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Article

The Importance of New EBMT Criteria on the Diagnosis of Veno-Occlusive Liver Disease in Children

by
Mária Füssiová
1,*,
Peter Švec
1,
Júlia Horáková
1,
Petr Sedláček
2,
Peter Rohoň
3,
Peter Celec
4,
Ivana Boďová
1,
Jaroslava Adamčáková
1,
Tomáš Sýkora
1,
Veronika Dobšinská
1,
Miroslava Pozdechová
1,
Dominika Dóczyová
1,
Santia Vargová
1 and
Alexandra Kolenová
1
1
Bone Marrow Transplantation Unit, Department of Pediatric Hematology and Oncology, National Institute of Children’s Diseases, Comenius University, 833 40 Bratislava, Slovakia
2
Department of Pediatric Hematology and Oncology, Charles University Motol, 150 06 Prague, Czech Republic
3
Department of Hematology and Transfusion, Faculty of Medicine, Comenius University, 812 50 Bratislava, Slovakia
4
Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, 811 08 Bratislava, Slovakia
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2023, 12(3), 826; https://doi.org/10.3390/jcm12030826
Submission received: 29 November 2022 / Revised: 16 January 2023 / Accepted: 18 January 2023 / Published: 20 January 2023
(This article belongs to the Special Issue Advances in Pediatric Cancer Therapy)
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Abstract

Background: Early recognition and specific therapy facilitate a favorable disease course in hepatic venous-occlusive disease (HVOD) following hematopoietic stem cell transplantation (HCT). Diagnostic and classification criteria, published by the European Society for Blood and Marrow Transplantation (EBMT), better account for clinical differences in disease presentation in pediatric populations. Objectives: To compare the course of HVOD in children before and after the implementation of new EBMT criteria. Material and methods: The study retrospectively evaluates 26 HVODs in 179 children treated in a single HCT unit (Slovakia) comparing the period of 2014–2017 using the Baltimore and modified Seattle criteria with the period of 2018–2021, when new EBMT criteria were adopted. Results: No difference in HVOD incidence (11.2% vs. 14.8%, p = 0.46) and in time of diagnosis post-HCT (15.6 days vs. 15.7 days, p = 0.75) was found. With EBMT criteria we observed more frequent anicteric disease at diagnosis (50% vs. 87.5%, p = 0.04), lower serum bilirubin at diagnosis (3.4 mg/dL vs. 1.23 mg/dL, p = 0.045), and non-significant trends of shorter defibrotide treatment (21.7 days vs. 15.6 days, p = 0.73), decreased mortality (30% vs. 6.2%, p = 0.10) and shorter hospitalization (73.1 days vs. 59.6 days, p = 0.54). Conclusions: Different time periods around the implementation of new criteria are evaluated, underling that pediatric EBMT criteria for post-transplant HVOD diagnosis appear more sensitive.
Keywords: veno-occlusive disease of the liver; hematopoietic stem cell transplantation; new diagnostic and severity EBMT criteria in childhood; retrospective analysis veno-occlusive disease of the liver; hematopoietic stem cell transplantation; new diagnostic and severity EBMT criteria in childhood; retrospective analysis

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MDPI and ACS Style

Füssiová, M.; Švec, P.; Horáková, J.; Sedláček, P.; Rohoň, P.; Celec, P.; Boďová, I.; Adamčáková, J.; Sýkora, T.; Dobšinská, V.; et al. The Importance of New EBMT Criteria on the Diagnosis of Veno-Occlusive Liver Disease in Children. J. Clin. Med. 2023, 12, 826. https://doi.org/10.3390/jcm12030826

AMA Style

Füssiová M, Švec P, Horáková J, Sedláček P, Rohoň P, Celec P, Boďová I, Adamčáková J, Sýkora T, Dobšinská V, et al. The Importance of New EBMT Criteria on the Diagnosis of Veno-Occlusive Liver Disease in Children. Journal of Clinical Medicine. 2023; 12(3):826. https://doi.org/10.3390/jcm12030826

Chicago/Turabian Style

Füssiová, Mária, Peter Švec, Júlia Horáková, Petr Sedláček, Peter Rohoň, Peter Celec, Ivana Boďová, Jaroslava Adamčáková, Tomáš Sýkora, Veronika Dobšinská, and et al. 2023. "The Importance of New EBMT Criteria on the Diagnosis of Veno-Occlusive Liver Disease in Children" Journal of Clinical Medicine 12, no. 3: 826. https://doi.org/10.3390/jcm12030826

APA Style

Füssiová, M., Švec, P., Horáková, J., Sedláček, P., Rohoň, P., Celec, P., Boďová, I., Adamčáková, J., Sýkora, T., Dobšinská, V., Pozdechová, M., Dóczyová, D., Vargová, S., & Kolenová, A. (2023). The Importance of New EBMT Criteria on the Diagnosis of Veno-Occlusive Liver Disease in Children. Journal of Clinical Medicine, 12(3), 826. https://doi.org/10.3390/jcm12030826

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