Prevalence and Associated Factors of Medication Non-Adherence in CRS Patients following Endoscopic Sinus Surgery
Abstract
:1. Introduction
1.1. Rationale
1.2. Objectives
2. Materials and Methods
2.1. Study Design
2.2. Participants and Setting
- Rare or complex sinus conditions
- CRS secondary to systemic disease such as cystic fibrosis and granulomatous disease
- Suspected malignancy
- Pregnant or lactating women
- Immunodeficiency states including HIV and selective or multiple antibody deficiency states
- Inability to give consent or to understand and comply with study instructions
2.3. Variables
2.4. Data Sources
2.5. Methods Used to Reduce Potential Bias
2.6. Sample Size
2.7. Quantitative Variables
2.8. Statistical Methods
3. Results
3.1. Participants and Descriptive Data
3.2. Outcome Data
3.2.1. Prevalence of Medication Adherence
3.2.2. Predictors of Adherence
3.2.3. Post-Operative SNOT-22 Scores
4. Discussion
4.1. Key Results
4.2. Limitations
4.3. Interpretation of Findings and Generalisability
4.4. Future Work
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Characteristic | A | INA | NINA | p-Value | |
---|---|---|---|---|---|
N | 32 | 31 | 31 | ||
Gender | Female | 14 (44%) | 10 (32%) | 13 (42%) | 0.61 |
Male | 18 (56%) | 21 (68%) | 18 (58%) | ||
Ethnicity | British | 30 (94%) | 28 (90%) | 30 (97%) | 0.34 |
Caribbean | 0 (0%) | 1 (3%) | 0 (0%) | ||
Irish | 2 (6%) | 0 (0%) | 0 (0%) | ||
Other | 0 (0%) | 1 (3%) | 1 (3%) | ||
White and black African | 0 (0%) | 1 (3%) | 0 (0%) | ||
Age, mean (SD) | 61.03 (11.72) | 58.84 (7.93) | 59.03 (9.80) | 0.63 | |
Smoking status | Ex-smoker | 17 (53%) | 10 (32%) | 13 (42%) | 0.55 |
Non-smoker | 14 (44%) | 19 (61%) | 17 (55%) | ||
Smoker | 1 (3%) | 2 (6%) | 1 (3%) | ||
Time suffering from CRS in years, mean (SD) | 21.83 (13.92) | 22.50 (11.40) | 21.98 (13.99) | 0.98 | |
SNOT-22 preop, mean (SD) | 38.24 (24.64) | 49.17 (23.96) | 43.05 (23.94) | 0.29 | |
SNOT-22 post op, mean (SD) | 17.69 (11.48) | 25.04 (21.43) | 10.52 (8.65) | 0.008 | |
LM score, mean (SD) | 18.41 (5.402) | 15.83 (7.33) | 19.04 (5.04) | 0.14 | |
Presence of comorbidities | No | 6 (19%) | 11 (35%) | 9 (29%) | 0.43 |
Yes | 26 (81%) | 20 (65%) | 22 (71%) | ||
Family history of airway disorders | No | 26 (81%) | 20 (64%) | 21 (67%) | 0.28 |
Yes | 6 (19%) | 11 (35%) | 10 (32%) | ||
Presence of nasal allergies | No | 15 (47%) | 11 (35%) | 13 (42%) | 0.66 |
Yes | 17 (53%) | 20 (65%) | 18 (58%) | ||
Presence of NSAID allergy | No | 25 (78%) | 27 (87%) | 23 (75%) | 0.53 |
Yes | 7 (22%) | 4 (13%) | 8 (26%) | ||
Asthma | No | 11 (34%) | 18 (58%) | 19 (61%) | 0.065 |
Yes | 21 (66%) | 13 (42%) | 12 (39%) |
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Gokani, S.A.; Clark, A.; Javer, A.; Philpott, C. Prevalence and Associated Factors of Medication Non-Adherence in CRS Patients following Endoscopic Sinus Surgery. J. Clin. Med. 2023, 12, 5381. https://doi.org/10.3390/jcm12165381
Gokani SA, Clark A, Javer A, Philpott C. Prevalence and Associated Factors of Medication Non-Adherence in CRS Patients following Endoscopic Sinus Surgery. Journal of Clinical Medicine. 2023; 12(16):5381. https://doi.org/10.3390/jcm12165381
Chicago/Turabian StyleGokani, Shyam Ajay, Allan Clark, Amin Javer, and Carl Philpott. 2023. "Prevalence and Associated Factors of Medication Non-Adherence in CRS Patients following Endoscopic Sinus Surgery" Journal of Clinical Medicine 12, no. 16: 5381. https://doi.org/10.3390/jcm12165381
APA StyleGokani, S. A., Clark, A., Javer, A., & Philpott, C. (2023). Prevalence and Associated Factors of Medication Non-Adherence in CRS Patients following Endoscopic Sinus Surgery. Journal of Clinical Medicine, 12(16), 5381. https://doi.org/10.3390/jcm12165381