Next Article in Journal
Safe Transition from Open to Total Minimally Invasive Esophagectomy for Cancer Utilizing Process Management Methodology
Previous Article in Journal
Remimazolam and Its Place in the Current Landscape of Procedural Sedation and General Anesthesia
 
 
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Review

Towards New Methodology for Cross-Validation of Clinical Evaluation Scales and Functional MRI in Psychiatry

1
Faculty of Medicine, Medical University, 4002 Plovdiv, Bulgaria
2
Department of Psychiatry, Medical University Plovdiv, 4000 Plovdiv, Bulgaria
3
Research Institute & Strategic Research and Innovation Program for the Development of MU-PLOVDIV–(SRIPD-MUP), European Union-NextGenerationEU, 4002 Plovdiv, Bulgaria
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2024, 13(15), 4363; https://doi.org/10.3390/jcm13154363 (registering DOI)
Submission received: 1 July 2024 / Revised: 14 July 2024 / Accepted: 23 July 2024 / Published: 25 July 2024

Abstract

Objective biomarkers have been a critical challenge for the field of psychiatry, where diagnostic, prognostic, and theranostic assessments are still based on subjective narratives. Psychopathology operates with idiographic knowledge and subjective evaluations incorporated into clinical assessment inventories, but is considered to be a medical discipline and, as such, uses medical intervention methods (e.g., pharmacological, ECT; rTMS; tDCS) and, therefore, is supposed to operate with the language and methods of nomothetic networks. The idiographic assessments are provisionally “quantified” into “structured clinical scales” to in some way resemble nomothetic measures. Instead of fostering data merging and integration, this approach further encapsulates the clinical psychiatric methods, as all other biological tests (molecular, neuroimaging) are performed separately, only after the clinical assessment has provided diagnosis. Translational cross-validation of clinical assessment instruments and fMRI is an attempt to address the gap. The aim of this approach is to investigate whether there exist common and specific neural circuits, which underpin differential item responses to clinical self-rating scales during fMRI sessions in patients suffering from the two main spectra of mental disorders: schizophrenia and major depression. The current status of this research program and future implications to promote the development of psychiatry as a medical discipline are discussed.
Keywords: fMRI; neuroscience; paranoid-depressive; review; scale; translational; connectivity; task-based; rs-fMRI fMRI; neuroscience; paranoid-depressive; review; scale; translational; connectivity; task-based; rs-fMRI

Share and Cite

MDPI and ACS Style

Najar, D.; Dichev, J.; Stoyanov, D. Towards New Methodology for Cross-Validation of Clinical Evaluation Scales and Functional MRI in Psychiatry. J. Clin. Med. 2024, 13, 4363. https://doi.org/10.3390/jcm13154363

AMA Style

Najar D, Dichev J, Stoyanov D. Towards New Methodology for Cross-Validation of Clinical Evaluation Scales and Functional MRI in Psychiatry. Journal of Clinical Medicine. 2024; 13(15):4363. https://doi.org/10.3390/jcm13154363

Chicago/Turabian Style

Najar, Diyana, Julian Dichev, and Drozdstoy Stoyanov. 2024. "Towards New Methodology for Cross-Validation of Clinical Evaluation Scales and Functional MRI in Psychiatry" Journal of Clinical Medicine 13, no. 15: 4363. https://doi.org/10.3390/jcm13154363

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop