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Towards New Methodology for Cross-Validation of Clinical Evaluation Scales and Functional MRI in Psychiatry
by
Diyana Najar
Diyana Najar 1
,
Julian Dichev
Julian Dichev 1 and
Drozdstoy Stoyanov
Drozdstoy Stoyanov 2,3,*
1
Faculty of Medicine, Medical University, 4002 Plovdiv, Bulgaria
2
Department of Psychiatry, Medical University Plovdiv, 4000 Plovdiv, Bulgaria
3
Research Institute & Strategic Research and Innovation Program for the Development of MU-PLOVDIV–(SRIPD-MUP), European Union-NextGenerationEU, 4002 Plovdiv, Bulgaria
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2024, 13(15), 4363; https://doi.org/10.3390/jcm13154363 (registering DOI)
Submission received: 1 July 2024
/
Revised: 14 July 2024
/
Accepted: 23 July 2024
/
Published: 25 July 2024
Abstract
Objective biomarkers have been a critical challenge for the field of psychiatry, where diagnostic, prognostic, and theranostic assessments are still based on subjective narratives. Psychopathology operates with idiographic knowledge and subjective evaluations incorporated into clinical assessment inventories, but is considered to be a medical discipline and, as such, uses medical intervention methods (e.g., pharmacological, ECT; rTMS; tDCS) and, therefore, is supposed to operate with the language and methods of nomothetic networks. The idiographic assessments are provisionally “quantified” into “structured clinical scales” to in some way resemble nomothetic measures. Instead of fostering data merging and integration, this approach further encapsulates the clinical psychiatric methods, as all other biological tests (molecular, neuroimaging) are performed separately, only after the clinical assessment has provided diagnosis. Translational cross-validation of clinical assessment instruments and fMRI is an attempt to address the gap. The aim of this approach is to investigate whether there exist common and specific neural circuits, which underpin differential item responses to clinical self-rating scales during fMRI sessions in patients suffering from the two main spectra of mental disorders: schizophrenia and major depression. The current status of this research program and future implications to promote the development of psychiatry as a medical discipline are discussed.
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MDPI and ACS Style
Najar, D.; Dichev, J.; Stoyanov, D.
Towards New Methodology for Cross-Validation of Clinical Evaluation Scales and Functional MRI in Psychiatry. J. Clin. Med. 2024, 13, 4363.
https://doi.org/10.3390/jcm13154363
AMA Style
Najar D, Dichev J, Stoyanov D.
Towards New Methodology for Cross-Validation of Clinical Evaluation Scales and Functional MRI in Psychiatry. Journal of Clinical Medicine. 2024; 13(15):4363.
https://doi.org/10.3390/jcm13154363
Chicago/Turabian Style
Najar, Diyana, Julian Dichev, and Drozdstoy Stoyanov.
2024. "Towards New Methodology for Cross-Validation of Clinical Evaluation Scales and Functional MRI in Psychiatry" Journal of Clinical Medicine 13, no. 15: 4363.
https://doi.org/10.3390/jcm13154363
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