Attenuated Amplitude of Pattern Electroretinogram in Glaucoma Patients with Choroidal Parapapillary Microvasculature Dropout
Abstract
:1. Introduction
2. Materials and Methods
2.1. Subjects
2.2. Measurements
2.3. Optical Coherence Tomography Angiography
2.4. Measurement of Parapapillary Choroidal Microvasculature Dropout
2.5. Electroretinography
2.6. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Mean ± SD | |
---|---|
Age (Year) | 54.33 ± 12.27 |
Sex (Male, %) | 46 (47.9%) |
HTN (Yes, %) | 14 (16.9%) |
DM (Yes, %) | 4 (4.8%) |
CCT (μm) | 540.37 ± 39.85 |
AL (mm) | 24.98 ± 1.25 |
Pattern Electroretinography | |
N35 implicit time (ms) | 22.75 ± 5.58 |
P50 implicit time (ms) | 48.31 ± 4.29 |
N95 implicit time (ms) | 101.72 ± 10.04 |
P50 amplitude (mV) | 2.70 ± 0.99 |
N95 amplitude (mV) | 4.67 ± 1.61 |
Visual Field | |
MD (dB) | −4.64 ± 6.53 |
PSD (dB) | 4.97 ± 3.50 |
OCT | |
Average RNFLT (μm) | 74.51 ± 13.23 |
Rim Area | 0.86 ± 0.22 |
Disc Area | 1.97 ± 0.46 |
Average CD ratio | 0.72 ± 0.11 |
Average GCIPLT (μm) | 69.58 ± 8.76 |
OCT Angiography | |
Signal Strength | 65.92 ± 5.91 |
Superficial VD | 39.36 ± 4.68 |
Macular superficial VD | 34.26 ± 2.71 |
Total PPA area (mm2) | 2.78 ± 4.64 |
PPA VD | 49.77 ± 12.26 |
Area of MvD (mm2) | 0.38 ± 0.40 * |
PPA area except MvD (mm2) | 2.45 ± 4.60 * |
Angle of MvD (°) | 52.21 ± 31.69 * |
Angle of RNFLD (°) | 60.95 ± 56.68 * |
MvD (−) (N, 33) | MvD (+) (N, 46) | p Value | ||
---|---|---|---|---|
Age (year) | 53.39 ± 13.01 | 55.93 ± 12.98 | 0.394 * | |
Sex (male, %) | 15 (45.5%) | 23 (50%) | 0.820 # | |
CCT (μm) | 531.79 ± 43.96 | 541.59 ± 32.65 | 0.275 * | |
AL (mm) | 25.08 ± 1.32 | 25.37 ± 1.04 | 0.346 * | |
Pattern Electroretinography | ||||
N35 implicit time (ms) | 22.20 ± 5.71 | 23.48 ± 5.59 | 0.322 * | |
P50 implicit time (ms) | 48.38 ± 4.38 | 48.57 ± 4.58 | 0.859 * | |
N95 implicit time (ms) | 100.89 ± 9.12 | 103.00 ± 11.45 | 0.383 * | |
P50 amplitude (mV) | 3.03 ± 1.10 | 2.42 ± 0.87 | 0.007 * | |
N95 amplitude (mV) | 5.24 ± 1.76 | 4.14 ± 1.53 | 0.004 * | |
Visual Field | ||||
MD (dB) | −3.67 ± 5.20 | −6.09 ± 7.92 | 0.107 * | |
PSD (dB) | 4.52 ± 3.55 | 5.37 ± 3.57 | 0.300 * | |
OCT | ||||
Optic disc parameter | Disc Area (mm2) | 1.92 ± 0.39 | 1.96 ± 0.52 | 0.729 * |
Rim Area (mm2) | 0.85 ± 0.17 | 0.82 ± 0.23 | 0.532 * | |
Average CD ratio | 0.72 ± 0.12 | 0.73 ± 0.12 | 0.600 * | |
Average RNFLT (μm) | 75.06 ± 13.06 | 72.02 ± 13.25 | 0.319 * | |
Average GCIPLT (μm) | 70.52 ± 8.70 | 67.82 ± 7.59 | 0.171 * | |
OCT Angiography | ||||
Signal Strength | 65.09 ± 6.73 | 65.37 ± 5.75 | 0.844 * | |
Parapapillary VD | 38.89 ± 5.09 | 39.54 ± 4.13 | 0.565 * | |
Macular VD | 33.63 ± 2.74 | 34.77 ± 2.65 | 0.193 * |
Univariate | Multivariate | |||
---|---|---|---|---|
β (95% CI) | p Value | β (95% CI) | p Value | |
Age (year) | 0.015 (0.980–1.051) | 0.416 | ||
MD (dB) | −0.057 (0.873–1.023) | 0.164 | ||
PSD (dB) | 0.075 (0.943–1.232) | 0.274 | ||
N35 implicit time (ms) | 0.038 (0.958–1.126) | 0.354 | ||
P50 implicit time (ms) | 0.018 (0.919–1.128) | 0.726 | ||
N95 implicit time (ms) | 0.017 (0.973–1.063) | 0.451 | ||
P50 amplitude (mV) | −0.620 (0.324–0.894) | 0.017 | ||
N95 amplitude (mV) | −0.390 (0.502–0.913) | 0.011 | −0.668 (0.296–0.887) | 0.017 |
Average RNFLT (μm) | −0.020 (0.946–1.015) | 0.260 | ||
Average CD ratio | 1.311 (0.083–165.9) | 0.499 | ||
Average GCIPLT (μm) | −0.041 (0.904–1.020) | 0.185 | ||
Peripapillary VD | 0.029 (0.927–1.144) | 0.583 | ||
Macular VD | 0.163 (0.974–1.423) | 0.091 |
Univariate | Multivariate | |||
---|---|---|---|---|
B | p Value | B | p Value | |
Age (year) | 0.354 | 0.347 | ||
MD (dB) | −1.371 | 0.023 | ||
PSD (dB) | 1.780 | 0.191 | ||
N35 implicit time (ms) | 0.869 | 0.319 | ||
P50 implicit time (ms) | −0.803 | 0.452 | ||
N95 implicit time (ms) | 0.029 | 0.946 | ||
P50 amplitude (mV) | −8.164 | 0.141 | ||
N95 amplitude (mV) | −7.612 | 0.014 | −7.612 | 0.014 |
Average RNFLT (μm) | −0.796 | 0.027 | ||
Average CD ratio | 73.736 | 0.065 | ||
Average GCIPLT (μm) | −0.965 | 0.188 |
P50 Amplitude | N95 Amplitude | |||||||
---|---|---|---|---|---|---|---|---|
Univariate | Multivariate | Univariate | Multivariate | |||||
β | p Value | β | p Value | β | p Value | β | p Value | |
Age (year) | −0.028 | 0.001 | −0.026 | 0.005 | −0.049 | <0.001 | −0.047 | 0.001 |
MD (dB) | 0.025 | 0.106 | 0.095 | <0.001 | ||||
PSD (dB) | 0.003 | 0.921 | −0.093 | 0.052 | ||||
Average RNFLT (μm) | 0.013 | 0.093 | 0.046 | <0.001 | ||||
Average CD ratio | −1.231 | 0.171 | −2.629 | 0.069 | ||||
Average GCIPLT (μm) | 0.036 | 0.003 | 0.038 | 0.007 | 0.086 | <0.001 | 0.067 | 0.003 |
Presence of MvD | −0.617 | 0.007 | −0.428 | 0.051 | −1.090 | 0.004 | −0.815 | 0.020 |
Superficial VD | −0.015 | 0.553 | −0.007 | 0.854 | ||||
Macular superficial VD | −0.034 | 0.421 | −0.018 | 0.782 |
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Lee, J.; Park, C.K.; Jung, K.I. Attenuated Amplitude of Pattern Electroretinogram in Glaucoma Patients with Choroidal Parapapillary Microvasculature Dropout. J. Clin. Med. 2022, 11, 2478. https://doi.org/10.3390/jcm11092478
Lee J, Park CK, Jung KI. Attenuated Amplitude of Pattern Electroretinogram in Glaucoma Patients with Choroidal Parapapillary Microvasculature Dropout. Journal of Clinical Medicine. 2022; 11(9):2478. https://doi.org/10.3390/jcm11092478
Chicago/Turabian StyleLee, Jiyun, Chan Kee Park, and Kyoung In Jung. 2022. "Attenuated Amplitude of Pattern Electroretinogram in Glaucoma Patients with Choroidal Parapapillary Microvasculature Dropout" Journal of Clinical Medicine 11, no. 9: 2478. https://doi.org/10.3390/jcm11092478