Prevalence of Thrombocytopenia in Pregnant Women with COVID-19: A Systematic Review and Meta-Analysis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Research Question and Eligibility Criteria
2.1.1. Inclusion Criteria
- Population: pregnant women.
- Exposure: COVID-19.
- Comparator: not applicable.
- Outcome: thrombocytopenia.
- Study design: prospective or retrospective observational studies (cross-sectional, case-control, or cohort studies), case studies and case series.
- Publication language: English or Spanish.
2.1.2. Exclusion Criteria
- Articles that did not report the prevalence of thrombocytopenia;
- Letters to the editor, personal opinions, books, book chapters, non-original reports, reviews, conference abstracts, editorials, commentaries or articles that did not contribute to or complement the study objectives;
- Articles in which the full text could not be obtained.
2.2. Sources of Information and Search Strategy
2.3. Selection of Studies
2.4. Data Extraction
2.5. Quality Assessment
2.6. Data Synthesis and Statistical Analysis
3. Results
Results of the Meta-Analysis
4. Discussion
Limitations
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Reference | Country | Type of Study | Sample Total | COVID-19 Cases | Thrombocytopenia Cases (n) | Prevalence (%) |
---|---|---|---|---|---|---|
Hirshberg A, 2019 [19] | USA | Case series | 5 | 1 | 1 | |
Tang MW, 2020 [29] | The Netherlands | Case report | 1 | 1 | 1 | |
Gouez AL, 2020 [30] | France | Case series | 3 | 3 | 3 | |
Kim J-H, 2020 [31] | USA | Case report | 1 | 1 | 1 | |
Nesr G, 2020 [32] | UK | Case report | 1 | 1 | 1 | |
Pereira A, 2020 [33] | Spain | Retrospective, observational | 60 | 20 | 5 | 25% |
Mendoza M, 2020 [34] | Spain | Prospective, observational | 42 | 42 | 1 | 2.4% |
Yang H, 2020 [35] | China | Retrospective, observational | 27 | 4 | 3 | 75% |
Braga LFB, 2020 [36] | Brazil | Case report | 1 | 1 | 1 | |
Yu N, 2020 [37] | China | Retrospective, observational | 7 | 7 | 2 | 29% |
Schnettler WT, 2020 [38] | USA | Case report | 1 | 1 | 1 | |
Federici L, 2020 [39] | France | Case report | 1 | 1 | 1 | |
Zheng T, 2020 [40] | China | Case report | 2 | 2 | 0 | |
Cao D, 2020 [41] | China | Case report | 2 | 2 | 2 | |
Al-Matary A, 2021 [42] | Saudi Arabia | Retrospective, observational | 288 | 288 | 35 | 12.15% |
Moltner S, 2021 [43] | Canada | Case report | 1 | 1 | 1 | |
Hansen JN, 2021 [44] | USA | Case report | 1 | 1 | 1 | |
Chen G, 2021 [45] | China | Case Control | 20 | 20 | 4 | 20% |
Eman A, 2021 [46] | Turkey | Retrospective, observational | 19 | 19 | 5 | 26.3% |
Rawat SK, 2021 [47] | India | Case report | 1 | 1 | 0 | |
Moses ML, 2021 [48] | USA | Case report | 1 | 1 | 1 | |
Kumar S, 2021 [49] | India | Case series | 4 | 4 | 4 | |
Defez M, 2023 [50] | Spain | Prospective, observational | 153 | 153 | 19 | 12.4% |
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Murillo-Llorente, M.T.; Ventura, I.; Tomás-Aguirre, F.; Defez-Martin, M.; Martín-Díaz, M.I.; Atienza-Ramirez, S.; Llorca-Colomer, F.; Asins-Cubells, A.; Legidos-García, M.E.; Pérez-Bermejo, M. Prevalence of Thrombocytopenia in Pregnant Women with COVID-19: A Systematic Review and Meta-Analysis. J. Clin. Med. 2024, 13, 4980. https://doi.org/10.3390/jcm13174980
Murillo-Llorente MT, Ventura I, Tomás-Aguirre F, Defez-Martin M, Martín-Díaz MI, Atienza-Ramirez S, Llorca-Colomer F, Asins-Cubells A, Legidos-García ME, Pérez-Bermejo M. Prevalence of Thrombocytopenia in Pregnant Women with COVID-19: A Systematic Review and Meta-Analysis. Journal of Clinical Medicine. 2024; 13(17):4980. https://doi.org/10.3390/jcm13174980
Chicago/Turabian StyleMurillo-Llorente, María Teresa, Ignacio Ventura, Francisco Tomás-Aguirre, Marta Defez-Martin, María Inmaculada Martín-Díaz, Sandra Atienza-Ramirez, Francisco Llorca-Colomer, Adalberto Asins-Cubells, María Ester Legidos-García, and Marcelino Pérez-Bermejo. 2024. "Prevalence of Thrombocytopenia in Pregnant Women with COVID-19: A Systematic Review and Meta-Analysis" Journal of Clinical Medicine 13, no. 17: 4980. https://doi.org/10.3390/jcm13174980