Rifaximin Improves Liver Functional Reserve by Regulating Systemic Inflammation

Kitsugi, Kensuke; Kawata, Kazuhito; Noritake, Hidenao; Chida, Takeshi; Ohta, Kazuyoshi; Ito, Jun; Takatori, Shingo; Yamashita, Maho; Hanaoka, Tomohiko; Umemura, Masahiro; Matsumoto, Moe; Suda, Takafumi

doi:10.3390/jcm12062210

Open AccessArticle

Rifaximin Improves Liver Functional Reserve by Regulating Systemic Inflammation

by

Kensuke Kitsugi

^*,

Kazuhito Kawata

,

Hidenao Noritake

,

Takeshi Chida

,

Kazuyoshi Ohta

,

Jun Ito

,

Shingo Takatori

,

Maho Yamashita

,

Tomohiko Hanaoka

,

Masahiro Umemura

,

Moe Matsumoto

and

Takafumi Suda

Department of Internal Medicine II, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan

^*

Author to whom correspondence should be addressed.

J. Clin. Med. 2023, 12(6), 2210; https://doi.org/10.3390/jcm12062210

Submission received: 20 January 2023 / Revised: 1 March 2023 / Accepted: 7 March 2023 / Published: 13 March 2023

(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

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Abstract

Rifaximin, a non-absorbable antibiotic, has been demonstrated to be effective against hepatic encephalopathy (HE); however, its efficacy on liver functional reserve remains unknown. Here, we evaluated the efficacy of rifaximin on the liver functional reserve and serological inflammation-based markers in patients with cirrhosis. A retrospective study was conducted on patients who received rifaximin for more than three months at our hospital between November 2016 and October 2021. The recurrence and grade of HE, serological ammonia levels, Child–Pugh score (CPS), and serological inflammation-based markers such as the neutrophil–lymphocyte ratio (NLR), lymphocyte–monocyte ratio (LMR), platelet–lymphocyte ratio (PLR), C-reactive protein (CRP), and CRP to albumin ratio (CAR) were evaluated. The correlations between serological inflammation-based markers and liver functional reserve were evaluated. HE grades, serum ammonia levels, and inflammation-based markers significantly improved at three months compared with those at baseline. Patients with improved albumin levels showed significantly higher CRP improvement rates at both 3 and 12 months. Patients with an improvement in CAR at 3 months demonstrated a significant improvement in CPS at 12 months. Rifaximin improved the liver functional reserve in patients with cirrhosis. Improvements in inflammation-based markers, particularly CRP and albumin, may be involved in this process.

Keywords: albumin; C-reactive protein; Child–Pugh–Turcotte score; cirrhosis

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MDPI and ACS Style

Kitsugi, K.; Kawata, K.; Noritake, H.; Chida, T.; Ohta, K.; Ito, J.; Takatori, S.; Yamashita, M.; Hanaoka, T.; Umemura, M.; et al. Rifaximin Improves Liver Functional Reserve by Regulating Systemic Inflammation. J. Clin. Med. 2023, 12, 2210. https://doi.org/10.3390/jcm12062210

AMA Style

Kitsugi K, Kawata K, Noritake H, Chida T, Ohta K, Ito J, Takatori S, Yamashita M, Hanaoka T, Umemura M, et al. Rifaximin Improves Liver Functional Reserve by Regulating Systemic Inflammation. Journal of Clinical Medicine. 2023; 12(6):2210. https://doi.org/10.3390/jcm12062210

Chicago/Turabian Style

Kitsugi, Kensuke, Kazuhito Kawata, Hidenao Noritake, Takeshi Chida, Kazuyoshi Ohta, Jun Ito, Shingo Takatori, Maho Yamashita, Tomohiko Hanaoka, Masahiro Umemura, and et al. 2023. "Rifaximin Improves Liver Functional Reserve by Regulating Systemic Inflammation" Journal of Clinical Medicine 12, no. 6: 2210. https://doi.org/10.3390/jcm12062210

APA Style

Kitsugi, K., Kawata, K., Noritake, H., Chida, T., Ohta, K., Ito, J., Takatori, S., Yamashita, M., Hanaoka, T., Umemura, M., Matsumoto, M., & Suda, T. (2023). Rifaximin Improves Liver Functional Reserve by Regulating Systemic Inflammation. Journal of Clinical Medicine, 12(6), 2210. https://doi.org/10.3390/jcm12062210

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Rifaximin Improves Liver Functional Reserve by Regulating Systemic Inflammation

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