Temporal Trends in Mental Disorder Rates among Patients with Colorectal Cancer: A Comprehensive Analysis
Abstract
:1. Introduction
2. Methods
2.1. Database
2.2. Study Population
2.3. Study Outcomes and Statistical Analyses
3. Results
3.1. Basic Characteristics of the Study Sample
3.2. Cumulative Incidence of Documented Psychiatric Disorders
3.3. Time Changes in the Association of CRC with Subsequent Psychiatric Disorders
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Variable | Proportion among Individuals with CRC (%) N = 15,619 | Proportion among Individuals without Cancer (%) N = 78,095 | p Value * |
---|---|---|---|
Age (Mean, SD) | 68.8 (12.4) | 68.8 (12.4) | 0.889 |
Age ≤50 | 1219 (7.8) | 6085 (7.8) | 0.999 |
Age 51–60 | 2471 (15.8) | 12,347 (15.8) | |
Age 61–70 | 4036 (25.8) | 20,176 (25.8) | |
Age 71–80 | 5325 (34.1) | 26,586 (34.0) | |
Age >80 | 2568 (16.5) | 12,901 (16.5) | |
Women | 6933 (44.4) | 34,774 (44.5) | 0.749 |
Men | 8686 (55.6) | 43,321 (55.5) | |
2005–2010 | 3782 (21.0) | 16,320 (20.9) | |
2011–2016 | 5882 (37.7) | 29,367 (37.6) | 0.912 |
2017–2022 | 6455 (41.3) | 32,408 (41.5) | |
Number of physician visits per year during the follow-up (Mean, SD) | 8.2 (4.5) | 8.2 (4.5) | 0.809 |
Charlson comorbidity score (Mean, SD) | 2.4 (2.0) | 2.4 (2.0) | 0.789 |
Patients Group | 2005–2010 | 2011–2016 | 2017–2022 |
---|---|---|---|
HR (95% CI) | HR (95% CI) | HR (95% CI) | |
Any psychiatric disorder | 1.64 (1.41–1.92) * | 1.86 (1.68–2.08) * | 1.90 (1.72–2.10) * |
Depression | 1.73 (1.45–2.07) * | 1.93 (1.70–2.19) * | 2.08 (1.83–2.36) * |
Anxiety | 1.86 (1.24–2.79) * | 1.81 (1.40.2.35) * | 2.59 (2.11–3.17) * |
Reaction to severe stress and adjustment disorder | 1.31 (0.91–1.89) | 1.67 (1.36–2.05) * | 1.55 (1.31–1.84) * |
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Roderburg, C.; Loosen, S.H.; Leyh, C.; Krieg, A.; Krieg, S.; Jördens, M.; Luedde, T.; Kostev, K. Temporal Trends in Mental Disorder Rates among Patients with Colorectal Cancer: A Comprehensive Analysis. J. Clin. Med. 2024, 13, 3649. https://doi.org/10.3390/jcm13133649
Roderburg C, Loosen SH, Leyh C, Krieg A, Krieg S, Jördens M, Luedde T, Kostev K. Temporal Trends in Mental Disorder Rates among Patients with Colorectal Cancer: A Comprehensive Analysis. Journal of Clinical Medicine. 2024; 13(13):3649. https://doi.org/10.3390/jcm13133649
Chicago/Turabian StyleRoderburg, Christoph, Sven H. Loosen, Catherine Leyh, Andreas Krieg, Sarah Krieg, Markus Jördens, Tom Luedde, and Karel Kostev. 2024. "Temporal Trends in Mental Disorder Rates among Patients with Colorectal Cancer: A Comprehensive Analysis" Journal of Clinical Medicine 13, no. 13: 3649. https://doi.org/10.3390/jcm13133649