The Impact of Hematological Indices on the Occurrence of Delayed Graft Function (DGF) of Transplanted Kidney
Abstract
:1. Introduction
2. Materials and Methods
- -
- NMR = Absolute Neutrophil Count (ANC)/Absolute Monocyte Count (AMC)
- -
- PLR = Absolute Platelets Count (AMC)/Absolute Lymphocyte Count (ALC)
- -
- NLR = Absolute Neutrophil Count (ANC)/Absolute Lymphocyte Count (ALC)
- -
- LMR = Absolute Lymphocyte Count (ALC)/Absolute Monocyte Count (AMC)
- -
- SII = NLR value × platelet count
3. Results
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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A | ||||
Parameters | N | |||
Sex | Females | 162 (44.38%) | ||
Males | 203 (55.62%) | |||
Age | 51.5 ± 12.46 | |||
BMI (kg/m2) | 25.15 ± 4.15 | |||
Cause of kidney failure | ADPKD | 44 (12.05%) | ||
Congenital malformations | 17 (4.66%) | |||
Glomerulonephritis | 119 (32.60%) | |||
Hypertensive nephropathy | 49 (13.42%) | |||
Diabetic nephropathy | 32 (8.77%) | |||
Unknown | 45 (12.33%) | |||
Other | 65 (17.81%) | |||
Dialysis technique | Haemodialysis (HD) | 296 (81.10%) | ||
Peritoneal dialysis (PD) | 40 (10.95%) | |||
HD+PD | 20 (5.48%) | |||
Pre-emptive transplantation | 9 (2.47%) | |||
pPRA (peak PRA) | 15 ± 25 | |||
HLA incompatibilities ABDR | 3 ± 1.2 | |||
CIT (h) | 18 ± 7 | |||
WIT (min) | 23 ± 7.26 | |||
Induction Therapy | Basiliksimab | 182 (49.86%) | ||
Antithymocyte Globulin | 23 (6.30%) | |||
Without | 162 (44.38%) | |||
B | ||||
Parameters | 0 Day | 1st Day | 7th Day | |
Creatinine (mg/dL) | 7.56 ± 2.65 | 6.49 ± 2.46 | 3.49 ± 2.87 | |
eGFR (mL/min/1.73 m2) | 8.44 ± 3.88 | 10.57 ± 6.27 | 36.8 ± 28.86 | |
Lymphocytes (G/L) | 1.72 ± 0.77 | 0.55 ± 0.37 | 1.76 ± 1.03 | |
Neutrophils (G/L) | 5.08 ± 2.67 | 10.8 ± 4.3 | 6.05 ± 3.22 | |
Monocytes (G/L) | 0.63 ± 0.28 | 0.49 ± 0.38 | 0.75 ± 0.34 | |
Platelets (G/L) | 214.02 ± 82.97 | 181.15 ± 58.75 | 207.32 ± 74,67 | |
NLR | 4.22 ± 6.73 | 27.81 ± 29.01 | 5.77 ± 8.39 | |
PLR | 152.92 ± 111.67 | 455.66 ± 383.55 | 170.23 ± 156.65 | |
NMR | 10.13 ± 9.89 | 33.17 ± 22.69 | 9.89 ± 10 | |
LMR | 3.19 ± 2 | 1.6 ± 1.23 | 2.69 ± 2.04 | |
SII | 904.15 ± 1544.85 | 5030.51 ± 5216.99 | 1103.95 ± 1515.25 |
Parameters | N | |
---|---|---|
Sex | Females | 76 (33.93%) |
Males | 148 (66.07%) | |
Age | 47.55 ± 15.31 | |
BMI (kg/m2) | 25.81 ± 3.64 | |
Last creatinine level (mg/dL) | 1.04 ± 0.42 | |
eGFR (mL/min/1.73m2) | 86.88 ± 35.58 |
Parameters | DGF | N | Mean | SD | Mann–Whitney U Test |
---|---|---|---|---|---|
p Value | |||||
Donor-dependent factors | |||||
Age | No | 221 | 46.49 | 15.472 | 0.238 |
Yes | 144 | 48.23 | 14.885 | ||
BMI (kg/m²) | No | 190 | 25.65 | 3.613 | 0.633 |
Yes | 124 | 25.55 | 3.372 | ||
Last Cr. level | No | 193 | 1.00 | 0.380 | 0.450 |
Yes | 128 | 1.07 | 0.47 | ||
eGFR (mL/min/1.73 m2) | No | 192 | 88.47 | 34.430 | 0.369 |
Yes | 128 | 84.03 | 34.182 | ||
Recipient-dependent factors | |||||
Age | No | 221 | 51.63 | 12.473 | 0.808 |
Yes | 144 | 51.43 | 12.507 | ||
BMI (kg/m²) | No | 216 | 24.85 | 4.033 | 0.110 |
Yes | 143 | 25.64 | 4.266 | ||
PD (months) | No | 219 | 5.63 | 16.298 | 0.001 |
Yes | 143 | 1.66 | 6.514 | ||
HD (months) | No | 215 | 27.35 | 26.637 | <0.001 |
Yes | 143 | 41.93 | 35.787 | ||
Peak PRA | No | 220 | 11.45 | 21.097 | 0.015 |
Yes | 144 | 19.97 | 29.842 | ||
PRA | No | 221 | 6.12 | 14.604 | 0.408 |
Yes | 143 | 11.44 | 23.219 | ||
HLA MM | No | 221 | 2.86 | 1.258 | 0.01 |
Yes | 144 | 3.22 | 1.07 | ||
Perioperative parameters | |||||
CIT (h) | No | 193 | 16.73 | 7.153 | 0.007 |
Yes | 125 | 19.02 | 7.481 | ||
WIT (min.) | No | 183 | 22.90 | 6.817 | 0.061 |
Yes | 112 | 24.55 | 8.127 |
Parameter | DGF | N | Mean | SD | Mann–Whitney U Test |
---|---|---|---|---|---|
p Value | |||||
Lymphocytes 0 (G/L) | No | 221 | 1.71 | 0.782 | 0.877 |
Yes | 144 | 1.73 | 0.767 | ||
Lymphocytes 1 (G/L) | No | 220 | 0.54 | 0.374 | 0.334 |
Yes | 143 | 0.58 | 0.374 | ||
Lymphocytes 7 (G/L) | No | 216 | 1.99 | 1.10 | <0.001 |
Yes | 142 | 1.42 | 0.78 | ||
Neutrophils 0 (G/L) | No | 221 | 5.04 | 2.305 | 0.398 |
Yes | 144 | 5.11 | 3.195 | ||
Neutrophils 1 (G/L) | No | 220 | 10.63 | 4.070 | 0.341 |
Yes | 143 | 11.06 | 4.670 | ||
Neutrophils 7 (G/L) | No | 216 | 6.12 | 3.54 | 0.797 |
Yes | 142 | 5.94 | 2.66 | ||
Monocytes 0 (G/L) | No | 221 | 0.61 | 0.281 | 0.028 |
Yes | 144 | 0.66 | 0.286 | ||
Monocytes 1 (G/L) | No | 220 | 0.44 | 0.357 | <0.001 |
Yes | 143 | 0.56 | 0.410 | ||
Monocytes 7 (G/L) | No | 216 | 0.75 | 0.33 | 0.873 |
Yes | 142 | 0.75 | 0.37 | ||
Platelets 0 (G/L) | No | 221 | 216.34 | 67.951 | 0.623 |
Yes | 144 | 211.16 | 62.674 | ||
Platelets 1 (G/L) | No | 220 | 183.35 | 59.991 | 0.321 |
Yes | 143 | 177.97 | 57.482 | ||
Platelets 7 (G/L) | No | 216 | 220.09 | 82.91 | <0.001 |
Yes | 142 | 187.46 | 56.02 | ||
NLR 0 | No | 221 | 4.10 | 5.903 | 0.431 |
Yes | 144 | 4.39 | 7.942 | ||
NLR 1 | No | 220 | 25.85 | 18.197 | 0.912 |
Yes | 143 | 30.91 | 40.690 | ||
NLR Δ1-0 | No | 220 | 21.78 | 18.894 | 0.892 |
Yes | 143 | 26.50 | 41.570 | ||
PLR 0 | No | 221 | 156.59 | 120.088 | 0.751 |
Yes | 144 | 147.39 | 98.651 | ||
PLR 1 | No | 220 | 452.28 | 341.643 | 0.297 |
Yes | 143 | 461.61 | 446.768 | ||
PLR Δ1-0 | No | 220 | 296.40 | 340.153 | 0.408 |
Yes | 143 | 314.25 | 448.774 | ||
NMR 0 | No | 221 | 10.11 | 8.011 | 0.048 |
Yes | 144 | 10.20 | 12.405 | ||
NMR 1 | No | 220 | 37.10 | 24.576 | <0.001 |
Yes | 143 | 27.34 | 18.111 | ||
NMR Δ1-0 | No | 220 | 27.12 | 25.597 | <0.001 |
Yes | 143 | 17.10 | 21.835 | ||
LMR 0 | No | 221 | 3.18 | 1.763 | 0.307 |
Yes | 144 | 3.19 | 2.315 | ||
LMR 1 | No | 220 | 1.77 | 1.302 | <0.001 |
Yes | 143 | 1.35 | 1.062 | ||
LMR Δ1-0 | No | 220 | −1.41 | 1.813 | 0.079 |
Yes | 143 | −1.84 | 2.241 | ||
SII 0 | No | 221 | 913.08 | 1482.584 | 0.502 |
Yes | 144 | 890.32 | 1661.570 | ||
SII 1 | No | 220 | 4746.57 | 3940.796 | 0.671 |
Yes | 143 | 5486.51 | 6790.670 | ||
SII Δ1-0 | No | 220 | 3840.95 | 3895.964 | 0.934 |
Yes | 143 | 4592.95 | 6880.85 |
Parameters | AUC | p Value | Cut-Off Point | 95% CI | Sensitivity | Specificity | Accuracy |
---|---|---|---|---|---|---|---|
Mono.0 | 0.566 | 0.034 | 0.71 | 0.505–0.628 | 0.458 | 0.697 | 0.603 |
Mono.1 | 0.623 | <0.001 | 0.21 | 0.565–0.680 | 0.888 | 0.345 | 0.559 |
NMR1 | 0.624 | <0.001 | 29.29 | 0.566–0.682 | 0.678 | 0.545 | 0.598 |
NMRΔ1-0 | 0.622 | <0.001 | 22.74 | 0.563–0.680 | 0.734 | 0.514 | 0.601 |
LMR1 | 0.610 | <0.001 | 0.790 | 0.550–0.670 | 0.790 | 0.409 | 0.559 |
HD (month) | 0.653 | <0.001 | 36 | 0.583–0.723 | 0.552 | 0.717 | 0.652 |
Peak PRA | 0.583 | 0.031 | 20 | 0.507–0.658 | 0.313 | 0.823 | 0.621 |
HLA MM | 0.578 | 0.012 | 3 | 0.521–0.634 | 0.750 | 0.384 | 0.529 |
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Pilichowska, E.; Ostrowski, P.; Sieńko, J. The Impact of Hematological Indices on the Occurrence of Delayed Graft Function (DGF) of Transplanted Kidney. J. Clin. Med. 2023, 12, 7514. https://doi.org/10.3390/jcm12247514
Pilichowska E, Ostrowski P, Sieńko J. The Impact of Hematological Indices on the Occurrence of Delayed Graft Function (DGF) of Transplanted Kidney. Journal of Clinical Medicine. 2023; 12(24):7514. https://doi.org/10.3390/jcm12247514
Chicago/Turabian StylePilichowska, Ewa, Piotr Ostrowski, and Jerzy Sieńko. 2023. "The Impact of Hematological Indices on the Occurrence of Delayed Graft Function (DGF) of Transplanted Kidney" Journal of Clinical Medicine 12, no. 24: 7514. https://doi.org/10.3390/jcm12247514