Characterization of a Romanian Pediatric Population with Eosinophilic Esophagitis
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Group 1 (EoE Patients) | Group 2 (Non-EoE Patients) | p-Value | |
---|---|---|---|
Number of patients | 17 | 55 | |
Age (mean ± SD, years) | 6.34 ± 1.34 | 4.44 ± 1.22 | 0.005 |
Male (n, %) | 12 (71) | 17 (32) | 0.002 |
Urban area (n, %) | 16 (94.11) | 35 (63.63) | NS |
Z-score BMI (<−1) (n, %) | 12 (71) | 42 (73.36) | NS |
Food allergy (n, %) | 6 (35.29) | 12 (21.81) | 0.005 |
Respiratory allergy (n, %) | 4 (23.52) | 6 (10.90) | 0.005 |
Time until diagnosis (mean ± SD, months) | 14.3 ± 2.1 | 6.7 ± 1.8 | 0.005 |
Abdominal pain (n, %) | 9 (52.94) | 22 (40) | NS |
Failure to thrive (n, %) | 12 (71) | 42 (73.36) | NS |
Dysphagia (n, %) | 2 (11.76) | 0 | NA |
Halitosis (n, %) | 2 (11.76) | 15 (27.27) | <0.005 |
Vomiting (n, %) | 8 (47.05) | 28 (50.90) | NS |
Lack of appetite (n, %) | 6 (35.29) | 22 (40) | NS |
Heartburn (n, %) | 3 (17.64) | 10 (18.18) | NS |
Nausea (n, %) | 10 (58.82) | 37 (67.27) | NS |
Eructation (n, %) | 14 (82.35) | 38 (69.09) | <0.005 |
Regurgitation (n, %) | 13 (76.47) | 39 (70.90) | NS |
Chest pain (n, %) | 3 (17.64) | 11 (20) | NS |
Group 1 (EoE Patients) | Group 2 (Non-EoE Patients) | p-Value | |
---|---|---|---|
Normal mucosa (n, %) | 1 (5.88) | 0 (0) | NA |
Longitudinal furrowing (n, %) | 16 (94.11) | 5 (9.09) | 0.005 |
Decreased vascular pattern (n, %) | 13 (76.47) | 2 (3.63) | 0.005 |
Whitish exudates (n, %) | 14 (82.35) | 1 (1.81) | 0.005 |
Esophageal erosion (n, %) | 15 (88.23) | 42(73.36) | NS |
Mucosal esophageal erythema (n, %) | 16 (94.11) | 48 (87.27) | NS |
Papules/plaques (n, %) | 11 (64.70) | 2 (3.63) | 0.005 |
Trachealization/rings (n, %) | 9 (52.94) | 0 (0) | NA |
Esophageal polyp (n, %) | 0 (0) | 6 | NA |
Esophageal hernia (n, %) | 0 (0) | 0 (0) | NA |
Mucosal eosinophil count (median ± SD) | 66.67 ± 12.34 | 6.2 ± 1.1 | 0.005 |
Eosinophilia (>400 eos/μL) (n, %) | 10 (58.85%) | 10 (18.18%) | 0.005 |
Hb (median ± SD) (g/dL) | 12.7 ± 6.2 | 13.15 ± 7.6 | NS |
CRP (median ± SD) (mg/dL) | 3.7 ± 1.2 | 2.2 ± 1.7 | NS |
PLT (median ± SD) (×103/μL) | 388.45 ± 66.67 | 289.72 ± 55.98 | NS |
Serum IgE (median ± SD) (IU/mL) | 98.65 ± 12.33 | 44.24 ± 12.56 | 0.002 |
25 hydroxy vitamin D (median ± SD) (ng/mL) | 32.38 ± 9.34 | 43.23 ± 13.32 | NS |
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Tincu, I.F.; Bordei, L.E.; Gales, L.L.; Duchi, L.A.; Dobrescu, L.; Chenescu, B.T. Characterization of a Romanian Pediatric Population with Eosinophilic Esophagitis. J. Clin. Med. 2024, 13, 5041. https://doi.org/10.3390/jcm13175041
Tincu IF, Bordei LE, Gales LL, Duchi LA, Dobrescu L, Chenescu BT. Characterization of a Romanian Pediatric Population with Eosinophilic Esophagitis. Journal of Clinical Medicine. 2024; 13(17):5041. https://doi.org/10.3390/jcm13175041
Chicago/Turabian StyleTincu, Iulia Florentina, Luiza Elena Bordei, Lucica Luminita Gales, Larisa Alexandra Duchi, Loredana Dobrescu, and Bianca Teodora Chenescu. 2024. "Characterization of a Romanian Pediatric Population with Eosinophilic Esophagitis" Journal of Clinical Medicine 13, no. 17: 5041. https://doi.org/10.3390/jcm13175041