Development of an Italian National Epidemiological Register on Endometriosis Based on Administrative Data
Abstract
:1. Introduction
2. Methods
Statistical Analysis
3. Results
Sensitivity Analysis
4. Discussion
4.1. Principal Results
4.2. Strengths and Limitations
4.3. Interpretation and Comparison with Prior Work
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Acronyms
References
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ICD-9-CM Diagnosis Code | ICD-9-CM Procedure Code | |
---|---|---|
617 or 617.0 or 617.1 or 617.2 or 617.3 or 617.4 or 617.5 or 617.6 or 617.8 or 617.9 | AND | 34.81 or 37.34 or 45.23 or 45.24 or 45.26 or 45.62 or 45.72 or 45.76 or 45.94 or 46.04 or 46.11 or 46.21 or 47.01 or 47.19 or 47.99 or 48.62 or 48.63 or 48.69 or 48.82 or 49.39 or 51.23 or 54.11 or 54.12 or 54.19 or 54.21 or 54.23 or 54.24 or 54.4 or 54.51 or 54.59 or 54.73 or 55.51 or 56.74 or 56.99 or 57.32 or 57.6 or 57.99 or 59.00 or 59.02 or 59.03 or 65.01 or 65.12 or 65.13 or 65.23 or 65.24 or 65.25 or 65.29 or 65.31 or 65.41 or 65.49 or 65.51 or 65.52 or 65.53 or 65.54 or 65.61 or 65.62 or 65.63 or 65.74 or 65.79 or 65.81 or 65.89 or 65.91 or 65.99 or 66.19 or 66.29 or 66.39 or 66.4 or 66.51 or 66.52 or 66.61 or 66.62 or 66.63 or 66.69 or 67.39 or 67.4 or 68.12 or 68.13 or 68.14 or 68.15 or 68.16 or 68.29 or 68.39 or 68.41 or 68.49 or 68.51 or 68.59 or 68.61 or 68.69 or 68.71 or 68.9 or 69.19 or 69.29 or 70.32 or 70.77 or 86.3 or 87.83 or 97.83 |
Region | Incidence Annual Rate ×1000 | Total 2011–2020 | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
2011 | 2012 | 2013 | 2014 | 2015 | 2016 | 2017 | 2018 | 2019 | 2020 | n | Rate | 95% CI | |
Piemonte | 1.064 | 1.022 | 0.878 | 0.937 | 0.841 | 0.771 | 0.688 | 0.766 | 0.835 | 0.540 | 7810 | 0.840 | (0.822–0.859) |
Valle D‘Aosta | 0.549 | 0.587 | 1.247 | 0.876 | 0.679 | 0.657 | 0.746 | 0.495 | 0.775 | 0.395 | 194 | 0.705 | (0.609–0.812) |
Lombardia | 1.118 | 1.068 | 1.001 | 0.942 | 0.941 | 0.930 | 0.945 | 0.856 | 0.687 | 0.597 | 20,126 | 0.912 | (0.900–0.925) |
Liguria | 0.964 | 1.051 | 0.958 | 0.853 | 0.721 | 0.778 | 0.758 | 0.532 | 0.754 | 0.561 | 2504 | 0.801 | (0.770–0.833) |
Northwest | 1.085 | 1.050 | 0.966 | 0.932 | 0.892 | 0.872 | 0.859 | 0.801 | 0.732 | 0.577 | 30,634 | 0.881 | (0.871–0.891) |
PA Bolzano | 1.677 | 1.867 | 1.762 | 1.688 | 1.651 | 1.374 | 1.158 | 1.014 | 0.997 | 0.884 | 1706 | 1.414 | (1.348–1.483) |
PA Trento | 1.259 | 1.051 | 1.149 | 1.212 | 1.001 | 0.888 | 0.797 | 0.943 | 0.993 | 0.689 | 1198 | 1.002 | (0.946–1.060) |
Veneto | 1.208 | 1.212 | 1.144 | 1.159 | 1.211 | 1.182 | 1.035 | 1.060 | 1.049 | 0.879 | 12,085 | 1.117 | (1.098–1.138) |
Friuli-Venezia Giulia | 1.074 | 0.952 | 0.882 | 0.864 | 0.830 | 0.921 | 0.799 | 0.808 | 0.905 | 0.695 | 2225 | 0.876 | (0.840–0.913) |
Emilia Romagna | 1.017 | 1.059 | 0.972 | 1.015 | 0.972 | 0.930 | 0.934 | 0.840 | 0.839 | 0.672 | 8963 | 0.928 | (0.909–0.947) |
Northeast | 1.147 | 1.151 | 1.082 | 1.102 | 1.093 | 1.055 | 0.968 | 0.943 | 0.949 | 0.772 | 26,177 | 1.030 | (1.017–1.042) |
Toscana | 0.938 | 0.885 | 0.804 | 0.791 | 0.683 | 0.607 | 0.596 | 0.668 | 0.646 | 0.495 | 5732 | 0.716 | (0.698–0.735) |
Umbria | 0.837 | 0.981 | 1.001 | 0.976 | 0.901 | 0.722 | 0.736 | 0.661 | 0.651 | 0.492 | 1532 | 0.802 | (0.763–0.844) |
Marche | 0.887 | 0.815 | 0.931 | 0.865 | 0.779 | 0.649 | 0.808 | 0.763 | 0.748 | 0.572 | 2616 | 0.785 | (0.755–0.816) |
Lazio | 0.980 | 0.937 | 0.869 | 0.803 | 0.790 | 0.721 | 0.721 | 0.699 | 0.661 | 0.629 | 10,346 | 0.784 | (0.769–0.799) |
Centre | 0.945 | 0.909 | 0.867 | 0.820 | 0.764 | 0.678 | 0.695 | 0.695 | 0.667 | 0.572 | 20,226 | 0.765 | (0.754–0.776) |
Abruzzo | 0.780 | 0.872 | 0.916 | 0.830 | 0.888 | 0.802 | 0.743 | 0.860 | 0.746 | 0.584 | 2355 | 0.805 | (0.773–0.838) |
Molise | 0.742 | 0.910 | 0.774 | 0.686 | 0.742 | 0.907 | 0.776 | 0.655 | 0.673 | 1.145 | 538 | 0.799 | (0.733–0.869) |
Campania | 0.633 | 0.659 | 0.650 | 0.609 | 0.586 | 0.551 | 0.587 | 0.532 | 0.557 | 0.429 | 8155 | 0.582 | (0.569–0.594) |
Puglia | 0.801 | 0.800 | 0.802 | 0.785 | 0.823 | 0.821 | 0.743 | 0.776 | 0.724 | 0.578 | 7189 | 0.768 | (0.750–0.786) |
Basilicata | 0.571 | 0.849 | 0.706 | 0.649 | 0.616 | 0.574 | 0.683 | 0.608 | 0.513 | 0.442 | 799 | 0.625 | (0.582–0.670) |
Calabria | 0.692 | 0.755 | 0.756 | 0.664 | 0.728 | 0.653 | 0.704 | 0.650 | 0.605 | 0.487 | 3031 | 0.673 | (0.649–0.697) |
South | 0.702 | 0.744 | 0.737 | 0.690 | 0.705 | 0.673 | 0.669 | 0.652 | 0.628 | 0.508 | 22,067 | 0.673 | (0.665–0.682) |
Sicilia | 0.955 | 0.923 | 0.847 | 0.863 | 0.909 | 0.833 | 0.849 | 0.781 | 0.867 | 0.659 | 9899 | 0.851 | (0.835–0.868) |
Sardegna | 1.174 | 1.219 | 1.147 | 1.056 | 1.176 | 1.122 | 1.085 | 1.012 | 0.945 | 0.812 | 3942 | 1.081 | (1.048–1.115) |
Islands | 1.008 | 0.994 | 0.919 | 0.909 | 0.972 | 0.902 | 0.905 | 0.835 | 0.885 | 0.695 | 13,841 | 0.906 | (0.891–0.921) |
ITALY | 0.966 | 0.960 | 0.907 | 0.880 | 0.868 | 0.823 | 0.806 | 0.775 | 0.753 | 0.610 | 112,945 | 0.839 | (0.834–0.844) |
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Maraschini, A.; Ceccarelli, E.; Giangreco, M.; Monasta, L.; Manno, V.; Catelan, D.; Stoppa, G.; Biggeri, A.; Ricci, G.; Buonomo, F.; et al. Development of an Italian National Epidemiological Register on Endometriosis Based on Administrative Data. J. Clin. Med. 2024, 13, 3087. https://doi.org/10.3390/jcm13113087
Maraschini A, Ceccarelli E, Giangreco M, Monasta L, Manno V, Catelan D, Stoppa G, Biggeri A, Ricci G, Buonomo F, et al. Development of an Italian National Epidemiological Register on Endometriosis Based on Administrative Data. Journal of Clinical Medicine. 2024; 13(11):3087. https://doi.org/10.3390/jcm13113087
Chicago/Turabian StyleMaraschini, Alice, Emiliano Ceccarelli, Manuela Giangreco, Lorenzo Monasta, Valerio Manno, Dolores Catelan, Giorgia Stoppa, Annibale Biggeri, Giuseppe Ricci, Francesca Buonomo, and et al. 2024. "Development of an Italian National Epidemiological Register on Endometriosis Based on Administrative Data" Journal of Clinical Medicine 13, no. 11: 3087. https://doi.org/10.3390/jcm13113087