Comparison of Functional, Structural, and Microvascular Features in Different Stages of Idiopathic Epiretinal Membrane
Abstract
:1. Introduction
2. Materials and Methods
2.1. Reading Performance Assessment
2.2. OCT Grading and Structural Assessment
2.3. Microvascular Assessment
2.4. Statistical Analysis
3. Results
3.1. Comparison between Functional Parameters in Different Stages of ERM
3.2. Comparison between Structural Parameters in Different Stages of ERM
3.3. Comparison between Microvascular Features in Different Stages of ERM
3.4. Multivariate Logistic Regression
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Stage 2 (n = 10) | Stage 3 (n = 24) | Stage 4 (n = 10) | p-Value * | |
---|---|---|---|---|
Age, years (±SD) | 73.40 (±4.08) | 74.09 (±3.33) | 69.25 (±6.75) | 0.225 a |
Gender | ||||
Women, n (%) | 4 (40.0%) | 10 (41.7%) | 5 (50.0%) | 0.881 b |
Men, n (%) | 6 (60.0%) | 14 (58.3%) | 5 (50.0%) | |
Lens Status | ||||
Pseudophakic, n (%) | 4 (40.0%) | 11 (45.8%) | 4 (40.0%) | 0.927 b |
Phakic, n (%) | 6 (60.0%) | 13 (54.2%) | 6 (60.0%) | |
Axial length, mm (±SD) | 24.14 (±1.08) | 24.35 (±1.21) | 24.22 (±1.33) | 0.753 b |
Stage 2 (n = 10) | Stage 3 (n= 24) | Stage 4 (n = 10) | p-Value * | |
---|---|---|---|---|
BCVA, LogMAR (±SD) | 0.31 (±0.16) | 0.38 (±0.20) | 0.71 (±0.24) | 0.008 a |
p-value (Mann–Whitney) | 0.461 b | 0.012 c | 0.003 d | |
Reading acuity, LogRAD (±SD) | 0.61 (±0.20) | 0.64 (±0.16) | 0.84 (±0.06) | 0.003 a |
p-value (Mann–Whitney) | 0.702 b | 0.002 c | 0.004 d | |
Maximum RS, wpm (±SD) | 125.63 (±57.79) | 109.10 (±50.57) | 47.29 (±30.06) | 0.006 a |
p-value (Mann–Whitney) | 0.473 b | 0.013 c | 0.003 d | |
Amsler grid test, n (%) | 6 (60.0%) | 18 (75.0%) | 10 (100.0%) | 0.095 e |
Stage 2 (n = 10) | Stage 3 (n= 24) | Stage 4 (n = 10) | p-Value * | |
---|---|---|---|---|
CMT, μm (±SD) | 444.50 (±49.02) | 485.22 ± 46.90 | 618.00 ± 109.93 | 0.004 a |
p-value (Mann–Whitney) | 0.191 b | 0.006 c | 0.003 d | |
Cotton ball sign, n (%) | 3 (30) | 2 (8.3) | 0 (0) | - |
Foveolar detachment, n (%) | 1 (10) | 1 (4.2) | 0 (0) | - |
Acquired vitelliform lesion, n (%) | 1 (10) | 3 (12.5) | 0 (0) | - |
EZ disruption, n (%) | 1 (10) | 4 (16.7) | 4 (40) | 0.292 e |
Tractional cysts, n (%) | 3 (30) | 12 (50) | 4 (40) | 0.548 e |
Stage 2 (n = 10) | Stage 3 (n= 24) | Stage 4 (n = 10) | p-Value *,a | |
---|---|---|---|---|
FAZ parameters | ||||
Area, mm2 (±SD) | 0.073 ± 0.058 | 0.069 ± 0.051 | 0.058 ± 0.041 | 0.885 |
Perimeter, mm (±SD) | 1.29 ± 0.65 | 1.21 ± 0.45 | 1.14 ± 0.43 | 0.915 |
Superficial capillary plexus | ||||
Central VD, % (±SD) | 14.63 ± 4.78 | 15.14 ± 4.94 | 15.24 ± 1.98 | 0.673 |
Inner VD, % (±SD) | 18.01 ± 4.51 | 18.27 ± 3.21 | 19.53 ± 2.48 | 0.662 |
Total VD, % (±SD) | 17.42 ± 4.31 | 17.90 ± 3.31 | 18.18 ± 2.32 | 0.999 |
Central perfusion, % (±SD) | 26.88 ± 9.12 | 27.49 ± 8.74 | 29.68 ± 3.94 | 0.957 |
Inner perfusion, % (±SD) | 34.13 ± 7.35 | 35.60 ± 5.34 | 37.68 ± 5.87 | 0.336 |
Total perfusion, % (±SD) | 33.51 ± 7.68 | 34.68 ± 5.61 | 37.68 ± 3.37 | 0.255 |
Independent Variables | Exp(B) | CI 95% | p-Value |
---|---|---|---|
Reading acuity | 0.010 | 0.001–0.018 | <0.01 |
Maximum RS | 0.011 | 0.006–0.016 | <0.01 |
ERM stage | 0.034 | 0.012-0.108 | 0.361 |
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Marolo, P.; Borrelli, E.; Caselgrandi, P.; Parisi, G.; Gelormini, F.; Ricardi, F.; Ceroni, L.; Fallico, M.; Toro, M.D.; Ventre, L.; et al. Comparison of Functional, Structural, and Microvascular Features in Different Stages of Idiopathic Epiretinal Membrane. J. Clin. Med. 2024, 13, 3188. https://doi.org/10.3390/jcm13113188
Marolo P, Borrelli E, Caselgrandi P, Parisi G, Gelormini F, Ricardi F, Ceroni L, Fallico M, Toro MD, Ventre L, et al. Comparison of Functional, Structural, and Microvascular Features in Different Stages of Idiopathic Epiretinal Membrane. Journal of Clinical Medicine. 2024; 13(11):3188. https://doi.org/10.3390/jcm13113188
Chicago/Turabian StyleMarolo, Paola, Enrico Borrelli, Paolo Caselgrandi, Guglielmo Parisi, Francesco Gelormini, Federico Ricardi, Luca Ceroni, Matteo Fallico, Mario Damiano Toro, Luca Ventre, and et al. 2024. "Comparison of Functional, Structural, and Microvascular Features in Different Stages of Idiopathic Epiretinal Membrane" Journal of Clinical Medicine 13, no. 11: 3188. https://doi.org/10.3390/jcm13113188