Vitamin D, Cholesterol, and DXA Value Relationship with Bimaxillary Cone Beam CT Values
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design and Characteristics
2.2. Sample Size Estimation and Outcome Variables
2.3. Statistical Analysis
3. Results
4. Discussion
Limitations
5. Conclusions
Author Contributions
Funding
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
Vit D | Vitamin D |
DXA | Dual-energy X-ray absorptiometry |
References
- Demes, B.; Creel, N. Bite Force, Diet, and Cranial Morphology of Fossil Hominids. J. Hum. Evol. 1988, 17, 657–670. [Google Scholar] [CrossRef]
- Al-Kazemi, F.; Al-Sabah, D.; Lucas, P. Effects of Masticatory Forces on Anterior Tooth Movement. 2013. Available online: http://www.hsc.edu.kw/fod/research/PDF_Files/FK_DS_13.pdf (accessed on 3 January 2023).
- Javed, F.; Malmstrom, H.; Kellesarian, S.V.; Al-Kheraif, A.A.; Vohra, F.; Romanos, G.E. Efficacy of Vitamin D3 Supplementation on Osseointegration of Implants. Implant. Dent. 2016, 25, 281–287. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Sahni, S.; Mangano, K.M.; McLean, R.R.; Hannan, M.T.; Kiel, D.P. Dietary Approaches for Bone Health: Lessons from the Framingham Osteoporosis Study. Curr. Osteoporos. Rep. 2015, 13, 245–255. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Winzenberg, T.; Powell, S.; Shaw, K.A.; Jones, G. Effects of Vitamin D Supplementation on Bone Density in Healthy Children: Systematic Review and Meta-Analysis. BMJ 2011, 342, 267. [Google Scholar] [CrossRef] [Green Version]
- De Lemos, J.A.; McGuire, D.K.; Drazner, M.H. B-Type Natriuretic Peptide in Cardiovascular Disease. Lancet 2003, 362, 316–322. [Google Scholar] [CrossRef]
- Bolland, M.J.; Grey, A.; Avenell, A. Effects of Vitamin D Supplementation on Musculoskeletal Health: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis. Lancet Diabetes Endocrinol. 2018, 6, 847–858. [Google Scholar] [CrossRef] [Green Version]
- Winslow, E.R.; Klingensmith, M.E.; Olson, J.A. Patient Selection and Preparation. In Laparoscopic Surgery: Principles and Procedures, 2nd ed.; Haworth Press: New York, NY, USA, 2004; pp. 7–13. ISBN 9781420030655. [Google Scholar]
- Carey, J.A.; Madill, A.; Manogue, M. Communications Skills in Dental Education: A Systematic Research Review. Eur. J. Dent. Educ. 2010, 14, 69–78. [Google Scholar] [CrossRef]
- Tang, Y.; Wang, S.; Yi, Q.; Xia, Y.; Geng, B. High-Density Lipoprotein Cholesterol Is Negatively Correlated with Bone Mineral Density and Has Potential Predictive Value for Bone Loss. Lipids Health Dis. 2021, 20, 75. [Google Scholar] [CrossRef]
- Mandal, C.C. High Cholesterol Deteriorates Bone Health: New Insights into Molecular Mechanisms. Front. Endocrinol. 2015, 6, 165. [Google Scholar] [CrossRef] [Green Version]
- Dimai, H.P. Use of Dual-Energy X-Ray Absorptiometry (DXA) for Diagnosis and Fracture Risk Assessment; WHO-Criteria, T- and Z-Score, and Reference Databases. Bone 2017, 104, 39–43. [Google Scholar] [CrossRef]
- Sghaireen, M.G.; Ganji, K.K.; Alam, M.K.; Srivastava, K.C.; Shrivastava, D.; Rahman, S.A.; Patil, S.R.; Al Habib, S. Comparing the Diagnostic Accuracy of CBCT Grayscale Values with DXA Values for the Detection of Osteoporosis. Appl. Sci. 2020, 10, 4584. [Google Scholar] [CrossRef]
- Hewison, M. Vitamin D and Immune Function: Autocrine, Paracrine or Endocrine? Scand. J. Clin. Lab. Invest. 2012, 72, 92–102. [Google Scholar] [CrossRef]
- Olsen, K.; Falch, B.M.; Danielsen, K.; Johannessen, M.; Ericson Sollid, J.U.; Thune, I.; Grimnes, G.; Jorde, R.; Simonsen, G.S.; Furberg, A.S. Staphylococcus Aureus Nasal Carriage Is Associated with Serum 25-Hydroxyvitamin D Levels, Gender and Smoking Status. The Tromsø Staph and Skin Study. Eur. J. Clin. Microbiol. Infect. Dis. 2012, 31, 465–473. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Krieger, M. The “best” of Cholesterols, the “Worst” of Cholesterols: A Tale of Two Receptors. Proc. Natl. Acad. Sci. USA 1998, 95, 4077–4080. [Google Scholar] [CrossRef] [Green Version]
- Lehmann, B. The Vitamin D3 Pathway in Human Skin and Its Role for Regulation of Biological Processes. Photochem. Photobiol. 2005, 81, 1246. [Google Scholar] [CrossRef] [PubMed]
- Holick, M.F. Medical Progress: Vitamin D Deficiency. N. Engl. J. Med. 2007, 357, 266–281. [Google Scholar] [CrossRef]
- Brinker, M.R.; O’Connor, D.P.; Monla, Y.T.; Earthman, T.P. Metabolic and Endocrine Abnormalities in Patients with Nonunions. Curr. Orthop. Pract. 2008, 19, 430–442. [Google Scholar] [CrossRef]
- Ackert-Bicknell, C.L. HDL Cholesterol and Bone Mineral Density: Is There a Genetic Link? Bone 2012, 50, 525–533. [Google Scholar] [CrossRef] [Green Version]
- Grarup, N.; Andreasen, C.; Andersen, M.K.; Albrechtsen, A.; Sandbæk, A.; Lauritzen, T.; Borch-Johnsen, K.; Jørgensen, T.; Schmitz, O.; Hansen, T.; et al. The −250G> A Promoter Variant in Hepatic Lipase Associates with Elevated Fasting Serum High-Density Lipoprotein Cholesterol Modulated by Interaction with Physical. J. Clin. Endocrinol. Metab. 2008, 93, 2294–2299. [Google Scholar] [CrossRef] [Green Version]
- Sentí, M.; Elosua, R.; Tomás, M.; Sala, J.; Masiá, R.; Ordovás, J.M.; Shen, H.; Marrugat, J. Physical Activity Modulates the Combined Effect of a Common Variant of the Lipoprotein Lipase Gene and Smoking on Serum Triglyceride Levels and High-Density Lipoprotein Cholesterol in Men. Hum. Genet. 2001, 109, 385–392. [Google Scholar] [CrossRef]
- Hossein-Nezhad, A.; Holick, M.F. Optimize Dietary Intake of Vitamin D: An Epigenetic Perspective. Curr. Opin. Clin. Nutr. Metab. Care 2012, 15, 567–579. [Google Scholar] [CrossRef]
- Kelly, J.; Lin, A.; Wang, C.J.; Park, S.; Nishimura, I. Vitamin D and Bone Physiology: Demonstration of Vitamin D Deficiency in an Implant Osseointegration Rat Model. J. Prosthodont. 2009, 18, 473–478. [Google Scholar] [CrossRef] [PubMed]
- Dvorak, G.; Fügl, A.; Watzek, G.; Tangl, S.; Pokorny, P.; Gruber, R. Impact of Dietary Vitamin D on Osseointegration in the Ovariectomized Rat. Clin. Oral. Implant. Res. 2012, 23, 1308–1313. [Google Scholar] [CrossRef] [PubMed]
- Mezquita-Raya, P.; Muñoz-Torres, M.; De Dios Luna, J.; Luna, V.; Lopez-Rodriguez, F.; Torres-Vela, E.; Escobar-Jiménez, F. Relation between Vitamin D Insufficiency, Bone Density, and Bone Metabolism in Healthy Postmenopausal Women. J. Bone Miner. Res. 2009, 16, 1408–1415. [Google Scholar] [CrossRef] [PubMed]
- Hmamouchi, I.; Allali, F.; Khazzani, H.; Bennani, L.; El Mansouri, L.; Ichchou, L.; Cherkaoui, M.; Abouqal, R.; Hajjaj-Hassouni, N. Low Bone Mineral Density Is Related to Atherosclerosis in Postmenopausal Moroccan Women. BMC Public Health 2009, 9, 388. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Samelson, E.J.; Cupples, L.A.; Hannan, M.T.; Wilson, P.W.F.; Williams, S.A.; Vaccarino, V.; Zhang, Y.; Kiel, D.P. Long-Term Effects of Serum Cholesterol on Bone Mineral Density in Women and Men: The Framingham Osteoporosis Study. Bone 2004, 34, 557–561. [Google Scholar] [CrossRef]
- Ponda, M.P.; Dowd, K.; Finkielstein, D.; Holt, P.R.; Breslow, J.L. The Short-Term Effects of Vitamin d Repletion on Cholesterol: A Randomized, Placebo-Controlled Trial. Arterioscler. Thromb. Vasc. Biol. 2012, 32, 2510–2515. [Google Scholar] [CrossRef] [Green Version]
- Garnero, P.; Munoz, F.; Sornay-Rendu, E.; Delmas, P.D. Associations of Vitamin D Status with Bone Mineral Density, Bone Turnover, Bone Loss and Fracture Risk in Healthy Postmenopausal Women. The OFELY Study. Bone 2007, 40, 716–722. [Google Scholar] [CrossRef]
- Maghbooli, Z.; Khorrami-Nezhad, L.; Adabi, E.; Ramezani, M.; Asadollahpour, E.; Razi, F.; Rezanejad, M. Negative Correlation of High-Density Lipoprotein-Cholesterol and Bone Mineral Density in Postmenopausal Iranian Women with Vitamin D Deficiency. Menopause 2018, 25, 458–464. [Google Scholar] [CrossRef]
- Sharma, H. Statistical Significance or Clinical Significance? A Researcher’s Dilemma for Appropriate Interpretation of Research Results. Saudi J. Anaesth. 2021, 15, 431–434. [Google Scholar] [CrossRef]
Variable | Study Group | p-Value | ||
---|---|---|---|---|
Control Group (n = 90) | Case Group (n = 97) | |||
Age | 55.5 ± 9.7 | 59.6 ± 8.2 | 0.37 | |
Gender | Male | 40 (45%) | 42 (44%) | 0.22 |
Female | 50 (55%) | 55 (56%) |
Variable | Study Group | p-Value | |
---|---|---|---|
Control Group (n = 90) | Case Group (n = 97) | ||
Vit D | 17.4 ± 5.2 | 13.6 ± 5.0 | p < 0.01 |
Cholesterol | 233.69 ± 24.950 | 247.73 ± 29.962 | p < 0.05 |
Variable | Study Group | p-Value | |
---|---|---|---|
Control Group (n = 90) | Case Group (n = 97) | ||
Anterior mandible | 897.67 ± 143.161 | 533.40 ± 83.633 | p < 0.001 |
Posterior mandible | 739.87 ± 178.623 | 351.77 ± 52.170 | p < 0.001 |
Anterior maxilla | 753.62 ± 186.895 | 381.58 ± 48.578 | p < 0.001 |
Posterior maxilla | 548.03 ± 110.584 | 149.06 ± 73.257 | p < 0.001 |
Variable | Study Group | p-Value | |
---|---|---|---|
Control Group (n = 90) | Case Group (n = 97) | ||
Z-Value | 0.241 ± 0.8565 | −2.996 ± 0.4510 | p < 0.001 |
Vit D | Cholesterol | Z-Value | Cone Beam Computed Tomography Value (Anterior Mandibular) | Cone Beam Computed Tomography Value (Posterior Mandibular) | Cone Beam Computed Tomography Value (Anterior Maxillary) | Cone Beam Computed Tomography Value (Posterior Maxillary) | |
---|---|---|---|---|---|---|---|
Vit D | - | 0.112 (−0.269) | 0.153 (0.243) | 0.003 ** (0.428) | 0.001 ** (0.526) | 0.001 ** (0.530) | 0.037 * (0.348) |
Cholesterol | 0.112 (−0.269) | - | 0.086 (−0.279) | 0.007 ** (−0.425) | 0.018 * (−0.378) | 0.086 (−0.279) | 0.021 * (−0.369) |
Z-value | 0.086 (−0.279) | 0.153 (0.243) | - | 0.000 *** (0.751) | 0.000 *** (0.774) | 0.000 *** (0.715) | 0.000 *** (0.787) |
Vit D | Cholesterol | Z-Value | Cone Beam Computed Tomography Value (Anterior Mandibular) | Cone Beam Computed Tomography Value (Posterior Mandibular) | Cone Beam Computed Tomography Value (Anterior Maxillary) | Cone Beam Computed Tomography Value (Posterior Maxillary) | |
---|---|---|---|---|---|---|---|
Vit D | - | 0.042 (−0.294) | 0.315 (0.148) | 0.194 (0.191) | 0.044 (0.292) | 0.066 (0.268) | 0.743 (0.049) |
Cholesterol | 0.042 (−0.294) | - | 0.272 (−0.162) | 0.782 (−0.041) | 0.751 (−0.047) | 0.309 (−0.150) | 0.177 (−0.198) |
Z-value | 0.315 (0.148) | 0.272 (−0.162) | - | 0.000 (0.652) | 0.000 (0.587) | 0.000 (0.621) | 0.000 (0.449) |
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Sghaireen, M.G.; Ganji, K.K.; Srivastava, K.C.; Alam, M.K.; Nashwan, S.; Migdadi, F.H.; Al-Qerem, A.; Khader, Y. Vitamin D, Cholesterol, and DXA Value Relationship with Bimaxillary Cone Beam CT Values. J. Clin. Med. 2023, 12, 2678. https://doi.org/10.3390/jcm12072678
Sghaireen MG, Ganji KK, Srivastava KC, Alam MK, Nashwan S, Migdadi FH, Al-Qerem A, Khader Y. Vitamin D, Cholesterol, and DXA Value Relationship with Bimaxillary Cone Beam CT Values. Journal of Clinical Medicine. 2023; 12(7):2678. https://doi.org/10.3390/jcm12072678
Chicago/Turabian StyleSghaireen, Mohammed G., Kiran Kumar Ganji, Kumar Chandan Srivastava, Mohammad Khursheed Alam, Shadi Nashwan, Fayeq Hasan Migdadi, Ahmad Al-Qerem, and Yousef Khader. 2023. "Vitamin D, Cholesterol, and DXA Value Relationship with Bimaxillary Cone Beam CT Values" Journal of Clinical Medicine 12, no. 7: 2678. https://doi.org/10.3390/jcm12072678
APA StyleSghaireen, M. G., Ganji, K. K., Srivastava, K. C., Alam, M. K., Nashwan, S., Migdadi, F. H., Al-Qerem, A., & Khader, Y. (2023). Vitamin D, Cholesterol, and DXA Value Relationship with Bimaxillary Cone Beam CT Values. Journal of Clinical Medicine, 12(7), 2678. https://doi.org/10.3390/jcm12072678