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Volume 13
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10.3390/jcm13020531
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Systematic Review

The Role of Vortioxetine in the Treatment of Depressive Symptoms in General Hospital Psychiatry: A Case-Series and PRISMA-Compliant Systematic Review of the Literature

by
Francesco Weiss
1,†,
Bruno Pacciardi
1,†,
Giulia D’Alessandro
1,
Valerio Caruso
1,
Icro Maremmani
1,2,*,
Stefano Pini
1 and
Giulio Perugi
1
1
Psychiatric Unit 2, Department of Clinical and Experimental Medicine, University of Pisa, 56121 Pisa, Italy
2
G. De Lisio Institute of Behavioural Sciences, 56121 Pisa, Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
J. Clin. Med. 2024, 13(2), 531; https://doi.org/10.3390/jcm13020531
Submission received: 15 December 2023 / Revised: 8 January 2024 / Accepted: 13 January 2024 / Published: 17 January 2024
(This article belongs to the Section Mental Health)
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Abstract

Depressive symptoms are a customary finding in hospitalized patients, particularly those who are undergoing long hospitalizations, underwent major surgical procedures or suffer from high levels of multimorbidity and frailty. The patients included in this case series shared high degrees of frailty-complexity and were evaluated within the ordinary consultation and liaison psychiatry service of the University Hospital in Pisa, Italy, from September 2021 to June 2023. Patients were administered at least one follow-up evaluation after a week and before discharge. To relate this case series to the extant literature, a comprehensive systematic review of vortioxetine safety and efficacy was performed. None of the six patients included developed serious safety issues, but one patient complained of mild-to-moderate nausea for some days after the vortioxetine introduction. Five out of six patients exhibited at least a slight clinical benefit as measured by the clinical global impression scale. Of the 858 entries screened via Scopus and Medline/PubMed, a total of 134 papers were included in our review. The present case series provides preliminary evidence for vortioxetine’s safety in this healthcare domain. The literature reviewed in this paper seems to endorse a promising safety profile and a very peculiar efficacy niche for vortioxetine in consultation and liaison psychiatry.
Keywords: vortioxetine; depressive symptoms; general hospital psychiatry vortioxetine; depressive symptoms; general hospital psychiatry

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MDPI and ACS Style

Weiss, F.; Pacciardi, B.; D’Alessandro, G.; Caruso, V.; Maremmani, I.; Pini, S.; Perugi, G. The Role of Vortioxetine in the Treatment of Depressive Symptoms in General Hospital Psychiatry: A Case-Series and PRISMA-Compliant Systematic Review of the Literature. J. Clin. Med. 2024, 13, 531. https://doi.org/10.3390/jcm13020531

AMA Style

Weiss F, Pacciardi B, D’Alessandro G, Caruso V, Maremmani I, Pini S, Perugi G. The Role of Vortioxetine in the Treatment of Depressive Symptoms in General Hospital Psychiatry: A Case-Series and PRISMA-Compliant Systematic Review of the Literature. Journal of Clinical Medicine. 2024; 13(2):531. https://doi.org/10.3390/jcm13020531

Chicago/Turabian Style

Weiss, Francesco, Bruno Pacciardi, Giulia D’Alessandro, Valerio Caruso, Icro Maremmani, Stefano Pini, and Giulio Perugi. 2024. "The Role of Vortioxetine in the Treatment of Depressive Symptoms in General Hospital Psychiatry: A Case-Series and PRISMA-Compliant Systematic Review of the Literature" Journal of Clinical Medicine 13, no. 2: 531. https://doi.org/10.3390/jcm13020531

APA Style

Weiss, F., Pacciardi, B., D’Alessandro, G., Caruso, V., Maremmani, I., Pini, S., & Perugi, G. (2024). The Role of Vortioxetine in the Treatment of Depressive Symptoms in General Hospital Psychiatry: A Case-Series and PRISMA-Compliant Systematic Review of the Literature. Journal of Clinical Medicine, 13(2), 531. https://doi.org/10.3390/jcm13020531

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