Next Article in Journal
Comparing Outcomes of Post-Cardiotomy Cardiogenic Shock Patients: On-Site Cannulation vs. Retrieval for V-A ECMO Support
Previous Article in Journal
A Phase III Head-to-Head Study to Compare the Efficacy and Safety of Fexuprazan and Esomeprazole in Treating Patients with Erosive Esophagitis
 
 
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Clinical and Functional Effects of Rehabilitation of Patients after COVID-19 Infection

by
Zofia Dzięcioł-Anikiej
1,*,
Anna Kuryliszyn-Moskal
1,
Monika Pociene
2,
Janusz Dzięcioł
3,
Agnieszka Dakowicz
1 and
Amanda Kostro
1
1
Department of Rehabilitation, Faculty of Health Sciences, Medical University of Białystok, Skłodowskiej-Curie 7A Street, 15-096 Białystok, Poland
2
Department of Physiotherapy and Beauty Therapy, Klaipedos Valstybine Kolegija, 91274 Klaipeda, Lithuania
3
Department of Human Anatomy, Faculty of Medicine, Medical University of Bialystok, Mickiewicza 2A Street, 15-230 Białystok, Poland
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2024, 13(11), 3257; https://doi.org/10.3390/jcm13113257
Submission received: 6 May 2024 / Revised: 27 May 2024 / Accepted: 29 May 2024 / Published: 31 May 2024
(This article belongs to the Section Clinical Rehabilitation)

Abstract

:
Background/Objectives: The most common post-acute consequences of SARS-CoV-2 include lung dysfunction, the impairment of cognitive functions and mental health, as well as the impairment of the musculoskeletal system in the form of fatigue and muscle weakness. Post-COVID-19 patients often experience impaired balance and reduced physical capacity. It is important to implement a rehabilitation program that eliminates the side effects of COVID-19 and allows for significant improvement in the patient’s functionality. The aim of our study was to assess patient functionality after a 6-week rehabilitation program on balance, foot pressure distribution, and physical capacity in post-COVID-19 patients. Methods: The clinical study group consisted of 53 people 3 months after COVID-19 infection, confirmed by a positive PCR test. Exclusion from the study included people with comorbidities that impaired balance and gait. The patients underwent a posturographic assessment—Romberg test, a baropodometric assessment—static and dynamic, and a performance assessment—a 6 min walk test determining shortness of breath on the mMRC scale, blood pressure, heart rate, and saturation. Patients participated in rehabilitation until the sixth week, after which they were assessed again. Comparisons were made using IBM SPSS Statistics 27.0 software using the Wilcoxon pairwise order test, at a significance level of p < 0.05. Results: The result of the postural control assessment showed an improvement in the ability to maintain the centre of gravity in terms of the foot support area—statistical decreases were observed in the ellipse area, from 745.28 mm2 to 453.52 mm2 (p = 0.009), as well as maximum (from 3133.5 gr/cm2 to 2994.2 gr/cm2; p = 0.065) and average load on the left foot (from 1010.1 gr/cm2 to 969.38 gr/cm2; p = 0.028). In the 6 min walk test before and after exercise, the heart rate decreased after the therapy (shortness of breath on the mMRC scale also decreased from 79.12 to 74.95). This means that patients achieved better physical fitness and efficiency. Conclusions: Rehabilitation significantly improved balance, as measured by a decrease in ellipse area during the Romberg test.

1. Introduction

Falling sick with COVID-19 results in a number of health hazards not only at the moment of infection but also in long-term sequelae after recovery [1,2]. The most frequently observed impairments include impaired respiratory function, cognitive functions, and mental functions as well as muscular functions manifesting themselves through muscle fatigue and weakness, which matters as far as a patient’s daily life is concerned [3]. Furthermore, other research indicates that it takes seven months for many patients to achieve full recovery, and a failure to do so causes persisting symptoms involving multiple-organ impairment such as impaired systemic functions, cognitive function, or neurological function [4]. Reduced physical activity or the lack of it due to a long-term hospitalisation are presumed to cause multiple-organ impairment in the case of individuals suffering from persisting COVID-19 symptoms or post-COVID-19 conditions, which may adversely impact the postural control system, for instance, while rising to an erect posture. The research indicates that post-COVID-19-hospitalised patients show impaired visual and somatosensory cognitive function in terms of erect posture [5]. Furthermore, other sources confirm the fact that post-COVID-19 patients obtain lower postural control test results as compared to the control group [6] and differ in terms of the foot pressure distribution as far as baropodometric assessment is concerned [7]. The neuromuscular system involves muscles and the nervous system to control movements of the body and maintain postural balance, and COVID-19, impairing that system, may result in long-term sequelae affecting the postural control system [8]. To prevent unfavourable post-COVID-19 symptoms, the available literature suggests implementing a hospital rehabilitation program. The results of research on the use of rehabilitation in people who have suffered from COVID-19 and were hospitalized in the ICU show an improvement in balance, muscle fitness, and strength, as well as the functioning of the respiratory system, which improves the quality of everyday life [9].

2. Purpose

The aim of this study was to conduct the functional assessment of static and dynamic baropodometric and postural control parameters and the physical capacity of patients undergoing 6-week outpatient rehabilitation, including physical efficiency training sessions as well as respiratory and multiple-organ function improvement exercises. The aim of our study was to assess the patient’s functionality after rehabilitation.

3. Methods

The clinical study was conducted at the Rehabilitation Clinic under the consent issued by the Bioethical Commission no APK.002.51.2022 at the Medical University of Białystok. The research was conducted from January 2022 to January 2023. Patients were assessed among people who were referred to a Rehabilitation Clinic for post-COVID rehabilitation. Patients participating in the study were present at each rehabilitation session. The qualified eligible patients were diagnosed at least 3 months prior to the study. At the moment of the study, no post-SARS-CoV-2 side effects were reported. Exclusion from the study included individuals with underlying conditions impairing postural control and gait such as obesity, neuromuscular disorders, neurological deficits or sensory disorders, spinal or lower limb surgery, or injury impairing stability, for instance, 2nd–3rd degree ankle joint sprain as well as the use of crutches, walking sticks, walking frames, etc., for the purpose of daily activities. The exclusion criteria also included smokers without any previous diseases or operations within internal organs such as the respiratory, cardiovascular, and digestive systems. All patients declared that their occupations did not involve physical labour.
During qualification, all patients reported dominance on the right side of both the upper and lower limbs.
Each of the patients issued informed consent to take part in the study and was notified of the effects and course of the study. The study group comprised 53 post-COVID-19 (30 women and 23 men) patients whose diagnosis had been confirmed by the clinical symptom-based examination results and positive PCR test—covering the polymerisation chain reaction (Table 1, Figure 1).
The patients suffered from moderate symptoms of the disease, the prevailing symptoms having been cough, fever, muscle pain, loss of the sense of smell, and taste disorders.
The patients underwent functional assessments to the extent of an interview, the assessment of postural control to maintain balance while standing by means of Romberg’s test, static and dynamic baropodometric parameters, as well as physical efficiency testing including blood pressure, pulse, and saturation measurement by means of a 6 min walk test. Furthermore, dyspnoea was assessed in terms of the mMRC Scale. Next, for a period of 6 weeks, the patients performed personalised training workout programmes, respiratory exercises, and multiple-organ function improvement exercises, after which they underwent a functional reassessment test procedure.
The training included resistance exercises for the upper and lower limbs, taking into account the movements of flexion and extension, abduction and adduction, as well as internal and external rotation. This was performed in two series, taking into account the number of repetitions at 70% load and the feeling of fatigue on the RPE scale up to 7. Included breathing exercises were based on relaxation exercises, extended exhalation exercises, diaphragmatic breathing exercises, and exercises increasing the respiratory movement of the lower ribs, and they were performed in two series—at the beginning and at the end of the therapy, with 10 repetitions each. So as not to lead to the patients’ hyperventilation, endurance training was performed on a cycloergonometer at a heart rate level that does not exceed an anaerobic metabolism of approx. 120–130 Hr max. The training was conducted on the basis of our own experience based on clinical work. Each patient was treated individually under the supervision of a therapist through a one-on-one method. The duration of the entire training session is 60 min of resistance exercises, 15 min on a cycloergometer, and 10 min of breathing. Resistance exercises were performed simultaneously on both limbs. (Figure 2. Description of rehabilitation patients post COVID-19).
The therapy was conducted by a qualified therapist under their constant supervision, at the same time and place, using the same device. Before and immediately after therapy, patients reported possible side effects and increased shortness of breath (above 1 on the mMRC scale). The exercises were based on the patient’s subjective feelings (Table 2).
Postural and baropodometric stability were assessed on the FreeMED Base tensometric platform by means of the dynamic, static, and postural control analysis based on a 1 min Romberg’s test with eyes closed and open. The patients were examined by means of the same device, in the same ambient conditions, at the time of a day, and by the same person performing the measurements. The measurements were analysed by means of the Free Step software version 1.3.5. The dynamic analysis involved each of the individuals under analysis, who walked a specific and equal distance on the tensometric platform while the foot pressure was being measured. Within the framework of the dynamic analysis, the right and left foot parameters were compared, namely, foot trace length (mm), gait length line (mm), foot surface (mm2), as well as the maximum and mean load (g/cm2). On the other hand, the static analysis encompassed the measurement of the foot pressure for 5 s while standing in the upright position with upper limbs. The following parameters were analysed: foot surface (cm2), foot load (%), and maximum and mean foot load (g/cm2). The postural control assessment entailed the continual measurement of the centre of the foot pressure (COP), the displacement of which enables us to obtain the balance details. The following parameters were compared: swing length (mm), surface area (mm2), speed (mm/s), and the length of the minimum and maximum swing of the patient’s centre of gravity. The 6 min walk test entailed the pre- and post-test measurement of the following parameters: systolic and diastolic blood pressure, pulse, saturation, and dyspnoea in terms of the mMRC Scale. The results obtained before and after the rehabilitation were compared. The research did not include comparisons with a control group. Only post-COVID-19 patients were assessed.
All the variables under study were quantified or ordinal. They were compared within independent groups by means of the Wilcoxon signed-rank test. All of the computations were conducted by means of the IBM SPSS Statistics 27.0 software. The statistical hypotheses were tested in terms of the statistical significance p < 0.05.

4. Results

The dynamic analysis indicated improvement—the maximum and mean left foot load in gait decreased statistically significantly, but the right foot one increased statistically insignificantly. The results showed no change with respect to the trace length, foot surface, or gait line length (Table 3). The static analysis indicated a decrease in the foot surface, and as far as the statistical significance is concerned, the whole foot surface decreased, and the left back and forefoot pressure decreased, too. Furthermore, the maximum and mean right lower limb load increased in correspondence with the previously assumed statistical significance (Table 3). The outcome of the postural control assessment indicated the capacity for improvement in maintaining the centre of gravity as far as the foot support surface is concerned. Romberg’s coefficients decreased with respect to the swings, ellipse surface, and mean speed with eyes open, and statistical significance was indicated with respect to the ellipse surface (Table 4). Saturation statistically significantly increased, and the pulse decreased throughout the course of the 6 min walk before effort. After the respiratory and physical capacity exercises, dyspnoea parameters improved in terms of the mMRC Scale—the majority of patients considered it to be at 1 and 0 after therapy. Similar results were delivered after the 6 min walk test. Pulse and dyspnoea decreased as a result of the therapy (Table 5).

5. Discussion

Post-COVID-19 syndrome constitutes a new clinical challenge that requires specific therapy involvement from the medical team for treatment and diagnosis purposes. SARS-CoV-2 infection symptoms may sustain for many months after a negative test or moderate course of the disease. The symptoms do not only refer to the lungs, which are most often affected in the first phase of the disease. Most of the time, the symptoms refer to the central and peripheral nervous system, manifesting themselves in peripheral neuropathy, headaches, dizziness, muscle pain, fatigue, memory loss, depression, or sleep disorders [10,11,12]. According to the research outcomes, the diaphragm, as the main respiratory muscle, also plays a number of essential physiological functions through the sense of pain, supporting stomach–oesophagus function, and finally through posture stabilisation supported by the lumbar spine, by means of the abdominal pressure that it produces. That fact may matter in the case of the rehabilitation of post-COVID-19 patients [13]. On the other hand, the balance assessment must be considered as the process integrating numerous stimuli, and the related notion of stability should be treated as the capability to regain balance and to lose it within the sphere that is controlled by means of many properly functioning systems, including the nervous and visual systems and the proper perception and integration of stimuli from the surrounding environment, for instance, proprioception. The analysis of the centre of the foot pressure is one of the sensitive balance assessment methods applied as an auxiliary statistical measure for postural control examination purposes [14]. On the other hand, in order to assess the gait and the migrating centre of gravity pressure, baropodometric assessment methods are applied that most frequently depict the differences in the diagnostics of rheumatic disease and related dysfunctions and foot deformities [15,16,17].
A number of studies indicate that the balance disorders occur in the case of post COVID-19 patients [10,17,18,19,20,21]. The provisional outcome of examinations carried out within a group of individuals who recovered from COVID-19 infection as compared to the healthy individuals examined before the pandemic indicate that past infection affects the baropodometric as well as postural control parameters [6,7]. Our study showed that patients coordinated actions aimed at balancing the centre of pressure during walking by loading the dominant side of the body (at the beginning of the study, all patients indicated that the right side of the body was dominant). This may suggest a benefit from breathing exercises as part of an assessment of balance-related postural control. A change in the foot surface, including the rear and forefoot, and the entire foot surface area may indicate an improvement in the efficiency of the foot muscles while maintaining the stability of the foot arch. After the therapy, the load on the lower limb changed—the load on the left foot decreased and the load on the right foot increased, which may indicate a beneficial effect of postural control on the movement of the centre of pressure to the benefit of the more efficient limb. The influence of the diaphragm, which is the main respiratory muscle and is activated during breathing exercises, on balance functions and postural stabilization was already confirmed in the works of Kocjan J. [13].
The study conducted by Leszczak J. et al. assessed the impact of rehabilitation in the case of patients who had recovered from a brain stroke or a brain stroke with concurrent COVID-19 infection to the extent of mobility and balance. The study was conducted by means of Time Up and Go testing as well as the Tinetti Test, confirming that hospital rehabilitation at an early stage after a brain stroke improved mobility and balance and mitigated the risk of falls amongst the patients after a brain stroke, both with the concurrent COVID-19 infection and without it [22].
Still, another study conducted by Paéz W. et al. was indicative of a significant improvement in quality of life and functional capacity as well as a reduction in mental and cognitive strain within an 8-week rehabilitation programme. The significant improvement was proven by a variety of physical capacity tests, including the 6 min walk test, 1 min sitting–rising test, dynamometry, the Tinetti Test, and the Berg Balance Test (p < 0.001) [23]. Accordingly, that study also indicated an improvement in the physical capacity measured by means of the 6 min walk test—the saturation and pulse parameters before the test improved, and the pulse parameters after the test improved due to the therapy that had been applied.
There are no relevant reports on the assessment of baropodometric parameters to the extent of foot pressure amongst post-COVID-19 patients after rehabilitation. However, researchers undertook the assessment of gait and respiratory function in the case of a patient who had undergone a severe COVID-19 course by means of a robot workout. The patient—a 48-year-old woman who had undergone a severe COVID-19 course—was subject to the 6-week hospital rehabilitation programme. The patient showed persisting lung function and physical capacity impairment, including gait and balance control disorders. After the training workout, the maximum inspiratory pressure and maximum exhalation pressure improved, the gait pace accelerated, and the balance control improved, too. As far as the physical efficiency was concerned, the distance covered during the 6 min walk test lengthened with concurrent pulse and saturation improvement [24]. The aforementioned study is indicative of similar results to those shown here.
An improvement in the result of the 6 min walk test was also achieved under the study conducted by Nopp S. et al. Patients improved their test results by 62.9 m (±48.2, p < 0.001) on average; moreover, a significant improvement was delivered with respect to dyspnoea (p < 0.001), fatigue (p < 0.001) and quality of life (p < 0.001). The lung function parameters (the expiratory volume per 1s, the lung diffusion capacity, and the inspiratory pressure increased) improved throughout the rehabilitation course. This result allows us plausibly to state that in patients who underwent a severe COVID-19 course, their physical efficiency, functional condition, dyspnoea, fatigue, and quality of life improved after 6 weeks of the personalised interdisciplinary respiratory rehabilitation workout programme [25]. In our study, the patients also achieved a better physical capacity after outpatient rehabilitation including respiratory rehabilitation.
The pandemic period contributed to the occurrence of many functional disorders throughout the body.
Restrictive measures against the effects of COVID-19 taken by the governments of many countries were aimed at eliminating the spread of the pandemic, which resulted in a reduction in the number of people suffering from otitis media, which is confirmed by the work of G. Iannella and co-authors [26].
This is why comprehensive preventive measures, including systemic rehabilitation, are so important.

6. Conclusions

Physical and respiratory capacity rehabilitation was very much beneficial for patients who underwent SARS-CoV-2 infection in terms of saturation, pulse, and dyspnoea.
Notwithstanding the lack of a training workout focusing on balance control, gait, and postural stability, a positive impact was provisionally confirmed to the extent of gait and balance control amongst post-COVID-19 patients who had undergone physical capacity and respiratory rehabilitation—an amazing effect was observed on the centre of gravity migration function while walking, and foot arch shape was achieved as a result of respiratory and physical capacity therapy, notwithstanding the lack of exercises focusing on foot muscle functional capacity.
These results may confirm a key role of the diaphragm as a stabiliser muscle contributing to static and dynamic function—gait—requiring further research.
Limitations, Recommendations, and Generalizations: The study conducted had both limitations and benefits. Limitations include the fact that the results of posturgraphic and functional tests may be influenced by the patient’s resting state or mood, which may reduce test values. Future studies should consider including an additional survey assessing the patient’s mood and wakefulness. Additionally, patients’ levels of physical activity may also impact their ability to maintain balance, which should be considered in further research. The presented posturographic and clinical assessment can be used both in the offices of primary care physicians and physiotherapists to detect balance disorders in people post-COVID-19. The research did not include comparisons with a control group. Only post-COVID-19 patients were assessed.

Author Contributions

Conceptualization Z.D.-A. and A.K.; Methodology: Z.D.-A., J.D. and A.K.; Software A.D. and M.P.; Validation A.K.-M.; formal analysis: Z.D.-A. and A.K.; investigation M.P. and J.D.; resources: A.D. and A.K.; data curation: J.D. and Z.D.-A.; writing—original draft preparation: Z.D.-A. and A.K.; writing—review and editing: Z.D.-A. and A.K.; visualization: Z.D.-A. and A.K.; supervision, J.D. and A.K.-M.; project administration, Z.D.-A.; funding acquisition J.D. and Z.D.-A. All authors have read and agreed to the published version of the manuscript.

Funding

The study was financed by the Medical University of Białystok in 2024.

Institutional Review Board Statement

Bioethical Commission no APK.002.51.2022, date: 20 January 2022.

Informed Consent Statement

Written informed consent has been obtained from the patient(s) to publish this paper.

Data Availability Statement

The data presented in this study are available on request from the corresponding author due to (The data presented in this study are made available at the request of the corresponding author due to the limitations of RODO data availability).

Conflicts of Interest

The authors report no conflicts of interest. All the authors have read the content of the manuscript and agree that there is no financial interest to report. We declare that the manuscript is an original work and has not been reviewed in any other publication.

References

  1. Aziz, R.; Siles, N.; Kelley, M.; Wylie, D.; Melamed, E.; Brode, W.M. Clinical characteristics of Long COVID patients presenting to a dedicated academic post-COVID-19 clinic in Central Texas. Sci. Rep. 2023, 13, 21971. [Google Scholar] [CrossRef] [PubMed]
  2. Soriano, J.B.; Murthy, S.; Marshall, J.C.; Relan, P.; Diaz, J.V. WHO Clinical Case Definition Working Group on Post-COVID-19 Condition. A clinical case definition of post-COVID-19 condition by a Delphi consensus. Lancet Infect. Dis. 2022, 22, e102–e107. [Google Scholar] [CrossRef] [PubMed]
  3. Groff, D.; Sun, A.; Ssentongo, A.E.; Ba, D.M.; Parsons, N.; Poudel, G.R.; Lekoubou, A.; Oh, J.S.; Ericson, J.E.; Ssentongo, P.; et al. Short-term and Long-term Rates of Postacute Sequelae of SARS-CoV-2 Infection: A Systematic Review. JAMA Netw. Open 2021, 4, e2128568. [Google Scholar] [CrossRef] [PubMed]
  4. Davis, H.E.; Assaf, G.S.; McCorkell, L.; Wei, H.; Low, R.J.; Re’em, Y.; Redfield, S.; Austin, J.P.; Akrami, A. Characterizing long COVID in an international cohort: 7 months of symptoms and their impact. E Clin. Med. 2021, 38, 101019. [Google Scholar] [CrossRef] [PubMed]
  5. Fonseca, B.H.S.; de Andrade, P.H.S.; Henrique, M.E.S.A.; Baggio, J.A.O.; Bazan, R.; de Souza, L.A.P.S.; Luvizutto, G.J. Perception of verticality in the post-COVID-19 condition correlates to infection severity. J. Cent. Nerv. Syst. Dis. 2023, 15, 11795735231195693. [Google Scholar] [CrossRef] [PubMed]
  6. Dzięcioł-Anikiej, Z.; Dakowicz, A.; Dzięcioł, J.; Kopko, S.; Moskal-Jasińska, D.; Gawlikowska-Sroka, A.; Kuryliszyn-Moskal, A.; Kostro, A.M. Balance Disorders in People with History of COVID-19 in Light of Posturographic Tests. J. Clin. Med. 2023, 12, 4461. [Google Scholar] [CrossRef] [PubMed]
  7. Dzięcioł-Anikiej, Z.; Dakowicz, A.; Pociene, M.; Dzięcioł, J.; Kuryliszyn-Moskal, A.; Kostro, A.M. Analysis of Static and Dynamic Baropedographic Parameters in Post COVID-19 Patients. Acta Balneol. 2023, 5, 276–284. [Google Scholar] [CrossRef]
  8. de Sousa, K.C.A.; Gardel, D.G.; Lopes, A.J. Postural balance and its association with functionality and quality of life in non-hospitalized patients with post-acute COVID-19 syndrome. Physiother. Res. Int. 2022, 27, e1967. [Google Scholar] [CrossRef] [PubMed]
  9. Rodrigues, M.; Costa, A.J.; Santos, R.; Diogo, P.; Gonçalves, E.; Barroso, D.; Almeida, M.P.; Vaz, I.M.; Lima, A. Inpatient rehabilitation can improve functional outcomes of post-intensive care unit COVID-19 patients-a prospective study. Disabil. Rehabil. 2023, 45, 266–276. [Google Scholar] [CrossRef] [PubMed]
  10. Gervasoni, F.; LoMauro, A.; Ricci, V.; Salce, G.; Andreoli, A.; Visconti, A.; Pantoni, L. Balance and visual reliance in post-COVID syndrome patients assessed with a robotic system: A multi-sensory integration deficit. Neurol. Sci. 2022, 43, 85–88. [Google Scholar] [CrossRef] [PubMed]
  11. Hu, J.; Jolkkonen, J.; Zhao, C. Neurotropism of SARS-CoV-2 and its neuropathological alterations: Similarities with other coronaviruses. Neurosci. Biobehav. Rev. 2020, 119, 184–193. [Google Scholar] [CrossRef] [PubMed]
  12. Fernandez, C.E.; Franz, C.K.; Ko, J.H.; Walter, J.M.; Koralnik, I.J.; Ahlawat, S.; Deshmukh, S. Imaging review of peripheral nerve injuries in patients with COVID-19. Radiology 2021, 298, E117–E130. [Google Scholar] [CrossRef] [PubMed]
  13. Kocjan, J.; Gzik-Zroska, B.; Nowakowska, K.; Burkacki, M.; Suchoń, S.; Michnik, R.; Czyżewski, D.; Adamek, M. Impact of diaphragm function parameters on balance maintenance. PLoS ONE 2018, 13, e0208697. [Google Scholar] [CrossRef] [PubMed]
  14. Błaszczyk, J.W.; Czerwosz, L. Stabilność posturalna w procesie starzenia. Gerontol. Pol. 2005, 13, 25–36. [Google Scholar]
  15. De la Torre, J.; Marin, J.; Polo, M.; Marin, J.J. Applying the Minimal Detectable Change of a Static and Dynamic Balance Test Using a Portable Stabilometric Platform to Individually Asses Patients with Balance Disorders. Healthcare 2020, 8, 402. [Google Scholar] [CrossRef] [PubMed]
  16. Konarzewski, P.; Konarzewska, U.; Kuryliszyn-Moskal, A.; Terlikowska, R.; Pauk, J.; Daunoraviciene, K.; Dakowicz, A.; Wojciuk, M.; Dzięcioł, J.; Dzięcioł-Anikiej, Z. What Influences Proprioceptive Impairments in Patients with Rheumatic Diseases? Analysis of Different Factors. Int. J. Environ. Res. Public Health 2023, 20, 3698. [Google Scholar] [CrossRef] [PubMed]
  17. Kuryliszyn-Moskal, A.; Hryniewicz, A.; Bagiński, N.; Moskal-Jasińska, D.; Dzięcioł-Anikiej, Z.; Dzięcioł, J. Foot static disturbances and clinical features in overweight patients with rheumatoid arthritis. Arch. Med. Sci. 2020, 19, 1774–1780. [Google Scholar] [CrossRef] [PubMed]
  18. Corrêa, B.D.C.; Santos, E.G.R.; Belgamo, A.; Pinto, G.H.L.; Xavier, S.S.; Silva, C.C.; Dias, Á.R.N.; Paranhos, A.C.M.; Cabral, A.D.S.; Callegari, B.; et al. Smartphone-based evaluation of static balance and mobility in long-lasting COVID-19 patients. Front. Neurol. 2023, 14, 1277408. [Google Scholar] [CrossRef]
  19. Hayes, L.D.; Sanal-Hayes, N.E.M.; Mclaughlin, M.; Berry, E.C.J.; Sculthorpe, N.F. People with Long Covid and ME/CFS Exhibit Similarly Impaired Balance and Physical Capacity: A Case-Case-Control Study. Am. J. Med. 2023; in press. [Google Scholar] [CrossRef]
  20. Cheung, G.; Beyene, K.; Yan Chan, A.H.; Drayton, B.A.; Jamieson, H.; Lyndon, M.; Hikaka, J.; Ma’u, E.; Meehan, B.; Walker, X.; et al. Falls Risk in Long-Term Care Residents with Cognitive Impairment: Effects of COVID-19 Pandemic. J. Am. Med. Dir. Assoc. 2024, 25, 177–182. [Google Scholar] [CrossRef] [PubMed]
  21. Alshehri, F.H. The effect of COVID-19 on the risk of falling in old age adult patients: A cross-sectional study. Eur. Rev. Med. Pharmacol. Sci. 2024, 28, 829–835. [Google Scholar] [CrossRef]
  22. Leszczak, J.; Pyzińska, J.; Baran, J.; Baran, R.; Bylicki, K.; Pop, T. Assessment of functional fitness impacted by hospital rehabilitation in post-stroke patients who additionally contracted COVID-19. PeerJ 2024, 12, e16710. [Google Scholar] [CrossRef] [PubMed]
  23. Paéz, V.; Rodriguez-Fernandez, M.; Morales, D.; Torres, C.; Ardiles, A.; Soza, S.; Bustos, C.; Manríquez, F.; García, C.; Rocco, R.; et al. Quality of life, exercise capacity, cognition, and mental health of Chilean patients after COVID-19: An experience of a multidisciplinary rehabilitation program at a physical and rehabilitation medicine unit. Front. Rehabil. Sci. 2023, 4, 1274180. [Google Scholar] [CrossRef] [PubMed]
  24. Lee, J.S.; Baek, C.Y.; Kim, H.D.; Kim, D.Y. Effect of robot-assisted stair climbing training as part of a rehabilitation program to improve pulmonary function, gait performance, balance, and exercise capacity in a patient after severe coronavirus disease 2019: A case report. Physiother. Theory Pract. 2023, 1–7. [Google Scholar] [CrossRef] [PubMed]
  25. Nopp, S.; Moik, F.; Klok, F.A.; Gattinger, D.; Petrovic, M.; Vonbank, K.; Koczulla, A.R.; Ay, C.; Zwick, R.H. Outpatient Pulmonary Rehabilitation in Patients with Long COVID Improves Exercise Capacity, Functional Status, Dyspnea, Fatigue, and Quality of Life. Respiration 2022, 101, 593–601. [Google Scholar] [CrossRef] [PubMed]
  26. Iannella, G.; Magliulo, G.; Lechien, J.R.; Maniaci, A.; Perrone, T.; Frasconi, P.C.; De Vito, A.; Martone, C.; Ferlito, S.; Cocuzza, S.; et al. Impact of COVID-19 pandemic on the incidence of otitis media with effusion in adults and children: A multicenter study. Eur. Arch. Otorhinolaryngol. 2022, 279, 2383–2389. [Google Scholar] [CrossRef] [PubMed] [PubMed Central]
Figure 1. Age in COVID-19 Group.
Figure 1. Age in COVID-19 Group.
Jcm 13 03257 g001
Figure 2. Description of rehabilitation patients post COVID-19.
Figure 2. Description of rehabilitation patients post COVID-19.
Jcm 13 03257 g002
Table 1. Demographic description of COVID-19 group.
Table 1. Demographic description of COVID-19 group.
BMIAge
GendernMeanMedianMinMaxMeanMedianMinMax
Woman3028.2827.6821.2640.7554.2355.0027.0085.00
Man2329.8329.8329.8329.8354.0455.0030.0086.00
Table 2. Descriptors for resistance training interventions.
Table 2. Descriptors for resistance training interventions.
DescriptorExample
Load magnitude70% 1RM
Maximal number of repetitions based on RPE (rating of perceived exertion) scale of 710
Number of sets2
Rest in between sets (seconds or minutes)1 min
Number of exercise interventions (per day or week)3 per week
Duration of the experimental period (days or weeks)6 weeks
Fractional and temporal distribution of the contraction modes per repetition and duration (seconds) of one repetition4 s shortening, 1 s isometric, 4 s lengthening
Rest in between repetitions (seconds or minutes)None
Range of motion100%
Recovery time in between exercise sessions (hours or days)48 h
Anatomical definition of the exerciseYes, must be included
Table 3. Dynamic and static analysis of the patients before and after the therapy.
Table 3. Dynamic and static analysis of the patients before and after the therapy.
MeanStandard DeviationMinimumQ1MedianQ3Maximump
Dynamic AnalysisTrace Length LF mmBefore Therapy252.3921.75220.19232.82249.23268.73308.180.072
After Therapy250.6923.98210.17237.64245.61261.74354.61
Trace Length RF mmBefore Therapy254.7926.46194.08234.76250.57276.69341.970.566
After Therapy252.7724.38210.73234.24250.17270.01309.57
Gait Line Length LF mmBefore Therapy213.8430.6460.21204217.83235.28255.050.695
After Therapy218.2419.44165.08205.79217.83232.11275.39
Gait Line Length RF mmBefore Therapy217.6325.6147.14201.15215.52240.05270.60.11
After Therapy214.4722.3165200.88217.08230.68267
Surface LF cm2Before Therapy117.6817.6784104116129.51530.678
After Therapy117.6620.4881103120131.5175
Surface RF cm2Before Therapy119.1520.5282101119131.51670.832
After Therapy118.4323.2680101116129.5195
Max Load LF gr/cm2Before Therapy3133.5442.87210828043100338441720.005
After Therapy2944.2381.122002686294831484068
Max Load RF gr/cm2Before Therapy3021.4462.36218826982944334446840.175
After Therapy3536.83226.72192828463152337026382
Mean Load LF gr/cm2Before Therapy1010.1145.6775588810031090.513550.028
After Therapy969.38126.757228719821046.51365
Mean Load RF gr/cm2Before Therapy963.36164.29664843.5978106714900.236
After Therapy1004163.5649928.5101110751476
Static AnalysisSurface LF cm2Before Therapy80.9822.79346579941280.01
After Therapy75.0618.893761.57486131
Surface RF cm2Before Therapy87.1124.834565881061540.653
After Therapy85.5122.61476984101153
Forefoot Surface LF cm2Before Therapy41.0216.1212304450.5740.028
After Therapy37.3812.5813273745.567
Forefoot Surface RF cm2Before Therapy46.2817.641730.548581000.492
After Therapy44.9414.31634.5465489
Back Foot Surface LF cm2Before Therapy39.949.9817343946600.015
After Therapy37.779.31831364664
Back Foot Surface RF cm2Before Therapy40.778.9723344246580.975
After Therapy40.559.724344048.564
Load LF %Before Therapy48.918.6525434854.5670.013
After Therapy45.37.92740455261
Load RF %Before Therapy51.098.653345.55257750.013
After Therapy54.77.93948556073
Max Load LF gr/cm2Before Therapy1257.1322.854831030.51240142020630.913
After Therapy1251.5295.96561047119114942042
Max Load RF gr/cm2Before Therapy1231.9297.327081017.511781428.521040.049
After Therapy1314.2293.88762111512211592.51899
Mean Load LF gr/cm2Before Therapy528.42139.39241424.5505598.59020.733
After Therapy517.75114.8267447500604912
Mean Load RF gr/cm2Before Therapy511.81124.72276425.54925658570.012
After Therapy553.92122.92327466.5522644804
Table 4. Analysis of the patients’ postural control parameters before and after the therapy.
Table 4. Analysis of the patients’ postural control parameters before and after the therapy.
Postural control parameters Swing Length OEBefore Therapy2354.98730.411092.791885.212254.82774.544215.750.195
After Therapy2210.12814.55975.241575.072149.62633.835364.26
Swing Length CEBefore Therapy2303.26714.711076.541757.72206.742713.844516.240.655
After Therapy2351.03836.93860.791826.642167.192821.855172.22
Ellipse Surface OEBefore Therapy745.281112.1273.33233.53425.5829.636758.890.009
After Therapy453.52410.2618.57185.045331.25585.8452274.39
Ellipse Surface CEBefore Therapy644.76505.7651.74255.085496.41955.962139.990.263
After Therapy561.28498.7562.23214.27463.39734.8652801.3
Mean Speed OEBefore Therapy38.712.0617.931.2736.9545.53570.940.18
After Therapy36.2713.3715.9525.83535.243.20588.02
Mean Speed CEBefore Therapy37.8711.7117.6729.53536.2544.47574.130.687
After Therapy38.5913.714.1230.0735.5746.2584.66
Max Deviation OEBefore Therapy2.372.550.921.551.862.25518.810.054
After Therapy1.860.780.951.421.732.0856.24
Max Deviation CEBefore Therapy2.141.131.231.5951.942.328.810.888
After Therapy2.110.930.861.471.832.455.19
Min Deviation OEBefore Therapy0.0030.00460000.010.010.251
After Therapy0.0040.00490000.010.01
Min Deviation CEBefore Therapy0.0040.00490000.010.010.336
After Therapy0.00490.0050000.010.01
Table 5. Comparison of the effect before and after the therapy with respect to dyspnoea in terms of mMRC Scale, saturation, systolic pressure, diastolic pressure, and pulse before and after the 6 min walk test [own source].
Table 5. Comparison of the effect before and after the therapy with respect to dyspnoea in terms of mMRC Scale, saturation, systolic pressure, diastolic pressure, and pulse before and after the 6 min walk test [own source].
MeanStandard DeviationMinimumQ1MedianQ3Maximump
Before the 6 min walk testDYSPNOEA mMRCBefore TherapyAfter TherapypSATURATIONBefore Therapy95.41.3693949596.25980
After Therapy97.261.589396.759898.2599
SYSTOLIC PRESSUREBefore Therapy133.9315.4797127.751371431610.242
02.40%11.90%0After Therapy131.4814.87102120.5131.5142.25159
116.70%71.40%DIASTOLIC PRESSUREBefore Therapy84.529.426378.258690.251060.121
257.10%11.90%After Therapy82.4310.3159748191106
321.40%4.80%PULSEBefore Therapy77.611.551698084.51070.033
42.40% After Therapy73.577.625269.75748092
After the 6 min walk testDYSPNOEA mMRCBefore TherapyAfter TherapypSATURATIONBefore Therapy96.571.1994969798980.088
After Therapy97.11.19496979899
SYSTOLIC PRESSUREBefore Therapy135.8121.3938126.25136.51481700.084
02.40%9.50%0After Therapy132.8813.3996125.75133.5140163
116.70%66.70%DIASTOLIC PRESSUREBefore Therapy83.887.96678084881100.172
252.40%11.90%After Therapy82.511.256276.758188137
326.20%11.90%PULSEBefore Therapy79.1212.39537079.584.51170.046
42.40% After Therapy74.959.874172758194
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.

Share and Cite

MDPI and ACS Style

Dzięcioł-Anikiej, Z.; Kuryliszyn-Moskal, A.; Pociene, M.; Dzięcioł, J.; Dakowicz, A.; Kostro, A. Clinical and Functional Effects of Rehabilitation of Patients after COVID-19 Infection. J. Clin. Med. 2024, 13, 3257. https://doi.org/10.3390/jcm13113257

AMA Style

Dzięcioł-Anikiej Z, Kuryliszyn-Moskal A, Pociene M, Dzięcioł J, Dakowicz A, Kostro A. Clinical and Functional Effects of Rehabilitation of Patients after COVID-19 Infection. Journal of Clinical Medicine. 2024; 13(11):3257. https://doi.org/10.3390/jcm13113257

Chicago/Turabian Style

Dzięcioł-Anikiej, Zofia, Anna Kuryliszyn-Moskal, Monika Pociene, Janusz Dzięcioł, Agnieszka Dakowicz, and Amanda Kostro. 2024. "Clinical and Functional Effects of Rehabilitation of Patients after COVID-19 Infection" Journal of Clinical Medicine 13, no. 11: 3257. https://doi.org/10.3390/jcm13113257

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop