Evaluating Mental Health Outcomes in COVID-19 ICU Survivors: A Scoping Review of Measurement Tools
1
School of Psychology, University of Queensland, Brisbane, QLD 4072, Australia
2
School of Social Sciences, Singapore Management University, 10 Canning Rise, Level 5, Singapore 179873, Singapore
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2024, 13(11), 3191; https://doi.org/10.3390/jcm13113191
Submission received: 5 April 2024
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Revised: 18 May 2024
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Accepted: 21 May 2024
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Published: 29 May 2024
(This article belongs to the Special Issue Clinical Consequences of COVID-19: 2nd Edition)
Abstract
:Objective: The objective of this scoping review was to map the range of measurement tools used to study the prevalence of common mental health conditions in COVID-19 ICU survivors. Introduction: Increased rates of admission to and survivorship from intensive care units (ICUs) have been observed in recent years, particularly during the global pandemic. ICU patients are at a higher risk of developing depressive, anxiety, and PTSD symptoms. Due to the high burden of disease, an accurate understanding of long-term mental health challenges for this population is key. Unfortunately, there is significant variability in reported prevalence rates. Heterogeneity in measurement tools potentially contribute to this. Inclusion criteria: Studies were eligible if they (a) reported mental health outcomes of adult patients diagnosed with COVID-19 and admitted to an ICU, (b) used standardised mental health outcome measures, and (3) were peer-reviewed. Methods: Searches were conducted in PubMed, PsycInfo, and Scopus. The initial search retrieved 1234 publications. After de-duplication and title and abstract screening, 72 full-text articles were examined for eligibility and 44 articles were excluded, leaving 28 eligible studies. Reference lists of the eligible studies were screened, and four other studies were added. 32 studies were ultimately included in this review. Results: Significant heterogeneity of measurement tools and clinical thresholds were observed. Only 6.25% of the studies compared changes in mental health outcomes to baseline measurements. Between five and nine unique measurement tools were used to study depression, anxiety, and PTSD, respectively. Studies were also observed to use up to 19 different thresholds to establish the prevalence of PTSD. Conclusions: The heterogeneity of measurement tools and thresholds continues to confound prevalence rate estimations of mental health complications post-ICU admission. Future research will benefit from consistency in the use of recommended outcome measures and the use of psychometrically comparable cut-off points between key measures.
1. Introduction
1.1. Post-Intensive Care Syndrome (PICS)
PICS is a syndrome characterised by new or worsened mental health, cognitive, or physical impairments after treatment in an intensive care unit (ICU) that can persist up to 15 years after discharge [1]. ICU survivorship can have a debilitating and lasting impact on patients in multiple domains of life. It is estimated that 50% of patients had a decreased ability to work and 25% needed assistance with activities of daily living 12 months after discharge from an ICU [2].
There is added reason to investigate PICS during the COVID-19 pandemic due to high rates of ICU admission and survival during the pandemic. In their systematic review and meta-analysis, Abate and colleagues [3] found that 32% of those infected with coronaviruses resulted in ICU admissions globally, and the prevalence rate of survival was 69%. COVID-19 ICU patients also tended to have medical complications including a longer ICU stay, the development of acute respiratory distress syndrome (ARDS) requiring sedation, and mechanical ventilation. Management of the global pandemic also required disease control measures, which potentially increased the risk of ICU survivors developing adverse psychological symptoms due to increased isolation (e.g., reduced visitation from family members) and reduced resources for psychosocial interventions [4]. Taken together, this means that there are now more critical illness survivors who have had ARDS but have had less psychosocial support during recovery and more environmental stressors than pre-pandemic patients.
1.2. Depression, Anxiety, and PTSD in ICU Survivors
The mental health domain of PICS includes symptoms of depression, anxiety, and post-traumatic stress disorder (PTSD) as they are the most common psychiatric complications after critical illness [1]. The experience of critical illness, or admission into an ICU, includes several stressors including invasive procedures, sleep deprivation, unnatural noise and light, difficulties communicating, and the threat of death due to critical illness [5]. Prior to COVID-19, pooled prevalence rates for mental disorders in ICU survivors were reported to be as high as 40% for anxiety [6], 34% for depression [7], and 34% for PTSD [8]. This is approximately ten times higher than the general population prevalence estimates [9,10].
The prevalence rate for mental health disorders might be even higher for ICU survivors with COVID-19. In total, 75% of COVID-19 ICU patients experience acute respiratory distress syndrome (ARDS) [11]. The hypoxemia and experience of dyspnoea (air hunger) during ARDS has been hypothesised to be psychologically traumatic for patients, contributing to post-ICU psychological sequelae [12]. Indeed, prior to the pandemic, depression, PTSD, and anxiety were, respectively, present in 36%, 39%, and 62% of ARDS ICU survivors [13]. Muysewinkel et al. [14] provided a comprehensive overview of PTSD studies during COVID-19 and found that a significant proportion of studies did not provide an index event for PTS symptoms and often used outdated DSM-IV criteria, potentially impairing the clinical relevance of the findings. It is thus likely that more COVID-19 ICU survivors are at risk of developing mental health complications post-ICU admission.
1.3. Prevalence Studies and Role of Outcome Measures
The prevalence of a disease indicates the number of people in a population that have a particular disease at a given point in time [15]. Having an accurate measure of prevalence rates is critical as it informs the magnitude of disease burden within a specific population. It serves to inform key community stakeholders on the development, prioritisation, delivery, and use of health services as well as their evaluation [16]. This need is particularly urgent, since depressive and anxiety disorders are the two most disabling mental disorders and are leading causes of the global health-related burden [17].
Unfortunately, there are large variances in reported prevalence rates of depression, anxiety, and PTSD within ICU survivors. Systematic reviews and meta-analyses indicate that prevalence rates ranged from 4% to 64% for depression [7], 5% to 73% for anxiety [6], and 4% to 62% for PTSD [8] in ICU survivors prior to COVID-19. Such variances have similarly been observed in research conducted on COVID-19 ICU survivors. For example, the prevalence rates for depression, anxiety, and PTSD a year after discharge were between 40% to 80% in one study [18] but 10% to 18% [19] in another. While COVID-19 has had a disproportionate impact on certain countries [20], variances in prevalence rates have also not been fully accounted for by geographical differences. Within the same country, depression was reported to be found in 37.8% [21] of patients in one study but 85.4% [22] in another study. This suggests that other factors might be at play.
The heterogeneity of measurements used between studies is one possible contributing factor to such variances. Systematic reviews conducted before COVID-19 reported significant heterogeneity in mental health outcome measures and cut-offs used for ICU survivors. Seven, four, and eight different measures were used for depression, anxiety, and PTSD, respectively, in three separate studies [6,7,8]). The I2 scores of pooled prevalence rates reported in the meta-analyses of those studies were also above 50%, indicating substantial heterogeneity [23]. All three reviews identified the heterogeneity in outcome measurement as a key inhibitor to a consolidated understanding of the prevalence rates of mental health concerns among ICU survivors. These findings were similarly echoed in the scoping review of ICU outcome measurements conducted by Turnbull and colleagues (2016) [24]. Despite being fairly dated, it is plausible that the heterogeneity in measurement tools used continues to limit this body of literature.
1.4. Research Gap
To the best of our knowledge, there have been no recent reviews focusing on outcome measures used to assess the mental health of COVID-19 ICU survivors. A preliminary search of the Cochrane Database of Systematic Reviews and PROSPERO was conducted on 5 April 2024 and no systematic reviews or scoping reviews on the topic were reportedly published or underway. A series of seminal reviews on the mental health outcomes of ICU survivors was also conducted approximately a decade ago between 2013 and 2015 [6,7,8,24]. Considering the long-lasting impact PICS can have and the mental health risks for COVID-19 ICU patients, an updated consolidation of prevalence rates and outcome measures used within the COVID-19 ICU population is needed.
A scoping review can be helpful to map the measurement tools used in research reporting the prevalence rates of mental health outcomes in COVID-19 ICU survivors. Compared to systematic reviews, scoping reviews are better suited to assess, understand, identify, map, and report the extent of the knowledge in an emerging field [25]. Within the context of this paper, a scoping review can be used to consolidate and map the tools used to measure mental health outcomes of COVID-19 ICU survivors and identify key research gaps so that future research efforts may be more strategically allocated.
1.5. Study Objective and Review Question
In an attempt to better understand the discrepancies in prevalence rates, this scoping review aims to (1) map out the mental health outcome measures used to measure the prevalence of mental health conditions in COVID-19 ICU survivors, and (2) preliminarily compare prevalence rates to those found before COVID-19. This study seeks to answer the following research question: How have differences in mental health assessment methods contributed to the variance in the prevalence of mental health conditions in COVID-19 ICU survivors?
2. Methods
2.1. Study Design
2.2. Search Strategy
The search strategy sought to locate published, English, peer-reviewed studies on the mental health outcomes of COVID-19 ICU survivors. A systematic search following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2009 flow diagram (Figure 1) was conducted on PubMed, PsycInfo, and Scopus on 1 July 2022. The specific search strategy for each database can be found in Appendix A.
The search terms across all databases included keywords related to COVID-19, ICU, survivors, and psychological distress. Where relevant, MeSH terms were used. Notably, although the search strategy was not limited by publication date, the nature of the topic meant that only articles published from 2020 were included. No contact with authors was initiated for further information on studies included.
2.3. Eligibility Criteria
Studies were eligible for inclusion if (1) the analysis included a full cohort or subgroup of critically ill adult patients with COVID-19, defined in our study as patients admitted to the ICU as a result of COVID-19, (2) mental health outcomes of ICU patients were reported, (3) study designs such as prospective and retrospective cohort studies, case–control studies, and cross-sectional studies were utilised, or (4) validated mental health measures were used.
Studies were excluded based on one or more of the following: (1) participants younger than 18 years and pregnant women; (2) no analysis of critically ill patients; (3) study designs that were qualitative, research letters, news reports, editorials, commentaries, case reports or case studies, recommendations, guidelines, or review articles; (4) non-English articles; (5) not peer-reviewed; (6) no full-text availability.
2.4. Study Selection
Following the search, all identified citations were collated and uploaded into Covidence [26] where duplicates were automatically omitted. The initial screening of titles and abstracts were completed by K.T. based on the outlined inclusion and exclusion criteria. Full-text screening was conducted by the same reviewer and reasons for exclusion were noted. Reference lists of eligible texts were also screened using the same process. Where there were areas of ambiguity, supervisor J.K. was consulted to confirm eligibility.
2.5. Data Extraction
Data extraction from papers included in the scoping review was completed by K.T. using a data extraction template developed by the reviewer. The data extracted included the following categories of relevant data: (1) lead author and year of publication; (2) country/region of the population studied; (3) study design; (4) sample size and demographic details; (5) outcome measures for depression, anxiety, and PTSD; (6) thresholds used; (7) prevalence of symptoms of depression/anxiety/PTSD; (8) key findings and implications of results.
The data extraction template was developed after the full-text eligibility of papers was determined. The extraction template focused only on assessment measures for depression, anxiety, and PTSD as these represented a comprehensive range of mental health challenges explored in the papers analysed. This review also focused on gaining an understanding of how the prevalence of mental health challenges has been studied. Data from the extraction process were then exported from Covidence to Microsoft Excel for further analysis. Authors of papers were not contacted for missing or additional data.
3. Results
Per JBI methodology, the PRISMA reporting guidelines were used in this segment [27]. The PRISMA flowchart in Figure 1 summarises the screening process performed for this scoping review [28]. The initial search retrieved 1234 publications. After the removal of 247 duplicates, 987 article titles and abstracts were screened according to a priori inclusion and exclusion criteria. Then, 915 articles were screened as irrelevant and full-text screening was undertaken on 72 studies.
In total, 44 articles were excluded at the full-text screening stage: 17 were excluded for lack of analysis on critically ill patients as defined by this review, 10 were excluded for a lack of target outcomes reported, eight for the wrong patient population (i.e., no analysis of COIVD-19 patients admitted to ICU), five for having an inappropriate study design, and four due to English full-text unavailability. Ultimately, 28 final studies were eligible for inclusion. Reference lists of the eligible studies were screened using the same process, and four other studies were assessed to be eligible. In total, 32 studies were included in this review.
3.1. Study Characteristics
Study characteristics have been summarised in Table 1. In total, the studies included 4318 participants, of which 1899 were admitted to the ICU. The total sample size in each of the 32 studies ranged from 9 to 675 participants. Of those participants, the ICU sample in each study ranged from 5 to 246 participants. The ICU samples predominantly consisted of male participants (n =1185). A detailed outline of the study characteristics may be found in Appendix B.
3.2. Use of Validated Measures
3.3. Mental Health History, Baseline Measures, and Multiple Follow-Up Points
Less than half of the included studies included comparison groups in the study design or reported a history of psychiatric disorders within their sample (Table 2). Additionally, 19% (6/32) of studies were longitudinal and only 6.25% (2/32) of studies compared target outcomes with the mental health status at baseline.
3.4. Depression
3.4.1. Measures
In total, 30 studies investigating depression used 5 different screening measures and 9 different thresholds to determine the presence of depression (Table 3). Additionally, 63% (19/30) of these studies used the Depression Subscale on the Hospital Anxiety and Depression Scale (HADS-D). While studies using the HADS-D varied slightly in thresholds, a majority (78%; 15/19) of these studies used the cut-off score of ≥8. The Patient Health Questionnaire (PHQ-9) was used in 26.67% (8/30) of studies reviewed, of which two used it in conjunction with a clinical interview. Studies using the PHQ-9 also varied in the thresholds used. Only 50% (4/8) used both ≥5 and ≥10 as thresholds for depression. 3.33% (1/30) used the Beck Depression Inventory, 3.33% (1/30) used the PROMIS-29, and 3.33% (1/30) used C19-YRS.
3.4.2. Prevalence
A large variance was observed in the prevalence rates of depression within COVID-19 patients admitted to the ICU, ranging from 6.06% [33] to 85.41% [22]. For studies assessing depression using the HADS-D subscale, the difference in prevalence rates reported was at least 25% across all time points (Table 4). Notably, regardless of country or assessment time point, studies using the PHQ-9 tended to report prevalence rates of ≥15% (Table 5). The PHQ-9 was used in conjunction with clinical interviews in two studies, one reporting 11.76% prevalence rate of depression [31] and the other 59.18% [32].
3.5. Anxiety
3.5.1. Measures
In total, 28 studies measuring anxiety used 5 different screening measures and 8 different thresholds to determine the presence of anxiety (Table 6). Additionally, 67.85% (19/28) of the studies included used the Anxiety Subscale on the Hospital Anxiety and Depression Scale (HADS-A). Moreover, 78.94% (15/19) of studies that used the HADS-A as a measurement included the cut-off score of ≥8. The General Anxiety Questionnaire (GAD-7) was used in 21.42% (6/28) of studies reviewed, of which one used it in conjunction with a clinical interview. Studies using the GAD-7 varied in the thresholds applied. Only 50% (3/6) used both ≥5 and ≥10 as thresholds for anxiety. The remaining 7.14% (2/28) used other measures of anxiety.
3.5.2. Prevalence
A large variance was observed in the prevalence rates of anxiety within COVID-19 patients admitted to the ICU, ranging from 2.94% [34] to 62.50% [22] (Table 7). For studies using HADS-A, with eight as a cut-off score, it was observed that the lowest prevalence at each time band tended to be reported by studies from Netherlands and tended to be between 11.25% to 16.67% (Table 8).
3.6. PTSD
3.6.1. Measures
In total, 22 studies measuring PTSD used 9 different measures with 19 different thresholds to determine the presence of PTSD. One study included the use of clinical interviews to identify PTSD. Additionally, 54% (12/22) of studies used the PCL-5, 27% (6/22) used the IES-R, 18% (4/22) used the IES-6, and 27% (6/22) used other PTSD measures. The IES-6 is a shortened version of the IES-R [45]. Notably, of these studies, two used different PTSD scales at different time points, but prevalence rates at each time point were not reported.
Studies that used the same PTSD screening measure also differed in the selected threshold. For PCL-5, the PTSD screening measure for most of the studies in this review, six different thresholds were used. Two studies using PCL-5 did not report the threshold used to determine prevalence. Five and three different thresholds were observed in studies using the IES-R and IES-6, respectively (Table 9). No two studies from the same country used the same measures and screening thresholds for PTSD.
3.6.2. Prevalence
A large variance was observed in the prevalence rates of PTSD within COVID-19 patients admitted to the ICU, ranging from 5.88% [31] to 65.85% [46]. The variance in prevalence rates was 5.88% to 40% for the PCL-5 (Table 10), 9.76% to 33.33% for the IES-6 (Table 11), and 11.11% to 65.85% for the IES-R (Table 11). For studies that used mixed measures and other measures, the prevalence rate varied between 7.01% and 12.70% (Table 12) and 22.58% and 46.87% (Table 13), respectively.
4. Discussion
This review of 32 studies aimed to map out the mental health outcome measures used to monitor COVID-19 ICU survivors and preliminarily compare prevalence rates to those found before COVID-19. Overall, most of the included studies were conducted at a single centre and assessed all three target outcomes (i.e., depression, anxiety, and PTSD) at one time point up to 12 months after hospital or ICU discharge. This review demonstrates that a large range of measurement instruments continue to be used in assessing mental health outcomes among COVID-19 ICU survivors. Prevalence rates found in this review are similar in range compared to previous general ICU survivors. Other methodological limitations (e.g., limited comparisons to premorbid or baseline functioning) were observed in the included studies that further impeded a consolidated understanding of mental health complications in ICU patients.
Echoing previous reviews, this review demonstrates that the heterogeneity in outcome measures used to capture ICU outcomes remains a confounding factor within the extant literature. Five unique measurement tools were used to measure depression and anxiety, and nine were used to measure PTSD. Heterogeneity was also found in the clinical thresholds used. While the number of unique measures for each mental health outcome has reduced slightly since Turnbull and colleagues’ review [24], the distribution of studies using different measures has remained largely the same. Up to 67% of the studies included used the same measure and at least 20% of studies used another competing measure. In addition, this present review identified another layer of variance as multiple different clinical thresholds and cut-off scores were used for the same measures across studies. Muysewinkel et al. [14] highlighted that this heterogeneity is not only due to divisions in expert opinion but also cultural differences in the adoption of diagnostic criteria. Specifically, American studies generally use DSM-5 measures, while Asian studies often rely on DSM-IV criteria. This highlights the extent of heterogeneity in outcome measures that persists within the literature on ICU survivorship and the critical need for standardised and updated measures across different regions.
Recent efforts to remedy this situation reveal a continued schism. Expert groups have offered competing recommendations to use the HADS and IES-R [13] or shortened versions of the PHQ-9, GAD-7, and IES-R [55] to measure mental health outcomes of ICU survivors. The situation appears to be particularly problematic for the measurement of PTSD as there have been major developments in its criteria. Revisions made in the criteria for PTSD in the Diagnostic and Statistical Manual (DSM-5) led directly to the retirement of the IES-R by its developer [56] and the development of the PCL-5 [57]. However, experts within this area have written strident letters cautioning the move away from the IES-R or IES-6 towards the PCL-5 [56,58]. According to these experts, caution is necessary because the PCL-5 assesses the cluster of PTSD symptoms that is of unknown importance to critical illness survivors. Further, the PCL-5 has yet to be validated in the ICU survivor population, whereas the IES-R [59] and IES-6 [60] have. Together, it appears that the heterogeneity observed in this review is at least in part a reflection of divisions within expert opinion in the field.
Moving forward, research efforts should be directed towards evaluating the performance of outcome measures used and identifying comparable cut-off points. For instance, Snijkers and colleagues [61] contributed to diagnosis-specific guidelines by finding custom cut-off scores on the HADS that made it comparable to PHQ-9 and GAD-7 scores for patients with irritable bowel syndrome (IBS). Replicating such efforts for ICU survivors will allow future work to draw on existing data collected on survivorship outcomes. This will be particularly urgent considering the number of critical illness survivors following the COVID-19 pandemic.
Notably, other methodological limitations observed in this review might compound existing difficulties in consolidating outcome measures. Expert panels have had differing opinions on suitable outcome measures in part due to the lack of validated mental health outcome measures among ICU survivors. However, previous attempts to evaluate the psychometric performance of outcome measures for adult ICU survivors found that poorly conducted studies limited the evaluation of measurement quality [62]. A small sample size was a specific methodological limitation that was similarly observed in this review. While this is a natural limitation of this population, a sufficient sample size remains critical to robust findings. Therefore, future research efforts should also be directed towards collaboratively conducting multi-centre trials, which will improve both the rigour and sample size of studies on adult ICU survivors.
A secondary aim of this review was to preliminarily compare prevalence rates before and during the pandemic. Compared to prevalence rates prior to COVID-19, the prevalence rates found in this review fell within a similar range. Prior to COVID-19, prevalence rates ranged from 4% to 64% for depression [7], 5% to 73% for anxiety [30], and 4% to 62% for PTSD [8] in ICU survivors. In this review, the prevalence ranged from 6.06% [33] to 85.4% [22] for depression, 2.94% [34] to 62.50% [22] for anxiety, and 5.88% [31] to 65.85% [46] for PTSD among COVID-19 ICU survivors. This is interesting given the unique restrictions in hospitals and strain in resources that many healthcare systems have been under. Two possible hypotheses might account for this: (1) These additional contextual stressors might have had a lower than anticipated impact on ICU patients’ mental health, and (2) ARDS may have had less of an impact on the development of mental health sequalae as compared to other reasons for ICU admission (e.g., terminal illness or major surgery).
4.1. Limitations and Future Direction
4.1.1. Within Studies
Studies in this review were predominantly in Western populations, conducted in single centres, with small sample sizes. This limits the rigour and generalisability of the findings. Studies in this review also had other methodological considerations that might affect the quality of their results. For instance, few studies within this review included an analysis of comparison groups, patients’ baseline measure of mental health, and patient history of psychiatric disorders. Notably, these methodological limitations have been cited in previous reviews. It appears that the field as a whole has had limited advancements. It is thus worth iterating that research efforts should focus on conducting multi-centre studies with a larger sample size to make findings in this body of literature more robust.
4.1.2. Within Review
This review has several limitations. First, this review was conducted by a single rater, which limited the transparency and reliability of the review process. This was mitigated by consultation with a supervisor. Study authors were also not contacted for additional information on study results, which limited the findings to published results.
Second, this review was limited to studies utilising standardised measures of mental health outcomes. Several studies that were excluded often used health-related quality of life (HR-QoL) measures to estimate the prevalence of anxiety and depression. While such HR-QoL measures capture some evidence of mental health challenges, these measures are designed and validated to examine many aspects of a patient’s life rather than the distinct psychopathology of specific psychological conditions.
Lastly, it should be noted that studies in this review were conducted concurrently with the publication of expert group recommendations on ICU outcome measures, so this review might have mapped this body of literature on the cusp of consolidation.
5. Conclusions
Despite the increased volume of research in this space, the heterogeneity of measurement tools and thresholds continue to impede a consistent understanding of the development of mental health symptoms after ICU admission in patients with COVID-19. Future research efforts will benefit from coming to a unified agreement on recommended outcome measures, and from establishing psychometric comparability between key measures currently used to best leverage past research efforts.
Author Contributions
Conceptualization, K.T.; methodology, K.T.; software, K.T.; validation, K.T. and J.K.; formal analysis, K.T; investigation, K.T.; resources, K.T.; data curation, K.T. and J.K.; writing—original draft preparation, K.T.; writing—review and editing, K.T., J.K. and A.H.; visualization, K.T.; supervision, J.K. and A.H.; project administration, K.T. All authors have read and agreed to the published version of the manuscript.
Funding
This research received no external funding.
Institutional Review Board Statement
Not applicable.
Informed Consent Statement
Not appliable.
Data Availability Statement
The raw data supporting the conclusions of this article will be made available by the authors on request.
Conflicts of Interest
The authors declare no conflict of interest.
Appendix A. Search Strategy
| Database | Search Strategy | Results |
| PubMed | (coronavirus OR “corona virus” OR coronavirinae OR coronaviridae OR betacoronavirus OR covid19 OR “covid 19” OR nCoV OR “CoV 2” OR CoV2 OR sarscov2 OR 2019nCoV OR “novel CoV” OR “Coronavirus”[Mesh] OR “Coronavirus Infections”[Mesh] OR “COVID-19” [Supplementary Concept] OR “severe acute respiratory syndrome coronavirus 2” [Supplementary Concept] OR “Betacoronavirus”[Mesh]) AND (“critical illness”[MeSH Terms] OR “critical care”[MeSH Terms] OR “critical care”[tiab] OR “critical illness”[tiab] OR “intensive care”[tiab] OR “acute disease”[MeSH Terms] OR “acute disease”[tiab] OR “intensive therapy”[tiab] OR “high dependency”[tiab] OR Critically ill*[tiab]) AND (“depress*”[tiab] OR “anxi*”[tiab] OR “Post-traumatic stress” [tiab] OR “mental health conditions”[tiab] OR “psychological impact”[tiab] OR “Mental Disorders”[MeSH Terms] OR “psychology” [Subheading]) AND (“patient*” [tiab] OR “survivor*”[tiab] OR “Survivors”[Mesh] OR “inpatient*” [MeSH Terms]) | 664 |
| Scopus | (TITLE-ABS-KEY((coronavirus OR “corona virus” OR coronavirinae OR coronaviridae OR betacoronavirus OR covid19 OR “covid 19” OR ncov OR “CoV 2” OR cov2 OR sarscov2 OR 2019ncov OR “novel CoV” OR “Coronavirus” OR “Coronavirus Infections” OR “COVID-19” OR “severe acute respiratory syndrome coronavirus 2” OR “Betacoronavirus”)) AND TITLE-ABS-KEY((“critical illness” OR “critical care” OR “critical care” OR “critical illness” OR “intensive care” OR “acute disease” OR “acute disease” OR “intensive therapy” OR “high dependency” OR critically AND ill*)) AND TITLE-ABS-KEY((“depress*” OR “anxi*” OR “Post-traumatic stress” OR “mental health conditions” OR “psychological impact” OR “Mental Disorders” OR “psychology”)) AND TITLE-ABS-KEY ((“patient*” OR “survivor*” OR “Survivors” OR “inpatient*”))) | 454 |
| PsycInfo | (Any Field: coronavirus OR Any Field: “corona virus” OR Any Field: coronavirinae OR Any Field: coronaviridae OR Any Field: betacoronavirus OR Any Field: covid19 OR Any Field: “covid 19” OR Any Field: nCoV OR Any Field: “CoV 2” OR Any Field: CoV2 OR Any Field: sarscov2 OR Any Field: 2019nCoV OR Any Field: “novel CoV” OR Any Field: Coronavirus OR Any Field: “Coronavirus Infections” OR Any Field: COVID-19 OR Any Field: “severe acute respiratory syndrome coronavirus 2” OR Any Field: Betacoronavirus) AND (Any Field: “critical illness” OR Any Field: “critical care” OR Any Field: “critical care” OR Any Field: “critical illness” OR Any Field: “intensive care” OR Any Field: “acute disease” OR Any Field: “acute disease” OR Any Field: “intensive therapy” OR Any Field: “high dependency” OR Any Field: “Critically ill*”) AND (Any Field: depress* OR Any Field: anxi* OR Any Field: “Post-traumatic stress” OR Any Field: “mental health conditions” OR Any Field: “psychological impact” OR Any Field: “Mental Disorders”) AND (Any Field: patient* OR Any Field: survivor* OR Any Field: Survivors OR Any Field: inpatient*) | 116 |
Appendix B. Study Characteristics
| Study ID | Country | Aim | Study Design | Data Collection Period | Year | Single/Multi Centre | History of Psychiatric Disorders Recorded | Total Sample (n=) | ICU Sample (n=) | Days in ICU (Mean, sd) | Age (Mean/Median) | Gender (% Male) | Comparison Group? | |
| Start | End | |||||||||||||
| Banno et al., 2021 [38] | Japan | To assess the 1-year prevalence of post-intensive care syndrome after coronavirus disease 2019 | Cohort study | Mar | Apr | 2020 | Single centre | No | 18 | 18 | 6 (5.0–12.5) | 57.5 (49.5–71.8) | 78% | No |
| Cansel et al., 2021 [41] | Turkey | To investigate the prevalence of generalised anxiety disorder, depression, PTSD, and the factors that may be associated with them in patients who were hospitalised and then discharged due to COVID-19. | Cross sectional study | Mar | Nov | 2020 | Single centre | Yes | 102 | 5 | 7.4 (5.1) | Not reported | Not reported | Yes |
| Carenzo et al., 2021 [46] | Italy | To describe the short-term HRQoL, physical function, and prevalence of post-traumatic stress symptoms of invasively mechanically ventilated COVID-19 patients treated in our urban tertiary academic ICU (more details on our ICU and hospital response to COVID can be found in reference 2). | Cohort study | Mar | May | 2020 | Single centre | No | 47 | 47 | 15 (9–19) | 59 (10) | 79% | No |
| Daher et al., 2021 [40] | Germany | To investigate symptoms, abnormalities in pulmonary function, the prevalence of non-pulmonary organ dysfunctions and psychological disorders in patients who had been treated with IMV due to COVID-19 ARDS six months after discharge from hospital. | Cross sectional study | Feb | Apr | 2020–2021 | Single centre | No | 18 | 18 | 34 (16) | 61 (7) | 61% | No |
| deGraaf et al., 2021 [31] | Netherlands | Potential sequelae of physiological and psychological impairment following SARS coronavirus variants warrant the need for a multidisciplinary evaluation of COVID-19 survivors to organise out-patient follow-up. | Cohort study | Mar | Jun | 2020 | Single centre | No | 59 | 34 | 19.8 (12.5) | 57.3 (11·1) | 62% | Yes |
| Gilmartin et al., 2022 [42] | Ireland | To characterise the cognitive, psychological, and physical consequences of COVID-19 in patients admitted to the ICU and discharged alive. | Cohort study | Mar | Oct | 2020 | Single centre | No | 22 | 22 | 21 (2–75) | 52.4 (15) | 68% | No |
| Halpin et al., 2021 [29] | United Kingdom | To inform service development, our multidisciplinary rehabilitation team examined the impact of COVID-19 on survivors discharged from hospital. | Cross sectional study | May | Jun | 2020 | Single centre | Yes | 68 | 32 | 4 | 58.5 (34–84) | 59% | Yes |
| Heesakkers et al., 2022 [19] | Netherlands | To assess the occurrence of physical, mental, and cognitive symptoms among patients with COVID-19 at 1 year after ICU treatment. | Cohort study | Mar | Jul | 2020 | Multi-centre | No | 246 | 246 | 18.5 (11–32) | 61.2 (9.3) | 72% | No |
| Heyns et al., 2021 [63] | Belgium | To retrospectively analyse data obtained from the multi-domain assessment of hospitalised COVID-19 patients, to describe their health status at discharge, and to investigate whether subgroups of patients, more specific ICU patients and older adults (> 70 years), had more (or less) risk to experience specific impairments. | Cross sectional study | Apr | Jun | 2020 | Single centre | No | 163 | 33 | Not reported | 60 (51.5–67.5) | Not reported | No |
| Horn et al., 2020 [51] | France | To assess the prevalence of and risk factors for post-traumatic stress disorder (PTSD) in patients with COVID-19. | Cohort study | Mar | May | 2020 | Single centre | Yes | 180 | 55 | 8 (median) | Not reported | Not reported | Yes |
| Kaur et al., 2021 [32] | India | To estimate the prevalence of major depressive disorder (MDD) at two time points in individuals who have been hospitalised for the treatment of COVID 19. | Prevalence study | May | Oct | 2020 | Single centre | Yes | 440 | 49 | Not reported | Not reported | Not reported | Yes |
| Kupeli et al., 2021 [35] | Turkey | To investigate the degree of anxiety and depression in the first 24 h of people who were taken to the intensive care unit (ICU) due to COVID-19 and had to use unfamiliar devices in an unfamiliar environment. | Cohort study | Jan | May | 2021 | Single centre | No | 62 | 62 | N/A | 57.1 (17.6) | 68% | No |
| Liu et al., 2020 [39] | China | To report the prevalence of anxiety symptoms, depression symptoms, and PTSD for the hospital-discharged COVID-19 patients, and clarify risk factors for mental health problems among discharged COVID-19 patients. | Cross-sectional study | Jan | Apr | 2020 | Single centre | No | 675 | 35 | Not reported | Not reported | Not reported | No |
| Maley et al., 2022 [50] | United States | To determine the prevalence and extent of impairments impacting health-related quality of life among survivors of COVID-19 who required mechanical ventilation, 6 months after hospital discharge. | Cohort study | Mar | Dec | 2020 | Multi-centre | Yes | 63 | 63 | Not reported | 59 (13) | 46% | No |
| Martillo et al., 2021 [21] | United States | To determine the characteristics of post-intensive care syndrome in the cognitive, physical, and psychiatric domains in coronavirus disease 2019 ICU survivors. | Cohort study | Apr | Jul | 2020 | Single centre | Yes | 41 | 41 | 10 (7–15) | 53.9 (12.9) | 80% | No |
| McPeake et al., 2021 [43] | United Kingdom | To understand the long-term psychosocial and physical consequences, including impact on employment, of severe COVID-19 infection, and explore if critically ill COVID-19 survivors have unique long-term outcomes, in relation to patients admitted to critical care without COVID-19. | Cohort study | Mar | May | 2020 | Multi-centre | Yes | 299 | 93 | 11.1 (5–25.3) | 59 (54–67) | 66% | Yes |
| Monti et al., 2021 [47] | Italy | To assess the quality of life of invasively ventilated COVID-19 ARDS survivors. | Cohort study | Feb | Apr | 2020 | Single centre | No | 39 | 39 | 10 (7–16) | 56 (10.5) | 90% | No |
| Nanwani-Nanwani et al., 2022 [36] | Spain | To determine the prevalence of PICS in a cohort of mechanically ventilated SARS- CoV-2 patients, assessed after 3 months of hospital discharge, in the ICU follow-up consultation facilities of three major hospitals in Spain. | Cohort study | Feb | May | 2020–2021 | Multi-centre | No | 186 | 186 | 27 (14–56) | 59 (12) | 68% | No |
| Negrini et al., 2021 [64] | Italy | Report the cognitive and psychological features of the first consecutive patients with severe COVID-19 entering the post-acute phase, defined as clinical stability and complete weaning from sedative and antipsychotic drugs. | Case series | Mar | Apr | 2020 | Single centre | No | 9 | 5 | 27 (21–29) | 59 (59–64) | 100% | No |
| Neville et al., 2022 [30] | United States | Examine long-term outcomes of patients who required intensive care unit (ICU) admission for severe COVID-19. | Cohort study | Mar | Dec | 2020 | Multi-centre | No | 275 | 132 | 60 (2–13) | 59.1 (47.5–68.8) | 55% | No |
| Ojeda et al., 2022 [34] | Barcelona | Investigate the prevalence and characteristics of new- onset pain in COVID-19 ICU survivors 1 month after hospital discharge. | Cohort study | May | Jun | 2020 | Single centre | No | 65 | 65 | 25 (15–33) | 65 (57–70) | 74% | Yes |
| Rajajee et al., 2021 [18] | United States | Prospectively describe 1-year outcomes, with a focus on functional outcome, cognitive outcome, and the burden of anxiety, depression, and post-traumatic stress disorder (PTSD) in COVID-19 patients managed with ECMO at our institution. | Prospective case series | Mar | Jul | 2020 | Single centre | No | 23 | 14 | 51 (40–60) | 41 (30–52) | 57% | No |
| Rass et al., 2021 [48] | Austria | Quantify the impact of COVID-19 on mental health and health-related quality of life (QoL) 3 months after disease onset. | Cohort study | Apr | Sep | 2020 | Multi-centre | No | 132 | 31 | Not reported | 58 (53–65) | 77% | Yes |
| Rousseau et al., 2021 [44] | Belgium | Describe the mid-term outcomes and to assess the main PICS symptom prevalence in critically ill COVID-19 survivors referred to a face-to-face consultation in our post-ICU follow-up clinic at 3 months following a prolonged ICU stay. | Cohort study | Mar | Jul | 2020 | Single centre | No | 32 | 32 | 23 (15–39) | 62 (49–68) | 72% | No |
| Schandl et al., 2021 [54] | Sweden | Evaluate long-term effects of COVID-19 in critically ill patients treated in ICU and whether invasive ventilation was associated with worse health-related quality of life and physical and psychological outcomes. To evaluate whether there were differences in lung capacity and function level at follow-up. | Cohort study | Mar | May | 2020 | Multi-centre | No | 113 | 113 | HFNo or NIV 4 (3–8) IMV 21 (15–30) | 58 (12 and 14, respectively) | 76% | No |
| Vannorsdall et al., 2022 [22] | United States | Prospectively characterise cognition, mental health symptoms, and functioning approximately 4 months after an initial diagnosis of COVID-19 in a racially and ethnically diverse group of patients. | Cohort study | Jul | Jan | 2020–2021 | Single centre | No | 82 | 48 | Not reported | 58 (14.8) | 48% | Yes |
| vanVeenendaal et al., 2021 [65] | Netherlands | Describe the physical, social and psychological impact on COVID-19 ICU survivors and their family members 3 and 6 months following ICU discharge. | Cohort study | Mar | Sep | 2020 | Single centre | No | 60 | 60 | 19.4 (12.3–31.7) | 62.5 (55.3–68) | 68% | No |
| ven den Borst et al., 2021 [52] | Netherlands | Comprehensively assess these health domains in patients 3 months after recovery from acute COVID-19. | Cohort study | Apr | Jul | 2020 | Single centre | No | 124 | 20 | 15 (8) | 57 (10) | 80% | Yes |
| Vlake et al., 2021 [37] | Netherlands | Quantify psychological distress up to three months after discharge in patients hospitalised during the first coronavirus disease 2019 (COVID-19) pandemic wave, assessed their HRQoL, explored predictors for psychological dis- tress and HRQoL, and examined whether psychological distress was more prevalent or more severe in COVID-19 confirmed patients, or in those treated in ICU. | Cohort study | Mar | Apr | 2020 | Single centre | Yes | 294 | 40 | 16 (0–52) | 62 (36–74) | 68% | Yes |
| Vlake et al., 2021 [33] | Netherlands | To quantify short- and long-term psychologic distress, that is, symptoms of post-traumatic stress disorder, anxiety, and depression, and the health-related quality of life in coronavirus disease 2019 ICU survivors. | Cohort study | May | Apr | 2020–2021 | Multi-centre | No | 238 | 118 | 10 (0–49) | 61 (36–77) | 67% | Yes |
| Weidman et al., 2022 [53] | United States | To report the prevalence of physical, psychological, and cognitive impairment among COVID-19 intensive care unit (ICU) survivors receiving follow-up care in an ICU recovery clinic, to assess for associations between PICS and ICU-related factors, and to compare the cohort of ICU survivors who attended a post-ICU clinic with a cohort of ICU survivors who did not. | Cohort study | Mar | May | 2020 | Single centre | No | 87 | 87 | 22 (11–42) | 62 (50–70) | 74% | Yes |
| Zangrillo et al., 2022 [49] | Italy | 1-year follow-up study of the same cohort to investigate long-term mortality, quality of life, functional and psychological recovery of the patients, as well as computed tomography (CT) characteristics of the lungs. | Cohort study | Feb | Apr | 2020 | Single centre | No | 56 | 56 | 13 (9–21) | 56 (11.9) | 89% | No |
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Figure 1.
PRISMA flowchart.
Table 1.
Study characteristics.
| Categories | n (%) |
|---|---|
| Country | |
| Austria | 1 (3.13%) |
| Barcelona | 1 (3.13%) |
| France | 1 (3.13%) |
| Germany | 1 (3.13%) |
| Ireland | 1 (3.13%) |
| Italy | 4 (12.50%) |
| Netherlands | 6 (18.75%) |
| Sweden | 1 (3.13%) |
| United Kingdom | 2 (6.25%) |
| United States of America | 6 (18.75%) |
| China | 1 (3.13%) |
| Japan | 1 (3.13%) |
| India | 1 (3.13%) |
| Turkey | 2 (6.25%) |
| Data collection period | |
| 2020 | 27 (84.37%) |
| 2020–2021 | 4 (12.50%) |
| 2021 | 1 (3.13%) |
| Study design | |
| Prospective cohort | 24 (75%) |
| Retrospective cohort | 1 (3.13%) |
| Cross-sectional | 5 (15.63%) |
| Case–series | 2 (6.25%) |
| Single/multi-centre | |
| Single centre | 24 (75%) |
| Multi-centre | 8 (25%) |
| Target outcomes | |
| Depression, anxiety, and PTSD | 20 (62.50%) |
| Depression and anxiety | 8 (25%) |
| Depression only | 1 (3.13%) |
| PTSD only | 1 (3.13%) |
| Reported statistics | |
| Prevalence | 26 (81.25%) |
| Median | 16 (50%) |
| Mean, SD | 6 (18.75%) |
| Assessment time point | |
| Single time point | 26 (81.25%) |
| Two time points | 5 (15.63%) |
| Three time points | 1 (3.13%) |
| Studies at each follow-up time point | |
| Discharge up to 1 month | 11 (34.37%) |
| 1 months < x ≤ 3 months | 12 (37.50%) |
| 3 month < x ≤ 6 months | 7 (21.87%) |
| 6 months < x ≤ 1 year | 4 (12.50%) |
Table 2.
Use of control groups and baseline measures.
| Characteristic | Number of Studies (n/Total) |
|---|---|
| Included comparison groups in study design and analysis | 13/32 |
| Reported presence of history of psychiatric disorders | 10/32 |
| Provided details of psychiatric disorders | 1/32 |
| Compared target outcomes with baseline measure | 2/32 |
| Longitudinal (i.e., more than 2 follow-up points) | 6/32 |
Table 3.
Summary of measures and thresholds used to measure depression.
| Threshold | Number of Studies |
|---|---|
| Beck Depression Inventory | |
| Not reported | 1 |
| C19-YRS | |
| Not reported | 1 |
| HADS-D | |
| ≥8 borderline, ≥11 abnormal | 1 |
| ≥8 mild, ≥11 moderate, ≥15 severe | 2 |
| HADS-D >10 | 1 |
| HADS-D ≥10 | 1 |
| HADS-D ≥8 | 12 |
| Not reported | 2 |
| PHQ-9 and clinical interview | |
| PHQ-9 ≥10 | 2 |
| PHQ-9 | |
| Not reported | 1 |
| PHQ-9 > 10 | 1 |
| ≥5 mild, ≥10 moderate | 1 |
| 0–4 minimal, 5–9 mild, 10–14 moderate, 15 or more severe | 3 |
| PROMIS-29 | |
| Not reported | 1 |
| Total | 30 |
Table 4.
HADS-D ≥ 8: Lowest and highest prevalences of depression sorted by time.
| Time Frame | HADS-D ≥ 8 | |||
|---|---|---|---|---|
| Country; Reference | Lowest Prevalence (n/Total) | Country; Reference | Highest Prevalence (n/Total) | |
| Discharge up to 1 month | Barcelona; Ojeda et al. [34] | 7.69% (5/65) | Turkey; Kupeli et al. [35] | 43.54% (27/62) |
| 1 months < x ≤ 3 months | Netherlands; Vlake et al. [33] | 6.06% (2/33) | Spain; Nanwani-Nanwani et al. [36] | 20.96% (39/186) |
| 3 month < x ≤ 6 months | Netherlands; Vlake et al. [37] | 12.50% (10/80) | Japan; Banno et al. [38] | 33.33% (6/18) |
| 6 months < x ≤ 1 year | Netherlands; Heesakkers et al. [19] | 18.29% (45/246) | Japan; Banno et al. [38] | 44.44% (8/18) |
Table 5.
Prevalence and assessment time points for studies using PHQ9.
| Reference | Country | Threshold | Time Point from Discharge/Diagnosis | Prevalence | Type | Severity |
|---|---|---|---|---|---|---|
| Kaur et al. [32] | India | PHQ 9 ≥10 and clinical interview | Discharge | 59.18% (29/49) | Mean (SD) | 10.5(3.3) |
| Liu et al. [39] | China | PHQ > 10 | 2 weeks | 40% (14/35) | Not reported | Not reported |
| Martillo et al. [21] | United States | 0–4 minimal, 5–9 mild, 10–14 moderate, 15 or more severe | 1 month | 38.63% (17/44) | Mean (SD) | 5.7(6.9) |
| deGraaf et al. [31] | Netherlands | PHQ ≥10 and clinical interview | 6 weeks | 11.76% (4/34) | Not reported | Not reported |
| Vannorsdall et al. [22] | United States | ≥5 Mild, ≥10 Moderate | 4 months | 85.41% (41/48) | Mean (SD) | 6.7(4.6) |
| Daher et al. [40] | Germany | 0–4 minimal, 5–9 mild, 10–14 moderate, 15 or more severe | 6 months | Moderate—22.22% (4/18), Severe—5.55% (1/18) | Mean (SD) | 6(5) |
| Cansel et al. [41] | Turkey | 0–4 minimal, 5–9 mild, 10–14 moderate, 15 or more severe | 2–8 months | Not reported | Mean (SD) | 7.0(4.9) |
Table 6.
Summary of measures and thresholds used to measure anxiety.
| Threshold | Number of Studies |
|---|---|
| C19-YRS | |
| Not reported | 1 |
| GAD-7 | |
| GAD-7 > 10 | 1 |
| 0–4 minimal, 5–9 mild, 10–14 moderate, 15 or more severe | 2 |
| GAD-7 ≥ 5 mild, ≥10 moderate | 1 |
| Not reported | 1 |
| GAD-7 and clinical interview | |
| GAD-7 ≥ 10 | 1 |
| HADS-A | |
| ≥8 borderline or mild, ≥11 abnormal or moderate/severe | 3 |
| HADS-A > 10 | 1 |
| HADS-A ≥ 10 | 1 |
| HADS-A ≥ 8 | 12 |
| Not reported | 2 |
| PROMIS-29 | |
| Not reported | 1 |
| STAI | |
| Not reported | 1 |
| Total | 28 |
Table 7.
Prevalence and assessment time points for studies using GAD7.
| Reference | Country | Threshold | Time Point from Discharge/Diagnosis | Prevalence | Type | Severity |
|---|---|---|---|---|---|---|
| Liu et al. [39] | China | GAD-7 > 10 | 2 weeks | 17.14% (6/35) | ||
| deGraaf et al. [31] | Netherlands | GAD-7 ≥10; clinical interview | 6 weeks | 2.94% (1/34) | Not reported | Not reported |
| Vannorsdall et al. [22] | United States | 0–4 minimal, 5–9 mild, 10–14 moderate, 15 or more severe | 4 months | 62.50% (30/48) | Mean (SD) | 5.1(4.9) |
| Daher et al. [40] | Germany | 0–4 minimal, 5–9 mild, 10–14 moderate, 15 or more severe | 6 months | Minimal to mild—89% (16/18) Moderate—5% (1/18), Severe—5% (1/18) | Mean (SD) | 4(4) |
| Gilmartin et al. [42] | Ireland | Not reported | 6 months | Not reported | Mean (SD) | 5.8(6.1) |
| Cansel et al. [41] | Turkey | 0–4 minimal, 5–9 mild, 10–14 moderate, 15 or more severe | 2–8 months | Not reported | Mean (SD) | 6.0(6.8) |
Table 8.
HADS-A: Lowest and highest prevalence of anxiety sorted by time.
| Time Frame | HADS-A ≥ 8 | |||
|---|---|---|---|---|
| Country; Reference | Lowest Prevalence (n/Total) | Country; Reference | Highest Prevalence (n/Total) | |
| Discharge up to 1 month | Netherlands; Vlake et al. [33] | 16.67% (5/30) | United Kingdom; MePeake et al. [43] | 46.24% (43/93) |
| 1 months < x ≤ 3 months | Netherlands; Vlake et al. [33] | 15.15% (5/33) | Belgium; Rousseau et al. [44] | 25% (8/32) |
| 3 month < x ≤ 6 months | Netherlands; Vlake et al. [37] | 11.25% (9/80) | Japan; Banno et al. [38] | 44.44% (8/18) |
| 6 months < x ≤ 1 year | Barcelona; Ojeda et al. [34] | 10.76% (7/65) | United States; Rajajee et al. [18] | 60% (6/10) |
Table 9.
Summary of measures and thresholds used to measure PTSD.
| Threshold | Number of Studies |
|---|---|
| PCL-5 | |
| 1 re-experiencing, 1 avoidance, 2 negative alterations in cognition or mood symptoms, 2 arousal symptoms scored ≥2 | 1 |
| PCL-5 ≥ 38 | 1 |
| PCL-5 ≥ 31 | 3 |
| PCL-5 > 33 | 2 |
| PCL-5 ≥ 33 | 2 |
| PCL-5 (short form) ≥ 8 (sum) | 1 |
| Not reported | 2 |
| IES-R | |
| IES-R > 1.6 | 1 |
| IES-R > 33 | 1 |
| IES-R ≥ 33 | 2 |
| IES-R average ≥ 1.6 | 1 |
| IES-R > 24 (sum) | 1 |
| IES-6 | |
| IES-6 > 1.75 (average) | 1 |
| IES-6 ≥ 1.75 | 2 |
| IES-6 > 10 | 1 |
| TSQ | |
| TSQ ≥ 10 (sum) | 1 |
| PTSS | |
| PTSS-10 ≥ 35 | 1 |
| PTSD Symptom Severity Scale | |
| 1 re-experiencing, 2 increased activation, and 3 avoidance symptoms | 1 |
| PTSS14 | |
| PTSS-14 >45 | 1 |
| The National Stressful Events Survey PTSD Short Scale (NSESSS-PTSD) | |
| 1 re-experiencing symptom, 1 avoidance symptom, 2 negative alterations in cognition or mood symptoms, and 2 arousal symptoms scored 2 (moderate) or higher | 1 |
| C19-YRS | |
| Not reported | 1 |
Table 10.
Prevalence of PTSD measured by PCL-5, sorted by assessment time point.
| Reference | Country | Threshold | Time Point from Discharge/Diagnosis | Prevalence | Type | Severity |
|---|---|---|---|---|---|---|
| Liu et al. [39] | China | 1 re-experiencing, 1 avoidance, 2 negative alterations in cognition or mood symptoms, 2 arousal symptoms scored ≥ 2 | 2 weeks | 14.28% (5/35) | Not reported | Not reported |
| deGraaf et al. [31] | Netherlands | PCL-5 ≥ 38 | 6 weeks | 5.88% (2/34) | Not reported | Not reported |
| Martillo et al. [21] | United States | PCL-5 ≥ 31 | 1 month | 17.78% (8/45) | Mean (SD) | 18 (21.2) |
| Monti et al. [47] | Italy | PCL-5; Threshold not reported | 2 months | Not reported | Median (IQR) | 7 (4–16) |
| Rass et al. [48] | United States | PCL-5 ≥ 33 | 3 months | 12.90% (4/31) | Not reported | Not reported |
| Gilmartin et al. [42] | Ireland | PCL-5 ≥ 33 | 6 months | Not reported | Mean (SD) | 21.1 (17.5) |
| Neville et al. [30] | Italy | PCL-5 (short form) ≥ 8 (sum) | 6 months | 19.70% (26/132) | Mean (SD) | 2.48 (4.33) |
| Zangrillo et al. [49] | Italy | PCL-5; Threshold not reported | 2 months | Not reported | Median (IQR) | 7 (4–16) |
| 1 year | Not reported | Median (IQR) | 7.5 (2–15) | |||
| Rajajee et al. [18] | Barcelona | PCL-5 ≥31 | 1 year | 40% (4/10) | Median (IQR) | 24 (17–37) |
Table 11.
Prevalence of PTSD measured by IES-R and IES-6, sorted by assessment time point.
| Reference | Country | Threshold | Time Point from Discharge/Diagnosis | Prevalence | Type | Severity |
|---|---|---|---|---|---|---|
| Maley et al. [50] | United States | IES-6 > 1.75 (average) | Discharge | 33.33% (20/60) | Not reported | Not reported |
| Carenzo et al. [46] | Italy | IES-R > 1.6 | 2 months | 65.85% (27/41) | Mean (SD) | 1.94 (0.75) |
| Rousseau et al. [44] | Belgium | IES-R ≥ 33 | 3 months | 28.13% (9/32) | Median (IQR) | 11 (4–24) |
| Vannorsdal et al. [22] | United States | IES-6 ≥ 1.75 | 4 months | 25% (12/48) | Mean (SD) | 1.2 (1.4) |
| Banno et al. [38] | Japan | IES-R average ≥ 1.6 | 4 months | 11.11% (2/18) | Median (IQR) | 7.5 (4.0–25.8) |
| 1 year | 11.11% (2/18) | Median (IQR) | 12.5 (2.0–27.5) | |||
| Vlake et al. [33] | Netherlands | IES-R > 24 (sum) | 1 month | 16.67% (5/30) | Median (IQR) | 7 (1–51) |
| 3 months | 18.18% (6/33) | Median (IQR) | 8 (0–30) | |||
| Heesakkers et al. [19] | Netherlands | IES-6 ≥ 1.75 | 1 year | 9.76% (24/246) | Median (IQR) | 0.5 (0.2–1.2) |
Table 12.
Prevalence of PTSD measured by mixed tools, sorted by assessment time point.
| Reference | Country | Threshold | Time Point from Discharge/Diagnosis | Prevalence | Type | Severity |
|---|---|---|---|---|---|---|
| Horn et al. [51] | France | IES-6 > 10 (T1) and PCL-5 > 33 (T2) | 3 weeks | Not reported | Not reported | Not reported |
| 1 month after first evaluation | Not reported | Mean (SD) | 9.6 (12.8) | |||
| ven den Borst et al. [52] | Netherlands | PCL-5 > 33 IES-R > 33 | 3 months | PCL-5: 10% (1/10) IES-R 0% (0/20) | Not reported | Not reported |
| Vlake et al. [37] | Netherlands | IES-R ≥ 33 (sum) TSQ ≥ 10 (sum) | 6 weeks | 7.01% (4/57) | Median (IQR) | 9 (1–40) |
| 3 months | 10.22% (9/88) | Median (IQR) | Not reported | |||
| 6 months | 6.25% (5/80) | Not reported | Not reported | |||
| Weidman et al. [53] | United States | PTSS-10 ≥ 35, PCL-5 ≥ 31 | 20 days | 12.70% (8/63) | Not reported | Not reported |
Table 13.
Prevalence of PTSD measured by other tools, sorted by assessment time point.
| Reference | Country | Measure; Threshold | Time Point from Discharge/Diagnosis | Prevalence | Type | Severity |
|---|---|---|---|---|---|---|
| Nanwani-Nanwani et al. [36] | Spain | PTSD Symptom Severity Scale; 1 re-experiencing, 3 avoidance, 2 increased activation symptoms | 3 months | 22.58% (42/186) | Not reported | Not reported |
| Schandl et al. [54] | Sweden | PTSS-14; >45 | 5 months | 34.78% (24/69) | Not reported | Not reported |
| Cansel et al. [41] | Turkey | The National Stressful Events Survey PTSD Short Scale (NSESSS-PTSD); 1 re-experiencing, 1 avoidance, 2 negative alterations in cognition or mood and 2 arousal symptoms scored 2 (moderate) or higher | 2–8 months | Not reported | Mean (SD) | 11.8 (14) |
| Halpin et al. [29] | United Kingdom | C19-YRS; Not reported | 48 days | 46.87% (15/32) | Not reported | Not reported |
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T’ng, K.; Kenardy, J.; Hartanto, A. Evaluating Mental Health Outcomes in COVID-19 ICU Survivors: A Scoping Review of Measurement Tools. J. Clin. Med. 2024, 13, 3191. https://doi.org/10.3390/jcm13113191
AMA Style
T’ng K, Kenardy J, Hartanto A. Evaluating Mental Health Outcomes in COVID-19 ICU Survivors: A Scoping Review of Measurement Tools. Journal of Clinical Medicine. 2024; 13(11):3191. https://doi.org/10.3390/jcm13113191
Chicago/Turabian StyleT’ng, Kimberly, Justin Kenardy, and Andree Hartanto. 2024. "Evaluating Mental Health Outcomes in COVID-19 ICU Survivors: A Scoping Review of Measurement Tools" Journal of Clinical Medicine 13, no. 11: 3191. https://doi.org/10.3390/jcm13113191
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