Next Article in Journal
Anti-Inflammatory and Anti-Oxidant Properties of N-Acetylcysteine: A Fresh Perspective
Previous Article in Journal
Novel Techniques and Technologies for Surgical Aortic Valve Replacement: A Large Retrospective Cohort Analysis
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
JCM
Volume 13
Issue 14
10.3390/jcm13144128
jcm-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Decreased Cerebral Creatine and N-Acetyl Aspartate Concentrations after Severe COVID-19 Infection: A Magnetic Resonance Spectroscopy Study

by
Jelena Ostojic
1,*,
Dusko Kozic
1,
Sergej Ostojic
2,
Aleksandra DJ Ilic
1,
Vladimir Galic
1,
Jovan Matijasevic
1,
Dusan Dragicevic
3,
Otto Barak
1 and
Jasmina Boban
1
1
Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia
2
Faculty of Sport and Physical Education, University of Novi Sad, 21000 Novi Sad, Serbia
3
Oncology Institute of Vojvodina, Diagnostic Imaging Center, 21204 Sremska Kamenica, Serbia
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2024, 13(14), 4128; https://doi.org/10.3390/jcm13144128
Submission received: 25 May 2024 / Revised: 30 June 2024 / Accepted: 11 July 2024 / Published: 15 July 2024
(This article belongs to the Section Infectious Diseases)
Browse Figures
Versions Notes

Abstract

Background/Objectives: The aim of this study was to evaluate brain metabolism using MR spectroscopy (MRS) after recovery from Coronavirus disease (COVID-19) and to test the impact of disease severity on brain metabolites. Methods: We performed MRS on 81 individuals (45 males, 36 females, aged 40–60), who had normal MRI findings and had recovered from COVID-19, classifying them into mild (17), moderate (36), and severe (28) groups based on disease severity during the acute phase. The study employed two-dimensional spectroscopic imaging above the corpus callosum, focusing on choline (Cho), creatine (Cr), and N-acetylaspartate (NAA). We analyzed Cho/Cr and NAA/Cr ratios as well as absolute concentrations using water as an internal reference. Results: Results indicated that the Cho/Cr ratio was higher with increasing disease severity, while absolute Cho and NAA/Cr ratios showed no significant differences across the groups. Notably, absolute Cr and NAA levels were significantly lower in patients with severe disease. Conclusions: These findings suggest that the severity of COVID-19 during the acute phase is associated with significant changes in brain metabolism, marked by an increase in Cho/Cr ratios and a reduction in Cr and NAA levels, reflecting substantial metabolic alterations post-recovery.
Keywords: magnetic resonance spectroscopy; COVID-19; creatine; N-acetylaspartate; absolute metabolite concentrations; neuroinflammation; noninvasive biomarkers magnetic resonance spectroscopy; COVID-19; creatine; N-acetylaspartate; absolute metabolite concentrations; neuroinflammation; noninvasive biomarkers

Share and Cite

MDPI and ACS Style

Ostojic, J.; Kozic, D.; Ostojic, S.; Ilic, A.D.; Galic, V.; Matijasevic, J.; Dragicevic, D.; Barak, O.; Boban, J. Decreased Cerebral Creatine and N-Acetyl Aspartate Concentrations after Severe COVID-19 Infection: A Magnetic Resonance Spectroscopy Study. J. Clin. Med. 2024, 13, 4128. https://doi.org/10.3390/jcm13144128

AMA Style

Ostojic J, Kozic D, Ostojic S, Ilic AD, Galic V, Matijasevic J, Dragicevic D, Barak O, Boban J. Decreased Cerebral Creatine and N-Acetyl Aspartate Concentrations after Severe COVID-19 Infection: A Magnetic Resonance Spectroscopy Study. Journal of Clinical Medicine. 2024; 13(14):4128. https://doi.org/10.3390/jcm13144128

Chicago/Turabian Style

Ostojic, Jelena, Dusko Kozic, Sergej Ostojic, Aleksandra DJ Ilic, Vladimir Galic, Jovan Matijasevic, Dusan Dragicevic, Otto Barak, and Jasmina Boban. 2024. "Decreased Cerebral Creatine and N-Acetyl Aspartate Concentrations after Severe COVID-19 Infection: A Magnetic Resonance Spectroscopy Study" Journal of Clinical Medicine 13, no. 14: 4128. https://doi.org/10.3390/jcm13144128

APA Style

Ostojic, J., Kozic, D., Ostojic, S., Ilic, A. D., Galic, V., Matijasevic, J., Dragicevic, D., Barak, O., & Boban, J. (2024). Decreased Cerebral Creatine and N-Acetyl Aspartate Concentrations after Severe COVID-19 Infection: A Magnetic Resonance Spectroscopy Study. Journal of Clinical Medicine, 13(14), 4128. https://doi.org/10.3390/jcm13144128

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop