Abstract
Chronic wounds pose a significant clinical challenge due to their complex pathophysiology and the burden of long-term management. Monoclonal antibodies (mAbs) are emerging as a novel therapeutic option in managing difficult wounds, although comprehensive data on their use in wound care are lacking. This study aimed to explore existing scientific knowledge of mAbs in treating chronic wounds based on a rationale of direct inhibition of the main molecules involved in the underlying inflammatory pathophysiology. We performed a literature review excluding primary inflammatory conditions with potential ulcerative outcomes (e.g., hidradenitis suppurativa). mAbs were effective in treating wounds from 16 different etiologies. The most commonly treated conditions were pyoderma gangrenosum (treated with 12 different mAbs), lipoid necrobiosis, and cutaneous vasculitis (each treated with 3 different mAbs). Fourteen mAbs were analyzed in total. Rituximab was effective in 43.75% of cases (7/16 diseases), followed by tocilizumab (25%, 4/16 diseases), and both etanercept and adalimumab (18.75%, 3/16 conditions each). mAbs offer therapeutic potential for chronic wounds unresponsive to standard treatments. However, due to the complex molecular nature of wound healing, no single target molecule can be identified. Therefore, the use of mAbs should be considered as a translational approach for limited cases of multi-resistant conditions.
Share and Cite
MDPI and ACS Style
Manzo Margiotta, F.; Michelucci, A.; Fidanzi, C.; Granieri, G.; Salvia, G.; Bevilacqua, M.; Janowska, A.; Dini, V.; Romanelli, M.
Monoclonal Antibodies in the Management of Inflammation in Wound Healing: An Updated Literature Review. J. Clin. Med. 2024, 13, 4089.
https://doi.org/10.3390/jcm13144089
AMA Style
Manzo Margiotta F, Michelucci A, Fidanzi C, Granieri G, Salvia G, Bevilacqua M, Janowska A, Dini V, Romanelli M.
Monoclonal Antibodies in the Management of Inflammation in Wound Healing: An Updated Literature Review. Journal of Clinical Medicine. 2024; 13(14):4089.
https://doi.org/10.3390/jcm13144089
Chicago/Turabian Style
Manzo Margiotta, Flavia, Alessandra Michelucci, Cristian Fidanzi, Giammarco Granieri, Giorgia Salvia, Matteo Bevilacqua, Agata Janowska, Valentina Dini, and Marco Romanelli.
2024. "Monoclonal Antibodies in the Management of Inflammation in Wound Healing: An Updated Literature Review" Journal of Clinical Medicine 13, no. 14: 4089.
https://doi.org/10.3390/jcm13144089
Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details
here.
Article Metrics
Article Access Statistics
For more information on the journal statistics, click
here.
Multiple requests from the same IP address are counted as one view.