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Open AccessArticle
Evaluation of the Effect of Topical Prostaglandin Analog Treatment on Orbital Structures in Open-Angle Glaucoma with Computed Tomography
by
Berire Şeyma Durmuş Ece
Berire Şeyma Durmuş Ece 1,*,
Zübeyir Yozgat
Zübeyir Yozgat 1,
Hüseyin Bayramlı
Hüseyin Bayramlı 1,
Bunyamin Ece
Bunyamin Ece 2 and
Sonay Aydin
Sonay Aydin 3
1
Department of Ophthalmology, Kastamonu University, Kastamonu 37150, Turkey
2
Department of Radiology, Kastamonu University, Kastamonu 37150, Turkey
3
Department of Radiology, Erzincan Binali Yıldırım University, Erzincan 24100, Turkey
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2024, 13(19), 5808; https://doi.org/10.3390/jcm13195808 (registering DOI)
Submission received: 19 August 2024
/
Revised: 17 September 2024
/
Accepted: 26 September 2024
/
Published: 28 September 2024
Abstract
Background/Objectives: This study aims to evaluate the computed tomography (CT) scans of glaucoma patients using prostaglandin analogs (PGA) in one eye, investigate findings associated with prostaglandin-associated periorbitopathy (PAP), and compare these findings with those of the contralateral eyes. Methods: Patients with open-angle glaucoma who had CT images of the orbital region taken for another reason at least one month after starting PGA treatment in one eye were included in the study. Enophthalmos measurements from thin-slice CT images, along with 3D volume measurements of orbital fat tissue, periorbital muscles, and the optic nerve, were performed. Ophthalmological examination findings and treatment information were collected. The values were compared with those of the contralateral eyes of the same patients not using PGA. Intraclass correlation coefficients (ICCs) were computed to evaluate measurement repeatability. Results: Forty patients were included in the study. Among them, 29 (72.5%) used latanoprost, 9 (22.5%) used bimatoprost, and 2 (5%) used travoprost. The mean enophthalmos values on the treated side (15.5 ± 2.0 mm) were lower than on the untreated side (16.1 ± 1.4 mm), but this difference was not statistically significant (p = 0.07). In 29 patients (72.5%), enophthalmos measurements were smaller on the treated side, with 7 patients (17.5%) showing a difference of 2 mm or more. No significant correlation was found between the duration of PGA use and enophthalmos measurements (p = 0.768 r = −0.048). Additionally, no significant differences were found in orbital fat volume, total extraocular muscle volume, and optic nerve volume (p > 0.05). ICC values demonstrated excellent reliability (ICC > 0.75) for all measurements. Conclusions: We did not find significant differences in enophthalmos measurements, orbital fat volume, total muscle volume, and optic nerve volume between the PGA-treated and untreated eyes.
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MDPI and ACS Style
Durmuş Ece, B.Ş.; Yozgat, Z.; Bayramlı, H.; Ece, B.; Aydin, S.
Evaluation of the Effect of Topical Prostaglandin Analog Treatment on Orbital Structures in Open-Angle Glaucoma with Computed Tomography. J. Clin. Med. 2024, 13, 5808.
https://doi.org/10.3390/jcm13195808
AMA Style
Durmuş Ece BŞ, Yozgat Z, Bayramlı H, Ece B, Aydin S.
Evaluation of the Effect of Topical Prostaglandin Analog Treatment on Orbital Structures in Open-Angle Glaucoma with Computed Tomography. Journal of Clinical Medicine. 2024; 13(19):5808.
https://doi.org/10.3390/jcm13195808
Chicago/Turabian Style
Durmuş Ece, Berire Şeyma, Zübeyir Yozgat, Hüseyin Bayramlı, Bunyamin Ece, and Sonay Aydin.
2024. "Evaluation of the Effect of Topical Prostaglandin Analog Treatment on Orbital Structures in Open-Angle Glaucoma with Computed Tomography" Journal of Clinical Medicine 13, no. 19: 5808.
https://doi.org/10.3390/jcm13195808
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