Next Article in Journal
The Influence of Remnant Cholesterol on Cardiovascular Risk and Mortality in Patients with Non-Functional Adrenal Incidentalomas and Mild Autonomous Cortisol Secretion: A Retrospective Cohort Study
Previous Article in Journal
Unmet Financial Needs of People with Psychotic Disorders—A Cross-Sectional Study in People with Psychotic Disorders, Parents, Siblings, and Controls
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
JCM
Volume 13
Issue 19
10.3390/jcm13195946
jcm-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Desflurane Versus Sevoflurane and Postoperative Cardiac Biomarkers in Older Adults Undergoing Low- to Moderate-Risk Noncardiac Surgery—Secondary Analysis of a Prospective, Observer-Blinded, Randomized Clinical Trial

by
Alexander Taschner
1,
Christian Reiterer
1,*,
Edith Fleischmann
1,
Barbara Kabon
1,
Katharina Horvath
1,
Nikolas Adamowitsch
1,
David Emler
1,
Thomas Christian
1,
Nicole Hantakova
1,
Beatrix Hochreiter
1,
Laura Höfer
1,
Magdalena List
1,
Barbara Rossi
1,
Florian W. Zenz
1,
Giulia Zanvettor
1,
Oliver Zotti
1,
Melanie Fraunschiel
2 and
Alexandra Graf
3
1
Department of Anesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria
2
IT Services and Strategic Information Management, Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria
3
Institute of Medical Statistics, Center for Medical Data Science, Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2024, 13(19), 5946; https://doi.org/10.3390/jcm13195946
Submission received: 29 August 2024 / Revised: 29 September 2024 / Accepted: 4 October 2024 / Published: 6 October 2024
(This article belongs to the Section Anesthesiology)
Browse Figures
Versions Notes

Abstract

Background/Objectives: Previous preclinical studies have shown that desflurane might have the most significant cardioprotective effect of all volatile anesthetics. However, data regarding the cardioprotective effects of desflurane versus sevoflurane are lacking. Therefore, we evaluated the effect of the maintenance of anesthesia using desflurane versus sevoflurane on the postoperative maximum concentrations of cardiac biomarkers in older adults undergoing low- to moderate-risk noncardiac surgery. Methods: In this secondary analysis of a prospective randomized trial, we included all 190 older adults undergoing low- to moderate-risk noncardiac surgery. Patients were randomized to receive desflurane or sevoflurane for the maintenance of anesthesia. We administered desflurane or sevoflurane, aiming at a BIS value of 50 ± 5. The cardiac-specific biomarkers included troponin T, NT-proBNP, and copeptin, which were measured preoperatively, within one hour after surgery, and on the second postoperative day. Results: There were no significant differences between the desflurane and sevoflurane groups in the postoperative maximum concentrations of troponin T (11 ng.L−1 [8; 16] versus 13 ng.L−1 [9; 18]; p = 0.595), NT-proBNP (196 pg.mL−1 [90; 686] versus 253 pg.mL−1 [134; 499]; p = 0.288), or copeptin (19 pmol.L−1 [7; 58] versus 12 pmol.L−1 [6; 41]; p = 0.096). We also observed no significant differences in the troponin T, NT-proBNP, or copeptin concentrations between the desflurane and sevoflurane groups at any measured timepoint (all p > 0.05). Conclusions: In contrast to preclinical studies, we did not observe a significant difference in the postoperative maximum concentrations of cardiac biomarkers. It seems likely that desflurane does not exert significant clinical meaningful cardioprotective effects in older adults. Thus, our results do not support the use of desflurane in patients undergoing low- to moderate-risk noncardiac surgery.
Keywords: desflurane; sevoflurane; cardiac biomarkers; NT-proBNP; troponin T; copeptin; low- to moderate-risk noncardiac surgery; older adults desflurane; sevoflurane; cardiac biomarkers; NT-proBNP; troponin T; copeptin; low- to moderate-risk noncardiac surgery; older adults

Share and Cite

MDPI and ACS Style

Taschner, A.; Reiterer, C.; Fleischmann, E.; Kabon, B.; Horvath, K.; Adamowitsch, N.; Emler, D.; Christian, T.; Hantakova, N.; Hochreiter, B.; et al. Desflurane Versus Sevoflurane and Postoperative Cardiac Biomarkers in Older Adults Undergoing Low- to Moderate-Risk Noncardiac Surgery—Secondary Analysis of a Prospective, Observer-Blinded, Randomized Clinical Trial. J. Clin. Med. 2024, 13, 5946. https://doi.org/10.3390/jcm13195946

AMA Style

Taschner A, Reiterer C, Fleischmann E, Kabon B, Horvath K, Adamowitsch N, Emler D, Christian T, Hantakova N, Hochreiter B, et al. Desflurane Versus Sevoflurane and Postoperative Cardiac Biomarkers in Older Adults Undergoing Low- to Moderate-Risk Noncardiac Surgery—Secondary Analysis of a Prospective, Observer-Blinded, Randomized Clinical Trial. Journal of Clinical Medicine. 2024; 13(19):5946. https://doi.org/10.3390/jcm13195946

Chicago/Turabian Style

Taschner, Alexander, Christian Reiterer, Edith Fleischmann, Barbara Kabon, Katharina Horvath, Nikolas Adamowitsch, David Emler, Thomas Christian, Nicole Hantakova, Beatrix Hochreiter, and et al. 2024. "Desflurane Versus Sevoflurane and Postoperative Cardiac Biomarkers in Older Adults Undergoing Low- to Moderate-Risk Noncardiac Surgery—Secondary Analysis of a Prospective, Observer-Blinded, Randomized Clinical Trial" Journal of Clinical Medicine 13, no. 19: 5946. https://doi.org/10.3390/jcm13195946

APA Style

Taschner, A., Reiterer, C., Fleischmann, E., Kabon, B., Horvath, K., Adamowitsch, N., Emler, D., Christian, T., Hantakova, N., Hochreiter, B., Höfer, L., List, M., Rossi, B., Zenz, F. W., Zanvettor, G., Zotti, O., Fraunschiel, M., & Graf, A. (2024). Desflurane Versus Sevoflurane and Postoperative Cardiac Biomarkers in Older Adults Undergoing Low- to Moderate-Risk Noncardiac Surgery—Secondary Analysis of a Prospective, Observer-Blinded, Randomized Clinical Trial. Journal of Clinical Medicine, 13(19), 5946. https://doi.org/10.3390/jcm13195946

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop