinum), Johann Wolfgang Goethe-University Frankfurt am Main with the same surgical technique (for details, see Table 1). Despite being provided with extensive information about the importance of supportive implant therapy (SIT), Patient 1 participated in just one maintenance visit. Supportive implant therapy (SIT) consisted of oral hygiene instructions, professional implant cleaning (professional mechanical plaque removal [PMPR] and stain removal), and—bi-annually—a comprehensive periodontal/peri-implant examination. In this way, a rapid intervention was possible whenever needed. In probing pocket depths of 4 mm that showed bleeding on probing (BOP) and/or pockets that were deeper than 4 mm, subgingival/mucosal instrumentation (SI) with titan curettes and/or air-polishing with glycine powder, as well as instillation of 1% chlorhexidine gel, was performed. In the course of every maintenance visit, oral hygiene indices were assessed.
In patient 1, peri-implant mucositis and in two implants, peri-implantitis lesions could be detected already. In Patient 2, compliance improved over time. However, the patient participated in SIT only once a year. Peri-implant mucositis could also be clearly diagnosed in Patient 2 (Table 1).
In Patients 3 (see Figure 1), 4, and 5, implants were primarily inserted years before in different private practices (for details, see Table 1).

3.2. Clinical, Microbiological and Radiological Findings

At six sites per implant (mesiobuccal, midbuccal, distobuccal, distooral, midoral, mesiooral), probing pocket depths (PPD) were measured using a manual rigid periodontal probe (PCP UNC15, Hu-Friedy, Chicago, IL, USA) to the nearest millimetre. Bleeding on probing (BOP) was recorded 30 s after probing. Suppuration was documented for each implant (see Table 2). Three patients were already exhibiting PPD ≥ 7 mm. All patients exhibited high BOP scores (>20%) except for Patient 4, who took systemic antibiotics at the time of scoring.
Except for Patient 4, in each patient that was treated with systemic antibiotics, a microbiological examination was performed with sterile paper points from the deepest pocket of each quadrant. For analysis, a commercially available real-time PCR (Meridol Paro Diagnostik Test, Carpegen, Münster, Germany) for the quantitative determination of six periodontal pathogens (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Prevotella intermedia, and Fusobacterium nucleatum) was employed. None of the patients showed subgingival presence of the periodontal key pathogen, Aggregatibacter actinomycetemcomitans (see Table 2).
Panoramic radiographs were either performed on the day of investigation in the university hospital or earlier by private practices and collected at the following appointment. The proportional bone loss was determined by use of a Schei-ruler [22] on the mesial and distal aspect of each implant (distance of implant shoulder to implant apex) and was classified into three categories (Bone loss 0− < 25%, 25− < 50%, ≥50%) (see Table 3). Three (60%) patients demonstrated bone loss ≥50% around the implants.

4. Discussion

PLS is a rare genetic disease characterised by hyperkeratosis of the palms and soles. It also manifests in a rapidly progressive, severe periodontitis that leads to premature loss of the primary and secondary teeth if not treated early and consequently. A mutation affecting the CTSC gene on chromosome 11q14.1-q14.3 has been associated with the disorder [3]. The cathepsin C enzyme is expressed by epithelial and immune cells and mainly acts as a key enzyme in the activation of granule serine proteases, e.g., elastase. Several studies have studied the pathogenesis of periodontitis in PLS patients. Compromised neutrophil function, including phagocytosis, chemotaxis, and bacterial killing [23], as well as severely depressed natural killer cell cytotoxicity, have been described in patients with PLS [24,25]. Hence, it is plausible that patients with PLS are also very likely to develop disease around dental implants. For this reason, the use of dental implants in patients with severe forms of periodontitis secondary to systemic disorders was not a treatment option for a long time. As a result of young patients having a need for oral rehabilitation that would otherwise not be treated with fixed prosthetics, the question arises of whether dental implants could also elicit success in PLS patients. Swierkot et al. assessed the prevalence of peri-implant mucositis, peri-implantitis, implant success, and survival in patients with GAgP/periodontitis grade C and in periodontally healthy individuals [13]. They reported implant survival rates of 100% in periodontally healthy individuals versus 96% in patients with GAgP/periodontitis grade C. Further, the implant success rate was 33% in GAgP/periodontitis grade C patients and 50% in periodontally healthy patients. The implant success rate was defined by the following parameters: (1) no implant movement; (2) no discomfort (pain, foreign body sensation, paresthesia); (3) PD ≤ 5 mm without BOP; (4) no continuous radiologic translucency; and (5) annual peri-implant bone loss ≤ 0.2 mm 1 year after insertion of the superstructure. Implants that failed to meet ≥1 criteria were considered a failure. In the GAgP/periodontitis grade C group, peri-implant mucositis could be detected in 56% and peri-implantitis in 26% of the implants. In the periodontally healthy group, 40% of the implants exhibited mucositis and 10% peri-implantitis. In addition, GAgP/periodontitis grade C patients demonstrated a five times greater risk of implant failure, a three times higher risk of mucositis, and 14 times more obvious risk of developing peri-implantitis. Ultimately, the authors contended that patients with treated GAgP/periodontitis grade C are more susceptible to mucositis and peri-implantitis and had lower success rates and implant survival [13]. Actually, to the best of our knowledge, just eight articles have reported the outcomes of dental implants in PLS patients [11,14,15,16,17,18,19,20]. The exception is Nickles et al. [11]—all others only described the outcome in a single PLS patient with a follow-up period of up to 4.5 years. At first sight, the results are positive. Here, we present data from five PLS patients treated with dental implants. In two patients, dental implants were inserted at the Department of Oral Surgery and Implantology at the Johann Wolfgang Goethe-University Frankfurt am Main with state-of-the-art techniques. In one patient, peri-implantitis was already documented after 2.5 years (see Figure 2). Non-compliance to SIT seemed to be the most probable cause of peri-implant destruction in this patient.
All patients treated with dental implants many years earlier (approximately 20 years in Patients 3, 4, and 5) exhibited advanced bone loss around the implants and suffered substantial implant loss. What could be the reasons for these failures? In two patients, Brånemark implants were utilised. The Brånemark system is a well-documented implant system—Ross-Jansåker et al. evaluated the long-term results of implant therapy with implant loss as the outcome variable. In 294 patients, Brånemark implants were inserted between 1988 and 1992 in Kristianstad (Sweden). One and five years after the placement of the suprastructure, the patients were scheduled to the clinic. Between 2000 and 2002 (9–14 years after implant insertion), the patients again underwent a clinical and radiographic examination. In total, 218 patients treated with 1057 implants were assessed and the overall implant survival rate was 95.7%. A significant connection could be noticed between implant loss and periodontal bone loss of the residual teeth. Overall, it appeared that a history of periodontitis was related to implant loss [26].
Documentation of long-term results with the IMZ® system is rare. Haas et al. presented a cumulative survival rate of 83.2% after 100 months in a study with 1920 IMZ® implants. The results demonstrated a statistically significant lower cumulative survival rate of maxillary (37.9%) versus mandibular implants (90.4%) [27]. In contrast to these findings, Willer et al. documented similar survival rates for upper and lower jaw implants in a prospective observation of 1250 IMZ dental implants. The cumulative survival rate after 10 years (82.4%) was very similar to the findings of Haas et al. [28] The cumulative survival rates associated with the IMZ system (83.2%/82.4%) seemed to be lower than those presented by a working group from Frankfurt University [29] with the Ankylos® Implant system with a survival rate of 93.3% after 204 months (17 years). Whether the implant system utilised in our three PLS cases had any influence on the outcomes remains questionable.
In 2014, a Cochrane review was published by Esposito et al. [30] concerning the success rates of different types of dental implants. Based on the available results of randomised clinical trials (RCTs), the authors felt there was limited evidence demonstrating that implants with relatively smooth (turned) surfaces were less prone to bone loss because of chronic infection (peri-implantitis) than those with rougher surfaces. On the other hand, there was no evidence indicating that any particular type of dental implant had superior long-term success. These results were based on a small number of RCTs, often at high risk of bias, with few participants and relatively short follow-up periods. More RCTs should be conducted with a follow-up of at least 5 years that also ascertain the inclusion of a sufficient number of patients in order to detect a true difference [30].
As tooth loss in PLS patients is usually accompanied by severe loss of alveolar bone structures in the mandible as well as in the maxilla, bone-grafting methods seem to be particularly necessary with respect to the maxilla. In the mandible, an inter-foraminal implant placement appears to be possible even in cases with severe resorption when short- and narrow-diameter implants are used. These implants seem to be similarly successful to longer implants [29,31].
In the maxilla, depending on the amount of bone loss and the desired form of prosthetic reconstructions, vertical grafting with autologous bone transplants and sinus grafting are apparently possible options for implant-retained reconstructions. Sinus graftings seem to be equally successful when performed with bovine substitutes or autologous materials [32,33,34,35,36]. Iliac bone was employed in at least one of the three PLS patients here with a follow-up period of approximately 20 years. Fretwurst et al. [37] examined the long-term results after onlay grafting with iliac bone. The authors could demonstrate that in patients with atrophic jaws, an adequately long-term reconstruction could be achieved with iliac onlay grafting in combination with dental implants.
Another issue common in the literature was the time at which the implants were placed. In Patients 3, 4, and 5, the first implants were placed by and next to remaining teeth, meaning there was no edentulous period for these patients.
The most important reason for peri-implant disease, however, was the lack of any professional supportive periodontal/peri-implant therapy. Rocuzzo et al. [38] compared the long-term outcomes of implants placed in patients treated for periodontitis (periodontally-compromised patients; PCPs) and in periodontally healthy patients (PHP) in relation to the adherence of SPT. It was observed that patients with a history of periodontitis had a lower survival rate and a statistically significantly higher number of sites with peri-implant bone loss. Furthermore, PCPs that did not faithfully adhere to SPT exhibited a higher implant failure rate. This underlines the value of SPT for enhancing the long-term outcomes of implant therapy, particularly in subjects affected by periodontitis, in order to control reinfection and limit biological complications [38].
Although in Patients 3 and 4, professional dental/implant cleanings (professional mechanical plaque removal [PMPR] and stain removal) were performed every three months, no measurement of probing depths, assessment of BOP/suppuration, or subgingival/-mucosal cleaning took place. Instead, systemic amoxicillin + clavulanic acid and metronidazole were prescribed for seven days twice a year, though no subgingival cleaning was performed concordantly. Altogether, no professional supportive therapy was conducted on these patients. In Patient 5, no supportive therapy took place at all.
Fazele et al. [39] assessed the success of dental implant placement in PLS patients in a systematic review: the authors studied 15 cases with 136 dental implants and they concluded that dental implants may be a viable treatment option for PLS patients and implantation can help preserve alveolar bone if the patients’ immunological and growing conditions are well-considered and proper oral hygiene and compliance with the maintenance program are continued. Nevertheless, in 3 patients, 20 implants failed.
Some PLS patients receive systemic retinoid medication. In the literature, supposedly positive effects have been reported for a systemic medication with oral retinoids [40,41], but also not for others [42]. One of our patients (patient 2) is receiving a systemic retinoid (acitretin) for several years now—despite this, she has lost all of her teeth.

5. Conclusions

A history of periodontal disease is a risk factor for peri-implant disease in general and PLS periodontitis in particular. Thus, PLS patients are high-risk patients with regard to peri-implant disease. We report 5 PLS patients losing all teeth and being treated with dental implants. Only one patient receives proper (oral hygiene indices, PPD charting, PMPR, SI) SPT on a yearly basis. Patient 1 received just one proper SPT, Patients 3 and 4 received twice a year systemic antibiotics but only supramucosal PMPR, Patient 5 did not receive any maintenance treatment whatsoever. Thus, two main factors seem to drive bone loss: (1) time (which is trivial) and (2) lack of SPT (which is particularly evident in comparison to Patients 1 and 2).
In light of what we have presented in this work, it remains debatable whether implants should be used in patients with PLS-associated periodontitis. The impaired immune system in PLS patients represents a risk factor that cannot be controlled. These patients have to be classified as high-risk patients and informed of their circumstances. Many of these patients lose their teeth very early, yielding orthodontic and physiognomic, and, hence, psychosocial consequences. Implants often represent the only opportunity to insert fixed or at least stable prostheses in these patients. PLS patients—along with their treating dentist—should be aware of the risks associated with not complying with the prescribed regimen of supportive care, i.e., peri-implantitis and implant loss. Therefore it is of crucial importance that PLS patients are informed about the importance of supportive therapy.
The authors are aware of the fact that the number of patients included in the study was very small. Nevertheless, the manuscript clearly provides the prevalence, i.e., 1 to 4 under 1 million population. The authors are also aware of the fact that the treatment modalities (implant types, various bone grafts, etc.) are very heterogeneous and hard to compare.
In spite of everything, the present study represents the largest on implant treatment in PLS patients so far.

Author Contributions

All authors contributed substantially to the interpretation of the data for the work, they contributed to drafting and critically revising the manuscript, they agreed to be accountable for all aspects of the work. Additionally, P.E., M.K. and K.N. conceived the ideas for the concept and design of the study; K.N., M.K., B.S., H.P. and P.E. collected the data; B.S. and H.P. supervised methodical approaches; K.N. analysed the data and managed the group; P.E. and K.N. led the writing. All authors have read and agreed to the published version of the manuscript.

Funding

The microbiological examinations in four patients were partially funded by Carpegen GmbH, Münster.

Institutional Review Board Statement

The trial was approved by the Institutional Review Board for Human Studies of the Medical Faculty of the Johann Wolfgang Goethe-University Frankfurt/Main (31–05; 7 March 2005) with the 3rd Amendment (2015).

Informed Consent Statement

All participants were informed of the risks, benefits, and procedures of the study, and gave written informed consent.

Data Availability Statement

The data that support the findings of this study are not available due to data protection restrictions.

Acknowledgments

This study was kindly supported by Carpegen GmbH, Münster, Germany.

Conflicts of Interest

The authors declare that they have no conflict of interest. This study was self-funded by the authors and their institutions. The microbiological examinations in four patients were partially funded by Carpegen GmbH, Münster.

References

  1. Papillon, M.M.; Lefèvre, P. Two cases of symmetrically familiary palmar and plantar hyperkeratosis (Meleda disease) within brother and sister combined with severe dental alterations in both cases (in French). Soc. Franc. Dermat. Syph. 1924, 31, 82–84. [Google Scholar]
  2. Gorlin, R.J.; Sedano, H.; Anderson, V.E. The syndrome of palmar–plantar hyperkeratosis and premature periodontal destruction of the teeth. J. Pediatr. 1964, 65, 895–906. [Google Scholar] [CrossRef]
  3. Hart, T.C.; Hart, P.S.; Bowden, D.W.; Michalec, M.D.; Callison, S.A.; Walker, S.J.; Zhang, Y.; Firatli, E. Mutations of the cathepsin C gene are responsible for Papillon-Lefèvre syndrome. J. Med. Genet. 1999, 36, 881–887. [Google Scholar] [PubMed]
  4. Toomes, C.; James, J.; Wood, A.J.; Wu, C.L.; McCormick, D.; Lench, N.; Hewitt, C.; Moynihan, L.; Roberts, E.; Woods, C.G.; et al. Loss-of-function mutations in the cathepsin C gene result in periodontal disease and palmoplantar keratosis. Nat. Genet. 1999, 23, 421–424. [Google Scholar] [CrossRef] [PubMed]
  5. Rao, N.V.; Rao, G.V.; Hoidal, J.R. Human Dipeptidyl-peptidase I. J. Biol. Chem. 1997, 272, 10260–10265. [Google Scholar] [CrossRef] [Green Version]
  6. Bimstein, E.; Lustmann, J.; Sela, M.N.; Ben Neriah, Z.; Soskolne, W.A. Periodontitis Associated with Papillon-Lefèvre Syndrome. J. Periodontol. 1990, 61, 373–377. [Google Scholar] [CrossRef] [PubMed]
  7. Bullon, P.; Pascual, A.; Fernandez-Novoa, M.C.; Borobio, M.V.; Muniain, M.A.; Camacho, F. Late onset Papillon–Lefèvre syndrome? A chromosomic, neutrophil function and microbiological study. J. Clin. Periodontol. 1993, 20, 662–667. [Google Scholar] [CrossRef]
  8. de Vree, H.; Steenackers, K.; de Boever, J.A. Periodontal treatment of rapid progressive periodontitis in 2 siblings with Papillon–Lefèvre syndrome: 15-years follow-up. J. Clin. Periodontol. 2000, 27, 354–360. [Google Scholar] [CrossRef]
  9. Schacher, B.; Baron, F.; Ludwig, B.; Valesky, E.; Noack, B.; Eickholz, P. Periodontal therapy in siblings with Papillon–Lefèvre syndrome and tinea capitis: A report of two cases. J. Clin. Periodontol. 2006, 33, 829–836. [Google Scholar] [CrossRef]
  10. Nickles, K.; Schacher, B.; Schuster, G.; Valesky, E.; Eickholz, P. Evaluation of Two Siblings with Papillon-Lefèvre Syndrome 5 Years After Treatment of Periodontitis in Primary and Mixed Dentition. J. Periodontol. 2011, 82, 1536–1547. [Google Scholar] [CrossRef]
  11. Nickles, K.; Schacher, B.; Ratka-Krüger, P.; Krebs, M.; Eickholz, P. Long-term results after treatment of periodontitis in patients with Papillon-Lefèvre syndrome: Success and failure. J. Clin. Periodontol. 2013, 40, 789–798. [Google Scholar] [CrossRef]
  12. Mengel, R.; Stelzel, M.; Hasse, C.; Flores-de-Jacoby, L. Osseointegrated implants in patients treated for generalized severe adult periodontitis. An interim report. J. Periodontol. 1996, 67, 782–787. [Google Scholar] [CrossRef] [PubMed]
  13. Swierkot, K.; Lottholz, P.; Flores-De-Jacoby, L.; Mengel, R. Mucositis, Peri-Implantitis, Implant Success, and Survival of Implants in Patients with Treated Generalized Aggressive Periodontitis: 3- to 16-Year Results of a Prospective Long-Term Cohort Study. J. Periodontol. 2012, 83, 1213–1225. [Google Scholar] [CrossRef]
  14. Ullbro, C.; Crossner, C.G.; Lundgren, T.; Stålblad, P.A.; Renvert, S. Osseointegrated implants in a patient with Papillon–Lefèvre syndrome. A 4 1/2-year follow up. J. Clin. Periodontol. 2000, 27, 951–954. [Google Scholar] [CrossRef]
  15. Woo, I.; Brunner, D.P.; Yamashita, D.-D.R.; Le, B.T. Dental Implants in a Young Patient with Papillon-Lefevre Syndrome: A Case Report. Implant Dent. 2003, 12, 140–144. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  16. Toygar, H.U.; Kircelli, C.; Firat, E.; Guzeldemir-Akcakanat, E. Combined Therapy in a Patient with Papillon-Lefèvre Syndrome: A 13-Year Follow-Up. J. Periodontol. 2007, 78, 1819–1824. [Google Scholar] [CrossRef] [PubMed]
  17. Etöz, O.A.; Ulu, M.; Kesim, B. Treatment of Patient With Papillon-Lefevre Syndrome with Short Dental Implants: A Case Report. Implant Dent. 2010, 19, 394–399. [Google Scholar] [CrossRef] [PubMed]
  18. Ahmadian, L.; Monzavi, A.; Arbabi, R.; Hashemi, H.M. Full-Mouth Rehabilitation of an Edentulous Patient with Papillon-Lefèvre Syndrome Using Dental Implants: A Clinical Report. J. Prosthodont. 2011, 20, 643–648. [Google Scholar] [CrossRef]
  19. Senel, F.C.; Altintas, N.Y.; Bagis, B.; Cankaya, M.; Pampu, A.A.; Satıroglu, I.; Senel, A.C. A 3-Year Follow-Up of the Rehabilitation of Papillon-Lefèvre Syndrome by Dental Implants. J. Oral Maxillofac. Surg. 2012, 70, 163–167. [Google Scholar] [CrossRef]
  20. Al Farraj, A.L.; Dosari, A. Oral rehabilitation of a case of Papillon-Lefevre syndrome with dental implants. Saudi. Med. J. 2013, 34, 424–427. [Google Scholar]
  21. Rüdiger, S.; Petersilka, G.; Flemming, T.F. Combined systemic and local antimicrobial therapy of periodontal disease in Papillon–Lefèvre syndrome. J. Clin. Periodontol. 1999, 26, 847–854. [Google Scholar] [PubMed]
  22. Schei, O.; Waerhaug, J.; Lovdal, A.; Arno, A. Alveolar Bone Loss as Related to Oral Hygiene and Age. J. Periodontol. 1959, 30, 7–16. [Google Scholar] [CrossRef]
  23. Liu, R.; Cao, C.; Meng, H.; Tang, Z. Leukocyte functions in 2 cases of Papillon-Lefèvre syndrome. J. Clin. Periodontol. 2000, 27, 69–73. [Google Scholar] [CrossRef] [PubMed]
  24. Lundgren, T.; Parhar, R.S.; Renvert, S.; Tatakis, D.N. Impaired cytotoxicity in Papillon–Lefèvre syndrome. J. Dent. Res. 2005, 84, 414–417. [Google Scholar] [CrossRef] [PubMed]
  25. Khocht, A.; Albandar, J.M. Aggressive forms of periodontitis secondary to systemic disorders. Periodontology 2014, 65, 134–148. [Google Scholar] [CrossRef] [PubMed]
  26. Roos-Jansaker, A.M.; Lindahl, C.; Renvert, H.; Renvert, S. Nine- to fourteen-year follow-up of implant treatment. Part I: Implant loss and associations to various factors. J. Clin. Periodontol. 2006, 33, 283–289. [Google Scholar] [CrossRef]
  27. Haas, R.; Mensdorff-Pouilly, N.; Mailath, G.; Watzek, G. Survival of 1920 IMZ implants followed for up to 100 months. Int. J. Oral Maxillofac. Implant. 1996, 11, 581–588. [Google Scholar]
  28. Willer, J.; Noack, N.; Hoffmann, J. Survival rate of IMZ implants: A prospective 10-year analysis. J. Oral Maxillofac. Surg. 2003, 61, 691–695. [Google Scholar] [CrossRef]
  29. Krebs, M.; Schmenger, K.; Neumann, K.; Weigl, P.; Moser, W.; Nentwig, G.H. Long-term evaluation of ANKYLOS® dental implants, part i: 20-year life table analysis of a longitudinal study of more than 12,500 implants. Clin. Impl. Dent. Rel. Res. 2015, 17, e275–e286. [Google Scholar] [CrossRef]
  30. Esposito, M.; Ardebili, Y.; Worthington, H. Interventions for replacing missing teeth: Different types of dental implants. Cochrane Database Syst. Rev. 2014, 22, CD003815. [Google Scholar] [CrossRef]
  31. Pohl, V.; Thoma, D.S.; Sporniak-Tutak, K. Short dental implants (6 mm) versus long dental implants (11–15 mm) in combination with sinus floor elevation procedures: 3-year results from a multi-center, randomized, controlled clinical trial. J. Clin. Periodontol. 2017, 44, 438–445. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  32. Sbordone, C.; Sbordone, L.; Toti, P.; Martuscelli, R.; Califano, L.; Guidetti, F. Apical and marginal bone alterations around implants in maxillary sinus augmentation grafted with autogenous bone or bovine bone material and simultaneous or delayed dental implant positioning. Clin. Oral Impl. Res. 2011, 22, 485–491. [Google Scholar] [CrossRef]
  33. Sbordone, C.; Toti, P.; Guidetti, F.; Califano, L.; Bufo, P.; Sbordone, L. Volume changes of autogenous bone after sinus lifting and grafting procedures: A 6-year computerized tomographic follow-up. J. Cranio-Maxillofac. Surg. 2013, 41, 235–241. [Google Scholar] [CrossRef] [PubMed]
  34. Sbordone, C.; Toti, P.; Guidetti, F.; Califano, L.; Pannone, G.; Sbordone, L. Volumetric changes after sinus augmentation using blocks of autogenous iliac bone or freeze-dried allogeneic bone. A non-randomized study. J. Craniomaxillofac. Surg. 2014, 42, 113–118. [Google Scholar] [CrossRef] [PubMed]
  35. Hatano, N.; Shimizu, Y.; Ooya, K. A clinical long-term radiographic evaluation of graft height changes after maxillary sinus floor augmentation with a 2: 1 autogenous bone/xenograft mixture and simultaneous placement of dental implants. Clin. Oral Implant. Res. 2004, 15, 339–345. [Google Scholar] [CrossRef] [PubMed]
  36. Zijderveld, S.A.; Schulten, E.A.J.M.; Aartman, I.H.A.; ten Bruggenkate, C.M. Long-term changes in graft height after maxillary sinus floor elevation with different grafting materials: Radiographic evaluation with a minimum follow-up of 4.5 years. Clin. Oral Implant. Res. 2009, 20, 691–700. [Google Scholar] [CrossRef]
  37. Fretwurst, T.; Nack, C.; Al-Ghrairi, M.; Raguse, J.; Stricker, A.; Schmelzeisen, R.; Nelson, K.; Nahles, S. Long-term retrospective evaluation of the peri-implant bone level in onlay grafted patients with iliac bone from the anterior superior iliac crest. J. Cranio-Maxillofac. Surg. 2015, 43, 956–960. [Google Scholar] [CrossRef]
  38. Roccuzzo, M.; De Angelis, N.; Bonino, L.; Aglietta, M. Ten-year results of a three-arm prospective cohort study on implants in periodontally compromised patients. Part 1: Implant loss and radiographic bone loss. Clin. Oral Implant. Res. 2010, 21, 490–496. [Google Scholar] [CrossRef]
  39. Atarbashi-Moghadam, F.; Atarbashi-Moghadam, S.; Kazemifard, S.; Sijanivandi, S.; Namdari, M. Oral rehabilitation of Papillon–Lefèvre syndrome patients by dental implants: A systematic review. J. Korean Assoc. Oral Maxillofac. Surg. 2020, 46, 220–227. [Google Scholar] [CrossRef]
  40. Nazzaro, V.; Blanchet-Bardon, C.; Mimoz, C.; Revuz, J.; Puissant, A. Papillon-Lefèvre Syndrome Ultrastructural Study and Successful Treatment with Acitretin. Arch. Dermatol. 1988, 124, 533–539. [Google Scholar] [CrossRef]
  41. Gelmetti, C.; Nazzaro, V.; Cerri, D.; Fracasso, L. Long-Term Preservation of Permanent Teeth in a Patient with Papillon-Lefevre Syndrome Treated with Etretinate. Pediatr. Dermatol. 1989, 6, 222–225. [Google Scholar] [CrossRef] [PubMed]
  42. Lundgren, T.; Renvert, S. Periodontal treatment of patients with Papillon-Lefevre syndrome: A 3-year follow-up. J. Clin. Periodontol. 2004, 31, 933–938. [Google Scholar] [CrossRef] [PubMed]
Jcm 11 02438 g001 550
Figure 1. Patient 3 (panoramic radiograph performed in 2008): Eight hollow-screw implants (mandible) inserted in 1992 (16 years in situ); Four Astra® implants (maxilla) inserted in 2008 (six months in situ), two implants (maxilla) have already been lost.
Figure 1. Patient 3 (panoramic radiograph performed in 2008): Eight hollow-screw implants (mandible) inserted in 1992 (16 years in situ); Four Astra® implants (maxilla) inserted in 2008 (six months in situ), two implants (maxilla) have already been lost.
Jcm 11 02438 g001
Jcm 11 02438 g002 550
Figure 2. Patient 1 (panoramic radiograph performed in 2010): 10 Ankylos® implants (2.5 years in situ).
Figure 2. Patient 1 (panoramic radiograph performed in 2010): 10 Ankylos® implants (2.5 years in situ).
Jcm 11 02438 g002
Table
Table 1. The patients included and their dental implant characteristics.
Table 1. The patients included and their dental implant characteristics.
FamilyPatientImplants In Situ
(Number/Jaw/Type);
Year Implants Were Placed; Follow-Up (Years)		Implants Lost (Number)Bone Grafting
(Yes/No/Material)		Prosthetic RestorationSupportive Therapy
(Yes/No/Main Contents)
A1 (♀/*1988)6× maxilla
4× mandible
Ankylos® (Dentsply Friadent, York, PA, USA)
(all Ø 3.5 mm, length 11 mm);
Placed in 2007; 2.5 years		-Yes (maxilla)
Bio-Oss Block® (Geistlich, Wolhusen, Switzerland),
autologous bone (zygomaticum),
Bio-Gide®
(Geistlich)		Removable telescopic crown-supported restoration (galvano)no
A2 (♀/*1991)6× maxilla
4× mandible
Ankylos® (Dentsply Friadent, York, PA, USA)
(all Ø 3.5 mm, length 9.5 and 11 mm);
Placed in 2010;
5 years		-Yes (maxilla)
Bio-Oss Block® (Geistlich),
autologous bone (zygomaticum),
Bio-Gide®
(Geistlich)		Removable telescopic crown-supported restoration
(galvano)		yes (but irregular): professional dental cleaning once a year; measuring of PPD (irregular), subgingival cleaning (glycine) in case of increased PPD+BOP
B3 (♀/*1974)4× maxilla
8× mandible
maxilla: Astra® (Dentsply, York, PA, USA)
mandible: Brånemark® (Nobel Biocare, Kloten, Switzerland) Placed in 1992; re-implantation maxilla in 2008 and 2010;
20 years (mandible), 4/2 years (maxilla)		4Yes (maxilla)
Autologous bone (iliac crest)		Removable bar-carried restorationyes:
professional dental cleaning every 3 months; no measuring of PPD, no subgingival cleaning; systemic amoxicillin + clavulanic acid and metronidazole for seven days twice a year; no professional supportive therapy
B4 (♀/*1983)1× maxilla
4× mandible
1 disc-shaped implant (unknown manufacturer); all others: Brånemark® (Nobel Biocare, Kloten, Switzerland) implants
Placed in 1993;
19 years		11Yes (maxilla)
Autologous bone and bone substitute (unknown material)		Removable telescopic crown- and ball-shaped head-supported restorationyes:
professional dental cleaning every 3 months; no measurement of PPD, no subgingival cleaning; systemic amoxicillin + clavulanic acid and metronidazole for seven days twice a year; no professional supportive therapy
C5 (♂/*1971)5× maxilla
6× mandible
1 Biomet® 3i implant, all other: IMZ® implants (Dentsply, York, PA, USA);
Placed in 1992;
20 years		Several implants were lost, number unknownYes (maxilla)
(unknown material)		Removable bar-supported (maxilla) and
removable telescopic crown-supported restoration (mandible)		no
♀ female, ♂ male, * born.
Table
Table 2. Clinical data: probing pocket depths (PPD), bleeding on probing (BOP), suppuration, and microbiological findings at last visit.
Table 2. Clinical data: probing pocket depths (PPD), bleeding on probing (BOP), suppuration, and microbiological findings at last visit.
PatientPPD 1–3 mm (%)PPD 4–6 mm (%)PPD ≥ 7 mm (%)BOP (%)Suppuration (Yes/No)AA +/−
155%45%0%38%noAA −
258%42%0%25%noAA −
371%22%7%20%yesAA −
480%20%0%9%no- *
532%54%14%26%YesAA −
* Patient was treated with systemic antibiotics at the time, - no microbiological examination.
Table
Table 3. Bone loss around implants (bone loss in % around implant [distance implant shoulder—implant apex], mesial and distal).
Table 3. Bone loss around implants (bone loss in % around implant [distance implant shoulder—implant apex], mesial and distal).
PatientBone Loss 0− < 25%Bone Loss 25− < 50%Bone Loss ≥ 50%
175%25%0%
295%5%0%
329%46%25%
460%20%20%
513%55%32%
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Nickles, K.; Krebs, M.; Schacher, B.; Petsos, H.; Eickholz, P. Long-Term Results after Placing Dental Implants in Patients with Papillon-Lefèvre Syndrome: Results 2.5–20 Years after Implant Insertion. J. Clin. Med. 2022, 11, 2438. https://doi.org/10.3390/jcm11092438

AMA Style

Nickles K, Krebs M, Schacher B, Petsos H, Eickholz P. Long-Term Results after Placing Dental Implants in Patients with Papillon-Lefèvre Syndrome: Results 2.5–20 Years after Implant Insertion. Journal of Clinical Medicine. 2022; 11(9):2438. https://doi.org/10.3390/jcm11092438

Chicago/Turabian Style

Nickles, Katrin, Mischa Krebs, Beate Schacher, Hari Petsos, and Peter Eickholz. 2022. "Long-Term Results after Placing Dental Implants in Patients with Papillon-Lefèvre Syndrome: Results 2.5–20 Years after Implant Insertion" Journal of Clinical Medicine 11, no. 9: 2438. https://doi.org/10.3390/jcm11092438

APA Style

Nickles, K., Krebs, M., Schacher, B., Petsos, H., & Eickholz, P. (2022). Long-Term Results after Placing Dental Implants in Patients with Papillon-Lefèvre Syndrome: Results 2.5–20 Years after Implant Insertion. Journal of Clinical Medicine, 11(9), 2438. https://doi.org/10.3390/jcm11092438

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